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All Journal ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Jurnal Ilmu-Ilmu Peternakan (Indonesian Journal of Animal Science) BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Jurnal Ilmiah Mahasiswa Veteriner Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Tropical Animal Science Journal Jurnal Resolusi Konflik, CSR dan Pemberdayaan (Jurnal CARE) Jurnal Medik Veteriner ARSHI Veterinary Letters JISIP: Jurnal Ilmu Sosial dan Pendidikan Jurnal Media Informatika Jurnal Natural Jurnal Kedokteran Hewan The International Journal of Tropical Veterinary and Biomedical Research Jurnal Pengabdian Bersama Masyarakat Indonesia Jurnal Veteriner dan Biomedis Current Biomedicine Jurnal Medika Veterinaria Jurnal Ilmu Sosial dan Humaniora Prosiding Pengabdian Ekonomi dan Keuangan Syariah Currency Mumtaza: Journal of Community Engagement
Safika S, Safika
Medical Microbiology Division, Department Of Animal Disease And Veterinary Public Health, Faculty Of Veterinary Medicine, IPB University, Bogor, Indonesia
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Aktivitas Imunomodulator Infusa Ginseng Jawa (Talinum paniculatum) pada Mencit (Mus musculus) Digyo, Oscar Daniel Kusumo; Safika; Andriyanto
Jurnal Veteriner dan Biomedis Vol. 2 No. 1 (2024): Maret
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.2.1.1-8.

Abstract

Ginseng jawa diketahui mengandung senyawa aktif yang berpotensi sebagai imunomodulator. Penelitian ini bertujuan mengidentifikasi kemampuan infusa ginseng jawa sebagai imunomodulator berdasarkan aktivitas dan indeks fagositosis makrofag peritoneal mencit serta menentukan dosis yang paling efektif sebagai imunomodulator. Penelitian ini menggunakan 30 ekor mencit galur DDY jantan yang dibagi dalam 5 kelompok, yaitu kontrol negatif (air mineral), kontrol positif (sediaan imunomodulator komersial), infusa ginseng jawa (IGJ) dosis 33 mg/kg BB, 66 mg/kg BB, dan 200 mg/kg BB. Pemberian infusa ginseng jawa dilakukan satu kali sehari selama 14 hari secara peroral dengan mikropipet. Mencit diinduksi dengan Staphylococcus aureus nonpatogen (108 CFU/ml) pada hari ke-15 secara intraperitoneal sebelum dilakukan koleksi cairan peritoneal. Cairan peritoneal lalu dibuat preparat ulas dan dilakukan pengamatan terhadap jumlah makrofag aktif dan S. aureus yang terfagositosis. Selanjutnya aktivitas fagositosis dan indeks fagositosis makrofag dihitung. Hasil pengujian menunjukkan aktivitas fagositosis dan indeks fagositosis pada seluruh kelompok yang diberikan infusa ginseng jawa berbeda nyata (p<0,05) dibandingkan dengan kelompok kontrol. Aktivitas dan indeks fagositosis tertinggi ditemukan pada kelompok IGJ 200 mg/kg BB dengan nilai berturut-turut 74,83%±2,32% dan 3,07±0,05. Infusa ginseng jawa memiliki kemampuan sebagai imunomodulator dengan meningkatkan respons imun nonspesifik berupa aktivitas dan indeks fagositosis makrofag.
Melacak Gen Faktor Virulensi Escherichia coli yang Tahan terhadap Siprofloksasin asal Usap Kloaka Ayam Petelur Peranginangin, Joen Firmanta; Safika, Safika; Palupi, Maria Fatima
Jurnal Sain Veteriner Vol 42, No 1 (2024): April
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.90358

Abstract

Avian Pathogenic Escherichia coli (APEC) is a cause of extraintestinal infections, particularly respiratory infections, pericarditis, and septicemia in poultry (colibacillosis). Research aimed at uncovering the virulence factors responsible for colibacillosis in poultry, especially laying hens in Indonesia, is still quite rare. The purpose of this study is to identify the virulence factors responsible for colibacillosis in E. coli strains resistant to ciprofloxacin. The virulence factors targeted in this research are the genes iss, iutA, iroN, ompT, and hlyF. The study utilized 327 E. coli isolates from the archives of the National Veterinary Drug Assay Laboratory, which were collected in 2021 in seven provinces.All isolates were tested for pathogenicity using Congo Red. Subsequently, E. coli strains determined to be pathogenic were tested for their sensitivity to ciprofloxacin using the agar dilution method. Isolates that were both resistant and pathogenic were then examined for the presence of the virulence genes using polymerase chain reaction (PCR). Based on the results of the Congo Red test, it was found that 59 isolates (18%) were pathogenic E. coli. Among the 54 pathogenic E. coli isolates subjected to sensitivity testing, 30 isolates were found to be resistant to ciprofloxacin. Subsequently, PCR analysis of these 30 ciprofloxacin-resistant pathogenic E. coli isolates revealed the presence of the iss gene in 29 isolates (96%), iutA in 23 isolates (76.6%), ompT in 19 isolates (63.3%), hlyF in 14 isolates (46.6%), and iroN in 11 isolates (36.6%). Eight isolates showed the presence of all five virulence genes, while the rest had one to three virulence genes. This study demonstrates that virulence genes are commonly found in ciprofloxacin-resistant pathogenic E. coli. This suggests a potential threat to the effectiveness of ciprofloxacin in managing colibacillosis in laying hens.             
Identification and antibiotic resistance patterns of Klebsiella sp. isolated from the feces of Bornean Orangutans (Pongo pygmaeus) at Taman Safari Indonesia, Bogor Nora Dyah Ayu Purnamaningrum; Usamah Afiff; Titiek Sunartatie; Safika Safika; Rahmat Hidayat; Supratikno Supratikno; Yohana Tri Astuti
ARSHI Veterinary Letters Vol. 8 No. 2 (2024): ARSHI Veterinary Letters - May 2024
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.8.2.39-40

