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Journal : Medula

Intoksikasi Pasca Ingesti Herbisida Paraquat Sany Setiawan; Risti Graharti; Winda Trijayanthi Utama
Medula Vol 10 No 3 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i3.104

Abstract

Paraquat dichloride is an active ingredient of the herbicide gramoxone which is often used for weed control and crop maintenance in the agricultural sector, paraquad dichloride is a broad spectrum contact herbicide which is geneally applied post growth. This herbicide is able to kill all types of weeds in the part that provides the herbicide solution direcly, because the dose and time of application used are correct so that the herbicide is effective in controlling weeds. Paraquat herbicide has a danger to organs such as eyes, skin, respiratory system, liver, heart, kidneys, and digestive tract. A man agreed to 56 years, a farmer, came with complacency since 3 days ago. Moisture with hoarseness, recovery, difficulty in carrying, and burning sensation in the chest. 5 days before admission, the patient inadvertently swallowed poison while working in the fields. On physical examination, hyperemic mucosa appears in the oral cavity, pharynx, and tonsils, as well as erosion in the posterior tongue and uvula. In indirect laryngoscopy, hyperemic mucosa and edema appear in the larynx and epiglottis. Investigations urea 276 mg / dl and creatinine 9.72 mg / dl. Patients diagnosed with acute laryngopharyngitis suspected corrosive esophagitis and post-intoxication of herbicides with acute kidney injury. Management of patients, namely: 1) 8 lpm oxygen with NRM, 2) IVFD RL 500 ml / 8 hours, 3) ceftriaxon 1 gr / 12 hours, 4) Furosemide / 8 hours, 5) Ranitidine 1 amp / 12 hours, 6) Metilprednisolone 125 mg / 12 hours, 7) Ketorolac 1 amp / 8 hours, 8) HD cito, 9) Bicnat 3 x 1000 mg, 10) Vit B12 3x1. The prognosis for paraquat poisoning greatly affects the amount of paraquat absorbed by the body, whereas the patient in this case is considered a good prognosis because the patient drank <20mg / kg of poison which could cause mild poisoning.
Hubungan Asupan Protein Nabati dengan Kadar Hemoglobin Pada Wanita Usia Remaja Vegan Eniwati Eniwati; Ratna Dewi PS; Winda Trijayanthi Utama
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.262

Abstract

Nutrition is one of the determinants of the quality of human resources. Malnutrition can cause failure of physical growth and development of intelligence, reduce work productivity and reduce endurance. The role of essential nutrients is basically not taken seriously by the community, especially adolescents. Insufficient nutritional needs in adolescents occur due to an imbalance in the intake of nutrients in the diet. The diet of adolescents is currently influenced by their environment, such as friends and media in choosing foods that tend to follow trends, coupled with wrong eating habits such as a vegetarian diet, dislike or abstinence from certain types of food. Vegetarian diets have a high risk for the occurrence of deficiency of several nutrients such as protein, iron, calcium, zinc, copper, amino acids, fatty acids, omega 3, omega 6, vitamin D, and Vitamin B12. Protein is the most high-risk nutrient that is deficient in vegetarians and has a function that is essential for the body in the formation of hemoglobin (Hb), protein plays an important role in the transportation of iron in the body. Therefore, a lack of protein intake can cause iron transport to be hampered resulting in iron deficiency resulting in anemia. Several studies have shown that there is a significant relationship between vegetable protein intake and hemoglobin levels.
‘Happy’ Hipoksemia pada pasien COVID-19 Dita Ayu Permata Dewi; Winda Trijayanthi Utama
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.107

