Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Jurnal Medik Veteriner

Genomic Characterization of Antimicrobial Resistance Genes in Pasteurella multocida Isolates from East Nusa Tenggara and Lampung, Indonesia Prihandani, Sri Suryatmiati; Wibawan, I Wayan Teguh; Noor, Susan Maphilindawati; Ekawasti, Fitrine; Khairullah, Aswin Rafif; Purba, Hastuti Handayani S.; Puarada, Alif Rahman Rohim; Safika, Safika
Jurnal Medik Veteriner Vol. 8 No. 2 (2025): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss2.2025.368-381

Abstract

Haemorrhagic Septicaemia (HS) is a devastating disease affecting cattle and water buffaloes in Indonesia, causing annual economic losses in livestock industries, particularly in Asia, Africa, and the Middle East. Pasteurella multocida, the causative agent of the disease, has shown increasing antimicrobial resistance, complicating treatment efforts. Therefore, this study aims to provide the first genomic analysis of P. multocida isolates from different Indonesian provinces, focusing on genes conferring resistance to beta-lactam antibiotics based on Whole Genome Sequencing (WGS) results. Genomic data can be used to confirm the results of phenotypic antibiotic resistance testing. P. multocida isolates analyzed in this study were sourced from the Indonesian Research Center for Veterinary Science (IRCVS) collection, which included 2 samples originating from different geographic locations within Indonesia. The samples were subjected to biochemical, molecular, and antimicrobial susceptibility testing. WGS was performed using Oxford Nanopore Technologies (ONT) with subsequent bioinformatics analysis for genome assembly and resistance profiling. Phenotypic analysis showed significant variations between the isolates. The NTT isolate showed resistance to Penicillin, while the Lampung 2952 remained susceptible in the disk antibiotic test. Genome sequencing revealed extensive resistance determinants, including β-lactamase genes (blaZ, blaR1) in the NTT isolate, correlating with its phenotypic resistance. The high-quality genome assemblies (N50: 17,225 bp for NTT; 12,662 bp for Lampung 2952) enabled comprehensive resistome characterization, identifying more than 22 resistance genes in each isolate, including novel variants not previously reported in Indonesian strains. Therefore, this study provides the first genomic and resistance analysis based on Whole Genomic Sequencing data of Indonesian P. multocida isolates. The results show the urgent need for enhanced surveillance and prudent antimicrobial use in livestock management.
Co-Authors . Darniati A. Indrawati A.Afif Amrullah Abdul Azis Abdul Harris Ach. Agil Dzikrullah Adelia Rahayu, Misye Ademi, Gressha Vionalle Afiff , Usamah Afton Attabany Agung Puji Haryanto Agung Satryo Wibowo Agus Wijaya Agus, M. Agustin Indrawati Akhmaloka Akhmaloka Al Azhar Alfred John Morris Kompudu Alla Asmara Almanda, Wisnu Rahmadan Ambar Retnowati Ambar Retnowati Andi Novita Andriyanto Andriyanto Andriyanto Aprilia Hardiati Arif Rachman Putra ARISANDI, FAUZAN Arsih, Ulfi Widi Arsyad, Annisa Wahyuni Asri Munzilin Astuti, Yohana Tri Ayundari Cahyani Azmansyah Azmansyah Beginer Subhan Citra Oktavina Eka Lidyawati Cut Lathifa Nurrady Darajaatul Aliyah, Nelud Darmawi . Darmawi Darmawi Darmawi Darmawi Darmawi Darmawi Darmawi Darmawi Deddy Cahyadi Sutarman Destri Prameswari, Alvira Didit Darmawan Digyo, Oscar Daniel Kusumo Edi Purwanto Eko Sugeng Pribadi El Zamzami, Arfah Herawana Eli Masnawati Erdiansyah Rahmi Erdiansyah Rahmi Erina Erina Erina Erina Erina Erina F Madayanti, F Fachriyan Hasmi Pasaribu FACHRIYAN HASMI PASARIBU Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Fadjar Sumping Tjatur Rasa Faisal Jamin Faisal Jamin Faisal Jamin Fakhrurrazi Fakhrurrazi Fakhrurrazi Fakhrurrazi FAUZAN ARISANDI Fitria Sari Ramadhani Fitrine Ekawasti, Fitrine Fitriyatus Sholichah, Laila Gressha Vionalle Ademi Gunawan Budi Utomo Hadisa Nadia Handayani Halik Hanifa Hanun Hardianti, Aprilia Hariani, Mila I wayan Teguh Wibawan Ichsan Maulana Ika Mayasari, Ni Luh Putu Imam Mawardi Indah Melzana Irbar, Nur Afmi Islami, Nurfara Ismail Ismail Japar, Wahyudi Juliadi Ramadhan K. Khoirani Karen Lee Keisha Farellia Putri Lindra Khairullah, Aswin Rafif Kheyene Molekandella Boer Kombo, Muhammad Piter Kurnia Tiara Aulia Latifa Suryandari Leng , Ang Jia Luuk Schoonman M Jalaluddin M. Jalaluddin M. Jalaluddin M. Nur Salim Mahdi Abral Maria Fatima Palupi Maryulia Dewi Masfufah Masfufah, Masfufah Mochammad Su’eb Mokhamad Fahrudin Moliwati Moliwati Moliwati, Moliwati Muh Ramadhan Muhammad Jalaluddin Muttaqien Muttaqien Nabila Swarna Puspa Hermana Nauval Firdana, Chorrysa Nazmi Zahir B. Mohd Zaini Ni Luh Putu Ika Mayasari Ni Luh Putu Ika Mayasari Ni Made Ria Isriyanthi Nihro Afandi Nor Jannah, Nor Nurhaspika Nurhaspika Nurhaspika, Nurhaspika nurjannaini nurjannaini NURLIANA NURLIANA Nurma Sari, Nurma Nuzul Asmilia P Aditiawati Parameshtya, Sadhira Peranginangin, Joen Firmanta Pratitis S Wibowo Pratitis S Wibowo Puarada, Alif Rahman Rohim Purba, Hastuti Handayani S. Purnamaningrum, Nora Dyah Ayu Putra, Hamdika Yendri Putra, Purniadi Rafico Rifki Febrian Rahayu Mardikaningsih Rahayu Mardikaningsih Rahmat Hidayat Rahmat Hidayat Rahmat Hidayat Harahap Ramadhan, Juliadi Ramadhani, Fitria Sari Rastina Rastina raudhatul jannah jannah Razali Daud5 Retno Damajanti Rinidar Rinidar Rotinsulu, Dordia Anindita S. G. Ningrum S. Setiyaningsih Sari, Wahyu Eka Sartika Juwita Sary, Kezia Arum Sinta Sri Utami Siti Aisyah Siti Aisyah Siti Hajar Siti Wardianah Matondang Sri Suryatmiati Prihandani Suhartila Suhartila Supratikno, Supratikno Susan M Noor Susan M Noor Susan Maphilindawati Noor Syahrir, Musdalifah T. Reza Ferasyi Titiek Sunartatie Tongku N Siregar U. Affif Ulandari, Rafika Ulfi Widi Arsih Upik Kesumawati Hadi Usamah Afif Uswatun Chasanah Uus Saepuloh Wardinal Wardinal Wenny Novita Sari Wilyo Hendro Fauzan Yamin Yaddi Yandi Syahputra Yulia Sari Ismail Zumala Nilasari