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Journal : Eduhealth

REGULASI CATECHINS GREEN TEA GMB-4 DALAM MENGHAMBAT OKSIDASI NADPH DAN PENIGKATAN EKSPRESI NITRIC OXIDE (NO) PADA KULTUR HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC) YANG MENGALAMI STRES OKSIDATIF Peristiowati, Yuly; -, Indasah
Eduhealth Vol 3, No 1 (2013): Jurnal Eduhealth
Publisher : Eduhealth

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Abstract

ABSTRAKPenanganan kondisi disfungsi endotel sebelum terjadi kerusakan lebih lanjut sangatlah penting, karena berakibat terjadinya resistensi insulin dan hiperglikemia. Diharapkan dengan pemberian Catechins Green tea GMB-4 dapat memperbaiki kerusakan endotel melalui penghambatan oksidasi NADPH dan peningkatan produksi NO sehingga dapat mencegah terjadinya komplikasi lanjut pada pasien dengan diabetes Millitus. Desain penelitian ini true eksperimen dengan pendekatan post test only control group design. Subyek penelitian ini adalah kultur sel endotel yang berasal dari Human Umbilical Vein Endothelial Cell (HUVEC) yang dipapar glukosa 30 mM dan diberi perlakuan dengan Catechins Green tea GMB-4 dengan 3 dosis yaitu 0,03 mg/ml;0,3 mg/ml dan 3 ng/ml. Setelah pemberian selama 12 jam selanjutnya dilakukan analisa kadar NADPH dan Nitric Oxide (NO) dengan metode Colorimeter menggunakan NADPH Assay kit ab65349 dan Nitric Oxide Assay kit KGE001.Hasil penelitian menunjukan ada penurunan kadar NADPH pada kultur HUVEC setelah perlakuan Catechins Green tea GMB-4 pada dosis 0,3 mg/ml, dan terjadi peningkatan kadar Nitric oxide pada perlakuan dosis 0,03 mg/ml dan dosis 0,3 mg/ml. Hasil uji statistic one way Anova didapatkan nilai signifikan 0,000 untuk kadar NO dan NADPH. Sehingga dapat di simpulkan pemberian Catechins Green tea GMB-4 pada dosis 0,3 mg/ml dapat menurunkan oksidasi NADPH dan meningkatkan produksi NO secara signifikan. Pemberian Catechins Green tea GMB-4 dapat mengaktivasi eNOS dan berperan dalam penghambatan oksidasi NADPH melalui pospotidylinositol-3 kinase, cAMP dependent protein kinase dan jalur Akt. Catechins juga mengkatalisis produksi NO dari L-arginin dan menghambat ROS dengan jalan mengikat ion metal pada reaksi redok, menghambat transkripsi faktor, menghambat enzim prooksidan dan meningkatkan enzim antioksidan.Kata kunci: antioksidan, Catechins Green tea GMB-4, NO, NADPH ABSTRACTHandling conditions of endothelial dysfunction before further damage is very important, because it results in insulin resistance and hyperglycemia. Expected by administration of Green Tea Catechins GMB-4 can improve endothelial damage through inhibition of NADPH oxidation and NO production increased so as to prevent the occurrence of further complications in patients with diabetes millitus. True experimental design of this study to approach post-test only control group design. The subjects of this study were cultured endothelial cells derived from Human Umbilical Vein Endothelial Cell (HUVEC) were exposed to 30 mM glucose and treated with Green Tea Catechins GMB-4 with 3 doses are 0.03 mg / ml, 0.3 mg / ml and 3 ng / ml. Analized NADPH levels and Nitric Oxide (NO) with Colorimeter method using NADPH Assay kit ab65349 and Nitric Oxide Assay kit KGE001. The results showed decrease in NADPH levels in cultured HUVEC