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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina journal of internal medicine Sport and Fitness Journal Buletin Udayana Mengabdi Jurnal Farmasi Udayana E-Jurnal Medika Udayana Jurnal Veteriner Majalah Ilmiah Fisioterapi Indonesia Majalah Obat Tradisional MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Vocational Health Studies Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Epidemiologi Kesehatan Komunitas Indonesian Journal for Health Sciences (IJHS) ISM (Intisari Sains Medis) : Jurnal Kedokteran Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of Clinical and Cultural Psychiatry Jurnal Health Sains Jurnal Kepelatihan Olahraga Open Access Indonesian Journal of Medical Reviews Jurnal Pengabdian kepada Masyarakat Wahana Usada Warmadewa Minesterium Medical Journal Medika Respati : Jurnal Ilmiah Kesehatan Journal of Global Pharma Technology Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Jurnal Penyakit Dalam Indonesia Paradharma: Jurnal Aplikasi IPTEK Gema Kesehatan Physical Therapy Journal of Indonesia Kinesiology and Physiotherapy Comprehensive Biosaintifika: Journal of Biology & Biology Education Indonesian Journal of Pharmacology and Therapy
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Journal : BALI MEDICAL JOURNAL (BMJ)

BLOOD ANTHOCYANIN LEVELS OF HEALTHY AND DIABETIC RATS AFTER FEED WITH A SINGLE DOSE OF PURPLE SWEET POTATO TUBERS AQUEOUS EXTRACT Sutirta-Yasa, I W. P.; Jawi, and I M.
BALI MEDICAL JOURNAL Vol 3 No 1 (2014)
Publisher : BALI MEDICAL JOURNAL

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Background: Aqueous extract of purple sweet potato tuber shown to decrease the blood glucose levels and has antioxidant properties in rats with streptozotocin-induced diabetes. The purpose of this study is to prove that an increase in anthocyanin levels in the blood of rats after administration of aqueous extract of purple sweet potato tubers in healthy and diabetic rats. Methods: This is an experimental study with randomized post-test only control group design. The subject of experiments were 72 rats, divided into two major groups, namely  diabetic rats (treatment group 36 rats) and control group (36 healthy rats). Each major group was divided into 6 small groups each 6 rats. The control group was given aqueous extract of purple sweet potato tuber with a dose of 4 ml single dose. The diabetic group were given streptozotocin and followed by aqueous extract of purple sweet potato tuber 4 ml single dose.  Observed variables include: blood glucose levels to define diabetes. To determine the levels of anthocyanin, the blood were taken and the level of anthocyanin were examination by HPLC method, in healthy  and diabetic rats after 30 min, 1 hours, 2 hours, 4 hours, 8 hours and 16 hours of giving single dose of aqueous extract of purple sweet potato tubers. Results: The results showed an increase in blood sugar levels were significant (p < 0.05) in group given streptozotocin compared to control. Anthocyanin levels in the blood of two groups were significantly different from 30 min after administration of the extract to 8 hours after administration of the extract (p < 0.05). Higher anthocyanin levels (p < 0.05) was observed in control group (healthy rats) compared to rats with streptozotocin-induced diabetes. Peak levels of anthocyanin in blood were achieved after 2 hours of feeding. Conclusion: The conclusion of this study is the absorption of anthocyanin in aqueous extract of purple sweet potato tuber better in healthy rats compared to diabetic rats. The peak levels of anthocyanin was reached after 2 hours of aqueous extract of purple sweet potato tubers single dose consumption either in healthy rats and in diabetic rats.
AQUEOUS EXTRACT OF BALINESE PURPLE SWEET POTATO (IPOMOEA BATATAS L.) PREVENTS OXIDATIVE STRESS AND DECREASES BLOOD INTERLEUKIN-1 IN HYPERCHOLESTEROLEMIC RABBITS Jawi, I M.; Indrayani, A. Wiwiek; Sutirta-Yasa, I W. P.
