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All Journal E-Jurnal Medika Udayana Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Medula Juke Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kedokteran Ibnu Nafis Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran JOURNAL OF Qualitative Health Research & Case Studies Reports Health & Medical Sciences Jurnal Ilmu Kedokteran dan Kesehatan Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Essentia: Journal of Medical Practice and Research

Indri Windarti

Universitas Lampung

Author-ID : 2391462

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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PERANAN MEDIA DALAM PEMBELAJARAN Rika Lisiswati; Oktadoni Saputra; Indri Windarti
Jurnal Kesehatan Vol 6, No 1 (2015): Jurnal Kesehatan
Publisher : Politeknik Kesehatan Tanjung Karang

Rika Lisiswanti1, Oktadoni Saputra2, Indri Windarti31,2,3Departemen Patology Anatomi, Fakultas Kedokteran Universitas Lampunge-mail: rika_lisiswanti@yahoo.com Abstrak: Peranan Media Dalam Pembelajaran. Penggunaan berbagai macam media, baik media cetak, elektronik atau lainnya dapat meningkatkankan perhatian pembelajar serta meningkatkan pemahaman dan retensi pengetahuan jika media tersebut didisain dan dibuat secara tepat. Penggunaan media berdasarkan teori belajar Mayer, landasan filosofis, teknologi dan empiris. Penggunanaan media harus sesuai dengan disain pengajaran. Pemilihan media harus disesuaikan juga dengan tujuan pembelajaran yang akan dicapai, siapakah pembelajarnya atau pesertanya, dimana tempatnya. Serta memperhatikan syarat-syarat penggunaan media pembelajaran. Media pembelajaran sangat penting dalam memberikan infomasi ataupun pengajaran. Media dapat meningkatkan ketertarikan para pembelajar sehingga informasi mudah diterima. Kata Kunci: media pembelajaran, multimedia

The Role of p24 Immunohistochemistry to Identify HIV Lymphadenitis Muhartono Muhartono; Indri Windarti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 3 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i3.119

Introduction : That was a difficulty to diagnose the early stage of HIV while the symptoms was only enlargement of the lymph nodes, so that the pattern A of HIV lymphadenitis that presented on histopathological examination is expected to be a determinant of early-stage. Although the staining of p24 antibody has already be used to detect HIV infection in the tissue, but the positivity of p24 in pattern A HIV lymphadenitis has not been investigated. Aim of study : To identify pattern A of HIV lymphadenitis on histopathological examination and to identify p24 antibody to be a determinant of early-stage HIV infection. Methods : This is a retrospective descriptive study. We collected 64 cases of non spesific lymphadenitis from the Anatomical Pathology archive, Cipto Mangunkusumo hospital and examined these cases by using the criteria of pattern A HIV lymphadenitis in the tissue specimen. Then we performed the staining of p24 antibody by immunohistochemistry. Results : There were twelve by sixty four (12/64) cases of that have pattern A HIV lymphadenitis on microscopic evaluation. Only three cases was clinically noted as Acquired Immunodeficiency Syndrome (AIDS) by clinician, while 11 of 12 cases showed immunohistochemistry positive for p24 antibody. Conclusion : Most of the patten A HIV lymphadenitis (11/12) showed the positive staining for p24 antibody. In patients who had received Anti Retro Viral (ARV) therapy, the staining of p24 antibody was negative. This study still needs more samples, the serologic data of the patient to be more reliable.

The ROLE OF OBESITY IN BREAST CANCER METASTASIS Fadila Gustiani Daraz; Indri Windarti; Putu Ristyaning Ayu Sangging
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.562

Breast cancer is the most common type of cancer in women worldwide. One of the factors that are believed to have a role in the development and growth of breast cancer is nutritional status which can be associated with the body mass index of adult patients. It is estimated that overweight and obesity are risk factors for the spread of breast cancer to distant metastases. Mechanism of spread through two ways, estrogen and leptin. Aromatase is an enzyme in estrogen biosynthesis that promotes tumor growth through its expression in breast adipose stromal cells. Meanwhile, leptin is produced by adipocytes. Adipocytes that experience hypertrophy and hyperplasia cause pathophysiological changes that affect the development of breast cancer. Various case studies show that a diet high in fat and calories is associated with breast cancer. The high risk of obesity for breast cancer metastases. This is important to be studied further because of the large number of cases of breast cancer both globally, in Indonesia and in Lampung. This review article is important to know the relationship between obesity and breast cancer metastases, as scientific information and knowledge, and can be used as material for dietary intervention in obese breast cancer patients.

