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Khairun Nisa
Universitas Lampung
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Hubungan Obesitas Sentral dengan Hitung Jenis Leukosit pada Laki-Laki Dewasa di Lingkungan Universitas Lampung Diva Iole Humaira; Khairun Nisa Berawi; Chicy WIdya Morfi
Medula Vol 10 No 1 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i1.16

Abstract

Obesity is a condition characterized by excessive accumulation of fat in the body. One form of obesity is central obesity which is characterized by the accumulation of fat, especially in the abdomen, and is more common in men. Central obesity has a stronger correlation with various diseases as a result of chronic inflammatory reactions that occur in adipose tissue. This ongoing inflammatory process will cause changes in various immunological parameters, one of which is leukocyte count. This study aims to determine the relationship between central obesity and leukocyte count in adult obese men. This research uses a cross-sectional approach. 59 study subjects were consisting of 39 central obese men and 20 non-obese central men. Venous blood samples were used in the calculation of differential counts and calculated Manually by microscope. The results showed a significant association between central obesity with neutrophil (p= 0,01), monocyte (p= 0,031) and lymphocyte counts (p= 0,003) but eosinophils and basophils did not have a significant relationship (p= 0,106 and p= 0,166). There is a relationship between central obesity with neutrophil type counts, monocytes, and lymphocytes in adult males with central obesity but eosinophils and basophils have no relationship.
Hubungan Obesitas dengan Perubahan Perilaku pada Remaja di SMPN 4 Bandar Lampung Putri Giani Purnamasari; Khairun Nisa Berawi; Fitria Saftarina
Medula Vol 10 No 1 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i1.24

Abstract

Obesity (overweight) is a fundamental disease from non-communicable diseases such as diabetes, hypertension, and cardiovascular disease who still becomes a major health issue in Indonesia and the world. The teenager is a transition period that involves changes in physiological, psychological, social, and can develop into overweight or obesity. The fear of being obese is more common in girls than boys, and this explains why an effort to lose weight is mostly found in girls. This study aimed to determine the relationship between obesity and teenagers' behavioral changes in 14-16 years old of SMPN 4 Bandar Lampung students. It was a comparative analytic with a cross-sectional study. The sampling method used a case-control and using a questionnaire as a measuring tool. Data were then analyzed with a chi-square test. The study was conducted against 77 respondents with 48 respondents (62.3%) who were obese and 29 respondents (37.7%) not obese. While as many as 20 respondents (26.0%) had problematic behavior and 57 respondents (74.0%) did not have problematic behavior. The result of the chi-square test with a p-value was 0.015. There was a significant association between obesity with the teenager's behavior change in SMP Negeri 4 Bandar Lampung.
Prediktor Komplikasi Dengue Shock Syndrome (DSS) pada Pasien Pediatri dengan Dengue Hemorrhagic Fever (DHF) Ahmad Arkan Ichsan; Khairun Nisa Berawi; Neema Putri Prameswari; Ratu Nirmala Wahyunindita
Medula Vol 10 No 1 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i1.42

Abstract

Dengue Hemorrhagic Fever (DHF) are tropical infectious diseases prevalent in tropical, subtropical and temperate climate countries, complications of DHF that leads to Dengue Shock Syndrome (DSS) may have drastic implications towards the mortality of pediatric patients. Ongoing assessment is still proceeding on Risk factors for the patient’s progression to DSS and there are several predictors utilized on patient follow-up that may indicate high risk of clinical symptom progression to DSS. Several predictors are identified to be the female gender, age between 6-10 years, hepatomegaly, late clinical management, heavy plasma leakage, obesity, spontaneous bleeding, gastrointestinal bleeding and presentations of ascites and pleural effusion. Several lab examinations include leucopenia, prolonged aPTT, low platelet count, thrombocytopenia, hematocrit of ≥ 40, low lipid profile, hypoalbuminemia, hypoproteinemia. There are also other predictors identified such as high Troponin T levels, NS1Ag expression, NK and NKT gene expression, elevated Vitamin D levels, Fatty acid levels. high sTM levels, elevated Chymase enzyme serum levels and elevated lactate serum levels. The usage of machine learning and algorithms may also prove useful in predicting DSS complications through pattern identification. There is a wide array of current and new methodologies to predict DHF progression to DSS, and further review analysis may be needed to determine concrete indicators for predicting DHF progression to DSS. Newer methods may prove useful, and would need further testing to ensure its capabilities on predicting DSS.
Hubungan Tahap Pengobatan dengan Kualitas Hidup Pasien Multidrug-resistant Tuberculosis di RSUD Dr. H. Abdul Moeloek Provinsi Lampung Muhammad Rifki Pratama; Asep Sukohar; Khairun Nisa Berawi
Medula Vol 10 No 1 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i1.48

