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Hubungan Karakteristik Pasien dan Rejimen Kemoterapi Terhadap Kualitas Hidup Pasien Kanker di RS PKU Muhammadiyah Yogyakarta : Relationship between Patient Characteristics and Chemotherapy Regimens on Quality of Life for Cancer Patients at PKU Muhammadiyah Hospital, Yogyakarta Fitri Ayu Wahyuni; Woro Supadmi; Endang Yuniarti
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i2.488

Abstract

Abstrak Kanker merupakan suatu kondisi sel yang telah mengalami kehilangan pengendalian dan mekanisme normalnya sehingga mengalami pertumbuhan sel yang tidak normal, cepat dan tidak terkendali. Kualitas hidup merupakan persepsi setiap individu terhadap fungsinya dalam kehidupan. Kualitas hidup merupakan suatu bagian penting dalam penilaian hasil terapi pada penyakit kanker. Karakteristik individu pada pasien berhubungan dengan persepsi kesehatan general dan kualitas hidup keseluruhan. Penelitian ini bertujuan utuk mengetahui hubungan karakteristik pasien dan rejimen kemoterapi dengan kualitas hidup pasien kanker di RS PKU Muhammadiyah Yogyakarta. Penelitian ini menggunakan desain cross sectional dengan subjek penelitian semua pasien kanker yang menjalani kemoterapi periode September-Oktober 2020 dan memenuhi kriteria inklusi. Data yang diperoleh dianalisis menggunakan uji statistik Mann-Whitney dan Kruskal Wallis. Dari hasil analisis diperoleh tidak terdapat hubungan yang bermakna antara karakteristik pasien dan rejimen kemoterapi dengan nilai kualitas hidup pasien kanker (p>0,05).
Medication Related Burden pada Pasien Gagal Ginjal Kronis di RSUD Kota Yogyakarta : Medication Related Burden in Patients with Chronic Kidney Failure at the Yogyakarta City Hospital Woro Supadmi; Muhammad Muhlis; Ilham Bintang Agung
Jurnal Sains dan Kesehatan Vol. 3 No. 6 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i6.575

Abstract

Chronic kidney disease (CKD) is a condition of chronic kidney function decline, progressive and irreversible. Treatment measures given to patients with chronic kidney disease depends on what stage obtained from treatment of comorbid conditions to renal replacement or hemodialysis. Prolonged drug consumption affects the burden of medication or medication related burden on patients. This study was conducted to determine the relationship between treatment load and the level of adherence in patients with chronic renal failure in RSUD Kota Yogyakarta. This study was observational study with a cross-sectional design. The instrument used was in the form of LMQ questionnaire to determine medication related burden and questionnaire MARS to determine the adherence. Data were analyzed by Spearman Test to determine the relationship between medication-related burden and patient compliance. The results showed that significant correlation between LMQ scores and MARS scores (correlation coefficient = -0.413, p = 0.001) and between VAS Score and MARS scores (correlation coefficient = -0.413, p = 0.001). The higher the medication related burden, the lower the patient's compliance.
Quality of Life and Costs of Illness of Dengue Patients at Pku Muhammadiyah Yogyakarta and Bantul Boisi, Cici Feronika; Purwanto, Barkah Djaka; Supadmi, Woro; Faridah, Imaniar Noor; Perwitasari, Dyah Aryani
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art5

Abstract

Background: The manifestation of dengue is a decrease in hematocrit and platelet levels, leading to a decrease in the patient’s quality of life and having an impact on the patient’s medical costs.Objective: This study objective was to ascertain the quality of life and medical costs associated with dengue patients.Method: This study employed a cross-sectional design at PKU Muhammadiyah Hospitals in Bantul and Yogyakarta from January to August in 2023. Pediatric patients’ quality of life was assessed using the EQ-5D-Y questionnaire, while adult patients’ using the EQ-5D-5L questionnaire. Data on patients’ medical costs was obtained from the hospital's financial database. The data were then analyzed descriptively and presented as a percentage of quality of life and average medical costs.Results: The results showed that pediatric DF patients in both hospitals reported anxiety and depression, with percentages of 100% (Yogyakarta) and 75% (Bantul), respectively. Meanwhile, most adult DF patients experienced problems in carrying out routines, 71.4% (Yogyakarta) and 50% (Bantul), respectively. Adult DHF patients in both hospitals reported pain and discomfort of 66.7% (Yogyakarta) and 100% (Bantul), respectively. The highest average medical costs paid by DF and DHF patients at PKU Jogja Hospital were IDR 4,919,450 and IDR 6,981,500. DF and DHF patients at PKU Hospital with BPJS insurance, with the highest average medical costs of IDR 2,726,245.5 (for DF patients) and IDR 4,797,700 (for DHF patients) to cover for laboratory costs.Conclusion: Dengue fever infections are impacting the patient's quality of life and medical costs.
Evaluation of erythropoietin therapy in hemodialysis patients at PKU Muhammadiyah Hospital Yogyakarta Adnan, Adnan; Dania, Haafizah; Supadmi, Woro
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.7725

