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All Journal Jurnal Anestesi Perioperatif Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Global Medical and Health Communication JPSriwijaya Sari Pediatri Biomedical Journal of Indonesia Syntax Literate: Jurnal Ilmiah Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) International Journal of Retina SRIWIJAYA JOURNAL OF MEDICINE Economics and Finance in Indonesia Oto Rhino Laryngologica Indonesiana Majalah Anestesia dan Critical Care Majalah Kedokteran Andalas Majalah Patologi Indonesia Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health) Jurnal Aisyah : Jurnal Ilmu Kesehatan Sriwijaya Journal of Surgery Indonesian Journal of Global Health research Eureka Herba Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal Of World Science Jurnal Penyakit Dalam Indonesia IJRETINA - International Journal of Retina
Muhammad Irsan Saleh
Bagian Farmakologi, Fakultas Kedokteran, Universitas Sriwijaya, Palembang, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Medica Hospitalia

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Nephrotoxicity and Kidney Fibrosis Due to Gentamicin in Wistar Rats Lusiana, Evi; Saleh, Irsan; Sinaga, Ernawati; Hafy, Zen
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.909

Abstract

Background : Gentamicin is an aminoglycoside used as a treatment for various infections. One of the side effects reported on the use of gentamicin is nephrotoxic. However, there are still many uses of gentamicin that have not been precisely indicated. Objective : To analyze the nephrotoxic effects leading to renal fibrosis due to gentamicin induction in Wistar rats. Methods : This research is an in vivo experimental study, pre- and post-test control group design, conducted in September and October 2022 at the Animal House Laboratory of the Faculty of Medicine, Sriwijaya University, and the Palembang Health Laboratory Center. There were 4 treatment groups: Group I, placebo; Group II, gentamicin-induced (GIG I) at 80 mg/kgBW; Group III, gentamicin-induced (GIG II) at 120 mg/kgBW; and Group IV, gentamicin-induced (GIG III) at 240 mg/kgBW. Gentamicin was administered intraperitoneally for 7 days, to 8 Wistar rats per group. Blood was taken from all Wistar rats in each group on days 0, 3, 7, and 14. The results of the study were tested for normality with the Shapiro-Wilk test and homogeneity with the Levene's test. The ANOVA test and the Post-Hoc test were used to conduct the analysis. Results :  Induction of gentamicin in the GIG I and GIG II groups was significant in increasing the mean creatinine and urea levels on day 0 and day 14 of treatment (p<0.05). In the GIG III group there was a 50% mortality in experimental animals showing a Lethal dose of 50 (LD50) at that dose. Conclusion : GIG I and GIG II have significant nephrotoxic effects in increasing creatinine and urea levels which lead to renal fibrosi.