Abstract

Orangutan adalah satu-satunya kera besar yang masih bertahan di wilayah Asia Tenggara. Namun, populasi mereka di habitat liar terus menurun, dengan perkiraan menunjukkan penurunan sebesar 50% selama 60 tahun terakhir. Data mikrobiologis mengenai resistensi antibiotik Klebsiella sp. dalam feses Orangutan Kalimantan (Pongo pygmaeus) masih terbatas. Penelitian ini bertujuan untuk mengidentifikasi keberadaan Klebsiella sp. dan mengkaji pola resistensinya terhadap berbagai antibiotik dalam feses Orangutan Kalimantan. Penelitian ini melibatkan isolasi, identifikasi, dan pengujian resistensi antibiotik. Hasilnya menunjukkan bahwa tiga isolat (37,5%) positif untuk Klebsiella sp. Uji sensitivitas mengungkapkan dua pola resistensi yang berbeda di antara isolat Klebsiella sp. dari feses P. pygmaeus yang sehat di Taman Safari Indonesia, Bogor. Isolat-isolat ini menunjukkan resistensi terhadap antibiotik β-laktam tetapi tetap sensitif terhadap antibiotik golongan aminoglikosida, tetrasiklin, dan fluorokuinolon.
Identification and antibiotic resistance testing of Gram-negative rod-shaped bacteria in birds of paradise (Paradisaeidae sp.) Sadhira Parameshtya; Agus Wijaya; Safika Safika
ARSHI Veterinary Letters Vol. 8 No. 4 (2024): ARSHI Veterinary Letters - November 2024
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.8.4.95-96

Abstract

Antibiotic resistance represents a critical global health challenge, and is characterised by the loss of effectiveness of antibiotics against bacterial growth. This phenomenon complicates treatment options for infections, underscoring the need to understand bacterial resistance mechanisms, particularly in protected species such as birds of paradise. This study aimed to identify the bacterial species present in faecal samples from three different species of birds of paradise and evaluate the efficacy of various antibiotics against these bacteria. Samples were collected from Taman Mini Indonesia Indah (TMII) in East Jakarta. Using MacConkey Agar for bacterial isolation and subsequent identification through Gram staining and biochemical tests, this study identified Serratia sp., Klebsiella sp., and Citrobacter sp. Antibiotic susceptibility was assessed using the Kirby-Bauer disk diffusion method against seven antibiotics: erythromycin, gentamicin, oxytetracycline, cefotaxime, sulfamethoxazole, doxycycline, and nalidixic acid. These findings revealed that sulfamethoxazole was notably more effective than the other antibiotics tested, highlighting its potential for treating infections in birds of paradise.
Antibiotics resistance patters of Pasteurella multocida isolation from cattle Usamah Afiff; Safika; Titiek Sunartatie; Ang Jia Leng
ARSHI Veterinary Letters Vol. 9 No. 1 (2025): ARSHI Veterinary Letters - February 2025
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.9.1.27-28

