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All Journal Jurnal Pendidikan Kimia Undiksha Journal of Education and Learning (EduLearn) Biology, Medicine, & Natural Product Chemistry PROSIDING SEMINAR KIMIA Alotrop Jurnal Pendidikan dan Ilmu Kimia Lantanida Journal INKUIRI : Jurnal Pendidikan IPA Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Indonesian Journal of Chemistry Jurnal Ilmiah Manuntung Paedagoria : Jurnal Kajian, Penelitian dan Pengembangan Kependidikan JOPS (Journal Of Pharmacy and Science) Jambura Journal of Educational Chemistry Jambura Journal of Chemistry Jurnal Mandala Pharmacon Indonesia JURNAL PENDIDIKAN MIPA Edukimia JPM: JURNAL PENGABDIAN MASYARAKAT Hydrogen: Jurnal Kependidikan Kimia Jurnal Kependidikan: Jurnal Hasil Penelitian dan Kajian Kepustakaan di Bidang Pendidikan, Pengajaran dan Pembelajaran CHEDS: Journal of Chemistry, Education, and Science Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Educational Sciences Arfak Chem: Chemistry Education Journal Research and Development in Education (RaDEn) Jurnal Pengabdian Pada Masyarakat Chimica Didactica Acta : Journal of Chemistry and Chemistry Education Jurnal Akademik Pengabdian Masyarakat Bulletin of Chemical Reaction Engineering & Catalysis Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Rahmadani, Agung
Departement Of Chemistry Education, Faculty Of Teaching And Education, Mulawarman University, Samarinda 75123, Kalimantan Timur, Indonesia
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Journal : Jurnal Sains dan Kesehatan

 1 
Profil Kromatografi Senyawa Aktif Antioksidan dan Antibakteri Fraksi Etil Asetat Daun Libo (Ficus variegata Blume.) Mega Rizky Novitasari; Risna Agustina; Agung Rahmadani; Rolan Rusli
Jurnal Sains dan Kesehatan Vol. 1 No. 3 (2015): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i3.30

Abstract

Tumbuhan Libo (Ficus variegata Blume.) memiliki buah yang tidak dimakan oleh hama/serangga, hal ini diduga karena kandungan metabolit sekunder tumbuhan libo mengandung senyawa aktif yang dapat berpotensi sebagai antibakteri maupun antioksidan. Penelitian ini bertujuan untuk mengetahui profil kromatografi senyawa antioksidan dan antibakteri, serta mengetahui golongan metabolit sekunder yang terdapat dalam fraksi aktif etil asetat daun libo. Sampel dimaserasi dengan pelarut metanol. Isolasi dilakukan sebanyak 2 kali yaitu dengan cara kromatografi cair vakum kemudian dilanjutkan dengan kromatografi kolom konvensional. Hasil pemisahan berdasarkan kromatografi kolom konvensional yaitu diperoleh sebanyak 16 fraksi. Dari hasil tersebut kemudian dilakukan pengujian aktivitas antioksidan terhadap DPPH dan pengujian aktivitas antibakteri terhadap bakteri uji dengan metode KLT Bioautografi. Hasil penelitian diperoleh profil kromatografi fraksi etil asetat daun Libo (Ficus variegata Blume.) aktif sebagai antioksidan terhadap DPPH, dan aktif terhadap bakteri, Eschericia coli dan Staphylococcusaureus. Golongan metabolit sekunder aktif fraksi etil asetat daun libo adalah alkaloid, steroid, terpenoid dan fenol.
Analisis GC-MS Senyawa Aktif Antioksidan Fraksi Etil Asetat Daun Libo (Ficus variegata Blume.) Mega Rizky Novitasari; Lizma Febrina; Risna Agustina; Agung Rahmadani; Rolan Rusli
Jurnal Sains dan Kesehatan Vol. 1 No. 5 (2016): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i5.43

