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All Journal PHARMACON Pharmaciana: Jurnal Kefarmasian BAHASA DAN SASTRA Jurnal Farmasi Klinik Indonesia English Review: Journal of English Education Syntax Literate: Jurnal Ilmiah Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JELL (Journal of English Language and Literature) STIBA-IEC Jakarta Silampari Bisa: Jurnal Penelitian Pendidikan Bahasa Indonesia, Daerah, dan Asing Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ JTP - Jurnal Teknologi Pendidikan Jurnal Teknik JURNAL FARMASI GALENIKA Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Dinamika UMT Lingua Rima: Jurnal Pendidikan Bahasa dan Sastra Indonesia Jurnal Insan Farmasi Indonesia Jurnal Abdimas Kartika Wijayakusuma Jurnal Kajian Ruang Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Locus Penelitian dan Pengabdian Jurnal Media Teknologi Jurnal Talenta Sipil Jurnal Pembelajaran Sastra The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Jurnal Farmasi Indonesia Edukasi Masyarakat Sehat Sejahtera (EMaSS) Guruku: Jurnal Pendidikan dan Sosial Humaniora Jurnal Sadewa: Publikasi Ilmu Pendidikan, Pembelajaran dan Ilmu Sosial Jurnal Gizi dan Dietetik Jurnal Medika Farmaka Journal of Innovative and Creativity Inaba of Community Services Journal The Indonesian Journal of Computer Science Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat Jurnal Teknik Sipil Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Agus Sulaeman
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POTENSI ANTIATEROGENIK KOMBINASI EKSTRAK ETANOL RIMPANG KUNYIT DAN DAUN PEGAGAN DALAM MENURUNKAN RISIKO PENYAKIT KARDIOVASKULAR PADA MODEL HEWAN TIKUS OBES Lestari, Kharina Septi; Istiqomah, Aulia Nurfazri; Farihah, Ai Siti; Ramadhan, Dika Azhar; Kaniawati, Marita; Sulaeman, Agus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2882

Abstract

Obesity is a major risk factor for atherosclerosis and cardiovascular disease, characterized by dyslipidemia and oxidative stress. This study aimed to evaluate the anti-atherogenic effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa) and gotu kola leaves (Centella asiatica) in obese–hyperlipidemic rats.  Male rats were divided into seven groups: normal, induction, comparator (orlistat 10.8 mg/kgBW), and treatment groups receiving single and combined extracts (ERK, EDP, ERKDP 200:100, ERKDP 100:200 mg/kgBW). Obesity and hyperlipidemia were induced using a high-fat and fructose diet for 60 days. Parameters measured included body weight, lipid profile (TG, HDL, LDL, total cholesterol), Atherogenic Index of Plasma (AIP), and aortic histology. The induction group showed significant increases in body weight, triglycerides, LDL, and AIP (P<0.05). All treatment groups significantly improved lipid profiles and reduced AIP compared to the induction group. The ERKDP 100:200 mg/kgBW combination showed the most optimal effect, with a 51.83% reduction in LDL, a 54.60% decrease in AIP, and a 146% increase in HDL. Histological analysis also demonstrated reduced foam cell formation and improved aortic structure in this group. In conclusion, the combination of turmeric and gotu kola extracts, particularly at a dose of 100:200 mg/kgBW, exhibits significant anti-atherogenic potential through lipid profile improvement, AIP reduction, and vascular protection.
ESRGAN untuk Memperbesar Resolusi pada Citra Bangunan Sulaeman, Agus; Rauda Ramdania, Diena; Adzkia, Muhammad Fasya
The Indonesian Journal of Computer Science Vol. 11 No. 1 (2022): The Indonesian Journal of Computer Science
Publisher : AI Society & STMIK Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33022/ijcs.v11i1.3038

Abstract

In the current era of technology, photos are an important existence for modern society where with photos we can get a lot of information. Quality photos must have a good resolution and level of sharpness, but sometimes the photos obtained are sometimes not satisfied, especially in the resolution section where there are some photos with low resolution. With the use of ESRGAN photos that have low resolutions can be increased so that the resolution without reducing the quality of the photo significantly.
ANALISIS PERBANDINGAN METODE TAM DAN METODE UTAUT 2 DALAM MENGUKUR KESUKSESAN PENERAPAN e-Puskesmas DI PUSKESMAS KABUPATEN GROBOGAN Indrasari, Ferika; Lestari, Windy Nur; Sulaeman, Agus
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.863