Co-Authors Abdi Wijaya Abdulwahab Hakimi Ade Suryaman Aditiawati Aditiawati Adnan Abadi, Adnan Adrian, Ronny Ahmad Rasyid ahmad rasyid, ahmad Ahmad, Zen AK Ansyori Akmal, Reza Ali Ghanie Ali Ghanie Ali Ghanie Alif Fathur Rachman, Muhammad Alvilusia, Alvilusia Alwi Shahab Amir Fauzi Amir Fauzi Andi Putra Siregar Anggeria, Septa Anita Tursia Ansyori, AK Anwar, Chairil Arlis Karlina Aseptianova Aseptianova Athiah, Medina Ayeshah A Rosdah Azhari Azhari Banun, Syahri Bastian Bastian Bastian Bintang Arroyantri Prananjaya Chairil Anwar Chakra, Aerul Dalillah Dalillah Dessy Adhriyani, Dessy Dian Wahyuni Dwi Handayani Dwi Handayani Dwirini Retno Gunarti Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim, Eddy Mart Eeng Yoneska Effendi, Ian Effendi, Kms. Yusuf Efman EU Manawan Efman Manawan Efrieni Yusuf Ella Amalia, Ella Emilia Eny Rahmawati, Eny Ernawati Sinaga Erwin Sukandi Erwin Sukandi Evi Lusiana Fatmawati Fatmawati Ferdi, Roni Ferry Usnizar Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fuad Bakry Gita Dwi Prasasty Hafizzanovian, Hafizzanovian Handayati, Debby Heni Maulani, Heni Herdana, Nova Hermansyah Hu, Owen Ian Effendi Iche Andriyani Liberty, Iche Andriyani Ika Kartika Imran Saleh Irfannuddin Irfannuddin Irfanuddin Irfanuddin Istiqomah, Amelia Izzah, Puspita Nurul Jayawarsa, A.A. Ketut Joko Marwoto Jusak Nugraha Kamaluddin Kamaluddin Kartini Wulan Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kendenan, Margaretha Kesty, Cindy Kms Yusuf Effendi Krisna Murti kurniati, nova Kusrini, Ida Kusuma Harimin, Kusuma Larasati, Veny Legiran Legiran Leni Wijaya, Leni Lubis, Fadhyl Zuhry Makbruri Amin Margaretha Kendenan Maria Ulfa Mediarty Medina Athiah Mega Sary Mezfi Unita Mudinillah, Adam Muhamad Ayus Astoni Muhammad Hadi Wijaya Muhammad Haryadi Ade Kurnadi Nadia Karimah Amalia Zulfadli Nita Parisa Nova Herdana Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Novadian Novadian Novadian, Novadian Nugroho, Suroso Adi Nur Riviati, Nur Nuswil Bernolian Oktariana, Desi Pahlawan, M Kaisar Patwa Amani, Patwa Peby Maulina Lestari, Peby Maulina Phey Liana Poedji Loekitowati Hariani Purwoko, Izazi Hari Puspa Zuleika, Puspa Putra, Hadrians Kesuma Rachmat Hidayat RACHMAT HIDAYAT Radiyati Umi Partan Rahadiyanto, Kemas Ya'Kub Rahadiyanto, Kemas Ya’kub Ramadhan, Philosophia Ramzi Amin Ramzi Amin, Ramzi Ratih Pratiwi Reza Akmal Riani Erna Rieke Cahyo Budi Utami Rizal Zainal Rizani Amran Rizda, Dian Permata Rizki Andini Nawawi Ronny Adrian Rostika Dewi Rukiah Chodilawati Rukiah Chodilawati Sabri Prihantika Safyudin Salmon Charles Pardomuan Tua Siahaan Salni Salni Salni Salutondok, Welly Sari, Febrina Sary, Mega Sastradinata, Irawan Shahab, Alwi Soenarto Kartowigno Sri Nita Sri Nita Sri Nita, Sri Stevanny, Bella Subandrate Sudarto Sudarto Sulfa Esi Warni Suprapti Suprapti Suprapti Suprapti Sutandar, Vivi Hendra Syamsu Indra Syifa Alkaf Tanoehardjo, Francisca Srioetami Tanoehardjo, Francisca Srioetami Tanzil, Iswadi Tati Lahmuddin, Tati Tatit Nurseta Taufik Indrajaya Taufik Indrajaya Taufik Indrajaya Taufik Indrajaya Taufik Indrajaya Tengku Arfi Sulaiman Theodarus, Theodarus Theodorus Theodorus Tiara Fatrin Triwani Triwani Triwani Triwani Tursia, Anita Usman Said, Usman Usman, Fatimah Widyastuti Wina Safutri Wresnindyatsih Wresnindyatsih, Wresnindyatsih Yeni Agustin Yenny Dian Andayani Yesi Astri Yudhie Tanta Yulia Farida Yahya Yundari, Yundari Zen Ahmad Zen Hafy Ziske Maritska Zulfadli, Nadia Karimah Amalia Zulfiawan, Zulfiawan Zulkarnain Musa, Zulkarnain Zulkhair Ali Zulkhair Ali Zulkhair Ali Zulkifli Zulkifli Zulkifli Zulkifli