Anemia pada Pasien Tuberkulosis Inna Kurniaji; Waluyo Rudiyanto; Indri Windarti
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.592

Tuberculosis (TB) is one of the most common causes of health problems in the world. The prevalence of TB in the world is estimated at 10.6 million, and 1.6 million of them died from TB, in Indonesia the incidence of TB reached 503,712. Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis, which is known to cause complex hematological disorders. The hematopoietic system is thought to be affected during TB infection, so that Hb levels tend to decrease along with bacterial increase, which eventually causes anemia. The article aims to determine the incidence of anemia in TB patients and the mechanism of anemia in TB patients. Based on the results of a literature review conducted on references found from 2012–2022, it shows that anemia is a common condition in TB. The mechanism that causes anemia in TB patients is due to its pathogenesis as a chronic inflammatory disease. Anemia is an indicator in providing clues to diagnosis, prognosis, complications and response to TB therapy. Nutritional intake and adherence to TB therapy need to be done properly to prevent the development of severe disease and improve the patient's quality of life.

PENGARUH TINGKAT PENYANGRAIAN EKSTRAK BIJI KOPI ROBUSTA (Coffea canephora) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI ASPIRIN ananti, anggini tasyakurillah; Rudiyanto, Waluyo; Ratna, Maya Ganda; Windarti, Indri
E-Jurnal Medika Udayana Vol 13 No 8 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i08.P03

Abstract Background: Coffee is a plant that widely consumed by the community. It contains antioxidant-rich compounds such as caffeine, chlorogenic acid, trigonelin, kafestol, and kahweol. Coffee quality related to the roasting process. This study aimed to determine the effect of different roasting level of robusta coffee extract (Coffea canephora) on liver histopathology of male Sprague Dawley strain white rats (Rattus norvegicus) induced by aspirin. Methods: This research is an experimental study with Post-Test Only Control Group design for 15 days. This research used 30 rats in 5 groups, K(-) (aquadest); K(+) (aspirin 90mg/day); P1 (aspirin and robusta coffee extract Light roast 25mg/kgBW/day); P2 (aspirin and robusta coffee extract Medium roast 25mg/kgBW/day); and P3 (aspirin and robusta coffee extract Dark roast 25mg/kgBW/day). Assessment of liver cell damage using modified Suzuki scoring. Results: Mean score of hepatocyte damage on the histopathological findings was K(-)=0,44; K(+)=1,92; P1=1,28; P2=1,20; and P3=1,68. Data analysis performed using One-Way ANOVA test followed by Post-Hoc LSD and obtained significant results between all groups. Conclusion: There is an effect of roasting level of robusta coffee extract (Coffea canephora) with the roasting level is Medium Roast on liver histopathology of male Sprague Dawley strain white rats (Rattus norvegicus) induced by aspirin. Key Words: aspirin, coffee roasting, liver histopathology, robusta coffee extract.

Ekstrak Lidah Buaya (Aloe Vera) Menurunan Kadar Glukosa Darah Tikus Putih (Rattus Norvegicus) Yang Diinduksi Streptozotocin Marzel, Rivaldi; Darwis, Iswandi; Windarti, Indri
Medula Vol 13 No 7 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i7.857

Diabetes mellitus (DM) is a chronic disorder in the metabolism of protein, fat and carbohydrates. Diabetes mellitus is described as an increase in blood glucose. DM cases in Indonesia rapidly increases. Diabetes mellitus is a disease that requires anti-diabetes drugs continuously. Continuous use will have side effects that encourages patients to look for alternative treatments that are cheaper, efficacious, without side effects, and easy to obtain such as herbal medicines. Many medicinal plants around the world contain antihyperglycemic compounds, such as Aloe vera.This is study experimental study using a randomized controlled design method with Post-test only Control Group Design. There were 24 rats consist of 4 treatment groups (K1, K2, K3, K4). (K1) = rats were given by a standard diet. K2 = rats induced streptozotocin 40 mg/kgBW.K3 = rats were treated with metformin. K4 = rats were treated with Aloe vera extract 250 mg/kg BW. After 21st day, blood glucose levels were measured. The research was conducted at the animal house of the Faculty of Medicine, University of Lampung. Samples were analyzed using the one way Annova test. Blood glucose levels of the 4 treatment groups were K1 = 67.16 mg/dl, K2 = 366.33 mg/ dl, K3 = 77.83 mg/dl, K4 = 127.16 mg /dl. The blood glucose level in the control and treatment groups were significantly different (p<0,05). Aloe vera extract ameliorates blood glucose levels of streptozotocin-induced diabetes in white rats (Rattus norvegicus).

