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Terapi Bekam: Efek Anti Peradangan dalam Pengobatan Tradisional Wahyuni, Dian; Legiran, Legiran; Saleh, Irsan; Salim, Eddy Mart
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.374-390

Abstract

This comprehensive literature review consolidates findings from 11 diverse scholarly articles exploring the efficacy of cupping therapy as an anti-inflammatory intervention. The review encompasses studies investigating various clinical applications and experimental models to delineate the therapy's anti-inflammatory effects. The research method utilized the Publish or Perish application to access databases such as PubMed, Scopus, and Google Scholar. The screening process was based on predetermined inclusion and exclusion criteria. Article quality was assessed using the Crowe Critical Appraisal Tool (CCAT). Standard forms were used to extract important information from articles: Authors’ name, Year; Research title; Population; data; Findings. Data were analyzed narratively to generate thematic synthesis. The reviewed studies revealed significant outcomes across multiple domains. Clinical trials demonstrated the efficacy of cupping therapy in managing pain in osteoarthritis and idiopathic menorrhagia. Narrative reviews and experimental studies highlighted its potential in sports injury management and its influence on changes in local blood flow. Additionally, investigations provided insights into its immunomodulatory effects in cancer patients, allergic asthma models, and inflammatory conditions like acute herpes zoster. Synthesizing these findings emphasized the diverse anti-inflammatory effects of cupping therapy across various health conditions, elucidating its mechanisms and potential applications. The therapy exhibited promising outcomes in pain management, inflammation reduction, and modulation of immune responses.
Ekspresi Transforming Growth Faktor Beta 1 (Tgfß) Pada Luka Diabetes Melitus Melalui Perawatan Luka Dengan Modern Dressing : Literature Review Indra Frana Jaya KK; Legiran
Cendekia Medika: Jurnal Stikes Al-Ma`arif Baturaja Vol. 9 No. 1 (2024): Cendekia Medika : Jurnal STIKes Al-Ma'arif Baturaja
Publisher : LPPM STIKES Al-Ma'arif Baturaja

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52235/cendekiamedika.v9i1.315

Abstract

Transforming Growth Factor Beta 1 (TGFß) merupakan salah satu faktor pertumbuhan yang memiliki peran penting dalam proses penyembuhan luka. Pentingnya pemahaman tentang ekspresi TGFß pada luka diabetes melitus menjadi krusial dalam upaya meningkatkan proses penyembuhan. Perawatan luka dengan menggunakan modern dressing telah menjadi pendekatan yang semakin diterapkan dalam upaya mempercepat penyembuhan luka pada pasien diabetes melitus. Penelitian ini bertujuan untuk mengetahui Ekspresi Transforming Growth Faktor Beta 1 (TGFß) Pada Luka Diabetes Melitus Melalui Perawatan Luka dengan Modern Dressing.  Metode literature review ini bertujuan untuk menyusun pemahaman yang komprehensif mengenai ekspresi TGFß pada luka diabetes melitus melalui perawatan luka menggunakan modern dressing. Artikel ini merupakan hasil telaah berbagai referensi penelitian yang berkaitan/mengaitkan Ekspresi Transforming Growth Faktor Beta 1 (TGFß) Pada Luka Diabetes Melitus Melalui Perawatan Luka dengan Modern Dressing.  Ekspresi Transforming Growth Faktor Beta 1 (TGFß) meningkat Pada Luka Diabetes Melitus Melalui Perawatan Luka dengan Modern Dressing.
Efek Sitokin Proinflamasi TnF - Alpha pada Penyakit Diabetes Melitus Tipe 2: Tinjauan Literatur Yusuf, Khaidir; Legiran, Legiran
Jurnal Integrasi Kesehatan dan Sains Vol 6, No 1 (2024): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v6i1.12780

