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All Journal Jurnal Kedokteran Brawijaya Jurnal Anestesi Perioperatif Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Damianus Journal of Medicine Global Medical and Health Communication IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) JPSriwijaya Sari Pediatri Biomedical Journal of Indonesia Syntax Literate: Jurnal Ilmiah Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) International Journal of Retina SRIWIJAYA JOURNAL OF MEDICINE Economics and Finance in Indonesia Oto Rhino Laryngologica Indonesiana Majalah Anestesia dan Critical Care Majalah Kedokteran Andalas Majalah Patologi Indonesia Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health) Jurnal Aisyah : Jurnal Ilmu Kesehatan Sriwijaya Journal of Surgery Indonesian Journal of Global Health research Eureka Herba Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal Of World Science Jurnal Penyakit Dalam Indonesia IJRETINA - International Journal of Retina
Muhammad Irsan Saleh
Bagian Farmakologi, Fakultas Kedokteran, Universitas Sriwijaya, Palembang, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : SRIWIJAYA JOURNAL OF MEDICINE

 1 
The Correlation Between Absolute Lymphocyte Count and Quantitative CRP Level Related to Disease Severity in COVID-19 Patients at RSUP dr. Mohammad Hoesin Palembang Nadia Karimah Amalia Zulfadli; Zen Ahmad; Mgs Irsan Saleh; Ahmad Rasyid
Sriwijaya Journal of Medicine Vol. 4 No. 2 (2021): Vol 4, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i2.107

Abstract

COVID-19 is a contagious acute respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Changes in some laboratory markers such as absolute lymphocyte count and quantitative CRP in COVID-19 can be associated with the course and clinical phases of the patient whose results can be useful in grading and predicting the severity of COVID-19 disease. This study aims to determine the correlation between absolute lymphocyte count and quantitative CRP on the severity of COVID-19. This study was an observational correlative analytic study with a cross sectional design. The research was conducted in all COVID-19 treatment isolation wards at RSMH Palembang from March 2021 to April 2021 with the research subjects being patients with confirmed cases of COVID-19 with various degrees of disease. Routine blood tests of absolute lymphocyte counts and quantitative CRP were performed at the Clinical Pathology Laboratory of RSMH Palembang. The statistical analysis of the correlation test with Spearman for numerical data was not normally distributed, and Gamma for categorical ordinal data was followed by a regression test to determine the prognostic value of the two parameters. Samples obtained were 83 patients, namely 24 patients (28.9%) mild degree, 40 patients (48.2%) moderate degree, 10 patients (12%) severe degree and 9 patients (10.8%) critical degree. The correlation between the absolute lymphocyte count and quantitative CRP obtained the correlation coefficient value r = – 0.525. The correlation between the absolute lymphocyte count and the degree of COVID-19 disease obtained a correlation coefficient of r = – 0.605, while the correlation between the quantitative CRP value and the degree of disease was obtained r = 0.875. Based on the prognostic test, the absolute lymphocyte count (cutoff point of 1,157 cells / mm3) was obtained with a sensitivity of 68.4% and a specificity of 68.75%. Meanwhile, quantitative CRP with a cutoff point of 77.5 mg/L obtained a sensitivity of 89.4% and a specificity of 89%. The absolute lymphocyte count has a strong negative correlation with the quantitative CRP value and the disease degree in COVID-19, while the quantitative CRP value has a positive correlation with a very strong degree. Thus these two parameters can be used as predictors of disease severity, however, the quantitative CRP value can be an independent prognostic marker or a single predictor of the severity of COVID-19 disease.
Efektifitas Pemberian Ekstrak Bawang Putih Terhadap Penurunan Kadar Interleukin-6 Serum dan Dialisat pada Pasien Continous Ambulatory Peritoneal Dialysis Margaretha Kendenan; Zulkhair Ali; Nova Kurniati; Irsan Saleh
Sriwijaya Journal of Medicine Vol. 4 No. 2 (2021): Vol 4, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i2.119

