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All Journal E-Jurnal Medika Udayana Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Medula Juke Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kedokteran Ibnu Nafis Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran JOURNAL OF Qualitative Health Research & Case Studies Reports Health & Medical Sciences Jurnal Ilmu Kedokteran dan Kesehatan Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Essentia: Journal of Medical Practice and Research
Indri Windarti
Universitas Lampung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Breast Cancer Metastases Based on Molecular Subtypes at RSUD Dr. H. Abdul Moeloek Lampung Nurmayeni; Islamy, Nurul; Tjiptaningrum, Agustyas; Siregar, Bintang Abadi; Kusumaningtyas, Aditya; Windarti, Indri
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.904

Abstract

BACKGROUND:Breast cancer is the most common cancer in Indonesia and is a leading cause of cancer-related deaths in the country. Metastases are responsible for most deaths among breast cancer patients. Breast cancer is typically classified into four subtypes based on immunohistochemistry: luminal A, luminal B, HER2+, and TNBC. OBJECTIVE:To determine the association between the metastatic pattern of breast cancer and their molecular subtypes at RSUD Dr. H. Abdul Moeloek Lampung. METHOD:This study was an observational analytic study with a cross-sectional design. The sample comprised 81 individuals who had suffered from breast cancer and were recorded in the medical records section of RSUD Dr. H. Abdul Moeloek Lampung between 2013 – 2021 and met the inclusion and exclusion criteria. The association between breast cancer subtypes and the incidence and metastase sites were tested using the Chi-Square test. RESULT:This study found a significant association between breast cancer subtypes and the incidence of metastases (p <0.05). The TNBC subtype had a more frequent rate of metastases (34.5%) than the other subtypes (31% luminal B, 20.7% luminal A, and HER2+ 13.8%). The study also revealed a relationship between ER status and the incidence of metastases (p < 0.05). The luminal A subtype tends to metastasize to the liver, luminal B tends to metastasize to the bone, HER2+ tends to metastasize to the lung and liver, and TNBC tends to metastasize to the lung. However, no significant association was found between breast cancer subtypes and metastatic sites. CONCLUSION:There was a significant association between breast cancer subtypes and the incidence of metastases, but not with the metastatic sites.  
Faktor Pengaruh Tekanan Darah dan Fungsi Ginjal terhadap Lama Rawat Inap Pasien Kanker Ginjal Post Nefrektomi Haikal Shiddiq; Exsa Hadibrata; Indri Windarti
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4382

Abstract

Kidney cancer is the third most common urological cancer, following prostate and bladder cancer, with renal cell carcinoma (RCC) being the most prevalent type, particularly in Europe and North America. Its incidence increases by approximately 0.5% each year as age advances, peaking between 60 and 70 years, and it is more frequently diagnosed in men at a ratio of 1.5:1. This study aims to analyze the impact of blood pressure and kidney function on the length of hospital stay for patients post-nephrectomy at RSUD H. Abdul Moeloek, Bandar Lampung, using a descriptive analytical method and a cross-sectional design with the entire population as the sample. The findings indicate a significant relationship between blood pressure and kidney function with the duration of hospitalization, where patients with high blood pressure are 6.41 times more likely to experience prolonged stays (p = 0.04), while those with elevated creatinine levels are 8 times more likely (p = 0.041). In conclusion, hypertension and decreased kidney function significantly contribute to the extension of hospital stays for patients after nephrectomy.
Characteristics of Thyroid Carcinoma Patients at Dr. H. Abdul Moeloek Hospital for the Period of January 2023 – August 2024 Qurani, Istiqomatul; Septiani, Linda; Kurniati, Intanri; Windarti, Indri
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1333

