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Journal : Medula

Optimasi Kadar Fenilbutazon dalam Pembawa Vesikular Etosom (Optimization of Concentration of Phenylbutazone in Ethosomes Vesicular Carrier) Nur Illiyyin Akib; Muhammad Handoyo Sahumena; Yunita Dawu; Vica Aspadiah; Indria Hafizah; Halimahtussaddiyah Ritonga
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 7, No 2 (2020)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v7i2.11968

Abstract

Background: Phenylbutazone is a class of non-steroidal anti-inflammatory drugs (NSAIDs) used in the treatment of rheumatoid arthritis. Phenylbutazone is used by the transdermal route to reduce the irritating effect on the gastrointestinal tract. Purpose: This study aims to obtain phenylbutazone suspensions with optimal levels in the ethosome vesicular carrier. Methods: Preparation was carried out by the hot method (40oC) and cold method (30oC) as well as variations in the concentration of phosphatidylcholine (2% and 3%) and ethanol (30%, 35%, and 40%). Characterization of vesicles, namely the shape and size of vesicles using optical microscopy and entrapment efficiency using the spectrophotometer method with λ maks 266.6 nm. Optimization of phenylbutazone levels was carried out at a concentration of 0.1%; 0.15%; 0.2%; and 0.25%. The optimum formula was obtained at a concentration of phosphatidylcholine 3% and ethanol 35% prepared by the hot method. Results:. The form of a Small Unilamellar Vesicle (SUV), a size of 23.7 nm, and entrapment efficiency is 88.358%. Optimization of phenylbutazone levels was obtained at a concentration of 0.1% with entrapment efficiency of 88.358%. Conclusion: The optimum level of phenylbutazone in the vesicular carrier ethosome was 0.1%.Keywords: ethosome, optimation, phenylbutazone, transdermal ABSTRAKLatar Belakang: Fenilbutazon merupakan golongan obat antiinflamasi non stroid (AINS) yang digunakan pada pengobatan penyakit rheumatoid arthritis. Fenilbutazon digunakan melalui rute transdermal untuk mengurangi efek iritasi pada saluran cerna. Tujuan: Penelitian ini bertujuan memperoleh suspensi fenilbutazon dengan kadar yang optimal dalam pembawa vesikular etosom. Metode: Preparasi dilakukan dengan metode panas (40oC) dan metode dingin (30oC) serta variasi konsentrasi fosfatidilkolin (2% dan 3%) dan etanol (30%, 35%, dan 40%). Karakterisasi vesikel yaitu bentuk dan ukuran vesikel menggunakan mikroskop optik serta efisiensi penjerapan menggunakan metode spektrofotometer pada λmaks 266,6 nm. Optimasi kadar fenilbutazon dilakukan pada konsentrasi 0,1%; 0,15%; 0,2%; dan 0,25%. Diperoleh formula optimum pada konsentrasi fosfatidilkolin 3% dan etanol 35% yang dipreparasi dengan metode panas Hasil: Vesikel yang diperoleh berbentuk Small Unilamellar Vesicle (SUV), ukuran 23,7 nm, dan efisiensi penjerapan 88,358%. Optimasi kadar fenilbutazon diperoleh pada konsentrasi 0,1% dengan efisiensi penjerapan 88,358%. Kesimpulan: Disimpulkan bahwa kadar optimum fenilbutazon dalam pembawa vesikular etosom adalah 0,1%.Kata kunci: etosom, optimasi, fenilbutazon, transdermal
Co-Authors Abrar Adryan Fristiohady Aftira, Nidya Ahmad, Murliyana Ali, Nur Fitriana Muhammad Amalia, Afriani Amilia Primawanty Andriani, Rina Anwar, Irvan Aprillia, Dilla Arba, Muhammad Armadhani, Fery Indradewi Asniar Pascayantri Asrianti, Wa Ode Asrul Sani Asrul Sani, Asrul Astrid Indalifiany Azzahra, Dhealfa Bafadal, Mentarry Baru Sadarun Chatarina Umbul Wahyuni Diana Pratiwi Fadhliyah Malik Faeni Feny Rizkiana Poko Fery Indradewi Firda, Andi Fristiohady, Adryan Gamoro, Ayu Riski Halik Halik, Halik Halimahtussaddiyah Ritonga Hamuni, Muhammad Farid Hanija, Nur Haris, Restu Hartawaty, Siska Septy Hasnawati Hasnawati Hasnawati Hasnawati Husniati Husniati, Husniati Idawati Idawati Indalifiany, Astrid Indria Hafizah Irmayani Jubir Jabbar, Asriullah Jumilta Karangan, Refky Caesar Kasmawati, Henny La Ode Nggawu Loly Subhiaty Idrus Loly Subhiaty Idrus Longgi, Anggun S. Mahmudah, Rifa’atul Mahmudah, Rifa’atul Malaka, Muhammad Hajrul Malina, Rachma Marchelda, Theyuci Masrida, Wa Ode Mega Fatimah Rosana Mesi Leorita, Mesi Mugiarno, Dita Oktavianti Muhammad Ammar Muhammad Handoyo Sahumena Munasari, Dian Murniati Muzuni, Muzuni Nabilah, Kezia Azzahra Nadiya Mutmainnah NASRUDIN Nauli, Agnes Negoro, Wianda Puspo Novani, Bestari Nur Aida Nur Annisa Nur Illiyin Akib, Nur Illiyin Nur Illiyyin Akib Nur Illiyyin Akib Nur Illiyyin Akib Nur Illiyyin Akib Nur Intan Darwis Nur Rayani Nurramadhani A. Sida Nursyam Nursyam Nurul Karina, Nurul Nurull Hikmah Nurull Hikmah Parawansah Parrung, Arsyani Pascayantri, Asniar Puspita Sari Putri, Riski Melani Rachma Malina RAHMAT MULIADI RAHMAT MULIADI, RAHMAT Ramadhani, Rizky Barkah Restu Nur Hasanah Restu Nur Hasanah Haris Rifa'atul Mahmudah Rifaldi, Aimar Rifa’atul Mahmudah Rina Andriani Rivai, Talitha Nayla Shabira Rosmaria, Rosmaria Ruslin, Ruslin Sabarudin Sabarudin Sabarudin Sabarudin Sahidin . Sahumena, Muhammad Handoyo Salam, Audi’ah Putri Amaliah Saputri, Wanda Januarty Sari, Dini Putri Sarry, Elita Puspita Septrilia, Shara Sitti Nuraisyah Wahyuningrum Sitti Raodah Nurul Jannah Sitti Zubaydah, Wa Ode Solly Aryza Sukma, Tsaqila Aulia Sunandar Ihsan, Sunandar SURYANI Suryani Suryani Tias, Ayuning Tolohuly, Syahril Musafir Ratu Wa O.S. Zubaydah Wa Ode Masrida Wa Ode Sitti Zubaydah Wa Ode Sitti Zubaydah Wahyuni wahyuni wahyuni Waode, Nurul Wardana, Gede Yogi Prana Yamin Yamin, Yamin Yunita Dawu Zubaydah, Wa Ode Sitti