Abstract

Penelitian Chronic Renal Insufficiency Cohort (CRIC) menunjukkan 86% subjek PGK terbukti menderita inflamasi. Sejumlah studi longitudinal melaporkan peningkatan inflamasi dengan mengukur interleukin-6 (IL-6) pada pasien PD baik kadarnya di sistemik dan intraperitoneal. Bawang putih dan komponennya memiliki aktivitas antiinflamasi dan antioksidan. Efek antiinflamasi dari ekstrak bawang putih, dengan menghambat aktivasi jalur pro-inflamasi serta menghambat aktivasi makrofag dan efek antioksidan dan menghambat enzim pro-oxidant. Penelitian ini merupakan studi crossover randomized placebo controlled double blind trial. Subjek penelitian 20 orang pasien PGK stadium 5 yang menggunakan CAPD, dibagi secara acak menjadi 2 kelompok, yaitu kelompok yang mendapat ekstrak bawang putih 800 mg perhari (2x400 mg) selama 8 minggu dan kelompok yang mendapatkan placebo, kemudian dilakukan periode wash out selama 2 minggu dan setelah itu kedua kelompok diberikan perlakuan bergantian. Masing masing kelompok diukur kadar IL-6 serum, IL-6 dialisat dan net ultrafiltrasi sebelum dan sesudah perlakuan. Didapati kadar IL-6 serum sebelum dan sesudah pemberian ekstrak bawang putih 7,10 ±2,30 pg/ml dan 5,00±3,00 pg/ml dengan p= 0,005. Kadar IL-6 dialisat sebelum dan sesudah pemberian ekstrak bawang putih 39,20±2,10 pg/ml dan 33,20±7,80 pg/ml dengan p = 0,000. Disimpulkan penurunan kadar IL-6 serum dan dialisat sesudah ekstrak bawang putih pada penderita PGK stadium V yang menggunakan CAPD di RSMH Palembang.
GLUT4 as A Protein Target for Type 2-Diabetes Mellitus Therapy With Natural Compounds Vivi Hendra Sutandar; Mgs. Irsan Saleh; Ziske Maritska
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.154

Abstract

WHO reported 1.9 million death cases of diabetes patients in 2019. Diabetes is caused by damage in the pancreas which resulted in a lack of insulin or insulin resistance.  Medication for Type 2-Diabetes Mellitus (T2DM) mainly focuses on lowering blood glucose and treating affected organs. Current medications are still lacking; thus research is needed in finding novel medications to accommodate T2DM. This paper aims to present the current research on potential plant extract in increasing GLUT4 translocation in diabetes conditions. insulin resistance state affecting GLUT4 translocation which is important in affecting glucose uptake. Some research shows that plant extract proved to be potential in increasing the translocation of GLUT4 and helping lowering blood glucose levels.
The Effect of Aloe Vera Topical Gel Extraction on Tgf-Β1 Expression in Thermal Burn Eyelid Grade II Rats Model Riani Erna; Kartini Wulan; Mgs. Irsan Saleh
Sriwijaya Journal of Medicine Vol. 5 No. 3 (2022): Vol 5, No. 3, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v5i3.197