Surgical Site Infection Lubis, Aisyah; Wintoko, Risal; Ismunandar, Helmi; Windarti, Indri
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.956

Surgical site infection (SSI) is a fairly common complication that can arise after surgery, both minor surgical procedures and more complex surgical procedures. This infection can occur due to the entry of pathogenic microorganisms into the surgical wound, causing an inflammatory reaction. This infection can prolong recovery time, increase mortality, require additional medical intervention, and affect the patient's quality of life. This impacts patient clinical outcomes as well as additional care costs. Factors such as surgical technique, cleanliness of the operating environment, use of implants, and the patient's health condition can influence and also contribute to increasing the risk of infection. Symptoms of surgical site infection include pain, swelling, redness, or the presence of pus in the surgical wound. When this infection occurs, immediate medical action is needed to prevent the spread of infection which can cause advanced conditions such as sepsis. Prevention of surgical site infections involves sterile measures before and during surgical procedures, the use of prophylactic antibiotics, and thorough post-operative monitoring. These efforts aim to reduce the risk of surgical site infections, ensure optimal recovery, and improve the overall results of the surgical procedure. An in-depth understanding of the risk factors and prevention of surgical site infections can help medical personnel provide quality care and ensure the success of the operation. There is also the importance of early detection and treatment of infections in patients undergoing surgery.

Anatomi dan Fisiologi Ginjal: Tinjauan Pustaka Alwiyah, Fadilah; Rudiyanto, Waluyo; Anggraini, Dwi Indria; Windarti, Indri
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.977

The kidneys are retroperitoneal organs located at the top on both sides of the III lumbar vertebra and attached directly to the abdominal or ventral wall of the M. psoas major and M. quadratus lumborum. The kidneys function to regulate the amount and concentration of ECF electrolytes and maintain nerve and muscle excitability, activating vitamin D which is important for calcium absorption in the digestive tract and producing erythropoietin which is a hormone to stimulate the bone marrow to form red blood cells. The main function of the kidneys is to filter and excrete metabolic waste products in the urine so that administration of toxic compounds or irritating compounds can cause degenerative changes such as fatty degeneration to necrosis of the kidneys. Disorders of the kidneys can disrupt kidney function. Chronic Kidney Disease (CKD) sufferers have several complications such as overhydration, hyperkalemia, metabolic acidosis, mineral and bone disorders, hypertension, anemia and dyslipidemia. The most common etiologies of CKD in adult patients are diabetes mellitus and hypertension. In children, the most common primary cause of PGTA is congenital abnormalities of the kidneys and urinary tract (such as obstructive uropathy, vesicoureteral reflux, renal dysplasia). Indonesian Nephrology Association (PERNEFRI) in 2006, which found that the prevalence of Chronic Kidney Disease (CKD) was 12.5%. Meanwhile, data according to the 2019 Health Insurance Administration (BPJS) shows that there were 1.93 million cases of kidney failure and 1.79 million cases in 2020. With this data, the author is interested in discussing the kidneys in more depth.

Pengaruh Ekstrak Bawang Putih (Allium Sativum) Terhadap Kadar Glukosa Darah Dan Gambaran Histopatologi Pankreas Pada Tikus Putih (Rattus Norvegicus) Galur Sprague-Dawley Yang Diinduksi Streptozotocin Cyntithia, L. Gita; Windarti, Indri; Soleha, Tri Umiana
Medula Vol 14 No 6 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i6.1138

Diabetes mellitus (DM) is one of the highest causes of death in the world whose prevalence increases every year, DM is characterized by elevated blood glucose levels and damage of the pancreas. Streptozotocin is a drug used to induce diabetes mellitus in experimental animals, single high dose administration can cause type 1 DM. Garlic has various component that have the potential as antidiabetic, anti-inflammatory and antioxidant. This study aim to determine the effect of garlic extract (Allium sativum) on blood glucose levels and pancreas histopathological images in white rats (Rattus norvegicus) Sprague-Dawley strain induced by streptozotocin. This research is an experimental study with a post test only control group design. This study used 24 rats and divided into 4 group, K- (normal group), K+ (STZ 60 mg/kgBB), P1 (STZ + garlic extract 500 mg/kgbb), P2 (STZ + garlic extract 750mg/kgBB). Blood glucose levels were assessed with a glucometer and the histopathological images of the pancreas was assessed by counting the number and size of the langerhans islet. The mean blood glucose levels for each group were K- = 73.3mg/dL, K+ = 400 mg/dL, P1=203.8 mg/dL, and P2=132.3 mg/dL. One Way ANOVA test obtained p value = 0.000. The mean number of langerhans islet in 10 fields of view obtained K- = 26.1; K+ = 4.6; P1= 7.8; P2=15.1. One Way ANOVA test obtained p = 0.000. The mean area of the langerhans islet in each group obtained K- = 19092.4 µm2; K+ = 4759.3 µm2; P1=8561,4 µm2; P2=9621.8 µm2. Kruskal-Wallis test obtained p = 0.000 (p <0.05). There is an effect of garlic extract (Allium sativum) on blood glucose levels and pancreas histopathological images in white rats (Rattus norvegicus) Sprague-Dawley strain induced by streptozotocin.