BALI MEDICAL JOURNAL Vol 4 No 1 (2015)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Hypercholesterolemia can cause oxidative stress, endothelial dysfunction and atherosclerosis. Anthocyanin can prevent oxidative stress, it will decrease the inflammation by decreasing the pro inflammatory cytokine in animal models. Purple sweet potato in Bali has been proven of having high anthocyanins content. The aim of these study was to prove the ability of aqueous extract of Balinese purple sweet potato (Ipomoea batatas L.) in decreasing the blood interleukin-1 level in hypercholesterolemic rabbits. Methods: Subjects of this study were 18 male adult rabbits divided into 3 groups with randomized post test only control group design. Group 1 rabbits were given standard diet as a control group. Group 2 rabbits were given high cholesterol diet. Group 3 rabbits were given aqueous extract of Balinese purple sweet potato 4 ml/Kg.BW/day and high cholesterol diet. After 60 days of treatment, the blood level of total cholesterol, MDA and interleukin- 1 were measured as post test examination. The data were analysed by using anova. Results: The results showed significant increases of blood total cholesterol, MDA, and interleukin-1 in group 2 (p
Antihypertensive and Antioxidant Potential of Purple Sweet Potato Tuber Dry Extract in Hypertensive Rats Jawi, I Made; Sutirta-Yasa, I. W. P.; Mahendra, Agung Nova
BALI MEDICAL JOURNAL Vol 5 No 2 (2016)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Purple sweet potato tuber extract in liquid form, shown to lower blood pressure of hypertensive rats and hypertensive patients. Liquid dosage form, increasingly unstable when stored for long periods, thus it is necessary to find a more stable dosage form. The objective of this research was to prove that dry extract of purple sweet potato tuber has the same effects with liquid extract in hypertensive rats. Method: The is a randomized pre-test and post-test control group design study. Thirty hypertensive model rats were divided into 5 groups (6 animals for each group). Group 1 was treated as a control group. Group 2 to group 5 were treated as treatment groups. Treatment groups were given liquid extract at a dose of 3 ml, dry extract with the dose of 200 mg, dry extract that stored in a certain time with a dose of 200 mg and given a mixture of dry extract with a carrier substance (capsule formula) with a dose of 200 mg, respectively, for 4 weeks. Variables observed were blood pressure, SOD and MDA level of the blood. Results: The results showed that the group given the purple sweet potato tuber extract lowers blood pressure were significantly in liquid extract or dry extract (p <0.01). The group that was treated with capsule formula showed more decrease in blood pressure than dry extract group (p <0.01). The similar results happened on MDA and SOD level in blood. Conclusions: Thus, it can be concluded that dried extract of purple sweet potato tubers has the same effectiveness with liquid extract, both as an antihypertensive and also antioxidant. Capsules formula is more effective than liquid extract and dry extract.
Co-Authors A.N. Mahendra A.W. Indrayani Adi Saputra Agung Bagus S. Satyarsa Agung Nova Mahendra Agung Wahyu Permadi Agung Wiwiek Indrayan Agung Wiwiek Indrayani Aman, I Gusti Made Aman, IGM Amaral, Meriana Barreto Anak Agung Gede Angga Puspa Negara Anak Agung Ngurah Subawa Anom Suardika Ardo Sabir, Ardo Arisandy Achmad Aryana, I Gust Putu Suka Astawastini, I Dewa Ayu Mas Manik Astika, I Nyoman Astini, Dewa Ayu Agung Alit Suka Bagus Komang Satriyasa Budayasa, Anak Agung Gede Raka Cokorda Agung Wahyu Purnamasidhi Cokorda Bagus Jaya Lesmana Dany Hilmanto Desak Ketut Ernawati Desak Made Puja Astuti Desak Made Widyanthari Desak Made Wihandani Desak Putu Citra Udiyani Dewa Ayu Putu Sri Ista Dewanti Dewa Ngurah Suprapta Dewa Ngurah Suprapta