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Journal : Medula

Gangguan Siklus Menstruasi Alghani, Sulthan Rafi; Sari, Ratna Dewi Puspita; Septiani, Linda; Utama, Winda Trijayanthi
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1048

Abstract

The female reproductive system undergoes regular cycles in preparation for pregnancy and fertilization, known as the menstrual cycle. This cycle involves hormonal changes and complex physiological processes, with the follicular phase dominated by estrogen and the luteal phase dominated by progesterone. Menstrual cycle disorders, such as amenorrhea, polymenorrhea, and oligomenorrhea, can be caused by various factors including hormonal imbalances, unhealthy lifestyles, and certain medical conditions. Management of menstrual disorders varies depending on their causes, which may require a holistic and individualized approach. A good understanding of the menstrual cycle and its disorders is crucial for accurate diagnosis and appropriate treatment. It is also important to promote overall women's reproductive health.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PEMERIKSAAN PAYUDARA SENDIRI SEBAGAI METODE DETEKSI DINI KANKER PAYUDARA DI PUSKESMAS TEGINENENG KABUPATEN PESAWARAN Bajuri, Annisa Nur Oktavia; Sari, Ratna Dewi Puspita; Soleha, Tri Umiana
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1069

Abstract

Breast cancer is the uncontrolled growth of cells in the lobules, ductus and supporting tissue of the breast that surrounds them. An examination for early detection of breast cancer is breast self-examination (BSE) which can reduce the mortality rate by 25-30%. Pesawaran District in 2018 had a coverage of the PTM indicator for BSE examination of 16,20%, with the highest achievement at the Gedong Tataan Community Health Center of 27,83% and the lowest in Tegineneng Community Health Center of 4,17%. This research was conducted to determine the factors associated with BSE behavior in women of childbearing age (WUS) in Tegineneng Community Health Center, Pesawaran Regency. The research used an analytical observational method with a cross sectional approach. The sampling technique was cluster sampling. Data was collected using a questionnaire and analyzed with chi-square test. The results showed that there was a significant correlation between knowledge (p-value 0.003) and media information (p-value 0.000) on BSE behavior. There was a significant relationship between knowledge and information media on BSE behavior. Meanwhile, there was no significant relationship between age, motivation, and the role of health workers on BSE behavior.
A 32-Year-Old Woman (G2P1A0) with Partial HELLP Syndrome and Severe Preeclampsia in a Term Pregnancy Arwin, Leonardo; Sari, Ratna Dewi Puspita
Medula Vol 14 No 6 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i6.1157

Abstract

Preeclampsia and HELLP syndrome are cases of obstetric emergencies that are still serious problems and have a high level of complexity. Preeclampsia is characterized by hypertension and proteinuria after 20 weeks of gestation, while HELLP syndrome is characterized by hemolysis, elevated liver enzymes, and thrombocytopenia. A 32 year old woman, term pregnant, G2P1A0, presented with a history of hypertension since pregnancy. The results of the physical examination, blood pressure was 165/120 mmHg, laboratory results showed that platelets were 150,000/µL, LDH 731 U/L, SGOT/SGPT 84/46 U/L and urine excretion showed proteinuria 500. The importance of knowing the risk factors for preeclampsia include the mother's age at the time. pregnant for more than 35 years, obesity, history of preeclampsia in a previous pregnancy, multiple pregnancies, and a history of certain diseases such as chronic hypertension, diabetes, kidney disease or degenerative diseases such as rheumatoid arthritis or lupus. Regular antenatal examinations and recognizing signs of preeclampsia as early as possible can prevent severe preeclampsia and its complications. Management of these patients includes stabilization, fluid management, preventing eclampsia, administering antihypertensive drugs and corticosteroids. Appropriate management in this case can prevent further complications and reduce maternal mortality. Diagnosis is based on anamnesis, physical examination and supporting support in patients given medical therapy in accordance with the theory and termination of pregnancy by caesarean section.
Sepsis neonatal atau biasa dikenal dengan sepsis neonatorum merupakan infeksi yang melibatkan seluruh aliran darah dan semua organ-organ pada bayi baru lahir yang berusia kurang dari 28 hari. Penyakit ini masih menjadi penyebab utama morbiditas dan mort Sabila, Ghina; Apriliana, Ety; Islamy, Suryadi; Sari, Ratna Dewi Puspita
Medula Vol 14 No 7 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i7.1258