Abstract

Tuberculosis (TB) is the number one infectious disease in the world as the most frequent cause of death. TB infects 10 million people each year and becomes the 10th highest cause of death in the world.Multidrug-resistant Tuberculosis (MDR-TB) is a type of TB germ resistance against at least two first-line anti-tuberculosis (OAT) drugs. MDR-TB treatment certainly takes longer than 18 months. This very long treatment can affect the quality of life of MDR-TB patients. This study is to determine the correlation between the treatment phases with the quality of life of patients with Multidrug-resistant Tuberculosis in Dr. H. Abdul Moeloek Hospital Lampung Province. This study used 68 respondents who had been diagnosed with MDR-TB by pulmonary specialists. Primary data was taken using SF-36 questionnaire to measure the quality of life of MDR-TB patients, then secondary data based on the treatment phases using the medical record of the patient who had filled out the questionnaire. The data is processed and analyzed by the program in the computer. Data were tested by chi-square test and the results were obtained from 30 respondents in the initial treatment phases, 22 people (73.3%) quality of life was poor and 8 people had good quality of life (26.7%), while from 38 respondents at the continued treatment phases, as many as 12 people (31.6%) quality of life is bad and 26 people have good quality of life (68.4%). The result of bivariate analysis showed the variable had a correlation with p-value=0,001. There is a correlation between the treatment phases with the quality of life of patients with Multidrug-resistant Tuberculosis in RSUD Dr. H. Abdul Moeloek.
Hubungan Indeks Masa Tubuh pada Balita Stunting Terhadap Kadar Hemoglobin di Kecamatan Gunung Sugih Kabupaten Lampung Tengah Frigandra Syahputri; Khairun Nisa Berawi; Eca Cania
Medula Vol 10 No 2 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i2.60

Abstract

The prevalence of stunting in Gunung Sugih District, Lampung Tengah Regency, Lampung Province is high for stunting category in Indonesia. Nutritional status in stunting can be measured by body mass index according to age (BMI /A). Stunting has anemia as hemodynamic problems due to lack of iron (Fe) intake. The parameter which is used for measure anemia is hemoglobin. This study aims to determine the relationship between BMI in stunting children and hemoglobin levels as a marker of anemia. Observational analytic method with cross sectional approach was used in this study with 35 samples (cluster random sampling). Primary data are height, weight, body mass index (BMI) and hemoglobin (Hb) levels as measured by Hb Meter (Dr.Family®). Data analysis was performed by Pearson correlation test. Obtained a normal BMI of -0.51SD with a percentage of 94.3%. Hb levels with a mean of 10.4 g/dL and 57.1% of children had anemia. The results of the Pearson correlation test found that Ho was received with value of p=0.511 (p>0.05) and had a positive correlation (r=0.115). This study did not show a significant relationship between body mass index (BMI) of hemoglobin (Hb) levels as a marker of anemia in stunting infants in Gunung Sugih District, Central Lampung Regency.
Efek Anti-Mikrobial pada Ekstrak Cinnamomum verum (Kayu Manis) sebagai Terapi Adjuvant pada Malaria Falciparum Khairun Nisa; Fitria Putridewi Abidin
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.167

