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Pudji Srianto
Department Of Veterinary Reproduction, Faculty Of Veterinary Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Engineering Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Social Sciences Veterinary

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Journal : Jurnal Veteriner

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Peningkatan Ekspresi Vascular Endothel Growth Factor dan Mitogen Activating Protein Kinase Plasenta Tikus yang Dipapar Carbon Black ((INCREASING EXPRESSION ON VASCULAR ENDOTHELIAL GROWTH FACTOR AND MITOGEN ACTIVATING PROTEIN KINASE IN PLACENTA RATS EXPOSE Viski Fitri Hendrawan; Widjiati Widjiati; Suherni Susilowati; Pudji Srianto
Jurnal Veteriner Vol 18 No 1 (2017)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.745 KB) | DOI: 10.19087/jveteriner.2017.18.1.59

Abstract

Carbon black is one of the components of particulate matter (PM), known as cytotoxic, causing inflammationin the respiratory and cardiovascular system, and able to pass through the placental barrier, which may affect the fetus. The effects caused by pollutants depend on the intensity and time length of the exposure.The objective of this study is to identify Vascular Endothelial Growth Factor (VEGF) and Mitogen Activating Protein Kinase (MAPK) as an indicator of maternal placental inflammation in pregnant rats (Rattus norvegicus) exposed to carbon black with immunohistochemical technique. This study was a laboratory experiment with three treatment groups and seven replications using pregnant female white rats (Rattus norvegicus). Pregnant female rats were exposed to carbon black with a dosage of 523 mg/m3 and 1064 mg/m3 during pregnancy of day 6 up to day 11. The next phase was the observation and examination of the expressions of VEGF and MAPK by immunohistochemical staining toward placenta of the white rats exposed to carbon black. The result of the study showed an increase in the expression of VEGF in the placenta of the rats exposed to carbon black with a dosage of 523 mg/m3 and 1064 mg/m3 per inhale during the mid-period (6-11) of pregnancy. In addition, there was also an increasein the expression of MAPK on the placenta of the rats exposed to carbon black with a dosage of 523 mg/m3and 1064 mg/m3 per inhale during the mid-period (day 6-11) of pregnancy. In conclusion, the expression of VEGF and MAPK are increased along with the increased dosage of carbon black and age of gestation. ABSTRAK Carbon black merupakan salah satu komponen partikulat matter (PM) yang diketahui bersifat sitotoksik serta menyebabkan terjadinya inflamasi pada sistem pernapasan dan kardiovaskular serta dapat melewati barier plasenta fetus sehingga dapat memengaruhi fetus. Efek yang ditimbulkan oleh polutan tergantung dari besarnya paparan dan lama waktu paparan. Penelitian ini bertujuan untuk mengidentifikasi Vascular Endothel Growth Factor (VEGF) dan Mitogen Activating Protein Kinase (MAPK) sebagai indikator imflamasi pada plasenta maternal tikus (Rattus norvegicus) yang dipapar carbon black dengan teknik imunohistokimia. Penelitian ini dilakukan dengan tiga kelompok perlakuan dan tujuh kali ulangan yang menggunakan tikus betina bunting. Tikus betina bunting dipapar dengan carbon black