Abstract

Most of the patients with end-stage renal disease who undergo hemodialysis receive erythropoietin (EPO) therapy for anemia treatment. Anemia with EPO deficiency is a common complication of chronic kidney disease (CKD). EPO therapy is expected to improve anemia and quality of life of patients. This analytic observational study was conducted in a cross-sectional design. It aimed to identify the difference in red blood cell profiles, namely hemoglobin (Hb), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and Mean Corpuscular Hemoglobin Concentration (MCHC), and quality of life of CKD patients on EPO and non-EPO therapy at PKU Muhammadiyah Hospital in Yogyakarta. The inclusion criteria were PGK ICD N18.9 outpatients who received hemodialysis therapy at this hospital and were literate, able to understand the questionnaire, and willing to be a respondent. The results showed that there was no significant difference (p>0,05) between the red blood cells (Hb, MCV, MCH, MCHC) of the EPO and non-EPO therapy groups. The correlation between the EPO and the quality of life of patients in all of the KDQOL domains was p> 0.05. Aside from the insignificant difference between the EPO and non-EPO therapy groups, the research concluded that there was no correlation between either the EPO or the non-EPO therapy with the quality of life of hemodialysis patients.
Assessing Direct Medical Costs and Quality of Life In Elderly Patients Using High-Alert Medications at Wongsonegoro Hospital Supadmi, Woro; Endang Darmawan; Rizky Budi Santoso; Sri Sulistyorini
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 2: September 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i2.30368

Abstract

High Alert Medications (HAM) are drugs that pose a significant risk of causing harm to patients if used incorrectly. This study aimed to evaluate the direct medical costs and quality of life of elderly patients aged 60 years and above using HAM at Wongsonegoro Hospital. An observational prospective cohort study design was employed, utilizing both secondary and primary data collection methods. Secondary data included patient demographics, medication usage, and direct medical costs obtained from hospital records and the finance department. Primary data on quality of life were gathered using the European Quality of Life 5 Dimensions (EQ-5D-5L) questionnaire. A total of 25 elderly patients were identified as users of HAM, with a gender distribution of 48% male and 52% female; 64% of these patients were aged between 60 and 70 years. The most prevalent medical condition among participants was diabetes mellitus, affecting 44% of one group and 32% of another. Sodium Chloride (NaCl) 500 mL infusion at a concentration of 3% was the most frequently administered medication (27.5%). The average direct medical cost for elderly patients using HAM was IDR 4,255,050. Additionally, the quality of life assessment revealed that 20% of patients experienced significant challenges in self-care activities. These findings highlight the impact of HAM on healthcare costs and quality of life among elderly patients, emphasizing the need for careful monitoring and management strategies to mitigate risks associated with high-alert medications.
Biaya Medis Langsung dan Efek Samping Kemoterapi Pasien Kanker Payudara di Rumah Sakit Swasta Kota Yogyakarta Giatna, Sifak; Supadmi, Woro; Yuniarti, Endang
Indonesian Journal of Clinical Pharmacy Vol 12, No 2 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2023.12.2.47215