after treatment of Green Tea Catechins GMB-4 at a dose of 0.3 mg / ml, and an increase in levels of nitric oxide in the treatment dose of 0.03 mg / ml and 0.3 mg / ml . Results of one way ANOVA statistical test obtained significant value of 0.000 for the levels of NO and NADPH.. So it can be concluded giving Green tea Catechins GMB-4 at a dose of 0.3 mg / ml can reduce the oxidation of NADPH and increased NO production significantly. Provision of Green tea Catechins GMB-4 can activate eNOS and play a role in the inhibition of NADPH oxidation through pospotidylinositol-3 kinase, cAMP dependent protein kinase and Akt pathways. Catechins also catalyze the production of NO from L-arginine and inhibited ROS by binding the metal ions on the reaction redok, inhibits transcription factor, inhibits prooxidant enzymes and increases antioxidant enzymes.Keywords: antioksidant, Catechins Green tea GMB-4, NO, NADPH
Co-Authors Abd. Rasyid Syamsuri Achmad Wahdi Achmad Zakaria Adelina Pinto Ady Purwoto Afridah, Wiwik Afzal, Ridha Agit Pratama Putra Agung Purnomo Agung Purnomo Agus Salim Burhanuddin Agusta Dian Ellina Agustin Agustin Agustin Widyowari Agustin Widyowati Ahmad Syauqi Mubarok Ahmadi Putri, Nabila Maharani Aini, Trianike Nor Alexius Andi Bur Ali Humardani Alin Ayuning Tyas Almas, Sri Warsuni Alya Tata Riani Amani, Tartilah Nur Amelindha Vania Ananda Wansika Dewi Andariningsih Andayani, Erisa Ariya Andre Bagaskara Angky Meilin Widi Sumijayanti Anis Ansyori Anna Indriani Anna Lince Dasmasela Anniza Pramesti, Adhe Anto, Ambo Anugraheni Wintari Soerya Arantrinita Arantriwardani Arantriwardhani Arief Churniawan Arief Fardiansyah Artha Budi Susila Duarsa Asri Dewi Wahyuningtyas Asri Putri Kisfandari Asruria Sani Fajria Asyafa'a Rizqi Fadilla Atmojo, Joko Tri Aulia Rahman Ayu E., Mas Roro Dyah Baiq Nirmalasari Baiq Reni Pratiwi Batewa, Erny Bayu Prabowo Bekti, Yhen Ari Benny Yoga Satria Betharia Mardiyani Bhisma Murti Birroudhoh, Fiqhiyah Budi Minarno Bur, Alexius Andi Byba Melda Suhita christianto nugroho Crystalia Darma Karno Dedy Mochtar Setiaji Demasa Maulana Seta Desak Gede Sri Baktiasih Dewi Kusumawati, Prima Dewi Retno Puspitosari Dian Jayantari Putri K Hedo Dita, Janny Doris Novelyn Lalamentik Dwi Helynarti Syurandhari Dwiana, Winda Gusya Edi Kurnianto Efendy, Muhamad As'ad Eka Lutfiatus Solehah Elina, Agusta Dian Elliana, Agusta Dian Ellina , Agusta Dian Elya Endriani Endah Pujiati Eni Natalia Teuf Etti Suryani Eva Agustin Fajriah, Asruria Sani Fajriah, Asuria Sani Fajriyah, Asruria Sani Farida Hidayati Feliciano De Araujo Ghazali, Muh Al Gunawan Handayani, Rina Tri Hangriani, Fransiska Xaveria Hardiani, Novita Hari Prasetyo Umar Hariyono Hariyono Hariyono Heri Suroso, Heri Herin Mawarti Herman Pratikto Herminofa, Irsyad Hidayat, Ichwan Hidayat, Poppy Hidayatur Rahman Hilda Dea Revani I Ketut Gede Muliarta I Putu Artawan Prayoga I'im Murtiawani Ida Winarni Ifa Artha Mefia Ike Nurrochmawati Ikke Winar Rachmawaty Ikke Winar Rachmawaty Imam Ghazali Imam Ghazali Imam Ghazali Indah Aprilia Angelina Indah Sri Wahyuni Indah Sri Wahyuni Indasah Indasah Iriawan Putra, Pujo Broto Istianah Istianah Jamhari Jamhari Janita Putri, Aqmarlia Jaswadi JASWADI, Jaswadi Joaquim Pinto Joko Prasetyo Joko Prasetyo Joko Prasetyo Joko Tri Atmojo Joko Tri