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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Syiah Kuala Jurnal Anestesi Perioperatif Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Damianus Journal of Medicine Mutiara Medika: Jurnal Kedokteran dan Kesehatan Majalah Obstetri dan Ginekologi Majalah Kedokteran Sriwijaya Jurnal Keperawatan Sriwijaya Biomedical Journal of Indonesia Paediatrica Indonesiana JURNAL KESEHATAN LINGKUNGAN: Jurnal dan Aplikasi Teknik Kesehatan Lingkungan Syntax Literate: Jurnal Ilmiah Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan IJEMS (Indonesian Journal of Environmental Management and Sustainability) Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) SRIWIJAYA JOURNAL OF MEDICINE Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ners Jurnal Aisyah : Jurnal Ilmu Kesehatan Sriwijaya Journal of Surgery Jurnal Integrasi Kesehatan dan Sains Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Majalah Kesehatan Indonesia Cendekia Medika : Jurnal Stikes Al-Ma`arif Baturaja CRJIM (Clinical and Research Journal in Internal Medicine) Journal of Community Development Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kesehatan Gigi dan Mulut (JKGM) PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Journal of Anesthesiology and Clinical Research Lentera Perawat Majalah Anestesia & Critical Care (MACC) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Neurona Multidisciplinary Indonesian Center Journal Stetoskop : The Journal Of Health Science Journal of Multidisciplinary Academic and Practice Studies Poltekita: Jurnal Pengabdian Masyarakat Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Legiran Legiran
Department Of Biomedical Science, Medical Faculty Of Sriwijaya Universiy, South Sumatera, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Polymorphism of the Klotho G-395a Gene Promoter with the Incidence of Preeclampsia Desi Arlindia; Mgs. Irsan Saleh; Zen Hafyy; Legiran; Erial Bahar; Kms. Yusuf Effendi; Ferry Yusrizal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 1 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.178

Abstract

A B S T R A C TIntroduction. Preeclampsia is one of the leading causes of maternal and perinatalmorbidity and mortality and is still a disease of theory. Klotho is a new gene, inseveral biological processes in the pathophysiology of preeclampsia that play a rolein regulating endothelial nitric oxide production, angiogenesis, production ofantioxidant enzymes and protection against endothelial dysfunction. The Klotho G-395A genotype AA promoter polymorphism is the cause of hypertension. This studyaims to determine the relationship of the Klotho G-395A promoter polymorphism tothe incidence of preeclampsia. Methods. This study is an analytical study with acase-control design. The research was conducted at Pembina community healthcentre of Palembang and the public hospital of Prabumulih in February - July 2020and involving 50 case group and 50 control group. To determine the genotype andallotype of the Klotho G-395A gene promoter polymorphism, using polymerase chainreaction examination. Result. The results showed that the risk factors for maternalage and maternal gestational age had a significant relationship with the incidence ofpreeclampsia (p-value 0.015; p-value 0.000). There was a significant relationshipbetween the Klotho G-395A genotype GA + AA promoter polymorphism and theincidence of preeclampsia (p-value 0.024; OR = 2.571; 95% CI = 1.122-5.895), whileallotypes in the study sample also had a significant relationship with the incidenceof preeclampsia. preeclampsia (p-value 0.025; OR = 1.978; 95% CI = 1.087-3.599).Conclusion: There is a significant relationship between the Klotho G-395A genepromoter polymorphism and the incidence of preeclampsia.
Correlation between the Serum Level of Interleukin-2 in Hemodialysis Patients and Severity of Renal Pruritus Radema Pranata; Yuli Kurniawati; Fitriani Fitriani; Legiran; Soenarto Kartowigno; Nopriyati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 5 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i5.226