Abstract

Kanker merupakan masalah kesehatan global. Di Indonesia, kanker payudara merupakan kasus terbanyak, yaitu 58.256 kasus dari total 348.809 kasus. Pada tahun 2017, Daerah Istimewa Yogyakarta (DIY) memiliki jumlah kasus kanker payudara terbanyak, yaitu sebesar 1.564 pasien rawat jalan dan 823 pasien rawat inap. Terapi kanker payudara dapat dilakukan dengan kemoterapi, radiasi, pembedahan dan terapi hormonal. Kemoterapi menimbulkan efek samping neutropenia, anemia, mual muntah, nyeri neuropati. Efek samping akibat penggunaan kemoterapi memengaruhi besarnya biaya perawatan. Penelitian ini merupakan studi observasional dengan metode pengambilan data secara retrospektif. Subjek penelitian adalah semua pasien kanker payudara yang sesuai dengan kriteria inklusi. Pengambilan data dilakukan secara retrospektif, yaitu dari Januari 2018 hingga Desember 2019. Data yang dikumpulkan dari rekam medis pasien meliputi biaya medis dari billing tagihan, profil kemoterapi dan efek samping kemoterapi. Efek samping diidentifikasi berdasarkan referensi buku dan artikel terkait. Data diolah menggunakan uji deskriptif untuk melihat gambaran biaya dan efek samping. Jumlah subjek penelitian adalah 53 subjek dengan 9 variasi regimen kemoterapi. Biaya medik langsung tertinggi adalah regimen docetaxel dan carboplatin (DC) 5 siklus sebesar Rp2.967.330, sedangkan terendah adalah regimen 5-fluorouracil (5-FU), adriamycin, cyclophosphamide (FAC) 8 siklus Rp2.024.165. Efek samping kemoterapi yang banyak terjadi adalah mual muntah (100%), neutropenia (86%), neuropati perifer (47%), pusing (42%), mukositis/stomatitis (25%), anemia (19%), diare (13%), infeksi kulit (11,3%), konstipasi (9%), serta penurunan nafsu makan (2%). Regimen 5-FU, adriamycin, cyclophosphamide, taxane (FAC-T) adalah regimen yang paling banyak digunakan (39,6%). Biaya medis langsung obat kemoterapi tertinggi adalah regimen DC. Efek samping yang paling umum adalah mual, muntah dan neutropenia.
Undesirable events in the use of high-alert medicine geriatric patients at RSUPN Dr. Cipto Mangunkusumo Malihi, La; Supadmi, Woro; Trisna , Yulia; Purwanto , Barkah Djaka
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.29643

Abstract

High-Alert Medications (HAM) are drugs that have a high risk of causing significant harm to patients if misused. It is estimated that one in ten geriatric patients experiences undesirable events during hospitalization related to medication use. Detect undesirable events due to the use of high-alert insulin and high-alert heparin drugs in geriatric patients at Rumah Sakit Umum Pusat Nasional (RSUPN) Dr Cipto Mangunkusumo using the trigger tool method based on positive predictive value (PPV) and determine the effect of using high-alert insulin and high alert heparin drugs on undesirable events. A retrospective cohort study will review secondary data from patient medical records (MR). The sample used was from 300 geriatric patients, 82 patients used insulin and 79 patients used heparin which met the inclusion criteria. Data were analyzed in the form of frequencies and percentages (%), calculation of PPV values, and the effect of using high-alert insulin and high-alert heparin on undesirable events using the Chi-Square test. There were 8 trigger-positive patients with undesirable events in the form of hypoglycemia from 82 insulin patients and 4 trigger-positive patients with undesirable events in the form of extended activated partial thromboplastin time (aPTT) values from 79 heparin patients. Based on the PPV value, both insulin (9.75%) and heparin (5.33%), the trigger tool has not been able to detect undesirable events when using high-alert insulin and high-alert heparin. Based on statistical tests, the p-value= 0.033 (p<0.05) for insulin and heparin p-value= 0.043 (p<0.05) meaning that there is an influence of the use of high-alert insulin and high-alert heparin on undesirable events when using both drugs. The trigger tool method cannot detect undesirable events when using high-alert insulin and high-alert heparin drugs based on laboratory triggers.
Sekolah Lansia “SEGAR” Berbasis Pemanfaatan Toga dalam Pencegahan Penyakit Degeneratif Supadmi, Woro; Dania, Haafizah; Akrom, Akrom; Saputri, Ginanjar Zukhruf; Mufidah, Syarifatul; Sari, Prita Anggraini Kartika
Jurnal Peduli Masyarakat Vol 7 No 3 (2025): Jurnal Peduli Masyarakat: Mei 2025
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jpm.v7i3.6595