Abstract

Neonatal sepsis is a systemic infection that involves the entire bloodstream and organs of newborns, making it one of the leading causes of neonatal morbidity and mortality, particularly in low- and middle-income countries. Neonatal sepsis is classified into early-onset sepsis (EOS) and late-onset sepsis (LOS), with varying etiologies involving gram-positive bacteria, gram-negative bacteria, and fungi. This article aims to provide a comprehensive review of the etiology, risk factors, diagnosis, and management of neonatal sepsis using an evidence-based approach. This article is based on an analysis of current literature relevant to the epidemiology, pathogenesis, and treatment of neonatal sepsis. EOS is primarily caused by vertical transmission of infection during delivery, with Group B Streptococcus (GBS) as the leading cause, while LOS is often associated with nosocomial infections caused by Staphylococcus epidermidis. Risk factors include prematurity, low birth weight, invasive procedures, and poor infection control. Management involves the administration of broad-spectrum empirical antibiotics within one hour of suspected sepsis, tailored to culture results. A holistic approach, including NICU care, family education, and optimization of infection prevention, has been shown to effectively reduce morbidity and mortality. Neonatal sepsis remains a significant challenge in perinatology, necessitating comprehensive management with an evidence-based approach encompassing timely antibiotic therapy, nosocomial infection control, and family education to improve neonatal outcomes. Preventive efforts, such as enhancing perinatal hygiene and neonatal care, must be optimized to reduce the incidence of neonatal sepsis.
Review Literature: Relationship of Food Intake and the Incidence of Dyspepsia Syndrome in Medical Students Napitupulu, Cindy Cecilia Anasthasya; Rahmanisa, Soraya; Happy, Terza Aflika; Sari, Ratna Dewi Puspita
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1443

Abstract

Dyspepsia syndrome is a digestive disorder characterized by symptoms such as epigastric pain, burning, bloating and nausea. In Indonesia, the prevalence is high, with most cases classified as functional dyspepsia. In medical students, poor and irregular diets are common due to academic pressure, busy schedules, and unhealthy lifestyles, which are thought to be the main risk factors for dyspepsia. These habits are further exacerbated by the consumption of unhealthy foods, such as fast food, as well as the habit of eating at irregular times. This study aimed to evaluate the relationship between diet and the incidence of dyspepsia syndrome in medical students in Indonesia through a literature review. A literature search was conducted online using Google Scholar with the keywords “dyspepsia syndrome,” “medical student dyspepsia syndrome,” and “medical student diet.” Of the 635 articles found, 16 were screened based on relevance of content, availability of full text, use of Indonesian language, and time of publication within the last 5 years. Five relevant articles were selected for further review. The review showed a significant association between disordered eating patterns and the incidence of dyspeptic syndrome. Habitual skipping of breakfast, consumption of fast food, eating under stressful conditions, and lack of balanced nutritional intake contributed to the risk of dyspepsia. This conclusion emphasizes the importance of health education on regular diet, stress management, and healthy lifestyle to prevent dyspepsia syndrome and improve the quality of life of medical students.
Tatalaksana Non-Farmakologis pada Dysmenorrhea Primer: Literature Review Ananda, Amallia; Ratna Dewi Puspita Sari; Septia Eva Lusina; Winda Trijayanthi Utama
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1559