Atmojo Joko Sutrisno Justanti, Chusnul Katmini Katmini, Katmini Khaerotib Koesnadi Krisnanda Aditya Pradana Krisnanda Aditya Pradana Krissanti, Hanny Kusumawardani, Nila Laily Indrayanti Yusuf Lalu Herman Mahaputra Lalu Iman Saptahadi Laluyan, Hilda Anggraeni Lamma, Nirwana Alef Lastari, Heni Latifah Latifah Latifah, Wing Umi Layla, Siti Farida Noor Lestaluhu, Masdarany Lilik Afifah Lingga Kusuma Wardani Lutfi Nur Aini M Al Farisi Manumara, Theophylia Melisa Maria Haryanti Butarbutar Maria Haryanti Butarbutar Maria Maria Marviyani Baisila Maryati Masrulloh Masrulloh Melda Suhita, Byba Melda, Byba Melur Belinda Menny Noviani Mohamad As'ad Efendy Mohammad Yusuf Alamudi Muh. Emilia Sa'id Rasyid Muhamad As’ad Efendy Muhamad Hadhikul Ichwan Muhamad Sardiman Muhammad Erfansyah Muhammad Maftukh Muhammad Miftachul Mafakhir Muhammad Munip Muhammad Roihan Mahesa Putra Muji Murtiningsih Mukhofi, Lutfi Murwani Murwani Mustofa Khairul Sholeh Ng Phi Shi Nia Sari Nian Afrian Nuari Ningtiyas, Linda Kristian Noer Istiqomah Nova Purma Hardini Novi Kusrini Noviani, Menny Novita Ana Anggraini Nur Alim Fatah Nurdina Nurdina Nurfitriani, Yuzita Nursini Juiban Hadi Nurwijayanti Nurwijayanti Kusumaningrum Octaviana Marta G.M. Gusmão Ode Muhammad Ady Ardyawan, La P H Livana Prananingtias, Rosita Prasetya, Fika Indah Pratiwi Yuliansari Predito Prihantoro Prima Dewi Kusumawati Pujo Broto Iriawan Putra Purmahardini, Nova Purwanti, Tentry Fuji Putri Amanda Oktavia Putri Nur Fadhilah Rahmadi, Syamsu Rahmanasari, Suska Evi Rahmania Ambarika Ratna Wardani Ratna Wardani Raysella Khaulla Miandi Reni Yuli Astutik Reny Maswiyati Restu Hadi P Ritalia Monika Kaka Riyad Hariyadi Rizal, Yusuf Rizki Fadila, Rizki Rokhmawan, Ulum Rokhmat Rumpiati, Rumpiati Rusady, Yulia Paramita Sadikin Apriadi Safrina Citra Salsabila Salsabila, Unik Hanifah Salva Ayu Vidias Putri Sandu Siyoto Sandu Siyoto Sandu Siyoto Sandu Siyoto Sandu Siyoto, Sandu Sani, Miftahuddin Sari Pratiwi Sarippy, Jesseline Sasmita, Hasri Yulia Sasmito, Armando Hadyono Joko Sasmito, Priyo Semiarto, Mufit Sentot Alibasah Sentot Imam Suprapto Septin Maisharah K Setyo Wahyudi Sih Winarti Sinambela, Sunggulan Siswanti Siswanti Siti Farida Siti Farida Noor Layla Siti Farida Noor Layla Siti Hasna Ulfiah Siti Nur Farida Siti Nur Hasina Slamet Djoko Sunarko Slamet Djoko Sunarko Slamet Hariadi Slamet Jayadi Soerya, Anugraheni Wintari Solehah, Eka Lutfiatus Stianto, Mitayakuna Subarkat Bangun Satoto sultan Sulton Ali M Sumarno . Sumiati Sumiyati Sunanto Sunanto Supangkat, Ismu Dwi Suprapto, Sentot Imam Susi Wirawati Triono Susiati, Asih Luklu Syahrul Hidayat Syarif Abdullah Tata Mahyuvi Tin Dwi Kartiningsih Titik Mariyati Titis Sulistyowati Tri Retnoningsih Triningsih, Indah Tutik Nushah Tutik Nusnah Undatun Ni'mah Upik Supiaty Ura, Rahmad Suryawan wahono, kaiden budi Wahyu Agung Wahyu Herwati Cahyo Wahyu Nur Chalamsa Wardani, Silvia Intan Wasita, Rangga Watna, Ida Wening Palupi Dewi Wibowo, Kevin Rachmalia Widi Ardian S. Widiastuti Widiastuti Widiyanto, Aris Widiyawati, Rina Winarti, Sih Winda Gusya Dwiana WULANDARI Yatimul Kais Diyanto Yenny Puspitasari Yhen Ari Bekti Yoga Satria , Benny Yoyok Yulianto Yulia Paramita Rusady Yulida Ti'ani Yusiana Vidhiastutik Zauhani Kusnul Zauhani Kusnul3 Zuhrotul Aini, Zuhrotul Zulkifli