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EVALUASI KEPATUHAN PASIEN DIABETES MELITUS TIPE 2 DI RUMAH SAKIT UMUM PKU MUHAMMADIYAH BANTUL, YOGYAKARTA Adikusuma, Wirawan; Perwitasari, Dyah Aryani; Supadmi, Woro
Media Farmasi: Jurnal Ilmu Farmasi Vol. 11 No. 2: September 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v11i2.1880

Abstract

Diabetes melitus merupakan sekumpulan penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin atau kedua-duanya. Penelitian ini dilakukan untuk mengetahui kepatuhan pasien DM tipe 2 di RSU PKU Muhammadiyah Bantul.Penelitian ini dilakukan dengan metode observasional crossectional dengan mengambil data pasien secara prospektif selama periode Oktober-Desember 2013. Subyek penelitian adalah pasien diabetes melitus tipe 2 rawat jalan di RSU PKU Muhammadiyah Bantul yang telah menerima antidiabetik oral minimal 6 bulan terapi sebelum pengukuran kepatuhan. Subyek yang memenuhi kriteria inklusi sejumlah 56 pasien diabetes melitus tipe 2 dibagi menjadi dua kelompok yaitu kelompok monoterapi sejumlah 24 pasien dan kelompok kombinasi terapi sejumlah 32 pasien. Pengumpulan data dilakukan dengan melakukan wawancara dan pengisian kuesioner Medication Adherence Report Scale (MARS) untuk mengukur kepatuhan.  Hasil penelitian menunjukkan bahwa tingkat kepatuhan antara monoterapi dan kombinasi terapi berbeda signifikan (p>0,05). Pada faktor karakteristik hanya jenis kelamin yang berpengaruh terhadap kepatuhan  [RR=0,463; interval kepercayaan 95%: 0,202-1,062]  
Proportion and Factors Predicted Self- Medication in Elderly Population in Yogyakarta Sari, Andriana; Supadmi, Woro; Perwitasari, Dyah Aryani
Media Farmasi: Jurnal Ilmu Farmasi Vol. 12 No. 1: Maret 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v12i1.3025

Abstract

Pharmacists should give more attention in giving pharmaceutical care services to the elderly patients, because the decrease of physiological function could result more drug related problems. Currently, elderly patients are interesting to do self- medication before visiting the physician. Thus, our study was aimed to understand  the proportion of elderly patients who are interesting to do the self-medication and to explore the factors predicted self-medication behavior. This study was carried out by cross-sectional design. Data was collected by doing interview and giving questionnaire to the 544 elderly patients in the pharmacies of YogyakartaProvince which were chosen by proportional area sampling method. Data was analyzed descriptively and using the chi square test to understand factors which could be influenced self medication behavior. Most of the patients choose to do the self medication (63.6%) rather than directly went to the physician (36.4%).  There were 3 predictors of self medication behavior in our study, which were occupation, income and type of disease with the RR were; 0.823 (95% CI:0.7010.965), 1.433 (95% CI:1.173-1.751) and 1.027 (95% CI: 1.059-1.376), respectively.The occupation, income and chronic disease could predict of self medication behavior in elderly patients.
Direct medical cost of metformin and metformin-glimepiride in type 2 diabetes mellitus patients Sulastri, Sulastri; Hadiq, Shabran; Supadmi, Woro; Perwitasari, Dyah Aryani
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.21588

Abstract

Diabetes mellitus (DM) requires long-term therapy. Selection of the right therapy was very important to provide optimal results at an affordable cost. One of the main standards of oral antidiabetic therapy prescribed for type 2 DM (T2DM) is metformin, either alone or in combination therapy. The purpose of this study was to describe the direct medical costs in type 2 DM patients between metformin and metformin-glimepiride therapy. This research was an observational and descriptive. Demographic and clinical data were taken prospectively from the complete medical records of data patients with the main diagnosis of DM who fulfilled the inclusion criteria in the period January 2019–November 2020 at RSU Nene Mallomo Sidenreng Rappang, South Sulawesi and the two Public Health Centers namely Puskesmas Galur. II and Panjatan II Kulon Progo Yogyakarta. Cost data includes total medical costs from the hospital/ healthcare perspective (cost of drugs, doctor's services and checkups, fees for checking Fasting Blood Glucose/ Gula darah Puasa (GDP) and Blood Glucose Level While/ Gula Darah Sewaktu (GDS)) and total costs from the Badan Penyelenggara Jaminan Sosial (BPJS)/ payer perspective (INA-CBG's rates) were covered by insurance. The results showed that the average direct medical costs at the hospital and the two Public Health Centers respectively were metformin therapy in IDR (Indonesian Rupiah) namely IDR 120.736 and IDR 9.072,- and metformin-glimepiride therapy of IDR 126.298,- and IDR 18.634,-. It can be concluded that the average direct medical cost of metformin therapy is lower than metformin-glimepiride therapy.
Cost-effectiveness analysis of metformin and metformin-glimepiride in patients with type 2 diabetes at nene mallomo sidrap general hospital Hadiq, Shabran; Supadmi, Woro; Perwitasari, Dyah Aryani
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.21608