Abstract

Tumor necrosis factor alpha (TNF-α) salah satu mediator proinflamasi terpenting yang secara kritis terlibat dalam perkembangan resistensi insulin dan patogenesis diabetes melitus tipe II (T2DM). Peningkatan kadar TNF-α menginduksi resistensi insulin pada adiposit dan jaringan perifer. Tinjaun literatur pada penelitian ini menggunakan database PubMed dan Science direct terhadap artikel yang membahas TNF-alpha pada diabetes melitus tipe 2 dalam 5–10 tahun terakhir. Kata kunci dicari dengan satu kata atau dikombinasikan dengan kata kunci lainnya. Penyaringan dilakukan dari artikel berbahasa inggris. Tnf-alpha dan penyakit diabetes melitus tipe 2 ada keterkaitan. Pada literatur dikatakan patogenesis diabetes mellitus tipe 2 (DMT2) dan perkembangan resistensi insulin ditandai oleh beberapa faktor stimulasi, terutama pembentukan spesies oksigen reaktif (ROS) dan peningkatan berbagai sitokin pro-inflamasi. Tumor necrosis factor-alpha (TNF-α) adalah salah satu mediator proinflamasi terpenting yang terlibat dalam perkembangan resistensi insulin dan patogenesis T2DM. Tumor necrosis factor-α (TNF-α) terlibat dalam banyak patologi manusia, termasuk penyakit autoimun, resistensi insulin terkait obesitas, komplikasi kardiovaskular dan kanker, serta berperan terjadi peradangan kronis pada ginjal yang merupakan bentuk komplikasi diabetes tipe 2. Pada penelitian lain juga menguatkan pendapat peneliti dijelaskan bahwa efek sitokin pro inflamasi dan anti-inflamasi (TNF-a) dapat mengganggu jalur persinyalan insulin sehingga menyebabkan resitensi insulin pada sel B-pancreas. Simpulan penelitian ini adalah TNF-α menyebabkan resistensi insulin dan menyebabkan seseorang menderita diabetes melitus tipe 2. Tumor necrosis factor-alpha (TNF-α) is one of the most crucial proinflammatory mediators critically involved in the development of insulin resistance and the pathogenesis of type 2 diabetes mellitus (T2DM). Elevated levels of TNF-α induce insulin resistance in adipocytes and peripheral tissues. A literature review was conducted using databases such as PubMed and Science direct to explore articles discussing TNF-Alpha in type 2 diabetes over the past 5–10 years. Keywords were searched individually or in combination with others, and articles in English were screened. The literature reveals a connection between TNF-alpha and type 2 diabetes mellitus. The pathogenesis of type 2 diabetes mellitus (T2DM) and the development of insulin resistance are characterized by various stimulating factors, particularly the formation of reactive oxygen species (ROS) and an increase in various pro-inflammatory cytokines. Tumor necrosis factor-alpha (TNF-α) is identified as one of the key proinflammatory mediators involved in insulin resistance development and T2DM pathogenesis. TNF-α is implicated in various human pathologies, including autoimmune diseases, obesity-related insulin resistance, cardiovascular complications, cancer, and plays a role in the occurrence of chronic inflammation in the kidneys, a form of complication in type 2 diabetes. Other studies support the notion that the effects of pro-inflammatory and anti-inflammatory cytokines (TNF-α) can disrupt insulin signaling pathways, leading to insulin resistance in pancreatic B cells. In conclusion, this research indicates that Tumor necrosis factor-alpha (TNF-α) can induce insulin resistance, contributing to the onset of type 2 diabetes.
A STUDY DESIGN REVIEW: OPHTHALMIC ARTERY DOPPLER IN PREECLAMPSIA STUDY KAMILA, YURI; LEGIRAN, LEGIRAN
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol. 7 No. 1 (2024): Al-Iqra Medical Journal: Jurnal Berkala Ilmiah Kedokteran
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v7i1.10931