Abstract

Malaria is a major public health problem in the world, especially in Indonesia. The prevalence of malaria in Indonesia reaches 6 percent with 2000 deaths each year, most of which are caused by Plasmodium falciparum. Various treatment options for falciparum malaria have been developed, but due to various factors, one of which is the adherence of patients who are not monitored medication, increases the risk of resistance to current malaria therapy. Therefore, the researchers conducted further research on alternative malaria therapies. Cinnamomun verum or cinnamon is known to contain cinnamaldehyde compounds which have antimicrobial properties. The purpose of this study was to determine the anti-microbial effect of Cinnamomun verum (cinnamon) extract as an adjuvant therapy in falciparum malaria. This literature review article takes 25 case report articles, research articles, and literature reviews. The conclusion of this study is that the cinnamaldehyde compound in the extract of Cinnamomun verum has an antiparasitic effect which can inhibit the denaturation potential of amino acids, inhibits β-hematin formation and activity of the reductase enzyme on Plasmodium falciparum enoyl-ACP reductase. It is known that these four things have an important role in the pathogenesis of falciparum malaria.
Hubungan Kualitas Tidur Dengan Tekanan Darah Pada Laki-Laki Penderita Obesitas Sentral Di Lingkungan Universitas Lampung Ester Krisdayanti; Khairun Nisa Berawi; Emantis Rosa
Medula Vol 12 No 2 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i2.432

Abstract

Obesity has a tendency to develop throughout the world, both in developed and developing countries. This is due to the prevalence which continues to increase preogressively from year to year. This central obesity is closely related to degenerative diseases such as hypertension that occur through the mechanism of Renost Angiotensin Aldostseron and sympathetic nerve activity. Poor sleep quality can increase the increase in blood pressure so that it worsens the development of hypertension in patients with central obesity. This type of research is a non-paired observational analytic type with cross sectional research design. This research was conducted in November 2012 in the University of Lampung. The sample used in this study was based on consecutive sampling and obtained as many as 80 men with central obesity. This research was conducted by interviewing the Pittsburgh Sleep Quality Index questionnaire and measuring blood pressure to respondents from all the academic community of men with central obesity selected in the University of Lampung. The results of this study were processed using computer software. The results of the analysis with Chi Square test of sleep quality on systolic blood pressure showed p value <0.05, namely p value 0.021 and PR 0.056 and 95% CI 0.320-0.932 and sleep quality on diastolic blood pressure obtained p values ​​0.013 and PR 0.531 and 95% CI 0.312-0.903. The conclusion of this study, there is a relationship between sleep quality and blood pressure in men with central obesity at Lampung University.
Hubungan Tingkat Stres Terhadap Kadar Glukosa Darah Puasa pada Laki-Laki Penderita Obesitas Sentral di Lingkungan Universitas Lampung Khalisah Nurjihany Salsabila; Khairun Nisa Berawi; Dwita Oktaria
Medula Vol 12 No 2 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i2.435

Abstract

The incidence of Diabetes Mellitus (DM) in the world and in Indonesia continues to increase. One factor that can affect high blood glucose levels and end up being DM is psychological stress. Patients with central obesity are more vulnerable and have a higher risk of experiencing stress caused by various psychological and emotional factors. The occurrence of stress will cause the activation of the Corticotropic-Releasing Hormone (CRH)-Adrenocorticotropic Hormone (ACTH)-cortisol hormone system which has a direct effect on increasing glucose levels in the blood (hyperglycemia) and if the condition continues, it will increase the risk of DM disease. Observational analytic method with a cross-sectional approach was used in this study. The study sample consisted of 82 patients with central obesity in the University of Lampung environment, with a consecutive sampling method. This research was conducted by filling in and direct interviewing the Perceived Stress Scale (PSS)-10 questionnaire and measuring fasting blood glucose levels in all the academic communities on men with central obesity at the University of Lampung. The results of the univariate analysis of the research sample were dominated by the age group of 18-25 years; the stress level was in the moderate category; with uncontrolled fasting blood glucose levels. The results of bivariate analysis with Chi-Square test showed p-value = 0.001 (p-value <0.05). There is a relationship between stress level and fasting blood glucose in men with central obesity at the University of Lampung.
Hubungan Indeks Massa Tubuh terhadap Volume Oksigen Maksimal (VO2max) Mahasiswa Tingkat Pertama Fakultas Kedokteran Universitas Lampung Salma Khairunnisa; Dewi Nur Fiana; Helmi Ismunandar; Khairun Nisa Berawi
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.610