Abstract

Dysmenorrhea is pain or cramps felt in the lower abdomen before or during menstruation. Dysmenorrhea is one of the most common problems experienced by adolescents and adult women. Dysmenorrhea is often accompanied by other symptoms such as dizziness, fatigue, sweating, back pain, headache, nausea, vomiting, and diarrhea. There are 2 types of dysmenorrhea, namely primary dysmenorrhea and secondary dysmenorrhea. Dysmenorrhea has a negative impact on women's quality of life. Pharmacological management has side effects of treatment, so there is a need for safer and more effective non-pharmacological management to reduce the intensity of dysmenorrhea pain. Non-pharmacological therapy consists of various non-invasive or minimally invasive treatments. This study uses a literature observation method or literature review, where the main sources of scientific articles come from national and international journals. The articles used in this study were articles published within a period of 5 years, namely 2020-2025 through the electronic databases PubMed and Google Scholar which were selected based on exclusion criteria and inclusion criteria. The purpose of this literature review is to determine non-pharmacological management of dysmenorrhea. The results of the literature review found 21 articles showing that there are several non-pharmacological therapies that are safe and effective in reducing the intensity of pain felt by dysmenorrhea sufferers such as Transcutaneous electrical Nerve Stimulation (TENS), music therapy, acupuncture, acupressure, warm compresses, exercise or aerobic exercise, and aromatherapy.
PENGARUH EKSTRAK DAUN RANDU (Ceiba pentandra) TERHADAP PROSES PENYEMBUHAN LUKA SAYAT PADA MENCIT (Mus musculus L) Jezmy, Beby Kelidia; Oktarlina, Rasmi Zakiah; Sari, Ratna Dewi Puspita; Kurniawati, Evi
Medula Vol 15 No 2 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i2.1607

Abstract

Wound causes mechanical bleeding, inducing a response of the body to fix itself which undergoes a wound healing process through a few phases; hemostasis, inflammation, proliferation, and maturation or remodelling. Wound healing is a complex process due to biocellular and biochemistry activities occuring continously. One of the natural treatments is the administration of randu (Ceiba pentandra) leaf, a Spermatophyte which has been identified and used for its healing properties. This study was an experimental study with a post-test-only control group design, and datas were analyzed using a non-parametric Kruskal Wallis test. Treatments were given randu (Ceiba pentandra) leaf extract, grouped into 4: (K1): a negative control group, (P1): 40 ml of randu (Ceiba pentandra) leaf extract, (P2): 60 ml of randu (Ceiba pentandra) leaf extract, and (P3): 80 ml of randu (Ceiba pentandra) leaf extract. Through this study, randu (Ceiba pentandra) leaf extracts were rated based on the its wound healing rate and showed results of 80 ml, 60 ml, and 40 ml respectively. There is an effect of administration of randu (Ceiba pentandra) leaf extract on cut wound healing in mice (Mus musculus L) (p=0,037)  
BODY STALK ANOMALY TIPE IV DENGAN OMFALOKEL BESAR PADA KEHAMILAN TRIMESTER TIGA: LAPORAN KASUS Saragih, Reynhard; Sari, Ratna Dewi Puspita
Medula Vol 15 No 2 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i2.1618

Abstract

Body stalk anomaly (BSA) is a rare and severe congenital malformation with an estimated incidence of approximately 1 in 14,000 births, and the majority of cases result in intrauterine death. Early detection of BSA is essential to differentiate it from exomphalos, which carries a significantly better prognosis. The exact etiology of BSA remains unclear, although chromosomal analyses have been conducted to investigate potential genetic abnormalities in affected fetuses. We report a case of a 35-year-old pregnant woman who presented to Dr. H. Abdul Moeloek General Hospital with complaints of premature rupture of membranes two hours prior to admission. A fetomaternal ultrasound examination revealed an intrauterine fetal demise in transverse lie, with a large omphalocele containing the small intestine, large intestine, liver, right kidney, and urinary bladder located outside the abdominal cavity. Additional findings included vertebral scoliosis and a short umbilical cord, with no other apparent major congenital anomalies. Biometric measurements were: BPD 80.7 mm, FL 54.4 mm, and HL 50.5 mm. The ultrasound impression concluded a diagnosis of body stalk anomaly. Early prenatal diagnosis using ultrasonography is feasible from 11 weeks of gestation, enabling detailed evaluation of fetal anatomy and abnormalities. Unlike gastroschisis and omphalocele, which are frequently associated with chromosomal abnormalities such as trisomy 18, 13, and 21, as well as Turner, Klinefelter, and triploidy syndromes, chromosomal aberrations in BSA are rarely reported, though mosaicism of 45,X and chromosome 16 polymorphisms have been documented.
Laporan Kasus: Kehamilan 36 Minggu dengan Ketuban Pecah Dini dan Skizofrenia tanpa Pengobatan Nirfandi, Haikal; Sari, Ratna Dewi Puspita; Saragih, Reynhard Theodorus
Medula Vol 15 No 2 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i2.1621