Abstract

The application of information technology in the health sector, especially the e-Puskesmas system, is intended to improve the quality of services at the Grobogan Regency Community Health Center. The main objective of the study was to analyze the comparison between two models: the Technology Acceptance Model (TAM) and the Unified Theory of Acceptance and Use of Technology 2 (UTAUT 2). The study was conducted at the Grobogan Regency Community Health Center from January to March 2025. The population in this study was pharmaceutical personnel at the Grobogan Regency Community Health Center, and the sample in the study consisted of 90 people. The method in this study was comparative quantitative, with data quality testing using validity tests, reliability tests, and one-way ANOVA tests. The results of the one-way ANOVA test showed no significant difference between the TAM method and the UTAUT 2 method, with a sig value of 0.773 > α (0.05), which means there was no significant difference between the TAM method and the UTAUT 2 method in measuring the success of the implementation of the Puskesmas at the Grobogan Regency Community Health Center. This study canit can be concluded that in this study there is no significant difference between the TAM Method and the UTAUT 2 Method in measuring the success of the implementatione-Puskesmasat the Community Health Centers in Grobogan Regency.
Analisis Stabilitas dan Mitigasi Longsor Menggunakan Regeometri serta Sistem Perkuatan Soil Nailing pada Longsoran di Area Waduk Cirata Julianty, Riska; Meiprastyo, Xbal; Sulaeman, Agus
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v11i4.64116

Abstract

Longsor pada kawasan waduk strategis seperti Waduk Cirata merupakan ancaman serius terhadap keberlanjutan operasional Pembangkit Listrik Tenaga Air (PLTA) serta keselamatan penduduk di sekitar daerah aliran sungai Citarum, Jawa Barat. Penelitian ini bertujuan untuk mengevaluasi stabilitas lereng eksisting yang telah mengalami longsor serta merancang sistem mitigasi yang efektif terhadap beban statik maupun dinamik menggunakan pendekatan forensik teknik sipil. Metode yang digunakan meliputi pemodelan numerik berbasis elemen hingga dengan perangkat lunak PLAXIS 2D melalui pendekatan Strength Reduction Method (SRM). Parameter tanah diperoleh dari uji laboratorium dan korelasi empiris, divalidasi melalui back analysis hingga mencapai kondisi kritis (SF ≈ 1,0). Simulasi dilakukan pada tiga skenario utama: kondisi eksisting, perbaikan geometri (regeometri) dengan sistem bench, serta kombinasi regeometri dan sistem perkuatan soil nailing serta shotcrete. Hasil penelitian menunjukkan bahwa lereng eksisting berada dalam kondisi tidak stabil dengan faktor keamanan (SF) 0,95. Regeometri berhasil meningkatkan SF statik menjadi 1,613, namun SF seismik hanya 1,065 (di bawah ambang batas). Setelah penambahan soil nailing dan shotcrete, SF statik meningkat menjadi 1,75 dan SF seismik menjadi 1,121, yang telah memenuhi kriteria keamanan minimum. Implikasi penelitian ini memberikan rekomendasi teknis bahwa mitigasi longsor di kawasan sesar aktif wajib mengintegrasikan perkuatan struktural aktif seperti soil nailing, karena regeometri saja tidak cukup terhadap beban gempa.
Peran Ekstrak Kunyit dan Pegagan dalam Modifikasi Ekspresi Gen eNOS: Implikasi Terhadap Gangguan Ginjal pada Obesitas Sulaeman, Agus; Perayani, Eci; Muhsinin, Soni; Selifiana, Nita; Susilawati, Elis; Kaniawati, Marita; Nafilah, Aghnia Nurvianti; Mahakam, Hendra; Putra, Putra
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.763