Abstract

Grade II eyelid burns are burns that reach the epidermis and part of the dermis of the palpebrae and can have impaired wound healing. TGF β1 has the broadest spectrum of action, affecting all cell types involved in all stages of wound healing. TGF β1 increases rapidly after injury and reaches peak levels three days after injury, which coincides with the peak of the inflammatory phase of wound healing. Decreased expression of TGF β1 is associated with impaired wound healing. Aloe Vera has long been known in Indonesia as a healing plant. Aloe Vera extract contains a variety of bioactive compounds that play a role in stimulating wound healing. The administration of Aloe Vera extract on thermal burns aims to reduce inflammation, increase collagen content, and increase the rate of re-epithelization. The administration of Aloe Vera gel extract allows faster healing of thermal burns and rebuilds the vascularity of the wound tissue. Objective of this study is to determine the difference between the expression of Transforming Growth Factor Beta 1 (TGF β1) in a rat model of thermal burn injury grade II of the eyelids treated with topical Aloe Vera gel extract with the concentrations of 20%, 40%, Balanced Salt Sodium (BSS) and a control group that was not given burn intervention. An experimental study with the post-test-only approach with a control group design. 24 Rats have induced grade II eyelid thermal burns, divided into four groups: Normal (without treatment), negative control (BSS), given Aloe vera 20%, 40%. Then TGF β1expression was quantified using the Image J application. The Topical application of Aloe vera gel can increase the expression of TGF along with the increase in dose. The highest rise in TGF expression was found in the group with 40% Aloe vera gel, followed by 20% Aloe vera gel compared to the negative control (BSS Balanced Salt Solution). Aloe Vera can increase TGF expression in a rat model of grade II palpebral burn injury and is dose-dependent.
Co-Authors Abdi Wijaya Abdulwahab Hakimi Ade Suryaman Aditiawati Aditiawati Adnan Abadi, Adnan Adrian, Ronny Ahmad Rasyid ahmad rasyid, ahmad Ahmad, Zen AK Ansyori Akmal, Reza Ali Ghanie Ali Ghanie Ali Ghanie Alif Fathur Rachman, Muhammad Alvilusia, Alvilusia Alwi Shahab Amir Fauzi Amir Fauzi Andi Putra Siregar Anggeria, Septa Anita Tursia Ansyori, AK Anwar, Chairil Arlis Karlina Aseptianova Aseptianova Athiah, Medina Ayeshah A Rosdah Azhari Azhari Banun, Syahri Bastian Bastian Bastian Bintang Arroyantri Prananjaya Chairil Anwar Chakra, Aerul Dalillah Dalillah Dessy Adhriyani, Dessy Dian Wahyuni Dwi Handayani Dwi Handayani Dwirini Retno Gunarti Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim, Eddy Mart Eeng Yoneska Effendi, Ian Effendi, Kms. Yusuf Efman EU Manawan Efman Manawan Efrieni Yusuf Ella Amalia, Ella Elza Iskandar, Elza Emilia Eny Rahmawati, Eny Ernawati Sinaga Erwin Sukandi Erwin Sukandi Evi Lusiana Fatmawati Fatmawati Ferdi, Roni Ferry Usnizar Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fuad Bakry Gita Dwi Prasasty Hafizzanovian, Hafizzanovian Handayati, Debby Heni Maulani, Heni Herdana, Nova Hermansyah Hu, Owen Ian Effendi Iche Andriyani Liberty, Iche Andriyani Ika Kartika Imran Saleh Indra, Bima Indrajaya, Taufik Irfannuddin Irfannuddin Irfanuddin Irfanuddin Istiqomah, Amelia Izzah, Puspita Nurul Jayawarsa, A.A. Ketut Joko Marwoto Jusak Nugraha Kamaluddin Kamaluddin Kartini Wulan Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kendenan, Margaretha Kesty, Cindy Kms Yusuf Effendi Krisna Murti kurniati, nova Kusrini, Ida Kusuma Harimin, Kusuma Larasati, Veny Legiran Legiran Leni Wijaya, Leni Lubis, Fadhyl Zuhry Makbruri Amin Margaretha Kendenan Maria Ulfa Mediarty Medina Athiah Mega Sary Mezfi Unita Mudinillah, Adam Muhamad Ayus Astoni Muhammad Hadi Wijaya Muhammad Haryadi Ade Kurnadi Nadia Karimah Amalia Zulfadli Nita Parisa Nova Herdana Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Novadian Novadian Novadian, Novadian Nugroho, Suroso Adi Nur Riviati, Nur Nuswil Bernolian Oktariana, Desi Pahlawan, M Kaisar Patwa Amani, Patwa Peby Maulina Lestari, Peby Maulina Phey Liana Poedji Loekitowati Hariani Purwoko, Izazi Hari Puspa Zuleika, Puspa Putra, Hadrians Kesuma RACHMAT HIDAYAT Rachmat Hidayat Radiyati Umi Partan Rahadiyanto, Kemas Ya'Kub Rahadiyanto, Kemas Ya’kub Ramadhan, Philosophia Ramzi Amin Ramzi Amin, Ramzi Rasidi, Syafran Ratih Pratiwi Reagen, Muhammad Reza Akmal Riani Erna Riani Erna, Riani Rieke Cahyo Budi Utami Rizal Zainal Rizani Amran Rizda, Dian Permata Rizki Andini Nawawi Ronny Adrian Rostika Dewi Rukiah Chodilawati Rukiah Chodilawati Sabri Prihantika Safyudin Salmon Charles Pardomuan Tua Siahaan Salni Salni Salni Salutondok, Welly Sari, Febrina Sary, Mega Sastradinata, Irawan Shahab, Alwi Soenarto Kartowigno Sri Nita Sri Nita Sri Nita, Sri Stevanny, Bella Subandrate Sudarto Sudarto Sulfa Esi Warni Suprapti Suprapti Suprapti Suprapti Surya Dharma Susilawati, Susilawati Sutandar, Vivi Hendra Syamsu Indra Syifa Alkaf Tanoehardjo, Francisca Srioetami Tanoehardjo, Francisca Srioetami Tanzil, Iswadi Tati Lahmuddin, Tati Tatit Nurseta Taufik Indrajaya Taufik Indrajaya Taufik Indrajaya Taufik Indrajaya Taufik Indrajaya Tengku Arfi Sulaiman Theodarus, Theodarus Theodorus Theodorus Tiara Fatrin Triwani Triwani Triwani Triwani Tursia, Anita Usman Said, Usman Usman, Fatimah Widyastuti Wina Safutri Wresnindyatsih Wresnindyatsih, Wresnindyatsih Yeni Agustin Yenny Dian Andayani Yesi Astri Yudhie Tanta Yulia Farida Yahya Yundari, Yundari Yuniarti, Fifi Zen Ahmad Zen Hafy Ziske Maritska Zulfadli, Nadia Karimah Amalia Zulfiawan, Zulfiawan Zulkarnain Musa, Zulkarnain Zulkhair Ali Zulkhair Ali Zulkhair Ali Zulkifli Zulkifli Zulkifli Zulkifli