Abstract

Maximum oxygen volume (VO2max) is the maximum oxygen uptake during exercise. People with good fitness have higher VO2max value ​​and can perform activities more vigorously than those with poor fitness. Body mass index (BMI) is one of the body composition factors that affect VO2max. VO2max can be measured through various methods, one of which is the Balke test. This study aims to determine the relationship of body mass index to VO2max in the first grade students of the Faculty of Medicine, University of Lampung. This research is a correlative analytic study with a cross-sectional approach using primary data which was conducted in one meeting in November 2022. The data is obtained using measuring body mass index (BMI) first, and followed by measuring VO2max using the Balke test method. This study uses sample of 39 batch 2022 male students of the Faculty of Medicine, University of Lampung who have previously passed the inclusion and exclusion criterias. The result in this study indicates that there is a significant relationship between body mass index and VO2max in the first grade students of the Faculty of Medicine, University of Lampung. In this study, the p value is <0.001 and the correlation coefficient is -0.812, which means that there is a very strong negative correlation between variables. This negative correlation relationship indicates that the higher the body mass index (BMI) will result in lower individual VO2max values, and vice versa.
Covid 19 with Kidney Failure Arsistya Ayu Marella; Khairun Nisa Berawi; Fitria Saftarina
Medula Vol 13 No 3 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i3.632