Abstract

Thyroid carcinoma is the most common cancer found in the endocrine system that arises from thyroid parenchymal cells.  Its prevalence has increased over the past few decades with a mortality rate of 0.5% per 100,000 cases. The incidence of thyroid carcinoma in 2020 ranks 7th in the world as the 9th most frequent incidence occurs from all types of cancer. Objective: This study aims to determine the characteristics of thyroid carcinoma patients at Dr. H. Abdul Moeloek Regional General Hospital for the period of January 2023 – August 2024. Method: This study used a descriptive observational design and Total Sampling technique with a data source in the form of secondary data on medical records from 82 thyroid carcinoma patients at the Dr. H. Abdul Moeloek Regional General Hospital for the period January 2023 to August 2024.  Results: In this study, thyroid carcinoma patients were mostly female, with an age group in the range of 41-60 years. The most common type of thyroid carcinoma is papillary carcinoma and the least common type is anaplastic carcinoma. Conclusion: In this study, the characteristics of thyroid carcinoma patients were obtained based on gender, age group, and type of histopathological diagnosis.
Profile of Melanoma and Non-Melanoma Skin Cancer based on Histopathology Results Zulfa, Fathimah; Windarti, Indri; Sutarto; Carolia, Novita
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1342

Abstract

Skin cancer is an abnormal condition in the structure of the skin that arises because the skin loses the ability to regenerate periodically. Skin cancer is high risk in people who live in tropical countries such as Indonesia. All provinces in Indonesia receive evenly distributed sunlight including Lampung province. Lampung Province is an agricultural province with the dominance of the population working in agriculture and marine sectors. Agriculture and marine sectors workers get continuous and long-term exposure to UV rays so that they are at high risk of skin disorders, one of them is skin cancer. This study was conducted in August-December 2024 in the medical record from Dr. H. Abdul Moeloek Hospital Bandar Lampung. This study was observational and was conducted by collecting data and univariate analysis on medical record data of skin cancer patients including the type of skin cancer, age, gender ], and location of tumor growth of skin cancer patients. The results showed that the most common type of skin cancer diagnosed at Dr. H. Abdul Moeloek Bandar Lampung Hospital in the 2019-2024 period was non-melanoma skin cancer (squamous cell carcinoma followed by basal cell carcinoma). The most common age of skin cancer patients is ≥40 years old, female and the location of tumor growth is mostly in the head and neck area.
Hubungan Kadar D-Dimer Dan Jenis Histopatologi Kanker Paru Karsinoma Bukan Sel Kecil Terhadap Respons Kemoterapi Berdasarkan Recist 1.1 Firdaus, Elman Dani; Infianto, Andreas; Windarti, Indri; Soemarwoto, Retno Ariza S; Ekawati, Diyan; Sinaga, Fransisca T.Y.; Hendarto, Gatot Sudiro; Lyanda, Apri; Kusumajati, Pusparini; Ajipurnomo, Adhari
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 7 (2025): Volume 12 Nomor 7
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i7.20247

Abstract

Kanker paru tetap menjadi penyebab utama kematian terkait kanker secara global, terutama pada pria di Indonesia. Sekitar 80 % kasus  didiagnosis sebagai Kanker Paru Bukan Sel Kecil (KPKBSK), terutama Adenokarsinoma dan Karsinoma Sel Skuamosa. Kadar D-Dimer yang meningkat, yang menunjukkan keadaan hiperkoagulasi, dapat menjadi penanda potensial untuk memprediksi hasil pengobatan dan prognosis keseluruhan.  Metode: Dalam penelitian ini, 61 pasien KPKBSK yang menjalani tiga siklus kemoterapi lini pertama dilibatkan. Sebelum pengobatan, kadar D-Dimer diukur, dan jenis histopatologi ditentukan melalui pemeriksaan patologi anatomi. Respons kemoterapi dinilai menggunakan RECIST 1.1. Distribusi respons: Partial Response (27,9 %), Stable Disease (19,7 %), dan Progressive Disease (52,5 %). Terdapat perbedaan signifikan secara statistik dalam kadar D-Dimer antar kelompok tersebut (p = 0,001). Kelompok Partial Response memiliki median kadar D-Dimer 1.229 ng/mL (Mean Rank = 18,32), kelompok Stable Disease menunjukkan mean 1.335,67 ng/mL (SD = 624,30; Mean Rank = 21,13), dan kelompok Progressive Disease memiliki median 2.586 ng/mL (Mean Rank = 41,44). Kadar D-Dimer ≥1.654 ng/mL secara signifikan terkait dengan peningkatan risiko Progressive Disease, dengan sensitivitas 78,1 % dan spesifisitas 76 %. Subtipe histopatologi (Adenokarsinoma vs. Karsinoma Sel Skuamosa) tidak berkorelasi signifikan dengan respons kemoterapi (p = 0,717). Kadar D-Dimer berkorelasi dengan respons kemoterapi pada pasien KPKBSK, menunjukkan potensi penggunaannya sebagai prediktor, sedangkan jenis histopatologi tidak memengaruhi hasil terapi.
Article Review: Risk of Lung Cancer in Patients with History of Pulmonary Tuberculosis and Chronic Obstructive Pulmonary Disease (COPD) Wahdah, Annisa Shohifatul; Windarti, Indri; Setyaningrum, Endah; Sukohar, Asep
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1344

