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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina journal of internal medicine Sport and Fitness Journal Buletin Udayana Mengabdi Jurnal Farmasi Udayana E-Jurnal Medika Udayana Jurnal Veteriner Majalah Ilmiah Fisioterapi Indonesia Majalah Obat Tradisional MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Vocational Health Studies Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Epidemiologi Kesehatan Komunitas Indonesian Journal for Health Sciences (IJHS) ISM (Intisari Sains Medis) : Jurnal Kedokteran Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of Clinical and Cultural Psychiatry Jurnal Health Sains Jurnal Kepelatihan Olahraga Open Access Indonesian Journal of Medical Reviews Jurnal Pengabdian kepada Masyarakat Wahana Usada Warmadewa Minesterium Medical Journal Medika Respati : Jurnal Ilmiah Kesehatan Journal of Global Pharma Technology Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Jurnal Penyakit Dalam Indonesia Paradharma: Jurnal Aplikasi IPTEK Gema Kesehatan Physical Therapy Journal of Indonesia Kinesiology and Physiotherapy Comprehensive Biosaintifika: Journal of Biology & Biology Education Indonesian Journal of Pharmacology and Therapy
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Journal : Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer)

Exercise and Chronic Diseases: A Scoping Review Imron, Moh. Ali; Adiatmika, I Putu Gede; Jawi, I Made
Review of Primary Care Practice and Education Vol 8, No 1 (2025): January
Publisher : Faculty of Medicine, Public Health, and Nursing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/rpcpe.103256

Abstract

Background: Regular exercise has been postulated as beneficial to prevent, treat, and manage a chronic disease that nowadays is caused by a sedentary life. However, its prescription and mechanism of how exercise positively affects health conditions is requiring further research. Objective: To investigate the types of regular exercise and exercise prescription and mechanisms in preventing or treating a chronic disease. Methods: This study reviewed articles from ProQuest, Science Direct, Wiley, and PubMed using the terms 'chronic disease', 'exercise', 'physical activity', and 'cytokine'. Results: Forty-six articles were reviewed in this study which originated from different regions spanning Asia, Europe, America, and Africa. The articles were categorized based on sample characteristics, which were; elderly, healthy adults, athletes, mice, and others. Each article describes an aerobic or anaerobic exercise performed under various interventions ranging from low, moderate, to high and comprehensively explains its effect on human biology, including on the body system, tissue adaptation, muscle hypertrophy, and neuroplasticity, by examining its effect on proteins, hormones, enzymes, microRNAs, as well as functional metrics pertaining to physical capacity enhancement. Conclusion: This review concludes that exercise will elicit effects on the immune and metabolic systems of people with chronic disease.
The Role of Antioxidant Therapy in the Management of Type 2 Diabetes Mellitus: A Literature Review Astini, Dewa Ayu Agung Alit Suka; Yasa, I Wayan Putu Sutirta; Jawi, I Made; Wande, I Nyoman
Review of Primary Care Practice and Education Vol 8, No 1 (2025): January
Publisher : Faculty of Medicine, Public Health, and Nursing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/rpcpe.104276

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disease and has become a global problem due to the rapid increase in the number of cases. This disease is characterized by chronic hyperglycemia caused by insulin resistance and pancreatic beta cell dysfunction. The occurrence of oxidative stress is known to play a central role in the development of T2DM complications, through increased reactive oxygen species (ROS) that worsen insulin resistance, worsen beta cell function, and trigger complications such as cardiovascular complications, nephropathy, and neuropathy. Objectives: This literature review aims to evaluate the scientific evidence supporting the use of antioxidant therapy as an additional approach in the management of T2DM, focusing on the effectiveness and mechanism of action of antioxidant compounds on glycemic parameters, oxidative stress, and diabetes complications. Methods: A literature search was conducted through databases on ScienceDirect, PubMed, and Google Scholar, with the keywords "antioxidant therapy", "type 2 diabetes mellitus", "oxidative stress", and "diabetes management". The selected articles included in vitro, in vivo studies, and clinical trials published in the period 2013-2023. Literature review focused on the biochemical mechanisms of antioxidant compounds and clinical outcomes related to glycemic parameters and diabetes complications. The literature extraction process was carried out from January to March 2024. Results: Supplementation of vitamin D, vitamin E, vitamin C, polyphenols, saponins, and flavonoids has been proven to reduce blood glucose levels and increase insulin sensitivity in type 2 diabetes mellitus. The mechanism involves increasing antioxidant activity, regulating glucose homeostasis, as well as modulating signaling pathways such as AMPK, PPAR, and GLUT4. Conclusions: This bioactive compound has potential as an adjunct therapy in the management of type 2 diabetes mellitus by targeting oxidative stress and insulin resistance. Further research is needed to determine optimal dosage and long-term effectiveness.
