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All Journal International Journal of Evaluation and Research in Education (IJERE) HAYATI Journal of Biosciences Jurnal Pangan dan Gizi Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences SAINSMAT Jurnal Nalar Pendidikan Jurnal Pendidikan Sains Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Pendidikan Indonesia Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Journal of Education and Learning (EduLearn) Pharmaciana: Jurnal Kefarmasian Biogenesis: Jurnal Ilmiah Biologi Jurnal Online Mahasiswa (JOM) Bidang Ilmu Ekonomi Jurnal Online Mahasiswa (JOM) Bidang Ilmu Keperawatan Jurnal Online Mahasiswa (JOM) Bidang Keguruan dan Ilmu Pendidikan Biotropika Biomedical Engineering AGRIVITA, Journal of Agricultural Science Jurnal Pendidikan Biologi Indonesia Mutiara Medika: Jurnal Kedokteran dan Kesehatan Bioeksperimen: Jurnal Penelitian Biologi Majalah Obat Tradisional Journal of Tropical Biodiversity and Biotechnology Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Majalah Lontar Jurnal Pendidikan Biologi Science and Technology Indonesia International Journal of Applied Biology Universa Medicina Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Akademika Kimia BIOEDUKASI Biosaintifika: Journal of Biology & Biology Education Berdikari: Jurnal Pengabdian Masyarakat Indonesia Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Lectura : Jurnal Pendidikan Amerta Nutrition AL-HAYAT: Journal of Biology and Applied Biology JPBIO (Jurnal Pendidikan Biologi) Scripta Biologica Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Jurnal Karinov El-Umdah Maternal Child Health Care Journal JURNAL GIZI DAN KESEHATAN JPP (Jurnal Pendidikan dan Pembelajaran) Journal of Community Service and Empowerment Window of Public Health Journal Bioscientist : Jurnal Ilmiah Biologi JIPB (Jurnal Inovasi Pembelajaran Biologi) Jurnal Studi Islam Lintas Negara (Journal of Cross-Border Islamic Studies) Proceeding Biology Education Conference Berkala Penelitian Hayati Jurnal Pijar MIPA Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Al-Hijr: Journal of Adulearn World Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Journal of Accounting and Finance Management (JAFM) SAINSMAT: Jurnal Ilmiah Ilmu Pengetahuan Alam ALSYS : Jurnal Keislaman dan Ilmu Pendidikan Acta Pedagogia Asiana Jurnal Kedokteran Hewan Jurnal Pendidikan Sains Indonesia (Indonesian Journal of Science Education) Molekul: Jurnal Ilmiah Kimia Berkala Ilmiah Biologi Prosiding Seminar Nasional Pengabdian kepada Masyarakat (SINAPMAS) Jurnal Ilmu Hayat Madrasah Ibtidaiyah Research Journal Jurnal Pemikiran dan Pengembangan Pembelajaran Prosiding Dedikasi: Pengabdian Mahasiswa Kepada Masyarakat Jurnal Info Kesehatan Berita Biologi
Sri Rahayu Lestari
Universitas Negeri Malang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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The Role of Black Soybean and Purple Sweet Potato Active Compound on Advanced Glycation End-Product in Streptozotocin-Induced Type 2 Diabetes Mellitus Rat Gofur, Abdul; Arifah, Siti Nur; Annisa, Yuslinda; Witjoro, Agung; Atho'illah, Mochammad Fitri; Lestari, Sri Rahayu
Journal of Tropical Life Science Vol 9, No 2 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.09.02.02

Abstract