Abstract

Metformin and metformin-glimepiride are cost-effective therapy options and are most commonly prescribed to treat type 2 diabetes mellitus (DM). This study aims to determine the cost-effectiveness of using metformin and metformin-glimepiride in patients with type 2 DM at Nene Mallomo Sidenreng Rappang General Hospital. This analytical descriptive observational research employed a retrospective cohort design. The data of type 2 DM patients, new and old patients, were obtained from the medical record unit. The target population was data of outpatients for the period January-December 2019. The parameter of the therapeutic effectiveness is the random blood sugar levels of the patients after receiving treatment. The data on cost from the hospital perspective were obtained from the administration and finance unit. Cost-effectiveness analysis employed calculations of the average cost-effectiveness ratio (ACER) and the incremental cost-effectiveness ratio (ICER). Meanwhile, the risk ratio (RR) employed the analytical chi-squared method to determine the relationship between the two types of therapies and their effectiveness. This study has revealed that 30 patients met the inclusion criteria; 14 patients received metformin therapy and 16 patients received metformin-glimepiride therapy. Metformin therapy is more effective (64.29%) and more costly (IDR120,736). The metformin's ACER value is 1877.99, and its ICER value is -3107.26. The cost-effectiveness analysis has revealed that metformin therapy is more cost-effective than metformin-glimepiride therapy. Meanwhile, the chi-squared analysis has discovered no relationship between the two therapies and their effectiveness. The RR value of 1.080 concludes that metformin has 1.080 as much therapeutic effectiveness as the metformin-glimepiride.
Quality of life of dengue patients in Panembahan Senopati regional general hospital Wigatiningtyas, Ariska; Perwitasari, Dyah Aryani; Faridah, Imaniar Noor; Dania, Haafizah; Supadmi, Woro
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.22509

Abstract

Yogyakarta is one of the top 10 cities with the highest number of dengue cases in Indonesia. One of the reasons for this is the lack of knowledge about the dengue virus in the community. To find out the quality of life of dengue patients in the Bantul Penembahan Senopati Public Hospital.This research uses the descriptive method with a cross-sectional design. The sampling technique utilized was the purposive sampling method. 18 research subjects were chosen as the sample with an inclusion criteria of patients undergoing inpatient treatment and aged > 4 years of age. This study used the EQ-5D-5L and EQ-5D-Y.The quality of life of 70% of the adult patients experienced pain of EQ-VAS 67 ± 17.191, while all child patients experienced pain of EQ-VAS 54.375 ± 11.783. The quality of life of dengue patients was measured with the EQ-5D-5L for adults and EQ-5D-Y for children and obtained a poor score due to a decrease in the dimension of pain felt and the usual activities done such as working, studying, and playing.
Identification of Biomarker for Stunting Through Prioritization of Gene-Assosiated Variants Wibowo, Anisa Devi Kharisma; Puspitaningrum, Anisa Nova; Ma’ruf, Muhammad; Irham, Lalu Muhammad; Supadmi, Woro; Kartikasari, Ayu Lifia Nur; Adikusuma, Wirawan; Chong, Rockie; Firman, Firman; Nugraha, Media Fitri Isma Isma; Siswanto, Lalu Muhammad Harmain; Khairi, Sabiah; Pranata, Satria
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.28297