Abstract

Kanker paru merupakan salah satu penyebab utama kematian akibat kanker di dunia, dengan angka kejadian yang sangat tinggi. Di Indonesia, kanker paru menduduki peringkat kedua setelah kanker payudara dengan jumlah kasus mencapai 38.904 pada tahun 2022. Penyakit ini lebih sering terjadi pada laki-laki dibandingkan perempuan. Berbagai faktor risiko berkontribusi terhadap kejadian kanker paru, termasuk kebiasaan merokok, paparan polusi udara, paparan radon, faktor genetik, serta riwayat penyakit paru seperti tuberculosis (TB) paru dan penyakit paru obstruktif kronik (PPOK). Tuberculosis paru adalah penyakit infeksi yang disebabkan oleh Mycobacterium tuberculosis dan masih menjadi masalah kesehatan utama di Indonesia, dengan lebih dari satu juta kasus pada tahun 2023. Infeksi TB dapat menyebabkan inflamasi kronik yang mengarah pada fibrosis jaringan paru, yang dapat meningkatkan risiko kanker paru. Inflamasi kronik ini juga memicu peningkatan Reactive Oxygen Species (ROS) dan sitokin proinflamasi, yang dapat menyebabkan kerusakan DNA serta memicu mutasi genetik yang berkontribusi terhadap karsinogenesis. PPOK, di sisi lain, merupakan penyakit tidak menular yang umumnya dikaitkan dengan paparan asap rokok dalam jangka panjang. PPOK ditandai dengan inflamasi kronik pada saluran napas yang menyebabkan penyempitan dan kerusakan alveoli secara ireversibel. Proses inflamasi ini melibatkan pelepasan berbagai mediator inflamasi seperti TNF-α, IL-6, dan IL-8, yang dapat memicu stress oksidatif dan mempercepat proses epithelial-mesenchymal transition (EMT), suatu mekanisme penting dalam perkembangan kanker paru. Hubungan erat antara TB paru, PPOK, dan kanker paru menunjukkan bahwa kedua penyakit paru ini bukan hanya sekadar faktor risiko, tetapi juga berkontribusi secara langsung dalam proses karsinogenesis melalui mekanisme inflamasi, fibrosis, dan mutasi genetik. Oleh karena itu, deteksi dini dan penanganan yang tepat terhadap TB paru dan PPOK dapat menjadi strategi penting dalam pencegahan kanker paru.
Eksplorasi Imunoterapi dan Terapi Gen dalam Pengobatan Tumor Otak: Literature Review Hana Muthi'a Putri; Windarti, Indri; Mayasari, Diana; Susianti, Susianti
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1378

Abstract

Brain tumors are a significant neurological disorder with a high mortality rate, especially in cases of glioblastoma, which is highly aggressive and difficult to treat. Conventional treatment methods, such as surgery, radiation therapy, and chemotherapy, are often not effective enough, particularly in advanced stages. This study aims to explore two innovative approaches, namely immunotherapy and gene therapy, as alternative treatments for brain tumors. Immunotherapy works by enhancing the immune system's ability to fight cancer cells through methods such as checkpoint inhibitors, cancer vaccines, and CAR-T therapy. However, the success of immunotherapy is often hindered by the blood-brain barrier (BBB), which limits the delivery of therapy to the brain. On the other hand, gene therapy offers a solution by modifying genetic material, either to repair damaged genes or to directly destroy cancer cells. Approaches such as the use of oncolytic viruses, CRISPR technology, and nanoparticles have shown promising results in preclinical research and early clinical trials, particularly for glioblastoma. The combination of immunotherapy and gene therapy opens new opportunities to enhance treatment effectiveness by strengthening the immune response and targeting tumors more specifically. However, challenges remain, including treatment resistance, side effects, and limitations in brain delivery methods. Further research is needed to ensure the safety, efficacy, and widespread application of this combination therapy. Immunotherapy and gene therapy have great potential as breakthroughs in the future treatment of brain tumors. Relevant literature, including articles and journals from both national and international sources, were gathered through online searches in various databases, such as Google Scholar, PubMed, and NCBI, and used to compile this article.
Pengaruh Pemberian Ekstrak Etanol Buah Pare (Momordica Charantia L) Terhadap Gambaran Histopatolgi Arteri Koronaria Tikus Putih (Rattus Norvegicus) Jantan Galur Sprague Dawley Yang Diinduksikan Minyak Jelant Joni, Agnesia Priskila; Windarti, Indri; Oktarlina, Rasmi Zakiah; Susianti, Susianti
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1392