Diabetic nephropathy is one of the diabetes complications attacking kidney leading to kidney damage. Hyperglycemia accompanying DM causes the increase of Ad-vanced Glycation End-Product (AGE) and Receptor Advanced Glycation End-Product (RAGE) activity, then develop kidney damage and other diabetes compli-cations. The study aimed to investigate the effect of black soybean, purple sweet potato, or their combination on the expression of AGE, RAGE, and kidney necro-sis T2DM model rats. The rats were given with high-calorie diet for five weeks and then injected with a low dose of streptozotocin (30 m/kg Body Weight) in intraperitoneal. DM rats were divided into: normal, K- (T2DM), K+ (T2DM + glibenclamide 0.6 mg/kg body weight), P1 (T2DM + black soybean), P2 (T2DM + purple sweet potato), and P3-5 Combination 1-3 (T2DM + combination of black soybean and purple sweet potato in ratio of 1 : 3, 2 : 2, and 3 : 1). DM rats were then given the treatments for thirty days. The effect of black soybean, purple sweet potato, or the combination of both was evaluated through the expression of AGE, RAGE, and necrosis of renal tubules. The changes in renal tubules histological characteristics were evaluated using hematoxylin-eosin (HE) staining. Immuno-histochemistry analysis of renal tubules was to evaluate AGE-RAGE expression after the treatments. The research results indicated that there was a significant dif-ference from the combination of black soybean and purple sweet potato in reduc-ing AGE, RAGE, and renal tubules necrosis. The BSB and PSP combination ratio of 1:1 was able to improve renal tubules, decrease the expression of AGE and RAGE towards near normal. The combination of black soybean and purple sweet potato could be used as one of the alternatives to improve kidney damage in dia-betic nephropathy.
The Role of Black Soybean and Purple Sweet Potato Active Compound on Advanced Glycation End-Product in Streptozotocin-Induced Type 2 Diabetes Mellitus Rat Abdul Gofur; Siti Nur Arifah; Yuslinda Annisa; Agung Witjoro; Mochammad Fitri Atho'illah; Sri Rahayu Lestari
Journal of Tropical Life Science Vol. 9 No. 2 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.09.02.02

Abstract

Diabetic nephropathy is one of the diabetes complications attacking kidney leading to kidney damage. Hyperglycemia accompanying DM causes the increase of Ad-vanced Glycation End-Product (AGE) and Receptor Advanced Glycation End-Product (RAGE) activity, then develop kidney damage and other diabetes compli-cations. The study aimed to investigate the effect of black soybean, purple sweet potato, or their combination on the expression of AGE, RAGE, and kidney necro-sis T2DM model rats. The rats were given with high-calorie diet for five weeks and then injected with a low dose of streptozotocin (30 m/kg Body Weight) in intraperitoneal. DM rats were divided into: normal, K- (T2DM), K+ (T2DM + glibenclamide 0.6 mg/kg body weight), P1 (T2DM + black soybean), P2 (T2DM + purple sweet potato), and P3-5 Combination 1-3 (T2DM + combination of black soybean and purple sweet potato in ratio of 1 : 3, 2 : 2, and 3 : 1). DM rats were then given the treatments for thirty days. The effect of black soybean, purple sweet potato, or the combination of both was evaluated through the expression of AGE, RAGE, and necrosis of renal tubules. The changes in renal tubules histological characteristics were evaluated using hematoxylin-eosin (HE) staining. Immuno-histochemistry analysis of renal tubules was to evaluate AGE-RAGE expression after the treatments. The research results indicated that there was a significant dif-ference from the combination of black soybean and purple sweet potato in reduc-ing AGE, RAGE, and renal tubules necrosis. The BSB and PSP combination ratio of 1:1 was able to improve renal tubules, decrease the expression of AGE and RAGE towards near normal. The combination of black soybean and purple sweet potato could be used as one of the alternatives to improve kidney damage in dia-betic nephropathy.
