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Aksono HP., Eduardus Bimo
Division Of Veterinary Basic Medicine, Faculty Of Veterinary Medicine, Universitas Airlangga, Surabaya-Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Journal of Applied Veterinary Science and Technology

 1 
The Influence of Oral Administration of Red Dragon Fruit Peels Extract (Hylocereus polyrhizus) on Increasing High Density Lipoprotein in Male White Rats (Rattus norvegicus) Hypercholesterolemia Ahmad Thoriqul Firdaus; Gandul Atik Yuliani; Tri Wahyu Suprayogi; Nusdianto Triakoso; Eduardus Bimo Aksono Herupradoto; Nanik Hidayatik
Journal of Applied Veterinary Science And Technology Vol. 4 No. 1 (2023): April 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/javest.V4.I1.2023.1-4

Abstract

Background: Hypercholesterolemia is one of the most common diseases in the world, with cholesterol levels exceeding normal levels. Hypercholesterolemia can cause various systemic disorders in the body. One of the signs is by decreasing HDL (High-Density Lipoprotein) cholesterol levels. Dragon fruit peel contains many ingredients, such as vitamin B3 (niacin), vitamin C, flavonoids, anthocyanins, and other minerals that can affect the increase in HDL production and reduce total cholesterol levels. Purpose: To know the effect of red dragon fruit peel extract (Hylocereus polyrhizus)on increasing levels of High-Density Lipoprotein (HDL) in male rats (Rattus norvegicus) hypercholesterolemia. Methods: Male rats were made hypercholesterolemic using a mixture of lard (3 ml) and egg yolk (1 g) for 14 days orally. 20 hypercholesterolemic male rats were further divided into 5 treatment groups and given dragon fruit peel extract therapy with different treatments, namely T0 negative control (CMC-Na 1% + aquadest), T1 positive control (Simvastatin 0.0013 mg/200 g BW), T2, T3 and T4 (each 100, 150, 200 mg/kg BW red dragon fruit peel extract) for 14 days orally.  Blood serum was taken on day 36 and tested in the laboratory using a chemical analyzer machine; then the data were analyzed using the univariant multiple way one-way ANOVA statistical test with a significant difference (p>0.05). Results: The P4 treatment group has an effective dose (200 mg/kg BW) to increase high-density lipoprotein (HDL) levels, while the P3 treatment group (dose 150 mg/kg BW) is less effective but can still have an effect. Conclusion: This research showed that red dragon fruit peel extract could increase HDL (High-Density Lipoprotein) cholesterol levels with an effective 200 mg/kg BW dose.
Co-Authors Adelina Grace Aditya Irawan Ahmad Thoriqul Firdaus Al arif, Mohammad Anam Al-Arief, Mohamad Anam Aldise Mareta Nastri, Aldise Mareta Amal, Mohammad Noor Azmai Ana Adelina Farahdiba Annas Salleh Anwar Ma'ruf Anwar Ma'ruf Aprinda Ratna Lovela Aquaresta, Febriana Arianto, Intan Diah Safitri Aryaloka, Suhita Aryati Aryati Ayuti, Siti Rani Bambang Sektiari Lukiswanto Billa, Lutfiah Annisa Boedi Setiawan BUDI UTOMO Candra Dwi Atma Choirul Oktavian Setiyadin Nayiron Chusniati, Sri Daruti Dinda Nindarwi Dewi, Nina Nurmalia Dita Wisudyawati Dyah Ajeng Suhita Eka Pramyrtha Hestianah Endang Suprihati Erlita Rusnaningtias Ernawati, Rahaju Fajar Ramadhan Subiyantoro Fedik Abdul Rantam Firnanda, Ferian Gandul Atik Yuliani Gazali Salim HAK HOTTA Hapsari, Nafisah Nurul Hasib, Abdullah Heni Puspitasari HERNOMO ONTOSENO KUSUMOBROTO Hestiana, Eka Pramyrtha Hidajati , Nove Hidajati, Nove Hidayatik, Nanik Ira Sari Yudaniayanti Ira Sari Yudaniyanti Ismudiono Iwan Sahrial Hamid Juniastuti Juniastuti Kadek Rachmawati Kadek Rachmawati Khairullah, Aswin Rafif Khanand, Nadeem Kuncorojakti, Suryo Kuncorojati, Suryo Kurniawan, Muhammad Ridho Hafid Kusnoto Kusnoto Lastoaji, Firman Lilis Mundri Jannah, Lilis Mundri Lovela, Aprinda Ratna Lucia Tri Suwanti, Lucia Tri M. Gandul Atik Yuliani Maria Inge Lusida MARIA INGE LUSIDA Meles, Dewa Ketut Mirni Lamid Mochamad Lazuardi Mohammad Noor Amal Azmai Moses, Ikechukwu Benjamin Muchammad Yunus Mufasirin Muhammad Qushai Y. Matondang, Muhammad Qushai Y. Muhammad Rivai Nanik Hidayatik Nasronudin Nasronudin Niken Meyliana Sari Nove Hidajati Nufus, Faizah Zakiyyatun Nur Syamsiatul Fajar, Nur Syamsiatul Nurfitri, Yulia Nurhusien Yimer Nurrahmad, Nanda Rino Nusdianto Triakoso Perdana, Rizka Fathoni Pinayungan, Probo Probo Warih Tatag Poedji Hastutiek Pudji Srianto Puput, Sesa Putri Desi Wulan Sari Rahmahani, Jola Rahmawati, Kadek Rochmah Kurnijasanti Rozi Salleh, Annas Santanumurti, Muhammad Browijoyo Sari, Aulia Puspita Sari, Putri Desi Wulan Sasmono, R. Tedjo Setiawan Koesdarto Shifa Fauziyah Sin War Naw SOETJIPTO . Sri Herawati Sri Pantja Madyawati Sri Subekti Srimaryanto, Leonardo Reza Sudar Itafarida Suherni Susilowati Sukmanadi, Mohammad Sunarso, Agus Suroso, Bakti Suwarno Suwarno Suwarno TAKAKO UTSUMI Tatik Hernawati Teguh Hari Sucipto, Teguh Hari Tita Damayanti Lestari Tri Wahyu Suprayogi Tyasningsih, Wiwiek Usma Nur Dian Rosyidah Wahyuni, Retno Sri Widiyatno, Thomas Valentinus Widya, Alicia Margaretta Wiwiek Tyasningsih Wiwik Misaco Yuniarti Woro Hastuti Setyantini Yohan, Benediktus YOSHIHIKO YANO YOSHITAKE HAYASHI Yuliani, Margareth Gandul Atik Yunus , Muchammad Yunus, Muchammad