Co-Authors A.N. Mahendra A.W. Indrayani Adi Saputra Agung Bagus S. Satyarsa Agung Nova Mahendra Agung Wahyu Permadi Agung Wiwiek Indrayan Agung Wiwiek Indrayani Aman, I Gusti Made Aman, IGM Amaral, Meriana Barreto Anak Agung Gede Angga Puspa Negara Anak Agung Ngurah Subawa Anom Suardika Ardo Sabir, Ardo Arisandy Achmad Aryana, I Gust Putu Suka Astawastini, I Dewa Ayu Mas Manik Astika, I Nyoman Astini, Dewa Ayu Agung Alit Suka Bagus Komang Satriyasa Budayasa, Anak Agung Gede Raka Cokorda Agung Wahyu Purnamasidhi Cokorda Bagus Jaya Lesmana Dany Hilmanto Desak Ketut Ernawati Desak Made Puja Astuti Desak Made Widyanthari Desak Made Wihandani Desak Putu Citra Udiyani Dewa Ayu Putu Sri Ista Dewanti Dewa Ngurah Suprapta Dewa Ngurah Suprapta Dewi, L. P. M. K. Dewi, Ni Wayan Eka Rahayu Dewi, Ni Wayan Eka Rahayu Dewi, Ni Wayan Sucindra Diaz, Leonardo Alpha Dimas Agusta Divasta, I G Mahapraja Dixon E.M. Taek Bete Dyah Kanya Wati Eka Putra Setiawan Elvina Veronica Endang Sri Widiyanti Eva Dharma Yanti Febrianda, Larasati Hanifa Gaga Irawan Nugraha Gede Agung Dhimasena Widyananda Gita Almira Putri Gitari, Ni Made Grudug, Kadek Agastya Widya Sedana Guna, I. M. A. W. Gusti Made Agung Mega Utama Hairudin - Hamsu Kadriyan Hervina Hervina I Dewa Ayu Inten Dwi Primayanti I Dewa Made Sukrama I Dewa Sutjana I Gede Widhiantara I Gusti Ayu Artini I GUSTI AYU MANIK ERMAYANTI I Gusti Bagus Wirawan I Gusti Kamasan Arijana I Gusti Made Gde Surya Chandra Trapika I Kadek Arya Gangga Permana I Ketut Suastika I Made Ady Wirawan I Made Agus Gelgel Wirasuta I Made Bakta I Made Dhita Prianthara I Made Dwi Ariyuda I Made Gde Sudyadnyana Sandhika I Made Krisna Dinata I MADE MULIARTA . I Made Sudarmaja I Nengah Sandi I Nyoman Adi Putra I Nyoman Adiputra I Nyoman Budi Hartawan I Nyoman Mangku Karmaya I NYOMAN MANTIK ASTAWA I Nyoman Wande I Pande Putu Deny Heriwijaya I Putu Adiartha Griadhi I Putu Astrawan . I Putu Eka Jaya I Putu Eka Widyadharma I Putu Gede Adiatmika I Putu Gede Andyka Yasa I Putu Gede Putra Darmawan I W. Sudarsa I Wayan Gede Artawan Eka Putra I Wayan Lolik Lesmana I Wayan Niryana I Wayan Putu Sutirta Yasa I Wayan Rosiana I Wayan Sugiritama I Wayan Suka Yasa I Wayan Sumardika I Wayan Weta I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika Ida Bagus Gede Suparyatha Ida Bagus Ngurah Ida Bagus