Abstract

Perinatal mental disorders, including schizophrenia, increase the risk of complications during pregnancy, labor, and neonatal health. Schizophrenia in pregnant women can lead to premature rupture of membranes, preterm labor, and fetal distress. The use of antipsychotics during pregnancy is also associated with an increased risk of obstetric and metabolic side effects. This case report presents a 38-year-old pregnant woman, G5P4A0, at 36 weeks of gestation, with a seven-year history of untreated schizophrenia, who presented with premature rupture of membranes. Examination revealed stable maternal condition, although fetal distress was suspected. The patient was treated with intravenous fluids, antibiotics, tocolytics, and antipsychotics (haloperidol, CPZ, risperidone), and subsequently underwent cesarean section due to fetal distress. Women with schizophrenia are at higher risk of premature rupture of membranes, fetal distress, and preterm delivery. Antipsychotic use during pregnancy also increases the risk of complications such as gestational diabetes and metabolic disorders. The management of pregnant women with mental disorders requires a multidisciplinary approach involving psychiatrists, obstetricians, and neonatologists to minimize risks to both mother and fetus. Close monitoring of maternal medical conditions, medication dosages, and fetal growth is essential to optimize care, and decisions regarding the mode of delivery should consider both psychiatric and obstetric conditions.
HUBUNGAN DIABETES MELITUS GESTASIONAL TERHADAP KEJADIAN BERAT BADAN LAHIR RENDAH DI RSUD DR H ABDUL MOELOEK TAHUN 2023 Suhaili, Gadis Bunga; Rukmono, Prambudi; Nareswari, Shinta; Sari, Ratna Dewi Puspita
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1304

