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Ratna Dewi Puspita Sari
Faculty Of Medicine, Universitas Lampung
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Journal : Archives Pharmacia

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Studi Perbandingan Efektivitas Penggunaan Antibiotik Pada Pasien Sectio Caesarea di RSUD Dr. H. Abdul Moeloek Provinsi Lampung Hardiyanti, Rahma; Rodiani, Rodiani; Kurniawati, Evi; Sari, Ratna Dewi Puspita
Archives Pharmacia Vol 2, No 1 (2020): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

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Abstract

ABSTRAKAngka kejadian persalinan dengan sectio caesarea sekitar 10-15% dari semua proses persalinan. Ada beberapa resiko dari sectio caesarea dan sekitar 90% morbiditas pasca operasi disebabkan oleh Infeksi Luka Operasi (ILO). Resiko ILO dari tindakan sectio caesarea tersebut dapat diturunkan dengan adanya pemberian antibiotik prabedah dan pascabedah. Penelitian ini bertujuan untuk menganalisis perbedaan efektivitas penggunaan antibiotik pada pasien sectio caesarea di RSUD Dr. H. Abdul Moeloek Provinsi Lampung.Desain penelitian analitik observasional dengan pendekatan cross sectional, menggunakan metode pengambilan sampel total sampling. Jumlah responden pada penelitian ini adalah 88 pasien section caesarea yang dibagi menjadi 2 kelompok. Kelompok pertama (n=44) adalah kelompok pasien yang mendapatkan antibiotik cefazoline 1gr IV prabedah dan kelompok kedua (n=44) adalah kelompok pasien yang mendapatkan antibiotik ceftriaxone 1gr IV dan cefotaxime 1gr IV pascabedah. Parameter penilaian perbedaan efektivitas penggunaan antibiotik prabedah dan pascabedah yaitu suhu tubuh, kadar leukosit dan lama perawatan pasien. Hasil analisis antara waktu pemberian antibiotik dengan suhu tubuh dan kadar leukosit pasien didapatkan p-value sebesar 0,016<0,05 dan 0,000<0,05 dan hasil analisis antara perbedaan waktu pemberian antibiotik dengan lama perawatan pasien didapatkan p-value sebesar 0,554>0,05.Kesimpulan terdapat perbedaan efektivitas penggunaan antibiotik prabedah dan pascabedah yang bermakna berdasarkan suhu tubuh dan kadar leukosit pasien sectio caesarea, namun tidak ditemukan perbedaan yang bermakna berdasarkan lama perawatan pasien. Kata kunci: antibiotik, lama perawatan, leukosit, sectio caesarea, suhu. ABSTRACTIncidence of cesarean sections about 10% and 15% of all labor process. There are several risks of cesarean section,  around 90% of postoperative morbidity is caused by Surgical Site Infection (SSI). Risks of SSI in a cesarean section can be reduced by an administration of preoperative and postoperative antibiotics. The study aimed was to analyze the difference in the effectiveness of antibiotic in cesarean section patientsat RSUD Dr. H. Abdul Moeloek Provinsi Lampung. Analytical observational design with cross-sectional, using a total sampling method. Respondents in this study were 88 cesarean section patients who were divided into 2 groups. The first group (n = 44) was a group of patients who received a preoperative antibiotic, cefazoline 1gr IV antibiotics and the second group (n = 44) were groups of patients who receivedpostoperative antibiotics, ceftriaxone 1gr IV antibiotics and cefotaxime 1gr IV. Parameters of the assessment of differences in the effectiveness between preoperative and postoperative antibiotics are body temperature, leukocyte levels and maternal hospitality stay. From research between the time difference of antibiotic administration with body temperature and leukocyte level obtained p-value of 0,016< 0,05 and 0,000<0,05 and the research between the time difference of antibiotic administration with maternal hospital stay obtained p value of 0,554>0,05. It can be concluded that there are significant differences in body temperature and leucocyte levels between the administrasion of preoperative and postoperative antibiotic.However, there are no significant differences in the matrenal hospitality stay of patients. Keywords:antibiotic, body temperature, cesarean section, leukocyte levels, maternal hospitality stay