PENGARUH EKSTRAK BAWANG PUTIH (Alium sativum) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR Sprague- dawley YANG DIINDUKSI STREPTOZOTOCIN Fadly, Ahmad Aulia; Windarti, Indri; Hanriko, Rizki
Medula Vol 14 No 6 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i6.1154

Diabetes Mellitus (DM) is a chronic disease characterized by blood sugar levels that exceed normal limits. Chronic DM can cause liver complications in the form of inflammation. Streptozotocin can induce mice to become a DM model and can also directly damage the liver. Garlic (Allium sativum) is a tuber that is often found in Indonesia. The various compounds contained in it have anti-diabetic and antioxidant effects which have the potential to prevent inflammation in the liver. This research was conducted to determine the effect of garlic extract (Allium sativum) on histopathological features in the form of lymphocyte cell infiltration in the portal and lobular tracts of the liver in white rats (Rattus norvegicus) of the Sprague-dawley strain induced by streptozotocin. The method used was a randomized controlled design with a pre-clinical Post-test Only Control Group Design pattern. This study used 24 mice divided into 4 groups with 6 mice in each group. The appearance of lymphocyte cell infiltration will be assessed based on the Omenetti scoring. The mean scores for lymphocyte cell infiltration in the portal tract obtained were KN=0.22, K+=2.10, P1=0.60, and P2=0.56. From the analysis using the One-Way ANOVA test followed by the Post Hoc Benferroni test, the results showed a significant difference in scores between K+ and P1 and P2. Meanwhile, the mean scores for lymphocyte cell infiltration in the lobular area obtained were KN=0.50, K+=1.16, P1=0.50, and P2=0.33. From the analysis using the Kruskal-Wallis test, no significant differences in scores were found between all groups. There was an effect of garlic extract (Allium sativum) on the infiltration of lymphocyte cells in the portal tract and no effect was found on the lobular area of the liver in white rats (Rattus norvegicus) of the Sprague-dawley strain which were induced by streptozotocin.

Co-Authors - Muhartono Agustyas Tjiptaningrum Aisyah Lubis, Aisyah Ajipurnomo, Adhari Alwiyah, Fadilah Amalia, Salsabila Ambarwati, Yuli ananti, anggini tasyakurillah Andreas Infianto Apri Lyanda Asep Sukohar Ayu Tiara FItri Bayu Putra Danan Jaya, Bayu Putra Danan Bayu Putra DJ Cyntithia, L. Gita Danan Jaya, Bayu Putra Devya Aulia Dewi Nur Fiana Diah Septia Liantari, Diah Septia Dwi Indria Anggraini Ekawati, Diyan Endah Setyaningrum, Endah Endang SR Hardjolukito Ety Apriliana Exsa Hadibrata Fadila Gustiani Daraz Fadly, Ahmad Aulia Fala, Arzety Rifda Firdaus, Elman Dani Fitria Saftarina Gatot Sudiro Hendarto, Gatot Sudiro Hadibrata, Exsa Haikal Shiddiq Ham, Maria Francisca Hana Muthi'a Putri Hanna Mutiara, Hanna Helmi Ismunandar Hendri Busman Hendri Tarigan S I Gede Eka Widayana Infianto, Andreas Inna Kurniaji Intanri Kurniati Iswandi Darwis Janar Wulan, Anggraini Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Joni, Agnesia Priskila Khairun Nisa Kusumajati, Pusparini Kusumaningtyas, Aditya Laisa Azka Liana Sidharti M. Aqmal Hidayah Marzel, Rivaldi Mayasari, Diana Mubarak, Raka Anzil Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Sudarmo Kasban Novita Carolia Nur Irawati Nurmayeni Nurmayeni Nurmayeni Nurul Islamy Oktadoni Saputra Qurani, Istiqomatul rahmawati, selvi Rajagukguk, Nanda Frisila Ramadhana Komala Rasmi Zakiah Oktarlina Ratna, Maya Ganda Reni Zuraida Resti Arania Rian Hendriyana Dwi Imanta Rika Lisiswati Risal Wintoko Risti Graharti Rizki Hanriko Rodiani, Rodiani Rosbhaiti Chodijah Rudiyanto, Waluyo Sangging, Putu Ristyaning Ayu Septiani, Linda Setiorini, Anggi Sezia Marina Sinaga, Fransisca T.Y. Siregar, Bintang Abadi Soemarwoto, Retno Ariza S Suryadi Islami Susianti Susianti Susianti Susianti, Susianti Sutarto Sutarto Sutarto Sutarto SYAIFUL BAHRI Syazili Mustofa Talin, Jinan Naura Tri Umiana Soleha Tubagus Djumhana Atmakusuma Wahdah, Annisa Shohifatul Waluyo Rudiyanto Wardani, Nanda Fitri Wulan, Anggraini Janar Wulyo Rajabto Yolanda Fratiwi Yunianto, Andi Eka Zulfa, Fathimah

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