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Journal : Jurnal Ilmu Medis Indonesia

Hubungan antara Mikrobiota dan Psoriasis Alinta Ayuningtyas Alinta; Khairun Nisa Berawi; Nurul Islamy
Jurnal Ilmu Medis Indonesia Vol. 1 No. 1 (2021): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (232.508 KB) | DOI: 10.35912/jimi.v1i1.277

Abstract

As the largest organ of the human body, the skin is colonized by a variety of microorganisms, most of which are harmless and have benefits for the host. This microbiota contributes to the metabolism and immunity of the host. The human microbiota includes bacteria, fungi, viruses and archaea, which inhabit various areas of the body. Most of the microbiota resides in the intestine, only a small part of which inhabit epithelial surfaces such as the mouth, airways, vagina and skin. The total number of microbiota on the surface of the skin is usually in the range 104 to 106 cells per cm2. Psoriasis is one of the most common immune-mediated inflammatory skin diseases. The prevalence of disease has been reported, with a range of 0.09- 11.43% by the WHO Global Report 2016. To date the causes of this disease are not fully understood, genetic and environmental interactions play an important role in disease progression. Recently, immunological approaches have helped to clarify the pathophysiology of the disease significantly. The skin microbiota has been shown to play a role in the pathogenesis of lichenified plaque formation in psoriasis. Corynebacterium, Propionibacterium, Staphylococcus, and also Streptococcus have been identified as the main microbiota. It has not been determined whether these changes in the microbiota are a cause or consequence of psoriasis. For this reason, further research on selective modulation of the skin microbiota is needed. This systematic review aims to elucidate the correlation between the microbiome and pathogenesis of psoriasis and the modulation of the microbiota that could lead to possible therapeutic interventions. Keywords: Microbiota, Psoriasis, Skin
Mikrobiota Usus dan Osteoartritis Redi Bintang Pratama; Khairun Nisa Berawi; Nurul Islamy
Jurnal Ilmu Medis Indonesia Vol. 1 No. 1 (2021): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.383 KB) | DOI: 10.35912/jimi.v1i1.279

Abstract

Osteoarthritis (OA) is one of the most commonly experienced musculoskeletal diseases. Various studies were conducted to find the relationship between the gut microbiota and the incidence of osteoarthritis. The gut microbiota encourages the production of proinflammatory cytokines and bacterial metabolites which are considered to be part of the pathophysiological mechanisms of osteoarthritis. Various risk factors that trigger osteoarthritis, such as age, gender, diet, and obesity have an influence on the gut microbiota. This suggests the possible involvement of the microbiota in the incidence of osteoarthritis. The increasing prevalence of osteoarthritis calls for an effective disease-modifying therapy strategy to relieve symptoms and slow the progression of the condition. The investigators hypothesized that modulation of the gut microbiota by external approaches might influence the progression of osteoarthritis. To date, some evidence suggests that gut microbiota intervention can be realized through probiotics, prebiotics, exercise, and fecal microbiota transplantation (FMT). Keywords: Osteoarthritis, Microbiota, Risk Factor
Manajemen Holistik dengan Pendekatan Kedokteran Keluarga pada Pasien Wanita 37 Tahun dengan Hipertensi Primer Annisa Putri Perdani; Khairun Nisa Berawi
Jurnal Ilmu Medis Indonesia Vol. 1 No. 1 (2021): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.251 KB) | DOI: 10.35912/jimi.v1i1.505

Abstract

Purpose: This study aimed to identify risk factors, clinical problems and provide management of patients with the implementation of holistic family physician services based on evidence-based medicine approach to patient and family-centered approach. Research methodology: This study is a case report. Primary data were obtained through history taking (directly from the patient and indirectly from family members), physical examination, and a home visit to complete the family, psychosocial and environmental data. Secondary data were obtained from the medical records of the patient at the health center. The assessment was based on a holistic diagnosis from the beginning, process, and the end of quantitative and qualitative studies. Results: A 37-year-old female was diagnosed with primary hypertension with worries that his disease would get worsen into a stroke. Patients do not know exactly what diet is recommended for hypertensive patients. The evaluation results obtained that complaints and worries of patients were reduced, the knowledge of patients and their families regarding hypertension increased and behavior related to hypertension improved. Contribution: Holistic management has been done with the approach of a family doctor, Mrs. S age 37 years with primary hypertension adjusted for EBM based on baseline holistic diagnostics. These interventions have increased the patient's knowledge and changed some of the patient's behavior and his family, as indicated by improvements in the final holistic diagnostics.
The Efek Neuroprotektif Kafein terhadap Fungsi Motorik pada Penyakit Parkinson Khairun Nisa Berawi; Ilham Nugroho
Jurnal Ilmu Medis Indonesia Vol. 1 No. 1 (2021): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.191 KB) | DOI: 10.35912/jimi.v1i1.510

