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All Journal Dialektika Bulletin of Scientific Contribution : Geology El-HARAKAH : Jurnal Budaya Islam IJOG : Indonesian Journal on Geoscience Jurnal Ilmu-Ilmu Pertanian Indonesia Jurnal RISET Geologi dan Pertambangan Journal of Degraded and Mining Lands Management Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Karet Jurnal Penelitian Sains Inklusi Journal of Disability Studies Jurnal Penelitian Pendidikan IPA (JPPIPA) IJoLE: International Journal of Language Education Syntax Literate: Jurnal Ilmiah Indonesia Diglosia: Jurnal Kajian Bahasa, Sastra, dan Pengajarannya Jurnal Mineral, Energi dan Lingkungan Jurnal Geosains dan Teknologi Jambura Geoscience Review JTP - Jurnal Teknologi Pendidikan Jurnal Geologi Kelautan: Media Hasil Penelitian Geologi Kelautan Magistra Andalusia : Jurnal Ilmu Sastra Jurnal Sastra Indonesia KOLOKIUM: Jurnal Pendidikan Luar Sekolah Jurnal Pena Indonesia Jurnal Mineral, Energi dan Lingkungan Indonesian Journal on Geoscience Jurnal Geosains dan Remote Sensing (JGRS) Jurnal Pendidikan, Sains, Geologi, dan Geofisika (GeoScienceEd Journal) Indonesian Journal on Geoscience Jurnal Cahaya Mandalika Journal of Earth and Marine Technology (JEMT) Journal of English Language and Education Bahterasia : Jurnal Ilmiah Pendidikan Bahasa dan Sastra Indonesia Journal of Language Education, Linguistics, and Culture MINERAL JURNAL TEKNIK GEOLOGI : Jurnal Ilmu Pengetahuan dan Teknologi Jurnal Indonesia Sosial Teknologi JAGE Innovative: Journal Of Social Science Research GMPI Conference Series Ranah Research : Journal of Multidisciplinary Research and Development International Proceedings of Nusantara Raya Indonesian Journal of Environment and Disaster OPHIOLITE : Jurnal Geologi Terapan Calvaria Medical Journal Bulletin of Geology Geo-Image Journal Prosiding Seminar Nasional COSMIC Kedokteran ANUFA Jurnal bahasa, sastra, seni, dan pengajarannya
Budhi Setiawan
Program Studi Teknik Geologi, Universitas Sriwijaya
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Journal : Calvaria Medical Journal

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Analisis Kejadian Adverse Drug Reaction Obat Anti-Tuberkulosis dengan Faktor Risiko pada Penderita Tuberkulosis Multi-Drug Resistant : Systematic Review Andili, Agshal Almachzumi; Setiawan, Budhi; Ama, Fuad; Raharjo, Budiono
Calvaria Medical Journal Vol 2 No 1 (2024): Edisi Juni 2024 (available online Juli 2024)
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v2i1.35

Abstract

Introduction: Tuberculosis patients must adhere to a six-month uninterrupted course of medication. The DOTS method is crucial in preventing resistance to anti-TB drugs, which can lead to stronger MDR-TB strains resistant to rifampicin and isoniazid. ADRs from these drugs include gastrointestinal disturbances, hepatotoxicity, dermatological and serious neurological disorders, prompting patients to discontinue treatment. Non-adherence can hinder tuberculosis recovery as patients tend to stop treatment. Patient compliance is pivotal in their decision to continue treatment. Therefore, further research is needed to explore the relationship between ADRs to anti-TB drugs and risk factors in active MDR-TB patients. Method: This qualitative study conducted a literature review using databases from 2014 to 2023 and keywords relevant to the study's title. Fifteen relevant journals were identified, comprising 11 international and 4 national journals. Results: The literature review found that the most influential factors in adverse drug reactions to OAT in outpatient MDR-TB patients were treatment history and medication adherence. Regarding individual factors such as age and gender, most journals indicated they are not significant risk factors for MDR-TB. Conclusion: Based on the literature review, it can be concluded that the most dominant factors affecting adverse drug reactions to OAT in outpatient MDR-TB patients are treatment history and medication adherence. As for individual factors like age and gender, nearly all journals indicate they are not significant risk factors for MDR-TB.
Peran Nutrasetikal dalam Mitigasi Inflamasi Kronis: Tinjauan Pustaka Setiawan, Budhi; Ernawati
Calvaria Medical Journal Vol 2 No 1 (2024): Edisi Juni 2024 (available online Juli 2024)
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v2i1.44

