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All Journal IAES International Journal of Artificial Intelligence (IJ-AI) International Journal of Public Health Science (IJPHS) Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Berkala Epidemiologi Jurnal Farmasi Klinik Indonesia Jurnal Farmasi Sains dan Komunitas JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmaseutik JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Kefarmasian AKFARINDO Jurnal Peduli Masyarakat Jurnal Farmagazine Journal of Holistics and Health Sciences (JHHS) Jurnal Insan Farmasi Indonesia Jurnal Serambi Abdimas Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kesehatan Prosiding University Research Colloquium International Journal of Health Science and Technology Sciences of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Jurnal Farmasi Galenika Clinical and Pharmaceutical Sciences Journal
Woro Supadmi
Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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The Relationship Between Medication-Related Burden and Therapy Compliance of Hypertension Patients Supadmi, Woro; Afifa, Shafira Diestra; Izzah, Fiya Nailil; Gustinanda, Rizky
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501420

Abstract

Hypertension prevalence in the Special Region of Yogyakarta (31.8%) is higher than the national average (30.8%), and long-term medication use may create a burden that negatively affects adherence. This study aimed to evaluate the relationship between medication-related burden and adherence among hypertensive outpatients at Panembahan Senopati Bantul Regional Hospital and Yogyakarta City Regional Hospital. Using a cross-sectional design, 161 patients were recruited between January and February 2025. Medication-related burden was assessed with the Living with Medicines Questionnaire version 3 (LMQ-3), while adherence was measured using the Medication Adherence Rating Scale-5 (MARS-5). Most patients experienced a low burden (76.4%), followed by no burden (15.5%) and moderate burden (8.1%). Regarding adherence, 83.2% showed moderate adherence and 16.8% high adherence. Spearman’s correlation analysis revealed a significant negative relationship between medication-related burden and adherence (p=0.000; Rho = -0.461). These findings suggest that a higher treatment burden reduces adherence to antihypertensive therapy, highlighting the need for strategies to minimize patient burden and improve treatment outcomes.
Potential Drug–Drug Interactions in Antihypertensive Therapy Among Outpatients with Comorbidities: Prevalence, Severity, and Clinical Implications Prita Anggraini Kartika Sari; Rahayu, Ade Rahmawati; Noor Faridah, Imaniar; Supadmi, Woro; Sari, Andriana; Ahmed, Bilal
Clinical and Pharmaceutical Sciences Journal Vol. 2 No. 1 (2026)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v2i1.563