Abstract

Daun Libo (Ficus variegata Blume.) memiliki daun yang tidak dimakan oleh hama/serangga, hal ini diduga karena kandungan metabolit sekunder daun libo mengandung senyawa aktif yang potensial salah satunya adalah sebagai antioksidan. Penelitian ini dilakukan untuk mengetahui komponen senyawa antioksidan fraksi etil asetat daun libo dengan metode GC-MS. Interpretasi spektrum massa GC-MS dilakukan dengan menggunakan database WILLEY9THN 08.L. Hasil analisis spektrum GC-MS fraksi etil asetat aktif antioksidan mengandung 2,5-Cyclohexadiene-1,4-dione, 2,6-bis(1,1-dimethylethyl (0,65%), 1-Octadecene (1,29%), 2-Hexadecen-1-ol, 3,7,11,15-tetramethyl- (1,54%), 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione (1,52%), 1-Nonadecene (3,39%), 1-Docosene (3,39%), Nonadecyltrifluoroacetate (2,12%), 1,2-Benzenedicarboxylic acid,(2-ethylhexyl) ester (45,53%), 1-Docosene (2,71%), Pyrene, hexadecahydro (4,56%), Urs-12-en-3-ol, acetate,(3.beta.) (1,97%), 12-Oleanen-3-yl acetate, (3.alpha.)- (5,19%), Urs-12-en-3-ol, acetate,(3.beta.) (1,53 %), Taraxasterol-acetate (0,30%), 1-(Dimethylamino)-5-{[4'-(5"-(4"'-iodophenyl ethynyl|)-1"-naphthylethynyl]-1(8,46%), dan 7,8,17,18-Tetrahydro-35-methoxy-1,3,21,23-tetramethyl-16H,31H-5,9,15,19-dime (10,04%).
Analisis Secara GC-MS Senyawa Aktif Antioksidan Fraksi N-Heksana Daun Libo (Ficus variegata Blume) Vina Maulidya; Myra Puspha Hardina; Lizma Febrina; Rolan Rusli; Agung Rahmadani
Jurnal Sains dan Kesehatan Vol. 1 No. 10 (2018): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i10.101

Abstract

Tanaman Libo (Ficus variegata Blume) merupakan salah satu tumbuhan liar khas Kalimantan Timur sebagai sumber bahan larvasida dan antioksidan. Penelitian bertujuan untuk mengetahui komponen senyawa aktif antioksidan dalam fraksi n-heksana daun Libo dengan metode GC-MS. Interpretasi spektrum GC-MS dilakukan menggunakan database standar National Institute Standard and Technology (NIST). Komponen mayor fraksi n-heksana yang memiliki aktivitas antioksidan antara lain: cyclotetracosane; 1-heneicosanol; 1-docosene; 1,2-benzenedicarboxilic acid; 1-heptacosanol; octacosanol; dan cyclooctacosane.
An In Silico Evaluation of the Anti-Wrinkling Potential of Certain Peptides in Relation to the Catalytic Domain of Matrix Metalloproteinase-1 Rahmadani, Agung; Sukemi, Sukemi; Tasya, Indriana; Olii, Nova Yunita Putri; Ridwansyah, Muhammad; Turista, Dora Dayu Rahma; Arifian, Hanggara
Jurnal Sains dan Kesehatan Vol. 7 No. 1 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i1.2518

Abstract

Skin wrinkles are caused by the cleavage of collagen fibers by the major collagenase enzyme matrix metalloproteinase-1 (MMP-1). Peptide-based matrix metalloproteinase-1 inhibitors present a potential new therapeutic strategy to prevent MMP-1-mediated collagenolysis, which is induced by UV-induced MMP-1 overexpression. This in silico study investigated the MMP-1 inhibitory capacity of carefully selected and well-designed hexapeptides. A molecular docking method was employed to screen 14 hexapeptides. The target ligands were observed to interact non-covalently. The LYYYGP peptide sequence was found to form three hydrogen bonds (H-bonds) with amino acid (AA) residues in the catalytic domain of MMP-1. Additionally, hydrophobic interactions between these peptides and the protein were observed at certain sites. The maximum binding affinity was observed for the LYYYGP sequence (binding free energy, ?G = -9.00 kcal/mol). These sequences exhibited binding energies comparable to those of the LSYYGP sequence (-8.48 kcal/mol) and YSGYYP sequence (-8.27 kcal/mol). The YSGYGY sequence demonstrated a lower binding affinity for the target receptor, with ?G = -5.59 kcal/mol. This study indicates that specific peptide sequence components are crucial for forming hydrogen bonds that link proteins to peptides. Further investigation, encompassing chemical synthesis and laboratory experimentation, is requisite to substantiate the efficacy of the two hexapeptides.
Sintesis, Molecular Docking dan Aktivitas Sitotoksik Senyawa Analog Kalkon Berbasis Alfa Tetralone terhadap Sel Kanker Payudara MCF-7: Synthesis, Molecular Docking, and Cytotoxic Activity of Alpha Tetralone Based Chalcone Analogue Compounds against MCF-7 Breast Cancer Cells Rahmadani, Agung; Tasya, Indriana; Lestari, Wahyu Yunita; Kadir, Nurdianah Abdul; Saputri, Mitha; Erika, Farah; Usman, Usman; Sukemi, Sukemi; Arifian, Hanggara; Salam, Supriatno; Herman, Herman; Rijai, Laode
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2092