Abstract

Renal pruritus (RP) is a condition or symptom that is often found in end-stage chronic kidney disease (CKD) undergoing hemodialysis (HD). The etiology of RP is multifactorial, one of it due to inflammation mediated by interleukin 2 (IL-2). Study on the correlation between serum level of IL-2 and the severity of RP is still limited. This study will analyze the correlation between serum level of IL-2 in patients undergoing HD and the severity of RP. Our method is cross sectional design at Hemodialysis Installation of Dr. Mohammad Hoesin Hospital. Serum level of IL-2 examined by ELISA, the severity of RP assessed by a 5 dimensional pruritus scale. Inclusion criteria in this study included HD patients with RP ≥ 9, age ≥ 18 years and willing to sign informed consent. The results from 28 male (59.6%) and 19 female (40.4%) are the mean serum level of IL-2 (pg/ml) is 0.424 ± 0.077. The mean RP severity score is 18.98 ± 2.74. A strong positive correlation between serum level of IL-2 and the severity of RP (r = 0.750, p = 0,000). Our conclusion is the increase of serum level IL-2 in line with severity of RP.
Epidemiology and Risk Factors for Cervical Cancer Patiyus Agustiansyah; Rizal Sanif; Siti Nurmaini; Irfannuddin; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 7 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i7.326

Abstract

Cervical cancer in Indonesia in 2018 ranks second in cancer in women in Indonesia with an incidence rate of 348.809 cases with a mortality rate of nearly 60% of the incidence, namely 207.210 deaths. Deaths from cervical cancer are projected to continue to increase and are estimated to reach 12 million deaths by 2030 if not treated properly. The incidence of cervical cancer in Indonesia is estimated to have 180.000 new cases per year and the death rate is thought to reach 75% in the first year. This death is mainly associated with the majority of newly diagnosed patients who are already at an advanced stage (70% of cases) and are already at the terminal stage at the time of diagnosis.
Human Papilloma Virus: Biomolecular Aspect Patiyus Agustiansyah; Rizal Sanif; Siti Nurmaini; Irfannuddin; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 8 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i8.327

Abstract

HPV is a sexually transmitted virus, and high-risk HPV DNA was found in 99.7%of cervical cancer specimens. Within 12 to 24 months of exposure to the virus,90% of HPV infections disappear or become inactive. However, infection with high-risk strains of HPV persist which then increases the risk of progression to cervicalcancer. The detection of precancerous lesions consists of various methods,including pap smear (conventional or liquid-base cytology / LBC), visualinspection of acetic acid (IVA), visual inspection of lugoliodine (VILI), and HPV DNAtest (genotyping / hybrid capture).
WHO Global Strategy in Eradication of Cervical Cancer Patiyus Agustiansyah; Rizal Sanif; Siti Nurmaini; Irfannuddin; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i9.328

Abstract

WHO has created a global strategy to accelerate the elimination of cervical canceras a public health problem and a world burden. Cervical cancer is a disease thatcan be prevented and cured, as long as it is detected early and treated effectively.Cervical cancer is also a disease that reflects global injustice. The burden isgreatest in low- and middle-income countries, where access to public healthservices is limited and screening and treatment for the disease has not been widelyapplied. In 2018, nearly 90% of all deaths worldwide occurred in low and middleincome countries. Furthermore, the proportion of women with cervical cancer whodie from the disease is more than 60% in these countries, more than double thenumber in many high-income countries, which is only 30%.
Screening for Cervical Cancer Patiyus Agustiansyah; Rizal Sanif; Siti Nurmaini; Irfannuddin; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.329

Abstract

Screening is a public health intervention administered to a target population without symptoms. Screening is not performed to diagnose a disease, but to identify individuals with a higher likelihood of developing the disease itself or a precursor to the disease. Not all diseases are suitable for screening programs. The following criteria help determine whether a disease is suitable for a screening program: (1) The disease is bound to have serious consequences. (2) The disease must have a detectable preclinical and asymptomatic stage. (3) Treatment at the preclinical stage should influence the long-term course and prognosis of the disease being screened. (4) Care must be available and accessible to those who have a positive screening test. History, screening tests and treatment options for cervical pre-cancer meet these criteria.
Correlation between Lgr5 Expression and 5-FU based Chemotherapy Response in Stage IV Colorectal Cancer Patients Kgs. M. Rosyidi; Mediarty Syahrir; Suly Auline Rusminan; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.358