Abstract

Preeclampsia screening is a must for all pregnant women. Predicting preeclampsia using the ocular artery Doppler and comparing its efficacy to the uterine artery Doppler, which is now believed to be the most accurate tool in use, have both been the subjects of several studies. Depending on the research design, a number of investigations were conducted using various methods. The research proccess and, naturally, the findings will be impacted by the study design chosen. This study aims to review and evaluate the study designs of numerous recent studies on ocular artery Doppler in preeclamptic patients. It is a literature review that compiles articles from current English-language publications published in the years 2020 to 2023. The articles were found using the PubMed, Wiley, and BMJ search engines. Our findings show that the various study designs that were used had advantages and disadvantages. Future research ought to evaluate the advantages and disadvantages before selecting a study design.Keywords:  preeclampsia, ophthalmic artery Doppler, study design
Ultrasound vs Nerve Conduction Studies: A Comparative Analysis in Carpal Tunnel Syndrome Diagnosis Hasnawi Haddani; Henry Sugiharto; Afriani; Theresia Christin; Legiran; Ferawaty
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1145

Abstract

Background: Carpal tunnel syndrome (CTS) is a prevalent entrapment neuropathy. While nerve conduction studies (NCS) remain the gold standard for diagnosis, ultrasound (USG) offers a non-invasive alternative. This study aimed to compare the diagnostic accuracy of USG and NCS in CTS at Dr. Mohammad Hoesin General Hospital Palembang, Indonesia. Methods: A cross-sectional study was conducted on patients presenting with CTS symptoms. Demographic and clinical data were collected. NCS and USG assessments were performed, blinded to each other's results. USG measurements included the cross-sectional area at the carpal tunnel inlet (CSAc), proximal to the carpal tunnel (CSAp), and the difference between them (∆CSA). Diagnostic accuracy was calculated, and agreement was assessed using Cohen's kappa. Results: A total of 86 wrists from 49 patients were included. The mean age was 52 ± 11 years, with a female predominance (86%). The majority had mild CTS based on NCS (55.8%). USG measurements showed mean CSAc of 13.1 ± 3.5 mm², CSAp of 10.6 ± 3.0 mm², and ∆CSA of 2.5 ± 0.9 mm². ∆CSA had the highest sensitivity (92.2%), specificity (88.9%), and accuracy (91.9%), with substantial agreement with NCS (Kappa = 0.65). Conclusion: USG, particularly using ∆CSA, demonstrates high diagnostic accuracy in CTS, comparable to NCS. It can serve as a valuable tool, especially in settings with limited NCS availability.
Systemic Inflammatory Immune Index (SII) Predicts Disease Activity in Systemic Lupus Erythematosus (SLE) Patients: A Cross-Sectional Study Susanto, Edi; Yuniza; Legiran; Nova Kurniati; Eddy Mart Salim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1237

Abstract

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by widespread inflammation and diverse clinical manifestations. The systemic inflammatory immune index (SII), calculated as platelet count * neutrophil count/lymphocyte count, has emerged as a potential marker of systemic inflammation in various conditions. This study aimed to investigate the relationship between SII and disease activity in SLE patients. Methods: We conducted a cross-sectional study involving 60 SLE patients diagnosed according to the 2019 EULAR/ACR classification criteria. Demographic and clinical data were collected, and disease activity was assessed using the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). Blood samples were analyzed to determine SII values. Statistical analysis included Spearman's correlation to assess the relationship between SII and MEX-SLEDAI scores. Results: The study population predominantly consisted of women (98.3%), with a median age of 29 years. A strong positive correlation was observed between SII and MEX-SLEDAI scores (r = 0.931, p < 0.001). Patients with higher SII values exhibited significantly greater disease activity. Conclusion: Our findings suggest that SII is a promising predictor of disease activity in SLE patients. This readily available index may aid clinicians in assessing disease severity and tailoring treatment strategies. Further research is warranted to validate these findings and explore the utility of SII in monitoring disease progression and treatment response.
RULA-Based Ergonomic Assessment of Sitting Posture as a Risk Factor for Neck Pain in Students Septadina, Indri Seta; Wardiansah; Suciati, Tri; Adnindya, Msy Rulan; Putri, Sima Asmara Dewa Marya Mahardika; Legiran; Malahayati, Putri; Odiesta, Muhammad Ramadhan; Hasbi, Alfian
Majalah Kesehatan Indonesia Vol. 6 No. 4 (2025)
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/makein.2025294

