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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Jurnal Kedokteran Syiah Kuala Jurnal Anestesi Perioperatif Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Mutiara Medika: Jurnal Kedokteran dan Kesehatan Majalah Obstetri dan Ginekologi Majalah Kedokteran Sriwijaya Jurnal Keperawatan Sriwijaya Biomedical Journal of Indonesia Paediatrica Indonesiana JURNAL KESEHATAN LINGKUNGAN: Jurnal dan Aplikasi Teknik Kesehatan Lingkungan Syntax Literate: Jurnal Ilmiah Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan IJEMS (Indonesian Journal of Environmental Management and Sustainability) Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) SRIWIJAYA JOURNAL OF MEDICINE Jurnal Biomedika dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ners Jurnal Aisyah : Jurnal Ilmu Kesehatan Sriwijaya Journal of Surgery Jurnal Integrasi Kesehatan dan Sains Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Majalah Kesehatan Indonesia Cendekia Medika : Jurnal Stikes Al-Ma`arif Baturaja CRJIM (Clinical and Research Journal in Internal Medicine) Journal of Community Development Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kesehatan Gigi dan Mulut (JKGM) PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Journal of Anesthesiology and Clinical Research Lentera Perawat Majalah Anestesia & Critical Care (MACC) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Neurona Multidisciplinary Indonesian Center Journal Journal of Multidisciplinary Academic and Practice Studies Poltekita: Jurnal Pengabdian Masyarakat Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) Jurnal Kesehatan Indonesian Journal of Global Health Research
Legiran Legiran
Department Of Biomedical Science, Medical Faculty Of Sriwijaya Universiy, South Sumatera, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Edukasi Postur Ergonomis dan Pencegahan Nyeri Muskuloskeletal di SMA IT Izzudin Palembang Indri Seta Septadina; Wardiansah Wardiansah; Tri Suciati; Sima Asmara Dewa Marya Mahardika Putri; Msy Rulan Adnindya; Legiran Legiran; Muhammad Ramadhan Odiesta
Journal of Community Development Vol. 6 No. 1 (2025): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v6i1.1750

Abstract

Santri merupakan kelompok yang berisiko tinggi mengalami keluhan muskuloskeletal akibat kebiasaan duduk statis dan postur tubuh yang tidak ergonomis selama belajar dan menghafal Al-Qur’an. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan santri mengenai postur duduk yang sehat dan pencegahan nyeri muskuloskeletal melalui edukasi ergonomis. Metode pelaksanaan meliputi penyuluhan interaktif ​menggunakan media booklet, video pendek, serta peragaan langsung teknik duduk ergonomis dan peregangan ringan bersama santri dan guru. Program ini diikuti oleh 82 peserta dari SMA IT Izzudin Palembang. Hasil evaluasi menunjukkan peningkatan pengetahuan yang signifikan, terutama pada aspek pemahaman tentang dampak keluhan muskuloskeletal (97,6%) dan gerakan peregangan (93,9%). Kegiatan ini efektif dalam meningkatkan kesadaran dan pemahaman santri mengenai pentingnya postur ergonomis, serta diharapkan menjadi langkah awal untuk penerapan perilaku duduk sehat di lingkungan pesantren.​
Adjuvant Resveratrol Reduces Albuminuria and Serum Transforming Growth Factor-β Without Improving Glomerular Filtration Rate in Diabetic Kidney Disease: A 12-Week Randomized Controlled Trial Eva Julita; Zulkhair Ali; Yulianto Kusnadi; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 7 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i7.1627

Abstract

Background: Diabetic kidney disease (DKD) progresses through inflammation and fibrosis, with transforming growth factor-β (TGF-β) as the principal profibrotic mediator and albuminuria as a clinical surrogate of glomerular injury. Methods: We conducted a 12-week, double-blind, placebo-controlled randomized trial at Dr. Mohammad Hoesin General Hospital, Palembang, between October 2025 and January 2026 to evaluate adjuvant resveratrol on serum TGF-β, urinary albumin-to-creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR). Results: Of 61 randomized adults with DKD on standard care, 54 were analyzed (resveratrol n=27 received 25 mg twice daily, derived from Polygonum cuspidatum in 95% lecithin; placebo n=27). Within the resveratrol group, serum TGF-β fell from 123.7 to 77.1 pg/mL (p=0.008) and UACR from 94.1 to 89.8 mg/g (p=0.017); within placebo, UACR rose from 81.9 to 112 mg/g (p=0.029) while TGF-β change was non-significant (p=0.428). Between-group ΔUACR was significant (p<0.001), whereas ΔTGF-β (p=0.303) and ΔeGFR (p=0.567) were not. Multivariable linear regression identified resveratrol as an independent predictor of UACR reduction (B=−394.12 mg/g; 95% CI −659.53 to −128.71; p=0.004; adjusted R²=0.129). Baseline TGF-β was the dominant predictor of ΔTGF-β (B=−0.81; p<0.001; adjusted R²=0.701), and baseline LFG stage predicted ΔeGFR (B=−4.76; p=0.021). Mild bloating was reported in 14.8% of resveratrol versus 11.1% of placebo recipients; no serious adverse events occurred. Conclusion: Adjuvant low-dose resveratrol reduces albuminuria and serum TGF-β over 12 weeks in DKD without short-term improvement in eGFR, supporting an antifibrotic biomarker signal that warrants longer trials.
Adjuvant Resveratrol Reduces Albuminuria and Serum Transforming Growth Factor-β Without Improving Glomerular Filtration Rate in Diabetic Kidney Disease: A 12-Week Randomized Controlled Trial Eva Julita; Zulkhair Ali; Yulianto Kusnadi; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 7 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i7.1627