Abstract

The chalcone compound is a precursor of flavonoid and pyrazoline compounds. Chalcone has two aromatic rings (A and B) and one ?,?-unsaturated carbon atom. Chalcone compounds can be synthesized via the Claisen Schmidt condensation reaction. Chalcone synthesis uses the basic ingredients of alpha tetralone and benzaldehyde analogues. In this research, chalcone synthesis took place for 48 hours at room temperature. Synthetic materials using ethanol solvent and sodium hydroxide catalyst, as well as basic ingredients alpha tetralone, 3,4-dimethoxybenzaldehyde and 4-methoxybenzaldehyde. Characterization of synthesized compounds using spectroscopic methods, including 1H-NMR, 13C-NMR, Fourier Transform Infrared (FTIR) and mass spectroscopy. Characterization results using spectroscopic methods showed that the two chalcone analogue compounds were successfully synthesized with yields above 70%. Both chalcone compounds showed low activity against MCF-7 cancer cells. Molecular docking simulations showed that both chalcone analogues produced energy levels and intramolecular interactions that were no better than 4-hydroxytamoxifen. Keywords:          chalcone analogues, alpha tetralone, cytotoxic   Abstrak Senyawa kalkon merupakan salah satu prekursor dari senyawa flavonoid dan pirazolina. Kalkon mengandung dua cincin aromatis (A dan B) dan satu atom karbon ?,?-tak jenuh. Senyawa kalkon dapat disintesis melalui reaksi kondensasi Claisen Schmidt. Kalkon disintesis menggunakan bahan dasar alfa tetralone dan analog benzaldehida. Dalam penelitian ini senyawa kalkon disintesis selama 48 jam pada suhu ruang menggunakan pelarut etanol dan katalis natrium hidroksida serta bahan dasar alfa tetralone, 3,4-dimetoksibenzaldehida dan 4-metoksibenzaldehida.  Senyawa hasil sintesis dikarakterisasi menggunakan metode spektroskopi meliputi 1H-NMR, 13C-NMR, Fourier Transform Infrared (FTIR) dan spektroskopi massa. Karakterisasi menggunakan metode spektroskopi menunjukkan kedua senyawa analog kalkon berhasil disintesis dengan rendemen diatas 70%. Hasil pengujian sitotoksik menunjukkan bahwa kedua senyawa analog kalkon tidak aktif terhadap sel kanker payudara MCF-7. Simulasi penambatan molekuler menunjukkan bahwa kedua analog kalkon menghasilkan tingkat energi dan interaksi intramolekuler yang tidak lebih baik dibandingkan dengan 4-hidroksitamoksifen. Kata Kunci:         analog kalkon, alfa tetralone, sitotoksik