Abstract

Hypertension is a condition that frequently coexists with comorbidities, often necessitating polypharmacy and consequently increasing the risk of drug-drug interactions (DDIs). This study aimed to analyze the pattern and severity of potential DDIs among hypertensive outpatients with comorbidities at North Lombok Regional General Hospital in 2024. This study employed a descriptive observational design with retrospective data collection. A total of 100 outpatient medical records meeting the criteria were selected via probability sampling from the hospital database during January to December 2024. Among the included patients, 50% were aged >60 years, 60% were female, and 91% were covered by the National Health Insurance. Potential DDIs were assessed using the Drugs.com drug interaction checker and categorized based on severity into major, moderate, and minor. A total of 257 potential DDI events were identified, consisting of 19 major interactions (7.4%), 205 moderate interactions (79.8%), and 33 minor interactions (12.8%). The most frequent major interaction was the combination of spironolactone and candesartan, which poses a significant risk of hyperkalemia and hypotension. Moderate interactions were predominantly observed with the combination of furosemide and bisoprolol, which may increase the risk of hyperglycemia and hypertriglyceridemia. Meanwhile, the most frequent minor interaction was aspirin with bisoprolol, which may reduced beta-blocker antihypertensive effect. In conclusion, this study found that moderate severity potential DDIs were the most prevalent and could significantly impact therapeutic outcomes in hypertensive patients with comorbidities. These findings highlight the critical role of clinical pharmacists in identifying and mitigating clinically significant interactions through rigorous prescription monitoring, patient education, and optimization of drug therapy. Strengthened monitoring and evaluation of drug regimens are recommended to minimize the risk of adverse drug reactions and enhance patient safety.
Co-Authors . Fitriyani Adnan Adnan Adnan, Adnan Adrian A. Kaptein Adrian A. Kaptein Afifa, Shafira Diestra Ahmed, Bilal Ajeng Diantini Akrom, Akrom Ambar Yunita Nugraheni Anak Agung Gede Sugianthara Andriana Sari Andriana Sari Anisa Devi Kharisma Wibowo Antoni, Priski Ardhiani, Menit Ardiansyah, Ryan Ari Kristina, Susi Ariska Wigatiningtyas Aristia, Bella Fevi Atikah Nur Shabrina Aulia Kurniapuri Auliya A. Suwantika Azis Ikhsanudin Bambang Purwoko Basuki, Adriyanto Rochmad Boisi, Cici Feronika Budiyono Budiyono Cahya Putri, Ardana Candradewi, Susan Fitria Chong, Rockie Cut Fatia Ulfa Cut Fatia Ulfa Damayanti, Elok Della Midi Wardhani Dewi, Masita Sari Dwi Hastuti Dwi Utami Dyah A. Perwitasari Dyah A. Perwitasari Dyah Aryani Perwitasari Ela Fadilah Pramsa Endah Karuniawati Endang Darmawan Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Endang Yuniarti Esty Elvinda Fahrian Hipmi, Ahmad Farid, Yandira Mifta Fasyir, Syaima’ Rihan Fatkhiya, Musa Fitri Fatma Nuraisyah, Fatma Feangi, Yanti Fitriani Firman Firman Fitri Ayu Wahyuni Fitri Nur Mahmudah Fitri Qoriawaty Fitriana, Elinda Fitriyani Fitriyani Fitriyani, Fitriyani Gailea, Astrimulyana Giatna, Sifak Gita Husna Rahmadani Gustinanda, Rizky Haafizah Dania Hadiq, Shabran Hanindia Riyani Hariadi Wijaya, Made Hasniah Hasniah Hendra Darmawan Hendy Ristiono, Hendy Herjanti Ratnawiningsih Hesty Riza Oktastika Hidayah Apriliawan Hidayati, Ana Iin Ike Ardiani Ilham Bintang Agung Imaniar Noor Faridah Imaniar Noor Faridah Izzah, Fiya Nailil Joko Sudibyo Jumiati Kaptein, Adrian A. Kartikasari, Ayu Lifia Nur Khairi, Sabiah Kristina, Susi Ari Kristina Kurniawan, Rendy Kurniyati, . Kurniyati, . Lalu Muhammad Irham Lolita Lukman Hakim Maharani, Fadya Bella Suci Malihi, La Mashita, Siti Masita Sari Dewi Ma’ruf, Muhammad Monica, Lia Mufidah, Syarifatul Muh Muhlis Muh Muhlis, Muh Muhammad Muhlis Muhammad Muhlis Muhammad MuMuhlis Muhammad Thesa Ghozali Muhartati, Sri Aisyah Muhlis, Muh Murwiningsih Murwiningsih Naguib Ahmed Osman, Ahmed Mohamed Yehia Novita, Sisri Nugraha, Media Fitri Isma Isma Nur P, Kanindya Nur Rahmatiya Abas, Siti Nur Shabrina, Atikah Nurfadilasari, Ulfa Mustofa Nurul Qomariyah Nuzulan, Moh. Aji Zulfan Perwitasari, Dyah A. Pranata, Satria Priski Antoni Prita Anggraini Kartika Sari Purwanto , Barkah Djaka Purwanto, Barkah Djaka Puspitaningrum, Anisa Nova Puspitasari, Kartini Qarriy 'Aina Urfiyya Qifari Nasrun, Rahmar Rahayu, Ade Rahmawati Rahmawati, Priska Ardya Rahmiati, Siti Rahmmawati, Rini Rassyifa, Aloina Jean Ratna R. Ratna, R Restu Pranandari Riat El Khair Rikifani, Shoma Rizky Budi Santoso Rizky Maulana, Nafta Rumambi, Tita Yulianti Ruri Renggani Sandra Saputri, Ginanjar Zukhruf Sari, Prita Anggraini Kartika Sary, Mega Indah Seseray, Yuliana Ludia Shoma Rikifani Siswanto, Lalu Muhammad Harmain Siti Rahmiati Siti Rahmiati Sri Aisyah Muhartati Sri Aisyah Muhartati Sri Awalia Febriana Sri Sulistyorini Stefy Muliyani Muljabar Sudibyo, Joko Sugiyarto Surono, Sugiyarto Sulastri Sulastri Sulastri Sulastri Supadmi, Woro Supadmi Susi Ari Kristina Susilo, Rinto Suwantika, Auliya Abdurrohim Tina Rostinawati Triandika, Rifaldy Trisna , Yulia Trisna, Yuliana Triyo Nova Wahyuni, Fitri Ayu Wijaya, Made Hariadi Wirawan Adikusuma Yulia Indah Widianti Yuni Lestari Yuptarol Mujahidah Zukhruf Saputri, Ginanjar