Abstract

Penelitian ini bertujuan untuk mengevaluasi efikasi beberapa antibiotik, termasuk oksitetrasiklin, enrofloksasin, gentamisin, ampisilin, dan eritromisin, terhadap isolat Pasteurella multocida dari sapi. Kerentanan antibiotik dinilai menggunakan metode difusi cakram. Hasilnya mengungkapkan sensitivitas P. multocida yang konsisten terhadap enrofloksasin dan gentamisin, sedangkan tiga dari lima isolat tetap rentan terhadap oksitetrasiklin. Sebaliknya, semua isolat menunjukkan resistensi terhadap eritromisin dan ampisilin. Khususnya, galur Tipe A menunjukkan resistensi yang lebih tinggi terhadap oksitetrasiklin daripada galur Tipe B, mungkin karena tekanan selektif yang berbeda. Temuan ini menggarisbawahi enrofloksasin dan gentamisin sebagai pilihan terapi yang paling efektif untuk septikemia hemoragik pada sapi, mengingat aktivitas antibakterinya yang kuat terhadap P. multocida.
Co-Authors . AKHMALOKA . Darniati A. Indrawati A.Afif Amrullah Abdul Harris Ach. Agil Dzikrullah Adelia Rahayu, Misye Ademi, Gressha Vionalle Afiff , Usamah Afton Attabany Agung Puji Haryanto Agung Satryo Wibowo Agus Wijaya Agus, M. Agustin Indrawati Al Azhar Alfred John Morris Kompudu Alla Asmara Ambar Retnowati Ambar Retnowati Andi Novita Andriyanto Andriyanto Andriyanto Ang Jia Leng Aprilia Hardiati Arif Rachman Putra ARISANDI, FAUZAN Arsih, Ulfi Widi Arsyad, Annisa Wahyuni Asri Munzilin Ayundari Cahyani Azmansyah Azmansyah Beginer Subhan Citra Oktavina Eka Lidyawati Cut Lathifa Nurrady Darajaatul Aliyah, Nelud Darmawi . Darmawi Darmawi Darmawi Darmawi Darmawi Darmawi Darmawi Darmawi Deddy Cahyadi Sutarman Destri Prameswari, Alvira Didit Darmawan Digyo, Oscar Daniel Kusumo Edi Purwanto Eko Sugeng Pribadi Eli Masnawati Erdiansyah Rahmi Erdiansyah Rahmi Erina Erina Erina Erina Erina Erina F Madayanti, F Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu FACHRIYAN HASMI PASARIBU Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Fadjar Sumping Tjatur Rasa Faisal Jamin Faisal Jamin Faisal Jamin Fakhrurrazi Fakhrurrazi Fakhrurrazi Fakhrurrazi FAUZAN ARISANDI Fitria Sari Ramadhani Fitrine Ekawasti, Fitrine Fitriyatus Sholichah, Laila Gressha Vionalle Ademi Gunawan Budi Utomo Hadisa Nadia Handayani Halik Hanifa Hanun Hardianti, Aprilia Hariani, Mila I wayan Teguh Wibawan Ichsan Maulana Ika Mayasari, Ni Luh Putu Imam Mawardi Indah Melzana Irbar, Nur Afmi Islami, Nurfara Ismail Ismail Japar, Wahyudi Juliadi Ramadhan K. Khoirani Karen Lee Keisha Farellia Putri Lindra Khairullah, Aswin Rafif Kheyene Molekandella Boer Kurnia Tiara Aulia Latifa Suryandari Luuk Schoonman M Jalaluddin M. Jalaluddin M. Jalaluddin M. Nur Salim Mahdi Abral Maria Fatima Palupi Maryulia Dewi Masfufah Masfufah, Masfufah Mochammad Su’eb Moliwati Moliwati Moliwati, Moliwati Muh Ramadhan Muhammad Jalaluddin Muttaqien Muttaqien Nabila Swarna Puspa Hermana Nauval Firdana, Chorrysa Nazmi Zahir B. Mohd Zaini Ni Luh Putu Ika Mayasari Ni Luh Putu Ika Mayasari Ni Made Ria Isriyanthi Nihro Afandi Nor Jannah, Nor Nora Dyah Ayu Purnamaningrum Nurhaspika Nurhaspika Nurhaspika, Nurhaspika nurjannaini nurjannaini NURLIANA NURLIANA Nurma Sari, Nurma Nuzul Asmilia P Aditiawati Peranginangin, Joen Firmanta Pratitis S Wibowo Pratitis S Wibowo Puarada, Alif Rahman Rohim Purba, Hastuti Handayani S. Putra, Hamdika Yendri Putra, Purniadi Rafico Rifki Febrian Rahayu Mardikaningsih Rahmat Hidayat Rahmat Hidayat Rahmat Hidayat Rahmat Hidayat Harahap Ramadhan, Juliadi Ramadhani, Fitria Sari Rastina Rastina raudhatul jannah jannah Razali Daud5 Retno Damajanti Rinidar Rinidar Rotinsulu, Dordia Anindita S. G. Ningrum S. Setiyaningsih Sadhira Parameshtya Sari, Wahyu Eka Sartika Juwita Sary, Kezia Arum Sinta Sri Utami Siti Aisyah Siti Aisyah Siti Hajar Siti Wardianah Matondang Sri Suryatmiati Prihandani Suhartila Suhartila Supratikno, Supratikno Susan M Noor Susan M Noor Susan Maphilindawati Noor T. Reza Ferasyi Titiek Sunartatie Titiek Sunartatie Tongku N Siregar U. Affif Ulandari, Rafika Ulfi Widi Arsih Upik Kesumawati Hadi Usamah Afif Uswatun Chasanah Uus Saepuloh Wardinal Wardinal Wenny Novita Sari Wilyo Hendro Fauzan Yamin Yaddi Yandi Syahputra Yohana Tri Astuti Yulia Sari Ismail Zumala Nilasari