Ngurah Ida Bagus Putra Manuaba Ida Bagus Putu Putrawan Ida Bagus Subanada Ida Sri Iswari Imakulata Magi Loda Imron, Moh. Ali Indra Lesmana J. A. Pangkahila Kamayoga, I Dewa Alit Ketut Agus Adrianta Ketut Budiasa Ketut Tirtayasa Kusuma, Anak Agung Ngurah Jaya La Ode Muhammad Gustrin Syah Lesmana, Cokorda Agung Bagus Jaya Losen Adnyan Luh Putu Ratna S Luh Putu Ratna Sundari Luh Putu Widiastini M. Irfan Made Agus Hendrayana Made Wiryana Maharianingsih, Ni Made Manuaba, I.A Ratih Wulansari Manuaba, Ida Bagus Tjakra Wibawa Mardaningrat, Kadek Herdana Vildan Muh. Irfan Muhammad Irfan Muhammad Irfan Muthia Munawaroh Muthiah Munawaroh N Adiputra N. Adiputra N. Adiputra N.W. Tianing N.W.S. Dewi Nabasa, Gayus Erino Naw, Sin War Ni Eka Dewi Ambarawati Ni Eka Dewi Ambarawati Ni Ketut Susilawati Ni Luh Suriani Ni Made Ari Purwaningrum Ni Made Linawati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Shinta Prasista Sari Ni Putu Sriwidyani Ni Putu Wirantari Ni Wayan Mutiara Warmasari Ni Wayan Saka Rahayu Ni Wayan Sinta Devi Arini Ni Wayan Sucindra Dewi Ode Mahesa Putra Oktovianus Fufu Pande Putu Karina Candra Pangala, Gustinara Bakti Permatasari, Anak Agung Ayu Putri Pramana, I Putu Yudi Pratiwi, Cokorda Agung Pratiwi, Kadek Prastiti Surya Prima S. Sudarsa Pujawan, I Made Naris Purnamawati, Susy Purnami, Ni Ketut Rai Puspitasari, Ni Putu Ayu Intan Putri, Kadek Wina Santhya Putu Angga Wiradana Putu Astawa Putu Ayu Sita Saraswati Putu Belly Sutrisna R. A.T. Kuswardhani Raka-Sudewi A. A. Regina Sesilia Noy Rita Maria Romdhoni, Achmad Chusnu Sang Ayu Arta Suyantari Sanjaya, Feliani Santosa, I Gusti Ngurah Putra Eka Sari, P. M. N. A. Sawitri, Anak Agung Sagung Silvana, Divika Sri Maliawan Sugijanto - Sugosha, M. J. Sukawati, C. B. A. C Sumawirawan, K. D. Sun, H. Sunny Suryawisesa, Ida Bagus Made Susy Purnawati Sutema, I.A Manik Partha Syahmirza Indra Lesmana Tang, Yen-An Thomas Eko Purwata Tirtha Yasa, I Nyoman Wawan Wahyuddin Wahyuddin Wahyuddin, Wahyuddin Wahyuni Novianti, I Gusti Ayu Sri Wayan Suardana Wibawa, I Gusti Ngurah Agung Satria Widhiantari, Ni Ketut Evitri Widia Danis Swari Widiarthini, Ida Ayu Alit Widiyanti, I Gusti Ayu Widnyana, M. Widowati, I Gusti Ayu Rai - Wiwekowati Wuga, Kristina Supartin Monika Yasa, I Nyoman Wawan Tirtha Yenny Kandarini Yogie Wiswadewa Yohanes Seran