Abstract

Background: Coffee is one of the most consumed drinks in the world and has become a routine part of everyday life. Coffee is known to be a stimulant because of its high caffeine content. Parkinson's disease is the second most common neurodegenerative disorder characterized by the clinical presentation of motor and non-motor disorders. Neuroinflammation plays a major role in the pathogenesis of Parkinson's disease which is regulated by reactive microglia and causes neurodegeneration of dopaminergic neurons. Consumption of caffeine can exert anti-inflammatory effects on nerves in a variety of pathological conditions. Method: The method used is a literature study from various national and international journals. This method is used with the aim of summarizing a current topic in order to increase an understanding. The literature study restates previously published material and reports new facts or analyzes from relevant literature studies and then compares the results in the article. Results: Caffeine can act as a neuroprotective against the development of Parkinson's disease by keeping the blood-brain barrier intact so that the function of the central nervous system remains stable. Caffeine can improve motor function in Parkinson's disease patients by modulating adenosine A2AR receptors at different doses. Caffeine as an adjuvant drug in the treatment of Parkinson's disease is given together with Trihexyphenidyl (THP) which is an anti-Parkinson's agent that has been used clinically to treat Parkinson's disease. Conclusion: Caffeine is a neuroprotective agent that is widely available and can be used in the treatment of Parkinson's disease with current therapies. However, the correct dosage and safety of caffeine are of particular concern, especially when given at high doses for a period of time and concurrently with other Parkinson's drugs.
Sindrom Rapunzel: Laporan Kasus Khairun Nisa Berawi; Fauziyyah Nuur Al Azizah
Jurnal Ilmu Medis Indonesia Vol. 1 No. 2 (2022): Maret
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1161.17 KB) | DOI: 10.35912/jimi.v1i2.730

Abstract

Purpose: This study aimed to summarize the general history, physical exam findings, confirmation test, and treatment of a patient with rapunzel syndrome. Research Methodology: This article is a pediatric surgery RSUD Abdoel Moeloek Lampung case report in 11 March 2020. The subject of the case is a 11-year-old girl who is hospitalized in the hospital ward with Rapunzel syndrome. Result: A 11-year-old girl, an inpatient in the Pediatric surgery Ward, RSUD Abdoel Moeloek Lampung, with abdominal pain such as squeezing, nausea and vomiting filled with water and hard and little bowel movements.. On physical examination, bloated abdomen, epigastric tenderness and left hypochondrium, mass (+).on ct scan examination with gastric contrast looks enlarged, isodense lesions appear, irregular edges in the gastric lumen to the duodenum, separated from the wall, post contrast does not appear enhanced. The patient was clinically diagnosed with “Rapunzel Syndrome.” Management of the patient during treatment was upper midline laparatomy. Limitations: This case report is limited to rapunzel syndrome cases with a scarce number of cases and rare cases in children. Contribution: This case report can be helpful in medical education or used as a reference in making relevant case reports and can be applied in the hospital area when there are cases of Rapunzel syndrome.
Laboratory and Clinical Manifestation Correlation of Neonatal Sepsis in Abdul Moeloek Hospital Ervina, Leni; Berawi, Khairunnisa; Busman, Hendri; Irawan, Bambang; Azizah, Nailul; Yolanda, Jennifer Ester
Jurnal Ilmu Medis Indonesia Vol. 4 No. 2 (2025): Maret
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jimi.v4i2.4250

