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REGULASI CATECHINS GREEN TEA GMB-4 DALAM MENGHAMBAT OKSIDASI NADPH DAN PENIGKATAN EKSPRESI NITRIC OXIDE (NO) PADA KULTUR HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC) YANG MENGALAMI STRES OKSIDATIF Peristiowati, Yuly; -, Indasah
Eduhealth Vol 3, No 1 (2013): Jurnal Eduhealth
Publisher : Eduhealth

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Abstract

ABSTRAKPenanganan kondisi disfungsi endotel sebelum terjadi kerusakan lebih lanjut sangatlah penting, karena berakibat terjadinya resistensi insulin dan hiperglikemia. Diharapkan dengan pemberian Catechins Green tea GMB-4 dapat memperbaiki kerusakan endotel melalui penghambatan oksidasi NADPH dan peningkatan produksi NO sehingga dapat mencegah terjadinya komplikasi lanjut pada pasien dengan diabetes Millitus. Desain penelitian ini true eksperimen dengan pendekatan post test only control group design. Subyek penelitian ini adalah kultur sel endotel yang berasal dari Human Umbilical Vein Endothelial Cell (HUVEC) yang dipapar glukosa 30 mM dan diberi perlakuan dengan Catechins Green tea GMB-4 dengan 3 dosis yaitu 0,03 mg/ml;0,3 mg/ml dan 3 ng/ml. Setelah pemberian selama 12 jam selanjutnya dilakukan analisa kadar NADPH dan Nitric Oxide (NO) dengan metode Colorimeter menggunakan NADPH Assay kit ab65349 dan Nitric Oxide Assay kit KGE001.Hasil penelitian menunjukan ada penurunan kadar NADPH pada kultur HUVEC setelah perlakuan Catechins Green tea GMB-4 pada dosis 0,3 mg/ml, dan terjadi peningkatan kadar Nitric oxide pada perlakuan dosis 0,03 mg/ml dan dosis 0,3 mg/ml. Hasil uji statistic one way Anova didapatkan nilai signifikan 0,000 untuk kadar NO dan NADPH. Sehingga dapat di simpulkan pemberian Catechins Green tea GMB-4 pada dosis 0,3 mg/ml dapat menurunkan oksidasi NADPH dan meningkatkan produksi NO secara signifikan. Pemberian Catechins Green tea GMB-4 dapat mengaktivasi eNOS dan berperan dalam penghambatan oksidasi NADPH melalui pospotidylinositol-3 kinase, cAMP dependent protein kinase dan jalur Akt. Catechins juga mengkatalisis produksi NO dari L-arginin dan menghambat ROS dengan jalan mengikat ion metal pada reaksi redok, menghambat transkripsi faktor, menghambat enzim prooksidan dan meningkatkan enzim antioksidan.Kata kunci: antioksidan, Catechins Green tea GMB-4, NO, NADPH ABSTRACTHandling conditions of endothelial dysfunction before further damage is very important, because it results in insulin resistance and hyperglycemia. Expected by administration of Green Tea Catechins GMB-4 can improve endothelial damage through inhibition of NADPH oxidation and NO production increased so as to prevent the occurrence of further complications in patients with diabetes millitus. True experimental design of this study to approach post-test only control group design. The subjects of this study were cultured endothelial cells derived from Human Umbilical Vein Endothelial Cell (HUVEC) were exposed to 30 mM glucose and treated with Green Tea Catechins GMB-4 with 3 doses are 0.03 mg / ml, 0.3 mg / ml and 3 ng / ml. Analized NADPH levels and Nitric Oxide (NO) with