Abstract

Background. Colorectal cancer is the third commonest malignancy and the second leading cause of cancer death in the world. 5-Fluorouracyl-based chemotherapy is the primary treatment modality for colorectal cancer. Cancer stem cells are known to be responsible for chemotherapy resistance. Lgr5 is a colorectal cancer stem cell marker that is the target gene for Wnt signaling. Lgr5 potentiates the Wnt signaling pathway through inhibition of a regulator that inhibits Wnt signaling. Lgr5 overexpression is associated with a worse prognosis and chemotherapy resistance. This study was aimed to investigate the correlation between Lgr5 expression and 5-FU-based chemotherapy response in stage IV colorectal cancer patients at Dr. Mohammad Hoesin Hospital Palembang.Methods. This study used a correlative analysis study with a retrospective design using secondary data from medical records and paraffin blocks of stage IV colorectal cancer patients who received 5-FU-based chemotherapy from September 2018 to September 2020. The number of samples was 30 subjects consisting of 22 cases of negative responses and eight positive responses. All samples were stained with Lgr5 immunohistochemistry. Data analysis used the contingency coefficient correlation test.Results. Of the 30 research subjects, 20 subjects (66.7%) had high Lgr5 expression and ten subjects (33.3%) with low Lgr5 expression. Correlation analysis using the contingency coefficient test showed a weak correlation between Lgr5 expression and 5-FU based chemotherapy response with a positive direction, which means the higher the Lgr5 expression, the less response to chemotherapy.Conclusion. There is a weak correlation between Lgr5 expression and 5-FU based chemotherapy response in stage IV colorectal cancer patients at dr.Mohammad Hoesin Hospital Palembang.
Perbandingan Efektivitas Metilprednisolon 1 mg/KgBB/i.v. dengan Deksametason 0,2 mg/KgBB/i.v. terhadap Nyeri Tenggorokan Pascaintubasi dinilai dengan Numeric Rating Scale (NRS) Rika Purnama Sari; Rose Mafiana; Rizal Zainal; Legiran Siswo
Majalah Anestesia & Critical Care Vol 37 No 3 (2019): Oktober
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif (PERDATIN) / The Indonesian Society of Anesthesiology and Intensive Care (INSAIC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.182 KB)

Abstract

Intubasi endotrakeal adalah tindakan yang dilakukan dalam anestesi umum dengan cara memasukkan pipa endotrakeal ke saluran napas. Tindakan ini dapat menimbulkan beberapa komplikasi mulai dari yang ringan sampai berat. Salah satu komplikasi ringan yang dapat terjadi pasca intubasi adalah nyeri tenggorokan. Tindakan farmakologis yang dapat dilakukan adalah pemberian obat anti inflamasi nonsteroid dan steroid seperti deksametason dan metilprednisolon. Sampai saat ini belum ada obat tunggal yang diterima secara luas dan dijadikan baku emas untuk terapi nyeri tenggorokan pasca operasi. Penelitian ini merupakan penelitian randomized post-test only double blinded yang dilakukan di RS Dr. Mohammad Hoesin Palembang pada bulan Juni 2019-Juli 2019 sampai jumlah sampel terpenuhi, didapatkan total 50 sampel. Rerata NRS 1 jam pascaekstubasi pada kelompok deksametason dan metilpredinosolon sebesar 0,88±0,927 dan 0,64±0,700. Rata-rata NRS 6 jam pascaekstubasikelompok deksametason dan metilprednisolon sebesar 0,64±0,70 dan 0,52±0,51. Uji Mann-Whitney menunjukkan bahwa tidak terdapat perbedaan rerata antar keduanya (p=0,420 dan p=0,671). Tidak terdapat perbedaan efektivitas pemberian injeksi metilprednisolon 1mg/kgBB/IV dengan injeksi deksametason 0,2mg/kgBB/IV terhadap nyeri tenggorokan pascaintubasi dinilai menggunakan NRS pada pasien dengan anestesi umum di RSUP Dr Mohammad Hoesin Palembang.
Relationship polymorphism exon 17 of insulin receptor (INSR) gene with polycystic ovarian syndrome among Malay ethnic in South Sumatera Okta Emilia; Legiran; Safyudin; Syifa Alkaf
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 1, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss1.art3