Potential of Single Garlic to Prevent Pro Inflammatory Macrophage and Inflammation in HFD Mice Putri Diyah Anggraini; Miftahul Mufinadiroh; Hendra Susanto; Betty Lukiati; Sri Rahayu Lestari
Journal of Tropical Life Science Vol. 12 No. 1 (2022)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.12.01.10

Abstract

A high-fat-enriched diet causes an increase in the level of oxidized LDL (Ox-LDL) in the blood. The presence of Ox-LDL will activate macrophages to secrete pro-inflammatory cytokines and lead to severe inflammation. Single bulb garlic has a potential anti-inflammatory effect due to of high-fat diet. This research aimed to investigate the effect of single bulb garlic extract (SBGE) on the pro-inflammatory cytokines TNF-α (CD11b+TNF-α+) and IL-1b (CD11b+IL-1b+) in the spleen, spleen weight, and TNF-α secretion in HFD mice. Twenty-four mice were divided into six groups: normal (healthy mice); HFD (HFD mice without any treatment); HFD + Simvastatin (HFD mice receiving simvastatin); HFD + SBGE 100; HFD + SBGE 200; and HFD + SBGE 400 (HFD mice receiving 100, 200, and 400 mg/kg BW of SBGE for 4 weeks). Blood serum was collected at the end of treatment, and macrophage was isolated from the spleen. The relative number of CD11b+TNF-α+ and CD11b+IL-1b+ were examined using flow cytometry. SBGE treatment significantly (p<0.05) reduced the spleen weight and the relative number of CD11b+TNF-α+ and CD11b+IL-1b+ in the spleen of HFD mice. SBGE treatment also prevents the elevation of TNF- α levels in the blood serum. The optimal dose of SBGE to diminish the relative number of CD11b+TNF-α+, CD11b+IL-1b+ in the spleen, and TNF-α in the serum was 100 mg/kg BW.
Co-Authors A. Irma Suryani Abdul Ghofur Abdul Ghofur Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Ade Wahyu Pratama Agnesa, Oki Sandra Agung Witjoro Agus Dharmawan Agus Muliadi Agustina Gubali Agustini, Ferina Ahmad Rudijanto Aisyah, Dahniar Nur Ajeng Daniarsih Ajeng Radhita Putri Azella Al Azhar A Alif Rofiqotun Nurul Alimah Alif Rosyidah El Baroroh Alwan Mahsul Amalia Nur Rahma Amy Tenzer Andi Esse Jumriani Andi Nurlinda Andi Rahmat Saleh Anggraini, Atika Anggraini, Lilik Anisah Mahmudah Anisya Purnamasari Annisa, Yuslinda Arindra Nirbaya Atho'illah, Mochammad Fitri Athoillah, M. Fitri Atik Kurniawati Atik Kurniawati, Atik Atika - Anggraini Atika Anggraini Atika Anggraini Aulia, Azra Azmi, Shafly Badriyatur Rahma Fidiya Bagus Priambodo Baroroh, Alif Rosyidah El Betty Lukiati Chasanah, Isfatun Chasanah, Isfatun Dahniar Nur Aisyah Daradjatul Aulia Deny Setiawan Dev Anand, Dev Dewi Murni Dewi Murni Dewi Sekar Miasih Dewi Sekar Miasih Dewi, Putri Elok Septiana Dianatur Raviqah Dimas Nur Ramadhani Dina Maulina Dina Maulina Dini Wijayanti Dio Rizki Nadar Putra Dita Purwinda Anggrella Djoa, Dominikus Djago Dyah Ayu Eka Fitriana Eka Pratama Putri Eka Pratama Putri Eko Sri Sulasmi El Baroroh, Alif