Abstract

Pendahuluan: Inflamasi kronis adalah respon biologis kompleks terhadap stimulus berbahaya seperti patogen, sel rusak, dan iritan, yang berperan penting dalam penyakit kronis.  Tujuan: Tinjauan pustaka ini bertujuan untuk menganalisis bukti ilmiah terkini mengenai mekanisme anti-inflamasi nutrasetikal dan potensi dalam mitigasi inflamasi kronis. Metode: Pencarian literatur dilakukan menggunakan PubMed, Scopus, dan Google Scholar, dengan fokus pada kata kunci seperti "nutrasetikal," "inflamasi kronis," "mekanisme anti-inflamasi," "kurkumin," "omega 3," "resveratrol," "quercetin," dan "jahe (Zingiber officinale)." Artikel yang dipilih meliputi penelitian asli, tinjauan pustaka, dan meta-analisis yang dipublikasikan dalam 10 tahun terakhir, terutama pada mekanisme kerja anti-inflamasi senyawa nutrasetikal pada. Hasil: Nutrasetikal seperti kurkumin, asam lemak omega-3, resveratrol, quercetin, dan jahe menunjukkan efek anti-inflamasi yang signifikan dengan menghambat jalur pro-inflamasi, mengurangi stres oksidatif, dan menurunkan produksi sitokin pro-inflamasi. Kurkumin menghambat enzim COX-2 dan iNOS serta menekan aktivasi NF-κB. Asam lemak omega-3 menghambat produksi eikosanoid dan memodulasi faktor transkripsi. Resveratrol menghambat aktivasi NF-κB dan mempengaruhi mikrobiota usus. Quercetin menghambat enzim COX-2 dan LOX serta memodulasi fungsi sel sel imun. Jahe mengandung senyawa bioaktif yang menghambat COX-2 dan iNOS, mengurangi stres oksidatif, dan menekan aktivasi NF-κB. Kesimpulan: Nutrasetikal menunjukkan potensi yang menjanjikan dalam mitigasi inflamasi kronis melalui berbagai mekanisme. Penelitian lebih lanjut diperlukan untuk memperjelas mekanisme molekuler dan mengembangkan pedoman klinis untuk penggunaannya.
Co-Authors Abdurrahman Hanif Albaihaqi Abimanyu, Gilang Agus Rahman Alamsyah Aldri Frinaldi Alfiati Alfuazri, M. Gilang Ama, Fuad Andayani Andayani Andayani Andili, Agshal Almachzumi Ani Rakhmawati Anton Wijaya Arief Setyawan Arieffiandhany, Riezal Asof, H. Marwan Atikah Anindyarini Atthoriq, Muhammad Hafidz Az Zahra, Salsabila Azzahra, Fade Risa Azzahra, Fadea Risa Bakri Bakri Cahyaningrum, Fitria Chaesar, Ari Suryawati Secio Chafit Ulya Charlos Togi Stevanus, Charlos Togi Dedi Rohendi Dyah Hastuti, Endang Wiwik Eddy Ibrahim Edi Riawan Edy Sutriyono Ernawati Faradila, Nanda Argi Noer Farahdila, Silvie Felicity, Felicity Firstya Evi Dianastiti Fitriani, Aula Gallant Dwi Pangestu Nugroho Akbar Gurada Capah, Ade Indra Harfiandri, Muhammad Said Harnani Harnani Harnani, Harnani Hartati, Restiana Dwi Haryanti, Rini Dwi Hastuti, Nuri Puji Hermawan, Muhammad Alfian Hibatullah, Kevin Nabil Islam, Muhammad Izzul Ismaryanto, Ismaryanto KAMIL, FADHELLATUL Kartika Ishartadiati Karyadi, Rian Khakim, Mokhamad Yusup Nur Kundharu Saddhono Kurniawan, Deviyanto Landia, Karmila Putri Lee, Jason Lusiani Tjandra Marswati, Ceria Masfufatun Masfufatun Muhammad Rohmadi Muhammad Taufik Toha Mukhlis, Muhammad Munib Ikhwatun Iman Murtianingsih Murtianingsih, Murtianingsih Nardi, Rajhi Febri Nugraheni Eko Wardani Oman Abdurahman Pebby Putra Juenda Pebrianto, Rosihan Permana, Lano Adhitya Pranata, Ridho Pratika Yuhyi Hernanda Putri, Atika Nabila Putri, Helen Dwi Putri, Zahrah Belinda RAHARJO, BUDIONO Rahaya, Ivana Septia Raheni Suhita Rahmatullah, Arif Ramadhani, Asri Kamila Rifki Aditya, Rifki Rio, Ferdinan Rizki, Kurnia Rahma Rizkie, Dania Rosihan, Pebrianto Sabaruddin Sabaruddin Safrihady, Safrihady Santoso, Nugroho Ponco Santoso, Nugroho Ponco Sari, Fatrina Aprilia Sarwiji Suwandi Setyaningsih, Arinda Oktariski Simanjuntak, Presli Panusunan Slamet Subiyantoro Sumarwati Suyeda, Fadhil D. Tri Indrayanti Utami, Sri Lestari Wahdini, Lisa Wahyu Wardana, Muhammad Aditya Wisnu Wicaksono, M. Dwiki Satrio Wijaya, Wildan Maulana Wulandari, Atik Sri Wulandari, Zhalsa Yogie Zulkurnia Rochmana Yuliningsih, Yuliningsih