Abstract

Background: A sedentary lifestyle is a risk of obesity. One of the negative effects of obesity is insulin resistance. Insulin resistance is found in 50% - 90% of women with Polycystic Ovary Syndrome (PCOS).Objective: This study aimed to analyse the relationship polymorphism exon 17 of insulin receptor (INSR) gene in Malay ethnicity in South Sumatera.Methods: This is an observational analytic study with a case-control design conducted at the Molecular Biology Laboratory, Faculty of Medicine, Sriwijaya University. This study sample used blood taken from 80 people consisting of 40 cases and 40 controls. Genotyping and allotypic were performed using PCR-RFLP. Analysis was performed using SPSS 16.Results: The statistical analysis using the Chi-Square test on IMT resulting p-value = 0.003 (OR = 4.660 95% CI = 1.764 - 12.311). (Wild type) CC, (Mutant heterozygous) CT, (Homozygous Mutant) TT. The statistical analysis using the Pearson Chi-Square Genotype PCOS resulting p-value = 0.970 and fisher exact test on SOPK allotype resulting p-value = 0.500 (OR = 0.949 95% CI = 0.503 - 1,790).Conclusion: In conclusion, there was a significant relationship between BMI and PCOS among Malay ethnic in South Sumatera. There was no significant relationship between genotypic polymorphism and allotype exon 17 of INSR with PCOS in Malay ethnic groups in South Sumatera.
Prevalensi Nyeri Muskuloskeletal Pada Pengemudi Becak Kayuh Di Palembang Henry Sugiharto; Novy Rosalia Chandra; Legiran
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Vol 3, No 1, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v3i1.60