Abstract

Coronary heart disease is one of the main causes of death in the world, with more than 17 million deaths every year due to heart and blood vessel diseases, with around 8.7 million of them caused by coronary heart disease and around 15 out of 1000 residents in Indonesia which is equivalent to around 2,78,064 people suffer from coronary heart disease. The high frequency of use of cooking oil means that cooking oil is often used repeatedly. Repeated use of cooking oil can cause damage to various body organs such as the liver, heart, kidneys and arteries. Exposure to free radicals and free fatty acids obtained from used cooking oil if it enters the body will result in oxidative stress. The atherosclerosis process is characterized by the change of k-LDL to Ox-LDL which triggers endothelial dysfunction and the formation of atherosclerotic plaque on the walls of blood vessels. The high fatty acid content in used cooking oil can easily stick to the walls of blood vessels, so that it will accumulate and form atherosclerotic plaque. One of the alternative antioxidants that comes from herbs is bitter melon (Momordica Charantia L). Bitter melon contains flavonoid compounds. Flavonoids are secondary metabolites which are antioxidants that can inhibit free radical activity and can prevent atherosclerosis. Antioxidant compounds can reduce atherosclerosis by inhibiting LDL metabolism in secondary atherosclerotic lesions to prevent LDL oxidation in these lesions.
Pengaruh Pemberian Ekstrak Etanol Lada Hitam (Piper nigrum L) Terhadap Kadar Gula Darah dan Jumlah Spermatogonia Model Diabetes Tikus Putih Jantan (Rattus norvegicus) Galur Sprague dawley Talin, Jinan Naura; Hadibrata, Exsa; Rudiyanto, Waluyo; Windarti, Indri
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1431

Abstract

Diabetes mellitus that is not treated properly can result in infertility. The piperine content in black pepper can help in the quality of spermatogenesis process and blood sugar levels. This study aims to determine the effect of black pepper (P. nigrum L) ethanol extract on blood sugar levels and the number of spermatogonia in a diabetes model of male white rats (R. norvegicus) Sprague dawley strain. The study used a Posttest-only Randomized Control Group on 24 rats divided into 4 groups. All groups were induced with alloxan 150 mg/kgBW except for KN. P1 and P2 were given 122.5 mg/kgBW and 245 mg/kgBW black pepper ethanol extract. Blood sugar levels were checked using Easy Touch GCU with a normal limit of 50-135 mg/dL. The number of spermatogonia was calculated using a tool, namely ImageJ. The data were analyzed using the Shapiro- Wilk normality test and homogeneity test, followed by the Kruskal Wallis non-parametric test and the Post Hoc test. The statistical results of blood sugar levels obtained normally distributed data p>0.05, non-homogeneous data p<0.05, significant Kruskal-Wallis test results and continued Post Hoc test obtained significant results at P2 and K-. The number of spermatogonia obtained normally distributed data p>0.05, non-homogeneous data p<0.05. The results of the Kruskal-Wallis test were significant p<0.05 and continued Post Hoc test obtained significant results at P2 and P1. There was a decrease in blood sugar levels in the administration of black pepper ethanol extract (P. nigrum L) in the diabetes model of male white rats (R. norvegicus) Sprague dawley strain. However, there was no effect of administering black pepper ethanol extract (P. nigrum L) on the number of spermatogonia in the diabetes model of male white rats (R. norvegicus) Sprague dawley strain.
Tinjauan Pustaka: Pengaruh Obesitas, Resistensi Insulin dan Sindrom Metabolik dengan Fungsi Tiroid Fala, Arzety Rifda; Windarti, Indri; Jausal, Anisa Nuraisa; Sukohar, Asep
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1459