Abstract

Purpose: The prognosis of neonatal sepsis critically depends on early detection; however, its nonspecific clinical signs and variable laboratory findings often complicate the timely diagnosis. This study aimed to assess the correlation between clinical manifestations and laboratory results in neonatal sepsis cases, focusing on patients at Abdul Moeloek Hospital. Methodology/approach: A cross-sectional approach was used to analyze the medical records of neonates diagnosed with sepsis between January and June 2024. All neonates admitted to the neonatal unit with suspected sepsis during this period were included in the study. Results/findings: The majority of patients were male (65.1%) and 1 week old (58.7%). Hyperthermia (44.4%) was the most common symptom, followed by a normal heart rate (68.3%) and respiratory rate (81%). Most patients had normal hemoglobin (55.6%) and leukocyte levels (71.4%), low platelet counts (50.8%), and negative culture results (74.6%). Statistically significant correlations were found between heart rate (OR=0.4) and respiratory rate (OR=0.3) and laboratory findings (p<0.05), although the strength was weak to moderate. No significant correlation was observed with body temperature (p=0.412). Conclusions: Heart and respiratory rates were significantly associated with sepsis-related laboratory results, whereas body temperature was not. Most affected neonates were male, one week old, and presented with hyperthermia but otherwise normal vital signs and blood cell counts. Limitations: The limited sample size and study duration suggest the need for further research. Contribution: These findings provide insights into improving the early detection and management of neonatal sepsis, particularly in pediatric care settings in Indonesia.
Co-Authors Adisti, Fransiska Admi Syarif Afifah, Syafira Hasna Agung, Leni Yulinda Kesuma Agus Wantoro Agustyas Tjiptaningrum Ahmad Arkan Ichsan Ahmad Arkan Ichsan Akuba, Nanda Nurrohim Al Ghifari, Ghaza Ahmad Alicia Rahma, Cinta Alinta Ayuningtyas Alinta Amir, Anzela Anggraeni Janar Wulan anggraini janar wulan Angraini, Dwi Indria Anisa Adelia Annisa Adietya Pratama Annisa Fath Annisa Putri Perdani Apri Lyanda Arsistya Ayu Marella Asep Sukohar Assidiq, Hans Pratama Astiti, Feni Ayu Dinda Fatimah Azizah, Nailul Azizza, Zahra Qori Bayu Anggileo Pramesona Candra Kurniawan Chicy WIdya Morfi Christy, Angelica Philia CNA Qolbi Daulay, Suryani Agustina Dea Okta Pabiola Dewi Nur Fiana Dewi Nur Fiana Dewi Nur Fiana Dian Isti Anggraini Dian Isti Angraini Dian Syafitri Dian Syafitri Dian Syafitri Diana Mayasari Dilangga, Pad Dinda Annisa Fitria Diva Iole Humaira Dwita Oktaria Dyah Wulan Sumekar Rengganis Wardani Eca Cania Efrida Warganegara Ekki Pirmansyah Emantis Rosa Ester Krisdayanti Ety Apriliana Exsa Hadibrata Farhati, Soraya Fauzi Ahmad Muda Fauziyyah Nuur Al Azizah Fitria Putridewi Abidin Fitria Saftarina Frigandra Syahputri Ghaitsa Lulua Giska Tri Putri Gozali, Achmad Haikal Nirfandi Hanif, Fauziah Happy, Terza Aflika Helmi Ismunandar Hendri Busman Heni Sulistiani Herdato, M. Junus Didiek Ilham Nugroho Ilham Nugroho Intanri Kurniati Irawati, Nur Ayu Virginia Iswandi Darwis Karima, Nisa Khalisah Nurjihany Salsabila Kurnia Muludi Kurniawan, Ryanda Masri Kurniawaty, Evi Kusumajati, Pusparini Latief, Adhi Nugroho Leni Ervina, Leni Lesilolo, Caroline Virgine Putri Liana Sidharti M Masykur Berawi M. Irfan zaki Rici Maharani, Atifah Fadilah Marcellia, Selvi Marzon, Mafalda Messah, Anse Diana Valentiene Muhammad Aditya, Muhammad Muhammad Aditya, Muhammad Aditya Muhammad Farid Adityo Muhammad Maulana Muhammad Ricky Ramadhian Muhammad Rifki Pratama Muhartono Muhartono Murfi, Syahrani Alya Neema Putri Prameswari Nelly Yuana Nisa Karima Nur Anggraini Nurhaliza, Suci Nurul Islamy Oktafany, Oktafany Oktavia Ningtias, Nabila Padmadisastra, Jauzaa Faishal Ahmad Perdami, Roro Rukmi Windi Pertiwi, Nabila Rahma Prambudi Rukmono Pramesona, , Bayu Anggileo Prayogi, Norbertus Marcell Puspaningrum, Dewi Ayu Putri Giani Purnamasari Qanita Arindia, Naifa Hana Rahma, Cinta Alicia Rahmah, Azizah Nur Ramadhan, Yasmine Aulia Ramadhana Komala Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratu Nirmala Wahyunindita Redi Bintang Pratama Reni Zuraida Rianto, Muhamad Arif Risti Graharti Riyan Wahyudo Roro Rukmi Windi Perdani, Roro Rukmi RR. Ella Evrita Hestiandari Safira, Ditya Ananda Salma Khairunnisa Samsul Bakri Sembiring, Rinawati Septiani, Linda Setiawan, Gigih Shiddiq, Haikal Shinta Nareswari, Shinta Siregar, Maulana Irfan Hazairin Smith Imanuel Saputra Soemarwoto, Retno Ariza S. Sri Ratna Sulistiyanti Suharmanto Suharmanto Suharmanto Suryadi Islami Susianti Susianti Susianti Susianti, Susianti Sutyarso Sutyarso Syahfira, Reisyah Syarel, Radin Ghefira Naura Ta Larasati TA Larasati Tasya Khariena Akbar Theodora Agverianti Verizka, Talitha Warsito Warsito Warsono Warsono Wibowo, Gatra Hadimuti Winda Trijayanthi Utama, Winda Trijayanthi Wiwi Febriani Wuryaningsih Dwi Sayekti Yoga, M. Agung Prasetya Adnyana Yolanda, Jennifer Ester Yulita Yulita Zahra, Tsurayya Fathma Zefanya, Ezekial