Abstract

Research on ergonomic risk factors for neck pain among Islamic boarding school students remains scarce, despite their prolonged study and Qur’an memorization activities in static sitting postures. Non-neutral body posture during learning may increase the risk of musculoskeletal disorders (MSDs), particularly neck pain, which can impair concentration and quality of life. This analytic cross-sectional study aimed to assess students’ body posture during study and memorization activities and to examine its association with neck pain. A total of 72 boarding and non-boarding students participated. Data were collected using questionnaires and the Rapid Upper Limb Assessment (RULA), and analyzed with chi-square tests and logistic regression to obtain prevalence ratios (PR) and p-values. Neck pain was reported by 63.9% of respondents; 72.2% exhibited poor sitting posture, and 80.6% reported moderate-to-severe stress. Bivariate analysis showed a significant association between stress level and neck pain (p = 0.033; PR = 2.19; 95% CI: 1.25–3.83). In multivariate logistic regression, no variable reached conventional statistical significance; however, students with moderate-to-severe stress had a 3.81-fold higher risk of neck pain (p = 0.057). These findings underscore the need for integrated ergonomic and psychosocial interventions in Islamic boarding school settings to reduce neck pain risk among students.
PHYSICAL ENVIRONMENTAL INFLUENCES ON SILICOSIS: A NARRATIVE REVIEW INTEGRATING COMMUNITY EXPOSURE AND WISTAR RAT EXPERIMENTAL FINDINGS IN COAL-HANDLING REGIONS Mustika Fatimah; Irsan Saleh; Susila Arita; Legiran
Multidisciplinary Indonesian Center Journal (MICJO) Vol. 2 No. 4 (2025): Vol. 2 No. 4 Edisi Oktober 2025
Publisher : PT. Jurnal Center Indonesia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62567/micjo.v2i4.1808

Abstract

Coal mining, handling, and transportation activities are major sources of airborne particulate matter containing respirable crystalline silica, which poses significant risks to respiratory health. Silicosis remains a serious occupational and environmental disease affecting not only workers but also communities living near coal-handling areas. Physical environmental factors, including air quality, temperature, humidity, and wind speed, play an important role in influencing dust generation, dispersion, and inhalation exposure. This narrative review aims to synthesize current evidence on the influence of physical environmental conditions on silica exposure and silicosis development, integrating findings from environmental monitoring studies, epidemiological research, and experimental Wistar rat models. A literature search was conducted using major scientific databases to identify relevant peer-reviewed articles published between 2010 and 2024. The reviewed evidence indicates that prolonged or high-intensity exposure to silica dust is strongly associated with chronic pulmonary inflammation and progressive fibrosis. Environmental conditions can exacerbate exposure risk by increasing airborne particulate concentrations and respiratory vulnerability. Experimental studies using Wistar rats provide mechanistic insights into silica-induced lung injury, supporting epidemiological observations in human populations. This review highlights the importance of integrating environmental, occupational, and biological perspectives to improve risk prediction, early detection, and preventive strategies for silicosis in coal-handling regions.
Improvement IL -10 and Reactive Oxygen Species (ROS) in HIV patients : Narrative Review Franajayakk, Indra; Legiran; Salim, Eddy Mart; Hafy, Zen
Jurnal Kesehatan - STIKes Prima Nusantara Vol 16 No 1 (2025): Jurnal Kesehatan Volume 16 Nomor 1 Tahun 2025
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v16i1.1234