Colorimeter method using NADPH Assay kit ab65349 and Nitric Oxide Assay kit KGE001. The results showed decrease in NADPH levels in cultured HUVEC after treatment of Green Tea Catechins GMB-4 at a dose of 0.3 mg / ml, and an increase in levels of nitric oxide in the treatment dose of 0.03 mg / ml and 0.3 mg / ml . Results of one way ANOVA statistical test obtained significant value of 0.000 for the levels of NO and NADPH.. So it can be concluded giving Green tea Catechins GMB-4 at a dose of 0.3 mg / ml can reduce the oxidation of NADPH and increased NO production significantly. Provision of Green tea Catechins GMB-4 can activate eNOS and play a role in the inhibition of NADPH oxidation through pospotidylinositol-3 kinase, cAMP dependent protein kinase and Akt pathways. Catechins also catalyze the production of NO from L-arginine and inhibited ROS by binding the metal ions on the reaction redok, inhibits transcription factor, inhibits prooxidant enzymes and increases antioxidant enzymes.Keywords: antioksidant, Catechins Green tea GMB-4, NO, NADPH
Co-Authors Abd. Rasyid Syamsuri Achmad Wahdi Achmad Zakaria Adelina Pinto Ady Purwoto Afzal, Ridha Agit Pratama Putra Agung Purnomo Agung Purnomo Agus Salim Burhanuddin Agusta Dian Ellina Agustin Agustin Agustin Widyowari Ahmad Syauqi Mubarok Ahmadi Putri, Nabila Maharani Aini, Trianike Nor Alexius Andi Bur Ali Humardani Alin Ayuning Tyas Almas, Sri Warsuni Alya Tata Riani Amani, Tartilah Nur Amelindha Vania Ananda Wansika Dewi Andariningsih Andayani, Erisa Ariya Andre Bagaskara Angky Meilin Widi Sumijayanti Anis Ansyori Anna Lince Dasmasela Anniza Pramesti, Adhe Anto, Ambo Anugraheni Wintari Soerya Arantrinita Arantriwardani Arantriwardhani Arief Churniawan Arief Fardiansyah Artha Budi Susila Duarsa Asri Dewi Wahyuningtyas Asri Putri Kisfandari Asruria Sani Fajria Asyafa'a Rizqi Fadilla Atmojo, Joko Tri Aulia Rahman Ayu E., Mas Roro Dyah Bayu Prabowo Bekti, Yhen Ari Benny Yoga Satria Betharia Mardiyani Bhisma Murti Birroudhoh, Fiqhiyah Budi Minarno Bur, Alexius Andi Byba Melda Suhita Crystalia Dedy Mochtar Setiaji Demasa Maulana Seta Deny Sumantoro Dewi Kusumawati, Prima Dewi Retno Puspitosari Dian Jayantari Putri K Hedo Dita, Janny Dony Wahyu Baktisiswoyo Doris Novelyn Lalamentik Dwi Helynarti Syurandhari Dwiana, Winda Gusya Edi Kurnianto Efendy, Muhamad As'ad Eka Lutfiatus Solehah Elina, Agusta Dian Elliana, Agusta Dian Ellina , Agusta Dian Endah Pujiati Eni Natalia Teuf Etti Suryani Eva Agustin Fajriah, Asruria Sani Fajriah, Asuria Sani Fajriyah, Asruria Sani Farida Hidayati Feliciano De Araujo Fransiska Xaveria Hangriani Ghazali, Muh Al Gunawan Handayani, Rina Tri Hardiani, Novita Hari Prasetyo Umar Hariyono Hariyono Hariyono Heri Suroso, Heri Heri Susanto Herin Mawarti Herman Pratikto Herminofa, Irsyad Hidayat, Ichwan Hidayat, Poppy Hidayatur Rahman Hilda Anggraeni Laluyan Hilda Dea Revani I Ketut Gede Muliarta I'im Murtiawani Ida Winarni Ifa Artha Mefia Ike Nurrochmawati Ikke Winar Rachmawaty Ikke Winar Rachmawaty Imam Ghazali Imam Ghazali Imam Ghazali Indah Aprilia Angelina Indah Sri Wahyuni Indah Sri Wahyuni