Abstract

Sistem muskuloskeletal adalah suatu sistem yang terdiri dari tulang, sendi, otot, tendon dan ligamen yang berfungsi sebagai penunjang bentuk tubuh dan bertanggung jawab terhadap pergerakan. Nyeri muskuloskeletal didefinisikan sebagai nyeri persisten atau berulang yang timbul sebagai bagian dari proses penyakit yang secara langsung mempengaruhi tulang, otot, sendi atau jaringan lunak terkait. Gangguan kesehatan yang dialami pekerja berdasarkan penelitian yang dilakukan pada 9.482 pekerja di 12 kabupaten/kota di Indonesia menunjukkan angka tertinggi diraih oleh gangguan muskuloskeletal (16%). Di antara berbagai jenis pekerjaan, prevalensi nyeri muskuloskeletal pada pengemudi angkutan umum di berbagai belahan dunia sangat tinggi yakni antara 53% hingga 91%. Penelitian ini merupakan penelitian deskriptif observasional dengan desain cross-sectional pada pengemudi becak kayuh di kecamatan Kemuning Kota Palembang. Data primer dikumpulkan melalui wawancara dan pemeriksaan klinis neurologis sederhana. Seluruh data diolah dengan menggunakan SPSS 22 for windows. Dari hasil penelitian didapatkan prevalensi usia terbanyak ialah pada usia lebih dari 51 tahun sebesar 60%, sebagian besar dengan status pekerjaan hanya bekerja sebagai pengemudi becak kayuh 74,3%. Sekitar 77,2% memiliki indeks massa tubuh yang normal. Dari penelitian ini didapatkan paling banyak keluhan nyeri muskuloskeletal di lokasi tubuh ektremitas bawah sebesar 77,1% dengan rata-rata memiliki intensitas nyeri ringan yaitu sebesar 64,7%.
Co-Authors Abdul, Zabidah Achmad Ridwan, Achmad Ade Dian Anggraini Ade Permana Adinda Adinda Adinda Adnindya, Msy Rulan Afriani Ahmat Umar Alibasyah A. Chakra Andrina, Hana Angella, Gita Ansyori Hatta Ariani Susanti Arwan Bin Laeto Asri Maharani Astuti, Syurmi Aswin Nugraha Ayeshah A Rosdah Baehaqi Bella Ria Astuti Benny Kusuma Bermansyah Bernhard Arianto Purba Bunga Anggreini Sari Chandra, Novy Rosalia Christin, Theresia Danny Amos Tarigan Desi Arlindia Dian Wahyuni Diana Dewi Sartika, Diana Dewi Diana Polania Dini Rizkie Wijayanti Dini Rizkie Wijayanti Dwi Ariska Eddy Mart Salim Eddy Mart Salim, Eddy Mart Edi Susanto Effendi, Kms. Yusuf Efman EU Manawan Efrieni Yusuf Eka Febri Zulissetiana Elvi Sunarsih Erial Bahar Febrianto, Yohanes Ferawaty Ferawaty, Ferawaty Ferry Yusrizal Fitri Nurjanah Fitri Nurjanah Fitriani Fitriani Fredi Heru Irwanto Fredy Ferdinand Carol Furqan Indah Gama Satria Gama Satria Ghanie Abla Hafid Komar Handayani, Sri Harun, Yusril Hasbi, Alfian Henry Sugiharto Indah, Furqan INDRA FRANA JAYA KK Indra, Bima Indrajaya, Taufik Indri Seta Septadina Irfannuddin Irfannuddin Irsan Saleh Irsan Saleh, Muhammad Islamia, Medina Putri Jayawarsa, A.A. Ketut Joneri, Alrahman KAMILA, YURI Kartika, Juspeni Kemas Muhammad Dahlan Kesty, Cindy Kgs. M. Rosyidi Kms Yusuf Effendi Kms. Yusuf Effendi Kurniawan, Didy Layal, Kamalia Lubis, Fadhyl Zuhry M. Afif Heldian Putra M. Zalili Azis Mahardika Putri, Sima Asmara Dewa Marya Malahayati, Putri Martinova, Vera Mediarty Mega Sary Mega Sary Meirisa Rahma Pratiwi Mgs. Irsan Saleh Mgs.Muhammad Irsan Saleh Misnaniarti Misnaniarti Muhammad Arma Muhammad David Riandy Muhammad Hasnawi Haddani Muhammad Ikhsan Kartawinata Muhammad Irsan Saleh Muhammad Reagan MUSTIKA FATIMAH Mutiara Budi Azhar Nadia Maharni Nadya Aviodita Nedya Bellinawati Nopriyati Nova Kurniati Novy Rosalia Chandra Nur Qodir Nur Qodir Nur Riviati, Nur Nurjanah, Fitri Odiesta, Muhammad Ramadhan Okta Emilia Patiyus Agustiansyah Patresia, Retta Pirma I.R.M Precelia Fransiska Puspa Zuleika, Puspa Putri Mirani Qodir, Nur Radema Pranata Rasidi, Syafran Reagen, Muhammad Ria Nova Rico Januar Sitorus Ridho Surya Putra Rika Purnama Sari Rini Nindela, Rini Rizal Sanif Rizal Zainal Rizma Adlia Syakurah Rose Mafiana Safyudin Saleh, Muhammad Irsan Salni Salni Sari, Sagita Darma Sary, Mega Sepiwiryanti, Wika Shafira Irmayati Sima Asmara Dewa Marya Mahardika Putri Siti Nurmaini Siti R. Nanin Siti Rusdiana Puspa Dewi Soenarto Kartowigno Sugiharto, Henry Suly Auline Rusminan Surya Dharma Susila Arita Syifa Alkaf Taufik Indrajaya Taufik Kurrohman Theresia Christin Tri Suciati Tri Suciati Vidro Alif Gunawan Wahyuni, Devi Azri Wardiansah Wardiansah, Wardiansah Wiria Aryanta Yangtjik Yangtjik Yuli Kurniawati Yuniarti, Fifi Yunindyawati Yunindyawati Yuniza Yusni Puspita Yusuf Effendi Yusuf, Khaidir Zakaria Mukalla Zen Hafy Zulkhair Ali Zulkifli