Abstract

Background: Infection Human Immunodeficiency Virus (HIV) is still become problem scary health​ for world community . This virus infection causes a bunch symptom disease characterized by with weakening system immunity body . A collection of symptoms This known with designation Acquired Immune Deficiency Syndrome (AIDS). Consequence the decline system immunity , HIV sufferers will prone to For caught various disease infections that can have fatal consequences. Objective: For know How improvement IL-10 and Reactive Oxygen Species (ROS) levels in HIV patients . Research methods: This use Narrative Review design . Articles searched from Google Scholar, PubMed, Science Direct, and EMBASE/ Elviser with use relevant keywords , then chosen based on criteria that have been set , and objectives study . Results: Increased levels of IL-10 and Reactive Oxygen Species (ROS) in patients results in a decrease in the immune system, this is characterized by increased virus replication, deactivation macrophages and depletion of the number of lymphocytes, so that the progression of the infection towards AIDS can occur. Conclusion: HIV infection causes the occurrence dysfunction mitochondria and enhancement production Reactive Oxygen Species (ROS) in cells CD4 + T lymphocytes. Various viral proteins, such as the envelope proteins Gp120, Tat, Nef and Vpr , are able to increase ROS production through various different pathways. The increase in ROS that occurs can increase mRNA expression through activation Nuclear Factor Kappa B ( NFκB ), increased IL-10 mRNA expression ultimately will increase IL-10 levels
Hubungan Morfologi Oosit dengan Angka Fertilisasi dan Kualitas Embryo Pada Program Fertilisasi In VitrO Gita Angella; Legiran Legiran; Yusuf Effendi
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.56144