Abstract

Obesity is a global health problem closely associated with endothelial dysfunction, oxidative stress, and renal impairment, where endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) levels serve as critical biomarkers for endothelial function. This study aimed to evaluate the effects of turmeric (Curcuma longa) extract, pegagan (Centella asiatica) extract, and their combination on body weight, organ index, fat index, blood biomarkers, and renal eNOS gene expression in obese rats. Male white rats were randomly divided into six groups: normal control, negative control (high-fat diet), positive control (orlistat 10.8 mg/kgBW), turmeric extract (200 mg/kgBW), pegagan extract (200 mg/kgBW), and a combination of turmeric–pegagan extracts (200:100 mg/kgBW). Treatments were administered for 60 days, and parameters assessed included body weight, organ index, fat index, blood biomarkers (ITT, creatinine, NO, elastin), and renal eNOS expression using PCR. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. The results demonstrated that the combination of turmeric and pegagan extracts significantly reduced body weight, liver, kidney, and heart indices, as well as visceral fat index, while improving blood biomarkers through the reduction of creatinine levels, along with an increase in NO serum approaching normal compared with the negative control group; the respective mean values were -10.14±0.57%, 5.52±0.73%, 1.23±0.21%, 0.64±0.06%, 1.35±0.05%, 0.33±0.06 mg/dL, dan 5.14±0.58 mmol/L. Renal eNOS expression exhibited an increasing trend in the combination group, although not statistically significant. In conclusion, the combination of turmeric and pegagan extracts exerts synergistic effects in improving endothelial dysfunction and renal impairment in obesity through lipid profile modulation, reduction of organ damage biomarkers, and enhancement of NO bioavailability.
Co-Authors Adinda, Deistha Adzkia, Muhammad Fasya Afriade Siregar, Chandra agung, fred Agustian, Salim Agustina Indri Hapsari Ahmad Suherman Akbar Rulazi, Bagus Ali Sulaiman Ali Sulaiman Anne Yuliantini Aolina, Shelin Apriyadi, Twe Endo M Ardadinata, Raihan Arief, Mansur Ariyana Ariyana Ariyana, Ariyana Asherlia, Dwita Astuti, Ayu Dwi Aulia Nurfazri Istiqomah Aulia, Arsy Auliyaa, Millata Azhari, Swary Anistri Bachrudin, Panji Bayinah, Ai Nur Bayu Laksmana Jati Deni Iskandar Destianto, Anto Dewi, Nova Freena Dhiani, Yanni Dimas R. Pambudi Djoko Widodo Dwitantika, Bryan Efraim Lian, Kevin Eka Cahyani, Dhiana Eka Gumilang, Nurani Eka Wardatul Jannah eko putra, eko Elysia, Syahda Embas Saraswati, Dewa Ayu Enawar, Enawar Ernawati Ernawati Farihah, Ai Siti Fatmawati, Eva Fauziyah, Azkia Nurul Fauziyah, Roro Nur Feliana, Marita Garnadi Jafar, Garnadi Gatot Susilo Lawrence Ghassani, R Wulandari Goziyah Goziyah Goziyah, Goziyah gumilar, mulus Gusrida Hamumeha, Abigail Diwa Hanna Sundari Hapsari , Agustina Indri Haryanti, Reni Hasimun, Patonah Hastuti, Widi Herdiansah , Yudi Herdiansah, Yudi Hoon, Kim Dong Hossanti Ntobu, Febri Hun, Kim Dong Idar Indrasari, Ferika Ira Miranti, Ira Irawan, Farid Irman, Deni Irviansyah, Cepy Okta Isdiany, Nitta Isnaeni Istiqomah, Aulia Nurfazri Isybillah Ahmad, Afifah Judiono Judiono Juli Yani Julianty, Riska Kamiri, Kamiri Larson Boling Sau, Barth Lestari, Kharina Septi Lestari, Windy Nur Lindasari, Heni Lutfiyah, Fifih M Ramadhan Saputro Mahakam, Hendra Maia de Fatima Freitas, Floriana Malik Al Akbar, Ayatullah Mamat Rahmat Marita Kaniawati Marliani, Lia Maryati Dewi, Maryati Maulana, Didit Meiprastyo, Xbal Mia N. A. Fatin Mona Fitria Muhamad Agung Muhamad Iqbal mulus gumilar Mutoharoh Mutoharoh Nafilah, Aghnia Nurvianti Nori Anggraini, Nori Novia Adiningsih, Arum Nurfadillah, Ilham Nurfazri Istiqomah, Aulia Nurfazri, Aulia Nurjaman, Jajang Patonah Perayani, Eci Prasasti, Tresna Dewi Pratiwi, Aulya Yudha Purawinangun, Ira Anisa Pusparini Pusparini Putra, Hendra Mahakam Putra, Putra Rafiansyah, Rafli Rizki Rahmat Santoso, Rahmat Rahmatullah, Muhammad Firdaus Ramadhan, Dika Azhar Rauda Ramdania, Diena Regi Fasya Septrian Resdiana, Rafli Aridzalrahman Reza Pratama Rizkyanto, Dheva Ferdinand Rofi’i, Agus Roni Farfian Roni Hidayat Rosmana, Dadang Rossa Rosefa Simanjuntak Royani, Ani Rum, Ira Adiyati Saleky, Yohannes Willihelm Salma Tia Salsabila Saputra, Nanda Saputro, M. Ramadhan SARI APRIYANI Sayeti, Ety Selifiana, Nita Siti Supriyati Soni Muhsinin Stiani, Sofi Nurmay SULASTRI, AAS Sulistyowati, Heny Sumarjo, Dwi Nur Ida Islamiati Suri Darmawan, Ammar Susilawati, Elis Syaharuddin Kasim Syahrizal Syahrizal Syarifuddin Wahid Syarifuddin Wahid Tundreng, Syarifuddin Udayanto, Nugroho Sungkono Vallini, Lia Wati, Afifah Ashma Widartika Widartika Widianto, Asriadi Prihandika Winara, Zahra Winasari, Winasari Winda Dwihudhana Witri Priawantiputri Xbal Meiprasetyo Yani Mulyani Yayuk Febriyanthi , Anggita Yenny Moviana, Yenny Yermia Ademi Dedeo Yuliani, Rany Yunita, Dilla Zinan, Daula Zahra