dosis 523 mg/m3 dan 1064 mg/m3 selama kebuntingan hari ke-6 sampai 11. Tahap berikutnya adalah pengamatan dan pemeriksaan ekspresi VEGF dan MAPK dengan pewarnaan imunohistokimia terhadap plasenta tikus putih yang telah dipapar dengan carbon black. Hasil penelitian adalah terjadi peningkatan ekspresi VEGF pada plasenta tikus yang dipapar carbon black dosis 523 mg/m3 dan 1064 mg/m3 per inhalasi selama masa pertengahan (6-11) kebuntingan. Selain itu terjadi peningkatan ekspresi MAPK pada plasenta tikus yang dipapar carbon black dosis 523 mg/m3 dan 1064 mg/m3 per inhalasi selama masa pertengahan(6-11) kebuntingan. Simpulan penelitian ini adalah ekspresi VEGF dan MAPK meningkat seiring dengan peningkatan dosis carbon black dan umur kebuntingan.
Co-Authors . Kholik Abdul Samik, Abdul Abdullah Hasib Aditya Irawan Aftabuddin Rz, Muhammad Agustono, Bodhi Aksono HP., Eduardus Bimo Al arif, Mohammad Anam Aldin Akbar Rahmatullah Ali Saifudin Andriyanti, Silvia Rani Azwani, Nabila Bambang Poernomo Berliana, Erprinanda Galuh Bhaskara, Alfiutha Propha Boedi Setiawan Brillianti, Febby Fairy BUDI UTOMO Budi Utomo Budiarto Budiarto Budiarto Cahya P., Aghid Cindy Ercha Aulia Putri Dadik Rahardjo Dadik Rahardjo, Dadik Dadik Raharjo Dadik Raharjo Daniel Leonardo Darsono, Roesno Deskayanti, Asih Dhesy Kartikasari Dian Ayu Permatasari Dian Ayu Permatasari Dikman, Dicky Mohammad Dimas Kunto Satrio Djoko Legowo Dwi Puspa Sukma Viranda Emy Koestanti Sabdoningrum Endang Suprihati Erlangga, Made Bagus Erma Safitri Erma Safitri ERMA SAFITRI Fajar Ramadhan Subiyantoro Febriano, Muhammad Galang Gandul Atik Yuliani Hani Plumeriastuti Hariadi, Mas'ud Heni Puspitasari Hermin Ratnani Herry Agoes Hermadi Imam Mustofa IMAM MUSTOFA Indah Norma Triana, Indah Norma Ira Sari Yudaniayanti Ismudiono Ismudiono Ismudiono Ismudiono, Ismudiono Iwan Sahrial Hamid Kadek Rachmawati Kartikasari, Dhesy Kholik, Kholik Kurniawan, Muhammad ‘Ahdi Laba Mahaputra Lailiyah, Fahlevi Luqman, Epy Muhammad Masyitoh, Herlina Mohammad Auzaie Afandi Muhammad Aulia Rahman Muhammad Munawaroh Muhammad Rama Imam Saputra Muhammad Yunus Munawaroh, Muhammad M’ Izi Kumala Lazuardi Sultoni Nidom, Chairul Anwar Nove Hidajati Nurhusien Yimer Nuurin Ajrin Karim Praja, Ratih Novita Prastiya, Ragil Angga Pratama, Hanif Sabekti Pristian Devon Martyas Wahyuningrum Rahmawati Rahmawati Rahmawati, Mitha Ardila Rahmawati, Rahmawati Rimayanti Rimayanti Rimayanti Rimayanti Rimayanti Ristiani, Widya Aulia Rizki, Andaru Rochmah Kurnijasanti Saputra, Muhammad Rama Imam Saputro, Amung Logam Seagames Waluyo, Seagames Setiawan Koesdarto Setyadi, Arda Wahyu Sintya Kumalasari Wibowo Sintya Kumalasari Wibowo Soeharsono Soeharsono Soeharsono Soeharsono Sofie Adi, Keren Jayanti Sri Hidanah Sri Mulyati Sri Mulyati Sri Mulyati Sri Pantja Madyawati Sri Pantja Madyawati, Sri Pantja Subagio, Muharam Suherni Susilowati Sukma, Puspa Permata Sunarso, Agus Supriyadi Supriyadi Suwarno Suwarno Suzanita Utama Tasya Apritalia Putri Tatik Hernawati Tita Damayanti Lestari Tjuk Imam Restiadi Tri Wahyu Suprayogi Trilas Sardjito Viski Fitri Hendrawan Warsito, Sunaryo Hadi Widjiati w Widjiati Widjiati Widjiati Widjiati, Widjiati Widodo, Oky Setyo Widya Paramita Lokapirnasari Wulandari, Shelly Wurlina, W Yustinasari, Lita Rakhma Zahrorona, Amira Halimah