Indasah Indasah Iriawan Putra, Pujo Broto Istianah Istianah Jamhari Jamhari Janita Putri, Aqmarlia Joaquim Pinto Joko Prasetyo Joko Prasetyo Joko Prasetyo Joko Tri Atmojo Joko Tri Atmojo Joko Sutrisno Justanti, Chusnul karyono, Septin Maisharah Katmini Katmini, Katmini Khaerotib Koesnadi Krisnanda Aditya Pradana Krisnanda Aditya Pradana Krissanti, Hanny Kusumawardani, Nila Lastari, Heni Layla, Siti Farida Noor Lestaluhu, Masdarany Lilik Afifah Lingga Kusuma Wardani Lutfi Nur Aini M Al Farisi Manumara, Theophylia Melisa Maria Haryanti Butarbutar Maria Haryanti Butarbutar Maria Maria Marviyani Baisila Maryati Masrulloh Masrulloh Melda, Byba Melur Belinda Menny Noviani Mohamad As'ad Efendy Mohammad Yusuf Alamudi Muhamad As’ad Efendy Muhamad Hadhikul Ichwan Muhammad Erfansyah Muhammad Maftukh Muhammad Miftachul Mafakhir Muhammad Roihan Mahesa Putra Muji Murtiningsih Mukhofi, Lutfi Murwani Murwani Mustofa Khairul Sholeh Nia Sari Nian Afrian Nuari Ningtiyas, Linda Kristian Nova Purma Hardini Novi Kusrini Noviani, Menny Novita Ana Anggraini Nurdina Nurdina Nurfitriani, Yuzita Nurwijayanti Nurwijayanti Nurwijayanti Kusumaningrum Octaviana Marta G.M. Gusmão Ode Muhammad Ady Ardyawan, La P H Livana Prananingtias, Rosita Prasetya, Fika Indah Pratiwi Yuliansari Predito Prihantoro Prima Dewi Kusumawati Pujo Broto Iriawan Putra Purmahardini, Nova Purwanti, Tentry Fuji Putri Amanda Oktavia Putri Nur Fadhilah Rahmadi, Syamsu Rahmanasari, Suska Evi Rahmania Ambarika Ratna Wardani Ratna Wardani Raysella Khaulla Miandi Rendy Mahendra Rendy Mahendra Reni Yuli Astutik Reny Maswiyati Restu Hadi P Ritalia Monika Kaka Riyad Hariyadi Rizal, Yusuf Rizki Fadila, Rizki Rokhmawan, Ulum Rokhmat Rumpiati, Rumpiati Rusady, Yulia Paramita Safrina Citra Salsabila Salsabila, Unik Hanifah Salva Ayu Vidias Putri Sandu Siyoto Sandu Siyoto Sandu Siyoto Sandu Siyoto Sandu Siyoto, Sandu Sani, Miftahuddin Sari Pratiwi Sasmita, Hasri Yulia Sasmito, Armando Hadyono Joko Sasmito, Priyo Semiarto, Mufit Sentot Alibasah Sentot Imam Suprapto Setyo Wahyudi Sih Winarti Sinambela, Sunggulan Siswanti Siswanti Siti Farida Siti Farida Noor Layla Siti Farida Noor Layla Siti Hasna Ulfiah Siti Nur Farida Siti Nur Hasina Slamet Djoko Sunarko Slamet Djoko Sunarko Slamet Hariadi Slamet Jayadi Solehah, Eka Lutfiatus Stianto, Mitayakuna Subarkat Bangun Satoto sultan Sulton Ali M Sumarno . Sumiati Sumiyati Supangkat, Ismu Dwi Suprapto, Sentot Imam Susiati, Asih Luklu Syahrul Hidayat Syarif Abdullah Tin Dwi Kartiningsih Titik Mariyati Titis Sulistyowati Tri Retnoningsih Triningsih, Indah Tutik Nushah Tutik Nusnah Undatun Ni'mah Upik Supiaty Ura, Rahmad Suryawan wahono, kaiden budi Wahyu Agung Wahyu Herwati Cahyo Wardani, Silvia Intan Wasita, Rangga Watna, Ida Wening Palupi Dewi Wibowo, Kevin Rachmalia Widi Ardian S. Widiastuti Widiastuti Widiyanto, Aris Widiyawati, Rina Widyowati, Agustin Winarti, Sih Winda Gusya Dwiana Wing Umi Latifah WULANDARI Yatimul Kais Diyanto Yenny Puspitasari Yhen Ari Bekti Yoga Satria , Benny Yoyok Yulianto Yulia Paramita Rusady Yulida Ti'ani Yusiana Vidhiastutik Zauhani Kusnul Zuhrotul Aini, Zuhrotul