Abstract

Corona virus disease 2019 or commonly called COVID-19 is a disease caused by infection with the SARS-CoV-2 virus and is one of the biggest challenges facing humanity in recent years. This disease is highly contagious with various manifestations and complications and poses a threat to public health. This virus can infect a large number of organs, including the lungs and upper respiratory tract, brain, liver, kidneys, intestines and many others. Although the greatest damage occurs in the lungs, the kidneys are no exception, and acute kidney injury (AKI) can occur in patients with COVID-19. AKI is one of the most frequent and serious organic complications of COVID-19. The incidence of COVID-19 AKI. During the COVID-19 pandemic, many patients were hospitalized with severe respiratory illnesses and experienced complications. Acute kidney injury (AKI) is one of the more dangerous complications that contributes to morbidity and mortality among patients. Kidney damage can occur due to direct attack by the virus itself, or due to a cytokine storm caused by an abnormality of the immune system. Hypotension or dehydration, hypoxaemia, sepsis and nephrotoxic drugs can also cause kidney failure. This research method begins by searching articles on Google Scholar, pubmed and ncbi within the year range determined by the researchers and using the keywords COVID-19, kidney failure, complications of kidney failure in COVID-19 patients. The results of the study found articles about producing several conclusions such as the effect of kidney failure on COVID-19 patients, then the long-term effects on the kidneys of patients with COVID-19.
Co-Authors Abimanyu Darmawan Adisti, Fransiska Admi Syarif Afifah, Syafira Hasna Agung, Leni Yulinda Kesuma Agus Wantoro Agustyas Tjiptaningrum Ahmad Arkan Ichsan Ahmad Arkan Ichsan Ahmad Farishal Akuba, Nanda Nurrohim Al Ghifari, Ghaza Ahmad Alicia Rahma, Cinta Alinta Ayuningtyas Alinta Amalia Tirzaningrum Amir, Anzela Andhika Mahatidanar Anggraeni Janar Wulan anggraini janar wulan Angraini, Dwi Indria Ani Yuli Yanti Puspitasari Anisa Adelia Annisa Adietya Pratama Annisa Fath Annisa Putri Perdani Apri Lyanda Aprilia, Sandrina Audy Arsistya Ayu Marella Asep Sukohar Asiah Nurul Izzah Assidiq, Hans Pratama Astiti, Feni Ayu Dinda Fatimah Azizah, Nailul Azizza, Zahra Qori Bayu Anggileo Pramesona Candra Kurniawan Chicy WIdya Morfi Christy, Angelica Philia CNA Qolbi Daulay, Suryani Agustina Dea Okta Pabiola Desty Marini Dewi Nur Fiana Dewi Nur Fiana Dewi Nur Fiana Dian Isti Anggraini Dian Isti Angraini Dian Isti Angraini Dian Syafitri Dian Syafitri Dian Syafitri Diana Mayasari Dilangga, Pad Dinda Annisa Fitria Diva Iole Humaira Dwita Oktaria Dyah Wulan Sumekar Rengganis Wardani Dyah Wulan Sumekar Rengganis Wardani Eca Cania Edward Sintong Samosir Efrida Warganegara Ekki Pirmansyah Emantis Rosa Ester Krisdayanti Ety Apriliana Exsa Hadibrata Farhati, Soraya Fathia Radinda Salsabila Fathia Sabila Umar Fauzi Ahmad Muda Fauziyyah Nuur Al Azizah Fitria Putridewi Abidin Fitria Saftarina Frigandra Syahputri Ghaitsa Lulua Giska Tri Putri Gozali, Achmad Haikal Nirfandi Hanif, Fauziah Hanna Mutiara Happy, Terza Aflika Helmi Ismunandar Helmi Ismunandar Hendri Busman Heni Sulistiani Herdato, M. Junus Didiek Hj. Rahma Amtiria Ilham Nugroho Ilham Nugroho Indri Windarti Intan Kusumaningtyas Intanri Kurniati Irawati, Nur Ayu Virginia Iswandi Darwis Karima, Nisa Khalisah Nurjihany Salsabila Kurnia Muludi Kurniawan, Ryanda Masri Kurniawaty, Evi Kusumajati, Pusparini Latief, Adhi Nugroho Leni Ervina, Leni Lesilolo, Caroline Virgine Putri Liana Sidharti Liana Sidharti M Masykur Berawi M. Aqmal Hidayah M. Irfan zaki Rici Maharani, Atifah Fadilah Marcellia, Selvi Marzon, Mafalda Messah, Anse Diana Valentiene Mia Trihasna Asrizal Muhammad Aditya, Muhammad Muhammad Aditya, Muhammad Aditya Muhammad Farid Adityo Muhammad Maulana Muhammad Morsa Habibie Muhammad Ricky Ramadhian Muhammad Rifki Pratama Muhartono Muhartono Murfi, Syahrani Alya Neema Putri Prameswari Nelly Yuana Ni MAde Ida Damma Nisa Karima Nisa Karimah Nur Anggraini Nurhaliza, Suci Nurul Islamy Nurul Utami Oktadoni Saputra Oktafany, Oktafany Oktavia Ningtias, Nabila Padmadisastra, Jauzaa Faishal Ahmad Perdami, Roro Rukmi Windi Pertiwi, Nabila Rahma Prambudi Rukmono Pramesona, , Bayu Anggileo Prayogi, Norbertus Marcell Purnama, Dara Marissa Widya Puspaningrum, Dewi Ayu Putri Giani Purnamasari Qanita Arindia, Naifa Hana Rahma, Cinta Alicia Rahmah, Azizah Nur rahmawati, selvi Ramadhan Triyandi Ramadhan, Yasmine Aulia Ramadhana Komala Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratu Nirmala Wahyunindita Redi Bintang Pratama Reni Zuraida Rianto, Muhamad Arif Risti Graharti Riyan Wahyudo Roro Rukmi Windi Perdani, Roro Rukmi RR. Ella Evrita Hestiandari Rudiyanto, Waluyo Safira, Ditya Ananda Salma Khairunnisa Samsul Bakri Sangging, Putu Ristyaning Ayu Sembiring, Rinawati Septiani, Linda Setiawan, Gigih Setiorini, Anggi Sheira Indah Anjani Shiddiq, Haikal Shinta Nareswari, Shinta Siregar, Maulana Irfan Hazairin Smith Imanuel Saputra Soemarwoto, Retno Ariza S. Sowiyah Sowiyah Sri Ratna Sulistiyanti Suharmanto Suharmanto Suharmanto Suryadi Islami Susianti Susianti Susianti Susianti, Susianti Sutarto Sutarto Sutyarso Sutyarso Syahfira, Reisyah Syarel, Radin Ghefira Naura Ta Larasati TA Larasati Tasya Khariena Akbar Theodora Agverianti Theodorus, Emeraldha Verizka, Talitha Warsito Warsito Warsono Warsono Wibowo, Gatra Hadimuti Winda Trijayanthi Utama, Winda Trijayanthi Wiwi Febriani Wuryaningsih Dwi Sayekti Yoga, M. Agung Prasetya Adnyana Yolanda, Jennifer Ester Yulita Yulita Zahra, Tsurayya Fathma Zefanya, Ezekial