Abstract

Lansia merupakan kelompok usia yang rentan terhadap penyakit degeneratif, seperti hipertensi, diabetes melitus, dan hiperkolesterolemia, yang memerlukan pengelolaan jangka panjang. Di Kelurahan Wirobrajan, Yogyakarta, prevalensi penyakit ini cukup tinggi, sementara pemahaman dan keterampilan lansia dalam pengelolaan kesehatan secara mandiri masih rendah. Program pengabdian ini bertujuan meningkatkan pengetahuan dan keterampilan lansia dalam pemanfaatan Tanaman Obat Keluarga (TOGA) secara tepat guna sebagai langkah preventif dan pengendalian penyakit degeneratif. Kegiatan dilaksanakan melalui program Sekolah Lansia Segar (Sehat dan Bugar) dalam tiga sesi edukatif yang bersifat partisipatif, diikuti oleh 63 lansia anggota Majelis Tabligh Aisyiyah Ketanggungan. Hasil evaluasi menunjukkan pengetahuan peserta mengenai penyakit degeneratif, penggunaan obat dan pemanfaatan TOGA. Seluruh peserta memahami bahwa TOGA memiliki khasiat sebagai obat, namun konsistensi dalam penggunaannya masih perlu ditingkatkan. Kegiatan ini terbukti efektif dalam memberdayakan lansia untuk mengelola kesehatannya secara mandiri.
Efektivitas Edukasi Berbasis Leaflet dalam Meningkatkan Pengetahuan Remaja tentang Kesehatan Mental Wijaya, Made Hariadi; Rahmmawati, Rini; Mashita, Siti; Supadmi, Woro
Jurnal Serambi Abdimas Vol 6 No 01 (2025): Jurnal Serambi Abdimas
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/sa.v6i01.14832

Abstract

Kesehatan mental remaja menjadi isu penting di Indonesia, terutama di Yogyakarta, seiring dengan meningkatnya tekanan akademik, sosial, dan emosional yang dihadapi oleh mereka. Pengabdian ini bertujuan untuk melihat pengaruh edukasi berbasis leaflet terhadap peningkatan pengetahuan siswa mengenai kesehatan mental. Kegiatan pengabdian dilakukan di SMK Muhammadiyah Mlati, Yogyakarta. Edukasi dilakukan dengan menggunakan media leaflet sebagai media edukasi yang berisi informasi tentang pengertian, penyebab, gejala, dampak, serta cara pencegahan dan penanganan gangguan mental. Pengukuran keberhasilan program dilakukan dengan meberikan pretest dan posttest untuk mengevaluasi perubahan pengetahuan siswa. Hasil pengabdian menunjukan peningkatan pemahaman siswa mengetai Kesehatan mental. Temuan ini memberikan kontribusi dalam upaya meningkatkan kesadaran kesehatan mental di kalangan remaja, serta dapat menjadi dasar pengembangan program edukasi yang lebih inovatif dan berkelanjutan untuk mendukung kesejahteraan mental remaja di Indonesia.
PROFIL PENGGUNAAN CHOP DAN RCHOP PADA PASIEN LIMFOMA NON-HODGKIN DI RSUP DR. SARDJITO Gustinanda, Rizky; Irham, Lalu Muhammad; Supadmi, Woro; Khair, Riat El
Jurnal Insan Farmasi Indonesia Vol 8 No 1 (2025): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v8i1.2529