Abstract

One of the dubious aspects for a doctor who treats COVID-19 patients with patients who have experienced hipoxia, but without the proper signs of respiratory distress, even the absence of complaints of shortness of breath. This phenomenon is referred to as ‘happy hipoxia’. For doctors, the presence of ‘happy hipoxia’ in a Covid-19 patient, even though the patient is in a hypoxemic state, can mistakenly lead to the message that the patient is not in a critical condition and is fine. These cases can rapidly skip the clinical evolutionary stage and develop Acute Respiratory Distress syndrome (ARDS), with cardiac and respiratory attacks simultaneously leading to sudden death. Pulse oximetry should be interpreted with caution, as the oxyhemoglobin dissociation curve shifts to the left. The pathophysiology of ‘happy hipoxia’ can be accepted by the hypothesis that neurological factors are involved. Hypoxia usually activates carotid body chemoreceptors, and afferent signals are transmitted through the nucleus tractus solitarius. This usually causes an increase in the respiratory rate and sensation of dyspnea. SARS-CoV-2 infects the brain via the olfactorial bulb and olfactory nerves, via trans-synaptic spread, eventually reaching the brain stem, and the nucleus tractus solitarius. Inflammation of the nucleus solitarius tract by viral invasion that stimulates afferent hypoxia from the carotid body may not be transmitted effectively to the nucleus solitarius tract, resulting in impaired efferent respiratory response. This explains why COVID-19 patients exhibit near normal breathing in the presence of severe hipoxia (Happy hypoxia). The clinician must not only trust a patient who appears ‘happy’ but must also trust the respiratory rate, signs of hyperventilation, oxygen saturation, and invasive measurements of hipoxia / hypocapnia at regular time intervals.
Pengaruh Konsumsi Teh Hijau Terhadap Penurunan Tekanan Darah Pada Pasien Hipertensi Andini Pramesti Ningrum; Winda Trijayanthi Utama; Intanri Kurniati
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.122

Abstract

Hypertension is one of the most common diseases found in primary medical practice. The manifestation of hypertension is a disorder of cardiovascular hemodynamic balance which has an increase in systolic blood pressure ≥ 140 mmHg and or diastolic blood pressure ≥ 90 mmHg which is persistent, on repeated examinations. Hypertension complications can affect various target organs such as the heart, brain, kidneys, eyes, and peripheral arteries. Hypertension is influenced by the role of intravascular volume, the role of autonomic nerve control, and the role of renin angiotensin aldosterone. Tea is thought to have a variety of health benefits and most of the evidence suggests that green tea consumption is associated with lowering blood pressure. Tea and its secondary metabolites, namely polyphenolic compounds called flavonoid, play an important roles in relaxing smooth muscle contraction, enhancing eNOS activity, reducing vascular inflammation, inhibiting rennin and endothelin-1 activity and anti-vascular oxidative stress. Consumption of green tea can significantly reduce systolic blood pressure by 1.98 mmHg and diastolic blood pressure by 1.92 mmHg. The positive effect of green tea on blood pressure was obtained after consuming low doses (<582.8 mg/day) with long-term duration (≥12 weeks). A drop in blood pressure can lower the chance of complications.
Manifestasi Kulit pada COVID-19; Pengulasan Syifa Rahmi Fadhila; Winda Trijayanthi
Medula Vol 11 No 1 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i1.132

Abstract

COVID-19 is a respiratory infection caused by the coronavirus. The main target of this virus attacks the mucosa of the upper respiratory tract and angiotensin-converting enzyme (ACE2) which is the receptor for viral entry. COVID-19 has many clinical manifestations. The clinical manifestations that appear in COVID-19 patients are similar to other respiratory viral infections, such as high fever, dry cough. However, over time there are many other manifestations such as fever, dry cough, diarrhea, shortness of breath (dyspnea), ageusia, anosmia, and the onset of skin manifestations. This article discusses skin manifestations in COVID-19 patients based on literature studies. The research method used in this journal is literature review. The author is looking for literature related to the topics discussed in this journal. From the research results, the skin can appear within 3 days before being diagnosed up to 13 days after being diagnosed with COVID-19. In the case of positive Covid-19 asymptomatic patients, clinical manifestations will appear on the 14th day and can be used as indicators of diagnosis. The most common skin manifestation that appears in COVID-19 patients is a maculopapular rash. Other lesions that can occur in COVID-19 patients, especially in young adults to the elderly, are urticaria, erythema nodosum, vesicular rash, petechiae / purpuric rash.
Kurkumin dan Inflammatory Bowel Disease Stevani Febeline; Winda Trijayanthi Utama; Waluyo Rudiyanto
Medula Vol 11 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Inflammatory Bowel Disease (IBD) is an inflammatory disease of the gastrointestinal tract. The exact cause of Inflammatory Bowel Disease is not yet known clearly. The diagnosis of inflammatory bowel disease is often delayed due to non-specific and intermittent symptoms. There are 2 types of IBD, namely Ulcerative Colitis and Crohn's Disease. Management of IBD can be done with drug therapy, surgery, or a combination of both. This therapy aims to reduce symptoms, improve quality of life, prevent disease recurrence and avoid complications. IBD treatment can occur over a long period of time, during which time it costs quite a bit and can cause various side effects that can be experienced by patients. Therefore, experts began to consider other alternative therapies that could be used, for example the use of curcumin compounds. Curcumin is the active pigment that gives turmeric its yellow color, a plant that belongs to the ginger family or Zingiberaceae and contains anti-inflammatory substances. The mechanism of action of curcumin is by suppressing activity of Nuclear Factor-Kappa B (NF-KB) and also plays a role in suppressing Interleukin-1 (IL-1), IL-6, IL-12, IL-17, and Tumor Necrosis Factor Alpha (TNF). -α), two major cytokines that play an important role in the regulation of the inflammatory response. Management of IBD can be done through the administration of drugs so that curcumin can be considered as one of the treatments for IBD.
Analisis Hipertensi Sebagai Faktor Risiko Terjadinya Penyakit Ginjal Kronik Satria Adi Nugraha; Sutarto; Winda Trijayanthi Utama
Medula Vol 12 No 4 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i4.527