Abstract

A low birth weight (LBW) infant is defined as an infant born weighing less than 2500 grams regardless of gestational age. The main factors causing LBW are maternal factors, fetal factors, and placental factors. Risk factors for LBW associated with maternal factors include a history of complications during pregnancy, one of which is gestational diabetes mellitus. This study used a cross-sectional design with Pearson Chi-Square statistical test conducted at Dr. H. Abdul Moeloek General Hospital, Lampung Province in October - November 2024. The study sample was infants born at Dr. H. Abdul Moeloek Hospital in the period January - December 2023. The results of this study indicate that 16% of infants born were extremely low birth weight (ELBW), 20% of infants born were very low birth weight (VLBW), and 64% of infants born were low birth weight (LBW). The results of the chi-square analysis showed that there was a relationship between gestational diabetes mellitus (p = 0.042) and low birth weight (LBW).  
Co-Authors Ahmad Fauzi Alghani, Sulthan Rafi Alvira Balqis Soraya Aminuyati Amir, Anzela Ananda, Amallia Andinatania, Marcella Ari Irawan Romulya Ari Wahyuni Arif Yudho Prabowo Arli Suryawinata Arwin, Leonardo Asep Sukohar Bajuri, Annisa Nur Oktavia Bakrie, Samsul Balqis, Gasela Zalianti Bawono, Aloysius Krishartadi Damar Budiman, Dicky Citra Yuliyanda Pardilawati Daulay, Suryani Agustina Dedy Miswar Desta Stallaza Alifka Dewi Nur Fiana Dian Isti Angraini Dian Novita Dian Pratiwi Diana Mayasari Dinda Annisa Fitria Dwi Rani Sukma Dyah Wulan SR Wardhani Dyah Wulan Sumekar Rengganis Wardani Dyah Wulan Sumekar Rengganis Wardani Efriyan Imantika Elma Sandya Ergidona Nurizqi Syiffatulhaya Ety Apriliana Ety Apriliana Evi Kurniawati, Evi Evriana Citra Fakhri Wisa Amrulloh Fatahillah, Fatahillah Fatharanni, Mentari Olivia Fauzia, Nikma Syalsabiela Febrina Halimatunisa nisa Femmy Andrifianie Ferdian, Ruben Fiana Deswita Fidela Anindya Atha Fitriani Antika Dhamayanti Hafizh, Ahmad Fauzan Hafshah, Hafshah Happy, Terza Aflika Haq, Rais Amaral Hardiyanti, Rahma Helmi Ismunandar Hisbul Waton Indah Salsabila Indriyani, Reni Intanri Kurniati Islamy, Suryadi Jeffrey Surya jefri irawan Jezmy, Beby Kelidia JM Seno Adjie Karina Azlia Amanda Karunia Santi Kenos Stefanus Khairun Nisa Kurniati, Intan M. Fitra Wardhana Maharani, Calista Putri Mallarangeng, Andi Nafisah Tendri Adjeng Mediansyah, Aulian Meilisa Hidayah Putri Mersiana, Putri Febi Morfi, Chicy Widya Muchtiar, Mulyadi Muhammad Hasbi Sahbani Muhammad Kaisar Febriantara Muhartono Muhartono Muslikh Muslikh Napitupulu, Cindy Cecilia Anasthasya Natasha, Messya Naza Tsasbita Hayuning Adila Nindia Dara Utama Nirfandi, Haikal Nirwan, Qurratul Aini Nurliwayka Qodri, Amari Nurul Islamy Nurul Islamy Nurul Utami Nurul Utami Oktadoni Saputra Oktafany, Oktafany Prabowo, Arif Yudho Prambudi Rukmono Prayogi, Norbertus Marcell Prianti, Vreyza Putra, Ruchpy Cahya Putri, Asyifa Dinda Putri, Tiara Triwansa Putu Ristyaning Ayu Rachmi Lestari Rukmono Rahmatullah, Muhammad Rayza Ramadhana Komala Rani Himayani Rasmi Zakiah Oktarlina Ratna, Maya Ganda Ratu Nirmala Wahyunindita Regina Pingkan Reni Indriyani Reni Indriyani Reni Indriyani Reni Indriyani Reni Zuraida Retno Arienta Sari Rika Lisiswanti Rika Oktaria Ringgi Tantra Setiawan Risti Graharti Rizki Hanriko Rizky Indria Lestari Rodiani Rodiani, Rodiani Romulya, Ari Irawan Rudiyanto, Waluyo Sabila, Ghina Sabrina, Michelle Sahputra, Rahmat Tridhandy Samsul Bakri Samsul Bakrie Sangging, Putu Ristyaning Ayu Saragih, Reynhard Saragih, Reynhard Theodorus Septia Eva Lusina Septiani, Linda Septina Ashariani Shafira Fauzia Shinta Nareswari, Shinta Sirait, Naomi Elfriede Situmorang, Cindy Miranda Sofyan Musabiq Wijaya Sofyan Musyabiq Wijaya Sono, Rafa Habiba Soraya Rahmanisa Suarto, Sutarto Suhaili, Gadis Bunga Suharyani Suharyani Suharyani Suryawinata, Arli Susan Yulia Laura Howay Susianti Susianti Sutarto Sutarto Sutarto Sutarto Sutarto Sutyarso Sutyarso Sutyarso Syazili Mustofa TA Larasati Taufiqurrahman Rahim Tesya Agustin Tiara Cornela Azqinar Tri Lamtiur Pakpahan Tri Umiana Soleha Trijayanthi Utama, Winda Trijayanthi, Winda Utama, Winda Winda Trijayanthi Wardani, Nanda Fitri Widjaja, Jovan Wijaya, Sofyan Musabiq Winda Trijayanthi Utama, Winda Trijayanthi Winda Trijjayanthi Utama Wulansari, Rifda Zahra Dewi Difa