Abstract

Non-Hodgkin lymphoma (LNH) is a heterogeneous malignancy of the lymphatic system with CHOP and RCHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone) chemotherapy regimens as main options. Local data on patient characteristics undergoing these treatments are still limited, especially at Dr. Sardjito General Hospital. This study evaluates the characteristics of LNH patients receiving both regimens at Dr. Sardjito (2020–2023). It is a descriptive observational study with a cross-sectional design. Data from patient medical records were analyzed descriptively. Of 176 patients, 80 received CHOP and 96 R-CHOP. Most were male (CHOP: 70%; R-CHOP: 60.4%) and aged >50 years, with peak age of 51–60 in CHOP (40%) and >60 in R-CHOP (44.8%). Comorbidities were found in one-third of patients. Advanced stage predominated (CHOP: 31.3% stage 4; R-CHOP: 38.5% stage 2), and most completed 6 chemotherapy cycles. Rituximab ≥550 mg was widely used in R-CHOP; cyclophosphamide >1100 mg, doxorubicin 70–79 mg, and vincristine ≥2 mg were standard in both regimens. Prednisone 100 mg was common. Diffuse Large B-Cell Lymphoma (DLBCL) dominated R-CHOP (98.96%), while CHOP patients included DLBCL (38.75%), FL, PTCL-NOS, and others. Findings highlight the importance of individualized treatment based on histopathology and disease stage.
Co-Authors . Fitriyani Adnan Adnan Adnan, Adnan Adrian A. Kaptein Adrian A. Kaptein Ajeng Diantini Akrom, Akrom Ambar Yunita Nugraheni Anak Agung Gede Sugianthara Andriana Sari Andriana Sari Anisa Devi Kharisma Wibowo Antoni, Priski Ardhiani, Menit Ardiansyah, Ryan Ari Kristina, Susi Ariska Wigatiningtyas Aristia, Bella Fevi Atikah Nur Shabrina Aulia Kurniapuri Auliya A. Suwantika Azis Ikhsanudin Bambang Purwoko Basuki, Adriyanto Rochmad Boisi, Cici Feronika Budiyono Budiyono Cahya Putri, Ardana Candradewi, Susan Fitria Chong, Rockie Cut Fatia Ulfa Cut Fatia Ulfa Damayanti, Elok Della Midi Wardhani Dewi, Masita Sari Dwi Hastuti Dwi Utami Dyah A. Perwitasari Dyah A. Perwitasari Dyah Aryani Perwitasari Ela Fadilah Pramsa Endah Karuniawati Endang Darmawan Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Esty Elvinda Fahrian Hipmi, Ahmad Farid, Yandira Mifta Fasyir, Syaima’ Rihan Fatkhiya, Musa Fitri Fatma Nuraisyah, Fatma Feangi, Yanti Fitriani Firman Firman Fitri Ayu Wahyuni Fitri Nur Mahmudah Fitri Qoriawaty Fitriana, Elinda Fitriyani Fitriyani Fitriyani, Fitriyani Gailea, Astrimulyana Giatna, Sifak Gita Husna Rahmadani Gustinanda, Rizky Haafizah Dania Hadiq, Shabran Hanindia Riyani Hariadi Wijaya, Made Hasniah Hasniah Hendra Darmawan Hendy Ristiono, Hendy Herjanti Ratnawiningsih Hesty Riza Oktastika Hidayah Apriliawan Hidayati, Ana Iin Ike Ardiani Ilham Bintang Agung Imaniar Noor Faridah Imaniar Noor Faridah Joko Sudibyo Jumiati Kaptein, Adrian A. Kartikasari, Ayu Lifia Nur Khairi, Sabiah Kristina, Susi Ari Kristina Kurniawan, Rendy Kurniyati, . Kurniyati, . Lalu Muhammad Irham Lolita Lukman Hakim Maharani, Fadya Bella Suci Malihi, La Mashita, Siti Masita Sari Dewi Ma’ruf, Muhammad Monica, Lia Mufidah, Syarifatul Muh Muhlis Muh Muhlis, Muh Muhammad Muhlis Muhammad Muhlis Muhammad MuMuhlis Muhammad Thesa Ghozali Muhartati, Sri Aisyah Muhlis, Muh Murwiningsih Murwiningsih Naguib Ahmed Osman, Ahmed Mohamed Yehia Novita, Sisri Nugraha, Media Fitri Isma Isma Nur P, Kanindya Nur Rahmatiya Abas, Siti Nur Shabrina, Atikah Nurfadilasari, Ulfa Mustofa Nurul Qomariyah Nuzulan, Moh. Aji Zulfan Perwitasari, Dyah A. Pranata, Satria Priski Antoni Purwanto , Barkah Djaka Purwanto, Barkah Djaka Puspitaningrum, Anisa Nova Puspitasari, Kartini Qarriy 'Aina Urfiyya Qifari Nasrun, Rahmar Rahmawati, Priska Ardya Rahmiati, Siti Rahmmawati, Rini Rassyifa, Aloina Jean Ratna R. Ratna, R Restu Pranandari Riat El Khair Rikifani, Shoma Rizky Budi Santoso Rizky Maulana, Nafta Rumambi, Tita Yulianti Ruri Renggani Sandra Saputri, Ginanjar Zukhruf Sari, Prita Anggraini Kartika Sary, Mega Indah Seseray, Yuliana Ludia Shoma Rikifani Siswanto, Lalu Muhammad Harmain Siti Rahmiati Siti Rahmiati Sri Aisyah Muhartati Sri Aisyah Muhartati Sri Awalia Febriana Sri Sulistyorini Stefy Muliyani Muljabar Sudibyo, Joko Sugiyarto Surono, Sugiyarto Sulastri Sulastri Sulastri Sulastri Supadmi, Woro Supadmi Susi Ari Kristina Susilo, Rinto Suwantika, Auliya Abdurrohim Tina Rostinawati Triandika, Rifaldy Trisna , Yulia Trisna, Yuliana Triyo Nova Wahyuni, Fitri Ayu Wijaya, Made Hariadi Wirawan Adikusuma Yulia Indah Widianti Yuni Lestari Yuptarol Mujahidah Zukhruf Saputri, Ginanjar