Abstract

Chronic kidney disease (CKD) is a disease that has a fairly high impact on morbidity and mortality in the community. The prevalence of CKD in the world reaches 8-16%, while in Indonesia according to basic health research data in 2018 at the age of 15 years the incidence of CKD is 0.64% and is increasing every year. Hypertension is one of the risk factors for CKD. Hypertension is the most common cardiovascular disease suffered by the community and according to WHO data in 2015 there were 1.13 billion people experiencing hypertension. The method used by the author in compiling this article is in the form of a literature review study covering the activities of collecting scientific sources both nationally and internationally and presenting a summary in the form of the most relevant publications. Hypertension has a relationship with the incidence of CKD. This is reinforced and in line with several studies that have been carried out and obtained the results that there is a significant relationship between hypertension and CKD.
Cara-cara mempercepat penyembuhan luka takhfa nur asyifa; Syazili Mustofa; Helmi Ismunandar; Winda Trijayanthi
Medula Vol 12 No 4 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i4.531

Abstract

A wound is a disconnection of tissue continuity due to damage, or loss of tissue substance due to injury or surgery. wounds are the most common injuries found in our daily lives. there are 3 phases of wound healing process are inflammatory phase, proliferation phase and maturation phase. this process is influenced by many factors like patient factors, wound factors and local factors. in the wound healing process, there are several things that can accelerate wound healing are away from cigarettes, reducing stress, improving nutrition by adding supplements (protein, vitamins and minerals), control chronic disease, stop consume alcohol, prevent infections (wound dressings and antibiotik), and avoid medical drugs that can affect wound healing. by understanding the physiology of good wound healing, we can accelerate wound healing and minimize unwanted effects
Pengelolaan Limbah Obat dalam Rumah Tangga Tasya Nadia Putri; Winda Trijayanthi Utama
Medula Vol 12 No 4 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i4.549

Abstract

Environmental pollution caused by drug waste has become a global concern because it can reduce the quality of human life. Based on Riskesdas 2018, 35.2% of households store drugs for self-medication. Drug waste is estimated to increase along with the population growth rate, followed by increased consumption of drugs in the community. Drug waste includes unused and expired drugs. Household drug waste is usually disposed of directly into landfills, so it has the potential to cause various problems in the environment, including damage to water, air, and soil, ecosystems, toxins for animals and humans. This article aims to determine the management of pharmaceutical waste in the household so that it does not cause negative impacts on health and the environment. The method of writing this article with a literature review is to analyze the management of drug waste in the household. Most people do not know the proper management of drug waste. Drug waste is disposed of without paying attention to the drug waste management system. The community is expected to be able to implement the management of drug waste in households to prevent environmental pollution that can reduce the quality of life.
PROFIL LIPID DAN TATALAKSANA PADA PENDERITA XANTHELASMA PALPEBRARUM Reynhard Theodorus Xaverius Saragih; Sutarto; Winda Trijayanthi Utama
Medula Vol 13 No 2 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i2.658