Abstract

The thyroid gland, located in the neck, is crucial for regulate metabolism, growth, and development by producing hormones like thyroxine (T4) and triiodothyronine (T3). These hormones influence various body functions, including heart rate, temperature control, energy production, and fat metabolism. When the thyroid gland doesn't function properly, it can cause conditions like hypothyroidism or hyperthyroidism. Factors such as obesity, insulin resistance, and metabolic syndrome can disrupt thyroid function. Obesity, characterized by excessive fat accumulation, is a global issue. This study examines how obesity, insulin resistance, and metabolic syndrome affect thyroid function. A review of fourteen relevant articles found that Thyroid Stimulating Hormone (TSH) levels are positively correlated with Body Mass Index (BMI), insulin resistance, and metabolic syndrome. The underlying mechanism is increased levels of leptin and inflammatory cytokines, which affect TSH production and thyroid function through disruption of T3 feedback. The findings indicate that obesity, insulin resistance, and metabolic syndrome lead to increased TSH as a compensatory response. This study highlights the importance of understanding the relationship between these conditions for better prevention and health management.
Co-Authors - Muhartono Agustyas Tjiptaningrum Aisyah Lubis, Aisyah Ajipurnomo, Adhari Alwiyah, Fadilah Amalia, Salsabila Ambarwati, Yuli ananti, anggini tasyakurillah Andreas Infianto Apri Lyanda Asep Sukohar Ayu Tiara FItri Bayu Putra Danan Jaya, Bayu Putra Danan Bayu Putra DJ Cyntithia, L. Gita Danan Jaya, Bayu Putra Devya Aulia Dewi Nur Fiana Diah Septia Liantari, Diah Septia Dwi Indria Anggraini Ekawati, Diyan Endah Setyaningrum, Endah Endang SR Hardjolukito Ety Apriliana Exsa Hadibrata Fadila Gustiani Daraz Fadly, Ahmad Aulia Fala, Arzety Rifda Firdaus, Elman Dani Fitria Saftarina Gatot Sudiro Hendarto, Gatot Sudiro Hadibrata, Exsa Haikal Shiddiq Ham, Maria Francisca Hana Muthi'a Putri Hanna Mutiara, Hanna Helmi Ismunandar Hendri Busman Hendri Tarigan S I Gede Eka Widayana Infianto, Andreas Inna Kurniaji Intanri Kurniati Iswandi Darwis Janar Wulan, Anggraini Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Joni, Agnesia Priskila Khairun Nisa Kusumajati, Pusparini Kusumaningtyas, Aditya Laisa Azka Liana Sidharti M. Aqmal Hidayah Marzel, Rivaldi Mayasari, Diana Mubarak, Raka Anzil Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Sudarmo Kasban Novita Carolia Nur Irawati Nurmayeni Nurmayeni Nurmayeni Nurul Islamy Oktadoni Saputra Qurani, Istiqomatul rahmawati, selvi Rajagukguk, Nanda Frisila Ramadhana Komala Rasmi Zakiah Oktarlina Ratna, Maya Ganda Reni Zuraida Resti Arania Rian Hendriyana Dwi Imanta Rika Lisiswati Risal Wintoko Risti Graharti Rizki Hanriko Rodiani, Rodiani Rosbhaiti Chodijah Rudiyanto, Waluyo Sangging, Putu Ristyaning Ayu Septiani, Linda Setiorini, Anggi Sezia Marina Sinaga, Fransisca T.Y. Siregar, Bintang Abadi Soemarwoto, Retno Ariza S Suryadi Islami Susianti Susianti Susianti Susianti, Susianti Sutarto Sutarto Sutarto Sutarto SYAIFUL BAHRI Syazili Mustofa Talin, Jinan Naura Tri Umiana Soleha Tubagus Djumhana Atmakusuma Wahdah, Annisa Shohifatul Waluyo Rudiyanto Wardani, Nanda Fitri Wulan, Anggraini Janar Wulyo Rajabto Yolanda Fratiwi Yunianto, Andi Eka Zulfa, Fathimah