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Winda Trijayanthi Utama, Winda Trijayanthi
Faculty Of Medicine, University Of Lampung
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Journal : Journal Medical Informatics Technology

 1 
Renewable Therapy Potential of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for Idiopathic Pulmonary Fibrosis Bawono, Aloysius Krishartadi Damar; Balqis, Gasela Zalianti; Haq, Rais Amaral; Sari, Ratna Dewi Puspita; Utama, Winda Trijayanthi; Daulay, Suryani Agustina
Journal Medical Informatics Technology Volume 2 No. 2, June 2024
Publisher : SAFE-Network

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37034/medinftech.v2i2.34

Abstract

Idiopathic pulmonary fibrosis (IPF) is a rare chronic respiratory disease characterized by progressive fibrotic changes in lung tissue of unknown origin, resulting in severe decline in lung function and poor prognosis with a median survival of 3 to 5 years. Current pharmacological therapies, including nintedanib and pirfenidone, aim to slow disease progression but are limited by side effects and lack of efficacy in reversing established fibrosis. This literature review explores emerging therapeutic approaches for IPF using data from PubMed, Google Scholar, and ScienceDirect databases. The review highlights mesenchymal stem cell (MSC) therapy, specifically allogeneic bone marrow-derived MSCs, as a promising option. MSC therapy demonstrates superior efficacy in improving forced vital capacity (FVC) by 3.7%, surpassing the effects of nintedanib (3.3%) and pirfenidone (-4.8%), while exhibiting minimal adverse effects. The findings underscore the potential of MSC therapy as a renewable treatment option for IPF, suggesting a paradigm shift towards addressing both disease progression and lung function restoration in affected individuals.
Co-Authors Aditia, Arianda Alghani, Sulthan Rafi Amanah, Nur Suci Amelia, Maya Rizky Amir, Anzela Ananda, Amallia Andini Pramesti Ningrum Andriani, Silvia Anggraini, Dian Isti Anisa Adelia Annisa Auliya Dien Safitrie Arifah Putri Desenia Asep Sukohar Azelia Nusadewiarti Azhar, Hafidz Sirojudhin Azmi, Aulia Salma Balqis, Gasela Zalianti Bawono, Aloysius Krishartadi Damar Bayu Anggileo Pramesona Daulay, Suryani Agustina Dharmesti, Rizky Aleyda Dian Pratiwi Dian Puspita Larasati Dita Ayu Permata Dewi Dwita Oktaria Dyah Wulan Sumekar Rengganis Wardani Eniwati Eniwati Evi Kurniawaty Fadhilah, Retno Suci Fadhillah, Paisal Fatharanni, Mentari Olivia Fathia, Nauriel Ferdian, Ruben Fitria Saftarina Hafizh, Ahmad Fauzan Haq, Rais Amaral Helmi Ismunandar Indika Poloriani Tunang Indriyani, Reni Intan Kusumaningtyas Intanri Kurniati Intanri Kurniati Iqbal Lambara Putra Istiqomah, Dinni Jovita, Hasna Laili Khairun Nisa Kurniawaty, Evi Kusuma, Febriyani Dyah Lariza Serafina Tobroni Maharani, Ardila Putri Maharani, Calista Putri Maharani, Raihan Syifa Maharani, Shella Marcellia, Selvi Mersiana, Putri Febi Muhammad Aditya, Muhammad Muhammad Maulana Muhartono Muhartono Nasser, Ghalib Abdul Novita Carolia Novita Carolia Nurhardita, Fika Nuriah Nuriah Nurladira, Salsanisa Tisno Nurliwayka Qodri, Amari Oktadoni Saputra Oktafany, Oktafany Pamarta, Rachel Dwyana Prayogi, Norbertus Marcell Puspitasari, Ratna Dewi Putra, Ruchpy Cahya Putri Puspa Devi Putri, Asyifa Dinda Raehana, Nabila Salwa Raharjo, Shafana Azzahra Rasmi Zakiah Oktarlina Ratna Dewi PS Ratna Dewi Puspita Sari Ratu Nirmala Wahyunindita Reni Indriyani Reni Indriyani Reni Indriyani Reynhard Theodorus Xaverius Saragih Riandini, Sabrina Risti Graharti Rizal Effendi, R E Sahputra, Rahmat Tridhandy Salma Alya Ihsan Salsabila Alifiyah Setiawan Salsabila Dzakiyyah Zahra Sany Setiawan Satria Adi Nugraha Septia Eva Lusina Septiani, Linda Setiorini, Anggi Shinta Nareswari, Shinta Silvia Andriani Sirait, Naomi Elfriede Situmorang, Cindy Miranda Sofyan Musabiq Wijaya Sofyan Musyabiq Wijaya Stevani Febeline Steven, Nixon Suarto, Sutarto Suharmanto Suharyani Suharyani Suryawinata, Arli Sutarto Sutarto Sutarto Sutarto Sutarto Sutyarso Sutyarso Syazili Mustofa Syifa Rahmi Fadhila TA Larasati takhfa nur asyifa Tasya Nadia Putri Tri Umiana Soleha Utomo, Muhammad Aditya W, Sofyan Musyabiq Waluyo Rudiyanto Wardani, Nanda Fitri Widjaja, Jovan Zahra, Tsurayya Fathma