Co-Authors Abdul Aziz Adam M. Ramadhan Adam M. Ramadhan Adhani, Aidhil Aditya Fridayanti Afif Ruchaemi Ahmed Jhordy Almeida, Maria Amanuddin Amanuddin Angga Cipta Narsa Anggraeni, Egi Syahrah Anjarwati, Dewi Arief Fadillah Arifian, Hanggara Arjuna Pramana Arum, Alvionita Puspa Asiyah, Mely Nor Ata, Putri Fritami Atin Nuryadin Atria Kent Aulia, Isma Awaliah, Meisya Adelia Salsabila Awaliyah, Nabilah Nailah Bayu Heris Apriyanto Bela Apriliana Ningsih Cahayani, Mega Cahyo, Risky Nor Debbi Pasedan Dewi Noorjannah Utami DEWI RAHMAWATI Dewi Rahmawati Dewi Rahmawati Diana Kurnia Apriani Diana Ntowe Didi Fadilla Eka Rizky Meilinda Elisa Yunita Emma Susilowati Shabir Enggar Wijayanti Erlin Dwi Nurrohimi Erwin Erwin Fairul Muflihah Fajar Prasetya Fajar Prasetya Farah Erika Farah Erika Farah Erika Farah, Harra Ismi Fika Aryati Firman Shantya Budi, Firman Shantya Firnanda Zuni Fransiska Ganjar Firmansyah Hadi Kuncoro Hadi Nur Hajrah Hajrah Hajrah Hajrah Hanggara Arifian Hanggara Arifian Harra Ismi Farah Hartandi, Dimas Hasan, Hafia Hazlina, Nur Helmi Helmi Herman Herman Herman Hilalliyah, Nur Husnul Khatimah Indah Silvia Sugiyamin Indriana Tasya Indriana Tasya Islami, Agustina Amalia Isyra, Klara Wahyu Jaka Fadraersada Jeremia Giawa, Agusto Kadir, Nurdianah Abdul Kama Tasawa, Gymnastiyar Laode Rijai Laode Rijai Laode Rijai Laras Indah Wulandari Larasati, Herlin Alfiana Lestari Lestari Lestari, Wahyu Yunita Lisna Meylina Lita Yulianti Lizma Febrina Lizma Febrina M Arifuddin M. Ari Prayogo Masruhim, Muh. Amir Maulina, Tiara Mega Cahayani Mega Rizky Novitasari Meiliawati, Ruli Mirhansyah Ardana Mitha Saputri Muhammad Ansar Muhammad Choirul Muhammad Ridwansyah Muhammad, Ridwansyah Mukhamad Nurhadi, Mukhamad Myra Puspha Hardina Myra Puspha Hardina Ni'mah, Fatchiyatun Nisa Naspiah Nova Yunita Putri Olii Nur Awaliah Nur Masyithah Zamruddin Nur Shidiq Nurdianah Abdul Kadir Nurdianah Abdul Kadir Nurlaili Nurlaili Nurramadhani, Aisyah Zahra Nursilawati, Nursilawati Nurul Fitriyah Sulaeman, Nurul Fitriyah Nurul Khotimah Olii, Nova Yunita Putri Pakaenoni, Frederich Palapa, Kaleb Gideon Pandiangan, Masda Prastika, Nanda Diah Purwita Sari, Regina Putri Fritami Ata Putri, Rizka Amalia Rachma Nadya Utami Rahayu, Rosika Rahman, Karisa Apriyani Rahman, Zainur Arif Ramadani, Pino Rengganis, Ajeng Ayu RISKA OKTAVIANI Risna Agustina Rizki Nur Analita Rolan Rusli Romisa, Fahmi Salam, Supriatno Saputri, Mitha Sarifah, Awalus Siburian, Putri Dela Silalahi, Yoisi Fortuna Simangunsong, Ari Putra Wijaya Sin Yuan Lai Sinaga, Hilga Natasya Sri Agung Fitri Kusuma Sri Lestari Sri Lestari Sri Wulandari Sriwidodo Sriwidodo Suandi Sidauruk Sukartiningsih Sukartiningsih Sukemi Sukemi Sukemi Sukemi sukmawati Supriatno Salam Supriatno Salam Susanti, Revi Syahputri, Salsabila Dia Tasya, Indriana Teguh Wirawan Tiara Maharani, Tiara Tri Woro Widyanti Tristania, Auriel Wafiq Turista, Dora Dayu Rahma Usman Usman Usman Usman VICTORIA YULITA FITRIANI Vina Maulidya Vina Maulidya Viriyanata Wijaya Wahyu Yunita Lestari Watulingas, Maasje Catherine Wirhanuddin, Wirhanuddin Yulian, Satifa Ananda Yulianti, Ayu Dwi Yuniar Ponco Prananto Yurika Sastyarina Yuspian Nur Zhiying Zhu