Rosyidah Endang Suarsini Eri Wiharni Eva Kristinawati Putri Farid, Ulfa Maulida fatchiyah . Fatchiyah Fatchiyah Fatchur Rohman Fatchur Rohman Fatmah Afrianty Gobel Febriani, Candra Putri Fikri, Ahmadani Darul Fine Reffiane Finga Fitri Amanda Finga Fitri Amanda* Firdaus, Laras Firnindia Putri Frida Kunti Setiowati Ghaziah Kusumawati Chusjairi Hadi Suwono Halisma Amili Helsa Rahmatika Hendra Susanto Herawati Susilo Herdini , Herdini Hisyam Baidlowi Hunaepi Hunaepi Ibrohim Ida Wulandari Ika Nurani Dewi Ikhtira, Dilla Anisa Ilda Sartifa Sari Ilmawati, Riza Rahayu Indriani, Wiwik Indriati, Ganis Istaufa, Inna Milki Amnun Ita Nur Eka Pujiastuti Izzalqurny, Tomy Rizky Jekti Prihatin Jevi Milda Rahmawati Jimatul Arrobi Joko Waluyo Joko Waluyo Kartikasari, Nur'aini Laras Firdaus Laras Firdaus Laras Firdaus Laras Firdaus Laras Firdaus Lelitawati, Mardiana Lianto Lianto Lutfiyanti Fanani M. Fitri Athoillah Mahmudah, Anisah Mahmudah, Anisah Maria Angelina Genere Koban Markus Diantoro Masiah Masiah Masiah Masiah Masiah Masiah Masiah, Masiah Mellinda Setiani Nusa Diennata Miasih, Dewi Sekar Miftahul Mufinadiroh Mimien Henie Irawati Moch Sasmito Djati Mochammad Fitri Atho'illah Mochammad Yordan Adi Pratama Moh. Hafidhuddin Karim Mohamad Amin Mohamad Amin Mohammad Amin Mohammed, Najib Muchtar Muchtar Mufidah, Ikfi Nihayatul Muhammad Amin Muhammad Andry Prio Utomo Muhammad Athoillah Muhammad Aziz Murni Sapta Sari Mustika Ayu Wulansari Nasikh Nenes Prastita Nesya Adiva Nurhasanah Nik Malek, Nik Ahmad Nizam Ningrum, Sansan Hastuti Novita Kartika Indah Nuning Wulandari Nur Fitriana Nur Fitriana Nursasi Handayani Oki Sandra Agnesa Paidi Paidi Prastita, Nenes Pujiyanto, Eko Putri Diyah Anggraini Putri Elok Septiana Dewi Qadariah, Nosi Qomaria, Durrotul Rachmawati , Hidajah Rahayu, Andriana Rahma, Amalia Nur Rahmawati, Jevi Milda Rahmi Masita Resty Noflidaputri Ria Nelly Sari Rifqi, Nadiya Dini Rinu Bhakti Dewantara Rissa Rizky Rahmawati, Maria Rizky Nurdiansyah Rochmatul Ummah Rohayati, Yulista Trias Rohman , Fatchur Rony Irawanto Roza Linda Rudianto, Rony SATRIYAS ILYAS Siti Imroatul Maslikah Siti Imrotul Maslikah Siti Nur Arifah Siti Nur Arifah Siti Nur Arifah Siti Nur Arifah, Siti Nur Siti Nurjanah Siti Rahma Lestaluhu Siti Zubaidah Siti Zubaidah Sitoresmi Prabaningtyas Sitti Saenab Sitti Saenab Sitti Saenab, Sitti Soeyati Poejiani Soeyati Poejiani Sri Endah Indriwati Sri Nopita Primawati Suharti Sunaryono Sunaryono Sunaryono, Sunaryono Supiani, Endang Susriati Mahanal Susriyati Mahanal Sutiman B Sumitro Sutiman B. Sumitro Sutiman Bambang Sumitro Syahru Ramadan, Syahru Umie Lestari Utami Sri Hastuti Vivi Novianti W. Wisanti Wahyuni, Dilla Santhia Wisanti Wisanti Wisanti Wisanti Wulandari, Ida Yesi Hasneli N Yeti S. Hasan Yunita Rakhmawati Yuslinda Anisa Yuslinda Annisa Yuslinda Annisa Yuslinda Annisa Zaenul Mujahidin Zahra Anggita Pratiwi Zulkifli, Muhammad Mauludi