Co-Authors Ahmad Fauzi Alghani, Sulthan Rafi Alvira Balqis Soraya Aminuyati Amir, Anzela Ananda, Amallia Andinatania, Marcella Ari Irawan Romulya Ari Wahyuni Arif Yudho Prabowo Arli Suryawinata Arwin, Leonardo Asep Sukohar Bajuri, Annisa Nur Oktavia Bakrie, Samsul Balqis, Gasela Zalianti Bawono, Aloysius Krishartadi Damar Budiman, Dicky Citra Yuliyanda Pardilawati Daulay, Suryani Agustina Dedy Miswar Desta Stallaza Alifka Dewi Nur Fiana Dian Isti Angraini Dian Novita Dian Pratiwi Diana Mayasari Dinda Annisa Fitria Dwi Rani Sukma Dyah Wulan SR Wardhani Dyah Wulan Sumekar Rengganis Wardani Dyah Wulan Sumekar Rengganis Wardani Efriyan Imantika Elma Sandya Ergidona Nurizqi Syiffatulhaya Ety Apriliana Ety Apriliana Evi Kurniawati, Evi Evriana Citra Fakhri Wisa Amrulloh Fatahillah, Fatahillah Fatharanni, Mentari Olivia Fauzia, Nikma Syalsabiela Febrina Halimatunisa nisa Femmy Andrifianie Ferdian, Ruben Fiana Deswita Fidela Anindya Atha Fitriani Antika Dhamayanti Hafizh, Ahmad Fauzan Hafshah, Hafshah Happy, Terza Aflika Haq, Rais Amaral Hardiyanti, Rahma Helmi Ismunandar Hisbul Waton Indah Salsabila Indriyani, Reni Intanri Kurniati Islamy, Suryadi Jeffrey Surya jefri irawan Jezmy, Beby Kelidia JM Seno Adjie Karina Azlia Amanda Karunia Santi Kenos Stefanus Khairun Nisa Kurniati, Intan M. Fitra Wardhana Maharani, Calista Putri Mallarangeng, Andi Nafisah Tendri Adjeng Mediansyah, Aulian Meilisa Hidayah Putri Mersiana, Putri Febi Morfi, Chicy Widya Muchtiar, Mulyadi Muhammad Hasbi Sahbani Muhammad Kaisar Febriantara Muhartono Muhartono Muslikh Muslikh Napitupulu, Cindy Cecilia Anasthasya Natasha, Messya Naza Tsasbita Hayuning Adila Nindia Dara Utama Nirfandi, Haikal Nirwan, Qurratul Aini Nurliwayka Qodri, Amari Nurul Islamy Nurul Islamy Nurul Utami Nurul Utami Oktadoni Saputra Oktafany, Oktafany Prabowo, Arif Yudho Prambudi Rukmono Prayogi, Norbertus Marcell Prianti, Vreyza Putra, Ruchpy Cahya Putri, Asyifa Dinda Putri, Tiara Triwansa Putu Ristyaning Ayu Rachmi Lestari Rukmono Rahmatullah, Muhammad Rayza Ramadhana Komala Rani Himayani Rasmi Zakiah Oktarlina Ratna, Maya Ganda Ratu Nirmala Wahyunindita Regina Pingkan Reni Indriyani Reni Indriyani Reni Indriyani Reni Indriyani Reni Zuraida Retno Arienta Sari Rika Lisiswanti Rika Oktaria Ringgi Tantra Setiawan Risti Graharti Rizki Hanriko Rizky Indria Lestari Rodiani Rodiani, Rodiani Romulya, Ari Irawan Rudiyanto, Waluyo Sabila, Ghina Sabrina, Michelle Sahputra, Rahmat Tridhandy Samsul Bakri Samsul Bakrie Sangging, Putu Ristyaning Ayu Saragih, Reynhard Saragih, Reynhard Theodorus Septia Eva Lusina Septiani, Linda Septina Ashariani Shafira Fauzia Shinta Nareswari, Shinta Sirait, Naomi Elfriede Situmorang, Cindy Miranda Sofyan Musabiq Wijaya Sofyan Musyabiq Wijaya Sono, Rafa Habiba Soraya Rahmanisa Suarto, Sutarto Suhaili, Gadis Bunga Suharyani Suharyani Suharyani Suryawinata, Arli Susan Yulia Laura Howay Susianti Susianti Sutarto Sutarto Sutarto Sutarto Sutarto Sutyarso Sutyarso Sutyarso Syazili Mustofa TA Larasati Taufiqurrahman Rahim Tesya Agustin Tiara Cornela Azqinar Tri Lamtiur Pakpahan Tri Umiana Soleha Trijayanthi Utama, Winda Trijayanthi, Winda Utama, Winda Winda Trijayanthi Wardani, Nanda Fitri Widjaja, Jovan Wijaya, Sofyan Musabiq Winda Trijayanthi Utama, Winda Trijayanthi Winda Trijjayanthi Utama Wulansari, Rifda Zahra Dewi Difa