Abstract

Stunting is a condition of impaired growth and development in children due to chronic nutritional disorders or infections. The risk factor for stunting is dominated by disease during 1000 days of life. The incidence of stunting in Indonesia is 21.6%, according to the Indonesian Nutrition Status Survey (SSGI) results. This study aimed to identify stunting biomarkers based on the priority scoring of gene variants. Identification of stunting risk genes used the Genome-Wide Association Studies (GWAS) approach and Haploreg v4.1. We found 33 genes that identifies as stunting risk gene. And then, we prioritize based on two functional annotation categories: missense-nonsense and cis-expression quantitative trait loci (cis-eQTL). Our analysis found 4 genes as biological stunting risk genes: MTRR, TTF1, CASP1, and CARD17. This research demonstrates the integration of genomic variants and bioinformatics approaches to reveal biological insights for stunting.
Co-Authors . Fitriyani Adnan Adnan Adnan, Adnan Adrian A. Kaptein Adrian A. Kaptein Ajeng Diantini Akrom Akrom Akrom, Akrom Ambar Yunita Nugraheni Anak Agung Gede Sugianthara Andriana Sari Andriana Sari Antoni, Priski Ardhiani, Menit Ardiansyah, Ryan Aristia, Bella Fevi Atikah Nur Shabrina Aulia Kurniapuri Auliya A. Suwantika Azis Ikhsanudin Bambang Purwoko Boisi, Cici Feronika Budiyono Budiyono Candradewi, Susan Fitria Chong, Rockie Cut Fatia Ulfa Cut Fatia Ulfa Damayanti, Elok Della Midi Wardhani Dwi Hastuti Dwi Hastuti Dwi Sulisworo Dyah A. Perwitasari Dyah A. Perwitasari Dyah Aryani Perwitasari Ela Fadilah Pramsa Endah Karuniawati Endang Darmawan Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Esty Elvinda Fahrian Hipmi, Ahmad Farid, Yandira Mifta Fasyir, Syaima’ Rihan Fatkhiya, Musa Fitri Fatma Nuraisyah, Fatma Firman Firman Fitri Ayu Wahyuni Fitri Nur Mahmudah Fitri Qoriawaty Fitriana, Elinda Fitriyani Fitriyani Fitriyani, Fitriyani Gailea, Astrimulyana Giatna, Sifak Gita Husna Rahmadani Gustinanda, Rizky Haafizah Dania Hadiq, Shabran Hanindia Riyani Hariadi Wijaya, Made Hasniah Hasniah Hendra Darmawan Hendy Ristiono Herjanti Ratnawiningsih Hesty Riza Oktastika Hidayah Apriliawan Hidayati, Ana Iin Ike Ardiani Ilham Bintang Agung Imaniar Noor Faridah Imaniar Noor Faridah Joko Sudibyo Jumiati Kanindya Nur P Kaptein, Adrian A. Kartikasari, Ayu Lifia Nur Khairi, Sabiah Kurniyati, . Kurniyati, . Lalu Muhammad Irham Lolita Lukman Hakim Maharani, Fadya Bella Suci Malihi, La Mashita, Siti Masita Sari Dewi Ma’ruf, Muhammad Monica, Lia Mufidah, Syarifatul Muh Muhlis Muhammad Muhlis Muhammad Muhlis Muhammad MuMuhlis Muhammad Thesa Ghozali Muhammad Yusron Maulana El-Yunusi Muhartati, Sri Aisyah Muhlis, Muh Murwiningsih Murwiningsih Novita, Sisri Nugraha, Media Fitri Isma Isma Nur Rahmatiya Abas, Siti Nur Shabrina, Atikah Nurfadilasari, Ulfa Mustofa Perwitasari, Dyah A. Pranata, Satria Priski Antoni Purwanto , Barkah Djaka Purwanto, Barkah Djaka Puspitaningrum, Anisa Nova Puspitasari, Kartini Qarriy 'Aina Urfiyya Rahmar Qifari Nasrun Rahmiati, Siti Rahmmawati, Rini Rassyifa, Aloina Jean Ratna R. Rendy Kurniawan Restu Pranandari Riat El Khair Rikifani, Shoma Rizky Budi Santoso Rumambi, Tita Yulianti Ruri Renggani Sandra Saputri, Ginanjar Zukhruf Sari, Prita Anggraini Kartika Sary, Mega Indah Seseray, Yuliana Ludia Shoma Rikifani Siswanto, Lalu Muhammad Harmain Siti Rahmiati Siti Rahmiati Sri Aisyah Muhartati Sri Aisyah Muhartati Sri Awalia Febriana Sri Sulistyorini Stefy Muliyani Muljabar Sudibyo, Joko Sugiyarto Surono, Sugiyarto Sulastri Sulastri Sulastri Sulastri Susan Fitria Candradewi Susilo, Rinto Suwantika, Auliya Abdurrohim Tina Rostinawati Triandika, Rifaldy Trisna , Yulia Trisna, Yuliana Triyo Nova Wibowo, Anisa Devi Kharisma Wigatiningtyas, Ariska Wijaya, Made Hariadi Wirawan Adikusuma Yulia Indah Widianti Yuni Lestari Yuptarol Mujahidah Zukhruf Saputri, Ginanjar