Abstract

Xanthelasma palpebrarum is the occurrence of yellowish flat lesions around the eyelids. Xanthelasma is generally found in adults over the age of fifty. It is not known exactly how xanthelasma can occur, but xanthelasma is thought to be related to atherosclerosis. In this study, lipid profile analysis and management of xanthelasma patients were carried out. Literature collection was carried out with the inclusion criteria in the form of literature published maximum in 2012. Meanwhile, the exclusion criteria were in the form of literature published in 2011 and below. The results of the study showed increased levels of serum cholesterol, triglycerides, VLDL, and HDL in xanthelasma patients. This study also found an increase in Epicardial Adipose Tissue (EAT) in xanthelasma patients, which these findings indicate that there is a relationship between xanthelasma and atherosclerosis.
Co-Authors Aditia, Arianda Alghani, Sulthan Rafi Amanah, Nur Suci Amelia, Maya Rizky Amir, Anzela Ananda, Amallia Andini Pramesti Ningrum Andriani, Silvia Anggraini, Dian Isti Anisa Adelia Annisa Auliya Dien Safitrie Arifah Putri Desenia Asep Sukohar Azelia Nusadewiarti Azhar, Hafidz Sirojudhin Azmi, Aulia Salma Balqis, Gasela Zalianti Bawono, Aloysius Krishartadi Damar Bayu Anggileo Pramesona Daulay, Suryani Agustina Dharmesti, Rizky Aleyda Dian Pratiwi Dian Puspita Larasati Dita Ayu Permata Dewi Dwita Oktaria Dyah Wulan Sumekar Rengganis Wardani Eniwati Eniwati Evi Kurniawaty Fadhilah, Retno Suci Fadhillah, Paisal Fatharanni, Mentari Olivia Fathia, Nauriel Ferdian, Ruben Fitria Saftarina Hafizh, Ahmad Fauzan Haq, Rais Amaral Helmi Ismunandar Indika Poloriani Tunang Indriyani, Reni Intan Kusumaningtyas Intanri Kurniati Intanri Kurniati Iqbal Lambara Putra Istiqomah, Dinni Jovita, Hasna Laili Khairun Nisa Kurniawaty, Evi Kusuma, Febriyani Dyah Lariza Serafina Tobroni Maharani, Ardila Putri Maharani, Calista Putri Maharani, Raihan Syifa Maharani, Shella Marcellia, Selvi Mersiana, Putri Febi Muhammad Aditya, Muhammad Muhammad Maulana Muhartono Muhartono Nasser, Ghalib Abdul Novita Carolia Novita Carolia Nurhardita, Fika Nuriah Nuriah Nurladira, Salsanisa Tisno Nurliwayka Qodri, Amari Oktadoni Saputra Oktafany, Oktafany Pamarta, Rachel Dwyana Prayogi, Norbertus Marcell Puspitasari, Ratna Dewi Putra, Ruchpy Cahya Putri Puspa Devi Putri, Asyifa Dinda Raehana, Nabila Salwa Raharjo, Shafana Azzahra Rasmi Zakiah Oktarlina Ratna Dewi PS Ratna Dewi Puspita Sari Ratu Nirmala Wahyunindita Reni Indriyani Reni Indriyani Reni Indriyani Reynhard Theodorus Xaverius Saragih Riandini, Sabrina Risti Graharti Rizal Effendi, R E Sahputra, Rahmat Tridhandy Salma Alya Ihsan Salsabila Alifiyah Setiawan Salsabila Dzakiyyah Zahra Sany Setiawan Satria Adi Nugraha Septia Eva Lusina Septiani, Linda Setiorini, Anggi Shinta Nareswari, Shinta Silvia Andriani Sirait, Naomi Elfriede Situmorang, Cindy Miranda Sofyan Musabiq Wijaya Sofyan Musyabiq Wijaya Stevani Febeline Steven, Nixon Suarto, Sutarto Suharmanto Suharyani Suharyani Suryawinata, Arli Sutarto Sutarto Sutarto Sutarto Sutarto Sutyarso Sutyarso Syazili Mustofa Syifa Rahmi Fadhila TA Larasati takhfa nur asyifa Tasya Nadia Putri Tri Umiana Soleha Utomo, Muhammad Aditya W, Sofyan Musyabiq Waluyo Rudiyanto Wardani, Nanda Fitri Widjaja, Jovan Zahra, Tsurayya Fathma