Abstract

Background: Diabetic kidney disease (DKD) progresses through inflammation and fibrosis, with transforming growth factor-β (TGF-β) as the principal profibrotic mediator and albuminuria as a clinical surrogate of glomerular injury. Methods: We conducted a 12-week, double-blind, placebo-controlled randomized trial at Dr. Mohammad Hoesin General Hospital, Palembang, between October 2025 and January 2026 to evaluate adjuvant resveratrol on serum TGF-β, urinary albumin-to-creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR). Results: Of 61 randomized adults with DKD on standard care, 54 were analyzed (resveratrol n=27 received 25 mg twice daily, derived from Polygonum cuspidatum in 95% lecithin; placebo n=27). Within the resveratrol group, serum TGF-β fell from 123.7 to 77.1 pg/mL (p=0.008) and UACR from 94.1 to 89.8 mg/g (p=0.017); within placebo, UACR rose from 81.9 to 112 mg/g (p=0.029) while TGF-β change was non-significant (p=0.428). Between-group ΔUACR was significant (p<0.001), whereas ΔTGF-β (p=0.303) and ΔeGFR (p=0.567) were not. Multivariable linear regression identified resveratrol as an independent predictor of UACR reduction (B=−394.12 mg/g; 95% CI −659.53 to −128.71; p=0.004; adjusted R²=0.129). Baseline TGF-β was the dominant predictor of ΔTGF-β (B=−0.81; p<0.001; adjusted R²=0.701), and baseline LFG stage predicted ΔeGFR (B=−4.76; p=0.021). Mild bloating was reported in 14.8% of resveratrol versus 11.1% of placebo recipients; no serious adverse events occurred. Conclusion: Adjuvant low-dose resveratrol reduces albuminuria and serum TGF-β over 12 weeks in DKD without short-term improvement in eGFR, supporting an antifibrotic biomarker signal that warrants longer trials.
Hair Mercury Concentrations among Residents Living Near Artisanal and Small-Scale Gold Mining Activities in Indonesia Rini Maya Sari; Muhammad Irsan; Legiran Legiran; Poedji Loekitowati Hariani; Lia Nurbanillah Fujianti
Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Vol 23, No 2 (2026): July 2026
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/presipitasi.v23i2.651-662

Abstract

Mercury use in artisanal and small-scale gold mining (ASGM) remains a major public health concern in Indonesia. This cross-sectional biomonitoring study examined the factors associated with mercury exposure among 50 adults living near ASGM activities in the Bungo District. The interview data covered sociodemographic, occupational, behavioral, and exposure-related factors, while hair mercury concentrations were measured using inductively coupled plasma mass spectrometry. Descriptive analyses, bivariate logistic screening, and multivariable logistic regression with backward stepwise selection were performed. In the final model, non-mining participants had lower odds of higher mercury exposure than mining-related workers (OR = 0.164; 95% CI: 0.030–0.892; P = 0.036). Adults aged ≥45 years had lower odds than those aged 21–44 years (OR = 0.097; 95% CI: 0.020–0.474; p = 0.004), whereas women had higher odds than men (OR = 8.032; 95% CI: 1.586–40.675; p = 0.012). The model showed moderate explanatory performance (Nagelkerke R² = 0.414) and 78.0% accuracy. These findings indicate higher exposure among younger adults, women, and mining-related workers, supporting targeted biomonitoring, occupational risk reduction, and community-based interventions in areas affected by ASGM.
Factors Associated with Inpatient Hospitalization Costs in Stroke Patients Undergoing Mechanical Thrombectomy or Coiling Ardy Oktaviandi; Pinto Desti Ramadhoni; Legiran Legiran
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1940