Dewi, L. P. M. K. Dewi, Ni Wayan Eka Rahayu Dewi, Ni Wayan Eka Rahayu Dewi, Ni Wayan Sucindra Diaz, Leonardo Alpha Dimas Agusta Divasta, I G Mahapraja Dixon E.M. Taek Bete Dyah Kanya Wati Eka Putra Setiawan Elvina Veronica Endang Sri Widiyanti Eva Dharma Yanti Febrianda, Larasati Hanifa Gaga Irawan Nugraha Gede Agung Dhimasena Widyananda Gita Almira Putri Gitari, Ni Made Grudug, Kadek Agastya Widya Sedana Guna, I. M. A. W. Gusti Made Agung Mega Utama Hairudin - Hamsu Kadriyan Hervina Hervina I Dewa Ayu Inten Dwi Primayanti I Dewa Made Sukrama I Dewa Sutjana I Gede Widhiantara I Gusti Ayu Artini I GUSTI AYU MANIK ERMAYANTI I Gusti Bagus Wirawan I Gusti Kamasan Arijana I Gusti Made Gde Surya Chandra Trapika I Kadek Arya Gangga Permana I Ketut Suastika I Made Ady Wirawan I Made Agus Gelgel Wirasuta I Made Bakta I Made Dhita Prianthara I Made Dwi Ariyuda I Made Gde Sudyadnyana Sandhika I Made Krisna Dinata I MADE MULIARTA . I Made Sudarmaja I Nengah Sandi I Nyoman Adi Putra I Nyoman Adiputra I Nyoman Budi Hartawan I Nyoman Mangku Karmaya I NYOMAN MANTIK ASTAWA I Nyoman Wande I Pande Putu Deny Heriwijaya I Putu Adiartha Griadhi I Putu Astrawan . I Putu Eka Jaya I Putu Eka Widyadharma I Putu Gede Adiatmika I Putu Gede Andyka Yasa I Putu Gede Putra Darmawan I W. Sudarsa I Wayan Gede Artawan Eka Putra I Wayan Lolik Lesmana I Wayan Niryana I Wayan Putu Sutirta Yasa I Wayan Rosiana I Wayan Sugiritama I Wayan Suka Yasa I Wayan Sumardika I Wayan Weta I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika Ida Bagus Gede Suparyatha Ida Bagus Ngurah Ida Bagus Ngurah Ida Bagus Putra Manuaba Ida Bagus Putu Putrawan Ida Bagus Subanada Ida Sri Iswari Imakulata Magi Loda Imron, Moh. Ali Indra Lesmana J. A. Pangkahila Kamayoga, I Dewa Alit Ketut Agus Adrianta Ketut Budiasa Ketut Tirtayasa Kusuma, Anak Agung Ngurah Jaya La Ode Muhammad Gustrin Syah Lesmana, Cokorda Agung Bagus Jaya Losen Adnyan Luh Putu Ratna S Luh Putu Ratna Sundari Luh Putu Widiastini M. Irfan Made Agus Hendrayana Made Wiryana Maharianingsih, Ni Made Manuaba, I.A Ratih Wulansari Manuaba, Ida Bagus Tjakra Wibawa Mardaningrat, Kadek Herdana Vildan Muh. Irfan Muhammad Irfan Muhammad Irfan Muthia Munawaroh Muthiah Munawaroh N Adiputra N. Adiputra N. Adiputra N.W. Tianing N.W.S. Dewi Nabasa, Gayus Erino Naw, Sin War Ni Eka Dewi Ambarawati Ni Eka Dewi Ambarawati Ni Ketut Susilawati Ni Luh Suriani Ni Made Ari Purwaningrum Ni Made Linawati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Shinta Prasista Sari Ni Putu Sriwidyani Ni Putu Wirantari Ni Wayan Mutiara Warmasari Ni Wayan Saka Rahayu Ni Wayan Sinta Devi Arini Ni Wayan Sucindra Dewi Ode Mahesa Putra Oktovianus Fufu Pande Putu Karina Candra Pangala, Gustinara Bakti Permatasari, Anak Agung Ayu Putri Pramana, I Putu Yudi Pratiwi, Cokorda Agung Pratiwi, Kadek Prastiti Surya Prima S. Sudarsa Pujawan, I Made Naris Purnamawati, Susy Purnami, Ni Ketut Rai Puspitasari, Ni Putu Ayu Intan Putri, Kadek Wina Santhya Putu Angga Wiradana Putu Astawa Putu Ayu Sita Saraswati Putu Belly Sutrisna R. A.T. Kuswardhani Raka-Sudewi A. A. Regina Sesilia Noy Rita Maria Romdhoni, Achmad Chusnu Sang Ayu Arta Suyantari Sanjaya, Feliani Santosa, I Gusti Ngurah Putra Eka Sari, P. M. N. A. Sawitri, Anak Agung Sagung Silvana, Divika Sri Maliawan Sugijanto - Sugosha, M. J. Sukawati, C. B. A. C Sumawirawan, K. D. Sun, H. Sunny Suryawisesa, Ida Bagus Made Susy Purnawati Sutema, I.A Manik Partha Syahmirza Indra Lesmana Tang, Yen-An Thomas Eko Purwata Tirtha Yasa, I Nyoman Wawan Wahyuddin Wahyuddin Wahyuddin, Wahyuddin Wahyuni Novianti, I Gusti Ayu Sri Wayan Suardana Wibawa, I Gusti Ngurah Agung Satria Widhiantari, Ni Ketut Evitri Widia Danis Swari Widiarthini, Ida Ayu Alit Widiyanti, I Gusti Ayu Widnyana, M. Widowati, I Gusti Ayu Rai - Wiwekowati Wuga, Kristina Supartin Monika Yasa, I Nyoman Wawan Tirtha Yenny Kandarini Yogie Wiswadewa Yohanes Seran