Abstract

Infertilitas masih menjadi masalah kesehatan reproduksi yang signifikan, dan keberhasilan program in vitro fertilization (IVF) dipengaruhi oleh kualitas gamet, khususnya morfologi oosit. Penelitian ini bertujuan menganalisis hubungan morfologi oosit dengan angka fertilisasi serta kualitas embrio pada tahap pembelahan hari ke-3 dan blastokista hari ke-5. Penelitian ini merupakan penelitian analitik observasional dengan desain analitik komparatif menggunakan data sekunder pasien IVF di Blastula IVF Center Siloam Sriwijaya Palembang periode Maret 2021–Desember 2024. Sampel terdiri dari 213 pasien yang dipilih dengan teknik consecutive sampling. Variabel bebas meliputi parameter morfologi oosit (sitoplasma, polar bodi, ruang perivitelline , zona pelusida, dan bentuk oosit), sedangkan variabel terikat adalah angka fertilisasi dan kualitas embrio. Analisis data dilakukan menggunakan uji Chi-Square. Hasil penelitian menunjukkan bahwa morfologi dengan ruang perivitelline dan zona pelusida berhubungan signifikan dengan angka fertilisasi (p < 0,05). Pada kualitas embrio hari ke-3, ruang perivitelline dan bentuk oosit menunjukkan hubungan bermakna, sedangkan pada tahap blastokista hari ke-5 tidak ditemukan hubungan signifikan antara morfologi oosit dan kualitas embrio. Kesimpulannya, pengaruh morfologi oosit lebih dominan pada tahap awal perkembangan embrio dibandingkan tahap blastokista.
Co-Authors Abdul, Zabidah Achmad Ridwan, Achmad Ade Dian Anggraini Ade Permana Adinda Adinda Adinda Adnindya, Rulan Afriani Ahmat Umar Alibasyah A. Chakra Andrina, Hana Angella, Gita Ansyori Hatta Ardy Oktaviandi Ariani Susanti Arwan Bin Laeto Asri Maharani Astuti, Syurmi Aswin Nugraha Ayeshah A Rosdah Baehaqi Bella Ria Astuti Benny Kusuma Bermansyah Bernhard Arianto Purba Bunga Anggreini Sari Chandra, Novy Rosalia Christin, Theresia Danny Amos Tarigan Desi Arlindia Dian Wahyuni Diana Dewi Sartika Diana Polania Dini Rizkie Wijayanti Dini Rizkie Wijayanti Dwi Ariska Eddy Mart Salim Eddy Mart Salim, Eddy Mart Edi Susanto Effendi, Kms. Yusuf Efman EU Manawan Efrieni Yusuf Eka Febri Zulissetiana Elvi Sunarsih Erial Bahar Eva Julita Evi Lusiana Febrianto, Yohanes Ferawaty Ferawaty, Ferawaty Ferry Yusrizal Fitri Nurjanah Fitri Nurjanah Fitriani Fitriani Franajayakk, Indra Fredi Heru Irwanto Fredy Ferdinand Carol Furqan Indah Gama Satria Gama Satria Ghanie Abla Gita Angella Hafid Komar Handayani, Sri Harun, Yusril Hasbi, Alfian Henry Sugiharto Indah, Furqan INDRA FRANA JAYA KK Indri Seta Septadina Irfannuddin Irfannuddin Irsan Saleh Irsan Saleh, Muhammad Islamia, Medina Putri Joneri, Alrahman KAMILA, YURI Kartika, Juspeni Kemas Muhammad Dahlan Kesty, Cindy Kgs. M. Rosyidi Kms Yusuf Effendi Kms. Yusuf Effendi Kurniawan, Didy Layal, Kamalia Lia Nurbanillah Fujianti M. Afif Heldian Putra M. Zalili Azis Malahayati, Putri Martinova, Vera Mediarty Mega Sary Mega Sary Meirisa Rahma Pratiwi Mgs. Irsan Saleh Mgs.Muhammad Irsan Saleh Misnaniarti Misnaniarti Muhammad Arma Muhammad David Riandy Muhammad Hasnawi Haddani Muhammad Ikhsan Kartawinata Muhammad Irsan Muhammad Irsan Saleh Muhammad Ramadhan Odiesta Muhammad Reagan MUSTIKA FATIMAH Mutiara Budi Azhar Nadia Maharni Nadya Aviodita Nedya Bellinawati Nopriyati Nova Kurniati Novy Rosalia Chandra Nur Qodir Nur Qodir Nur Riviati, Nur Nurjanah, Fitri Odiesta, Muhammad Ramadhan Okta Emilia Patiyus Agustiansyah Patresia, Retta Pinto Desti Ramadhoni Pirma I.R.M Poedji Loekitowati Hariani Precelia Fransiska Puspa Zuleika, Puspa Putri Mirani Qodir, Nur Radema Pranata Ria Nova Rico Januar Sitorus Ridho Surya Putra Rika Purnama Sari Rini Maya Sari Rini Nindela, Rini Rizal Sanif Rizal Zainal Rizma Adlia Syakurah Rose Mafiana Safyudin Saleh, Muhammad Irsan Salni Salni Sary, Mega Shafira Irmayati Sima Asmara Dewa Marya Mahardika Putri Sima Asmara Dewa Marya Mahardika Putri Siti Nurmaini Siti R. Nanin Siti Rusdiana Puspa Dewi Soenarto Kartowigno Sugiharto, Henry Suly Auline Rusminan Susila Arita Syifa Alkaf Taufik Indrajaya Taufik Kurrohman Theresia Christin Tri Suciati Tri Suciati Tri Suciati Vidro Alif Gunawan Wahyuni, Devi Azri Wardiansah Wardiansah, Wardiansah Wardiansah, Wardiansah Wika Sepiwiryanti Wiria Aryanta Yangtjik Yangtjik Yuli Kurniawati Yulianto Kusnadi Yunindyawati Yunindyawati Yuniza Yusni Puspita Yusuf Effendi Yusuf Effendi Yusuf, Khaidir Zakaria Mukalla Zen Hafy Zulkhair Ali Zulkhair Ali Zulkifli