Abstract

Stroke is a catastrophic disease with a significant economic burden, particularly for neurointervention procedures such as mechanical thrombectomy and coiling. A disparity exists between standard costs and actual billing charges for these procedures at Dr. Mohammad Hoesin Hospital Palembang. This study aimed to analyze the factors influencing hospitalization costs of stroke patients undergoing mechanical thrombectomy or coiling. This was an analytical cross-sectional study with retrospective data collection from medical records of stroke patients who underwent mechanical thrombectomy or coiling at Dr. Mohammad Hoesin Hospital Palembang from January 2024 to September 2025. The study included 32 patients who underwent mechanical thrombectomy and 67 who underwent coiling. Sampling technique used was total sampling. Bivariate and multivariate analyses were performed to identify factors influencing hospitalization costs. The mean actual hospitalization cost for mechanical thrombectomy was IDR 97,679,947 ± 80,403,149, while for coiling it was IDR 119,286,035 ± 77,330,119 (approximately 20% higher). In the mechanical thrombectomy group, multivariate analysis revealed length of stay as the only significant independent factor influencing hospitalization costs (p<0.05). Meanwhile, in the coiling group, four significant independent factors were identified: complications, aggravating factors, NIHSS score, and number of coils (p<0.05). The factors influencing hospitalization costs differ between mechanical thrombectomy and coiling. For mechanical thrombectomy, length of stay is the dominant factor, whereas for coiling, clinical severity (complications, aggravating factors, NIHSS score) and procedural complexity (number of coils) are the main cost determinants.  
Co-Authors Abdul, Zabidah Achmad Ridwan, Achmad Ade Dian Anggraini Ade Permana Adinda Adinda Adinda Adnindya, Rulan Afriani Ahmat Umar Alibasyah A. Chakra Andrina, Hana Angella, Gita Ansyori Hatta Ardy Oktaviandi Ariani Susanti Arwan Bin Laeto Asri Maharani Astuti, Syurmi Aswin Nugraha Ayeshah A Rosdah Baehaqi Bella Ria Astuti Benny Kusuma Bermansyah Bernhard Arianto Purba Bunga Anggreini Sari Chandra, Novy Rosalia Christin, Theresia Danny Amos Tarigan Desi Arlindia Dian Wahyuni Diana Dewi Sartika Diana Polania Dini Rizkie Wijayanti Dini Rizkie Wijayanti Dwi Ariska Eddy Mart Salim Eddy Mart Salim, Eddy Mart Edi Susanto Effendi, Kms. Yusuf Efman EU Manawan Efrieni Yusuf Eka Febri Zulissetiana Elvi Sunarsih Erial Bahar Eva Julita Evi Lusiana Febrianto, Yohanes Ferawaty Ferawaty, Ferawaty Ferry Yusrizal Fitri Nurjanah Fitri Nurjanah Fitriani Fitriani Franajayakk, Indra Fredi Heru Irwanto Fredy Ferdinand Carol Furqan Indah Gama Satria Gama Satria Ghanie Abla Gita Angella Hafid Komar Handayani, Sri Harun, Yusril Hasbi, Alfian Henry Sugiharto Indah, Furqan INDRA FRANA JAYA KK Indri Seta Septadina Irfannuddin Irfannuddin Irsan Saleh Irsan Saleh, Muhammad Islamia, Medina Putri Joneri, Alrahman KAMILA, YURI Kartika, Juspeni Kemas Muhammad Dahlan Kesty, Cindy Kgs. M. Rosyidi Kms Yusuf Effendi Kms. Yusuf Effendi Kurniawan, Didy Layal, Kamalia Lia Nurbanillah Fujianti M. Afif Heldian Putra M. Zalili Azis Malahayati, Putri Martinova, Vera Mediarty Mega Sary Mega Sary Meirisa Rahma Pratiwi Mgs. Irsan Saleh Mgs.Muhammad Irsan Saleh Misnaniarti Misnaniarti Muhammad Arma Muhammad David Riandy Muhammad Hasnawi Haddani Muhammad Ikhsan Kartawinata Muhammad Irsan Muhammad Irsan Saleh Muhammad Ramadhan Odiesta Muhammad Reagan MUSTIKA FATIMAH Mutiara Budi Azhar Nadia Maharni Nadya Aviodita Nedya Bellinawati Nopriyati Nova Kurniati Novy Rosalia Chandra Nur Qodir Nur Qodir Nur Riviati, Nur Nurjanah, Fitri Odiesta, Muhammad Ramadhan Okta Emilia Patiyus Agustiansyah Patresia, Retta Pinto Desti Ramadhoni Pirma I.R.M Poedji Loekitowati Hariani Precelia Fransiska Puspa Zuleika, Puspa Putri Mirani Qodir, Nur Radema Pranata Ria Nova Rico Januar Sitorus Ridho Surya Putra Rika Purnama Sari Rini Maya Sari Rini Nindela, Rini Rizal Sanif Rizal Zainal Rizma Adlia Syakurah Rose Mafiana Safyudin Saleh, Muhammad Irsan Salni Salni Sary, Mega Shafira Irmayati Sima Asmara Dewa Marya Mahardika Putri Sima Asmara Dewa Marya Mahardika Putri Siti Nurmaini Siti R. Nanin Siti Rusdiana Puspa Dewi Soenarto Kartowigno Sugiharto, Henry Suly Auline Rusminan Susila Arita Syifa Alkaf Taufik Indrajaya Taufik Kurrohman Theresia Christin Tri Suciati Tri Suciati Tri Suciati Vidro Alif Gunawan Wahyuni, Devi Azri Wardiansah Wardiansah, Wardiansah Wardiansah, Wardiansah Wika Sepiwiryanti Wiria Aryanta Yangtjik Yangtjik Yuli Kurniawati Yulianto Kusnadi Yunindyawati Yunindyawati Yuniza Yusni Puspita Yusuf Effendi Yusuf Effendi Yusuf, Khaidir Zakaria Mukalla Zen Hafy Zulkhair Ali Zulkhair Ali Zulkifli