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All Journal HAYATI Journal of Biosciences ILMU KELAUTAN: Indonesian Journal of Marine Sciences Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Mandala Pharmacon Indonesia Pharmacoscript Nusantara Science and Technology Proceedings Jurnal Insan Farmasi Indonesia Current Research on Biosciences and Biotechnology Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Farmasi Sains dan Praktis Molekul: Jurnal Ilmiah Kimia Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Borneo Journal of Pharmacy Jurnal Sains dan Teknologi Pangan
Yodha, Agung Wibawa Mahatva
Politeknik Bina Husada Kendari
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : HAYATI Journal of Biosciences

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The Inhibition of 15-Lipoxygenase by Blechnum orientale Leaves and its Glycoside-flavonoid Isolates: In Vitro and In Silico Studies Rissyelly Rissyelly; Syaikhul Aziz; Frangky Sangande; Agung Wibawa Mahatva Yodha; Krisyanti Budipramana; Elfahmi Elfahmi; Sukrasno Sukrasno
HAYATI Journal of Biosciences Vol. 29 No. 3 (2022): May 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.3.353-359

Abstract

Fern is one of the groups of primitive plants rich in secondary metabolites that are commonly used to treat various diseases, including antioxidant, anti-hyaluronidase, anti-inflammation, and respiratory disease but less investigated. Flavonoid is one of the secondary metabolites abundantly present in ferns. This study aims to isolate major compounds found in Blechnum orientale act as 15-lipoxygenase (15-LOX) inhibitors. Inhibition of lipoxygenase decrease the production of leukotriene that induces bronchoconstriction in asthma. Isoquercitrin (Quercetin-3-O-β-glucopyranoside) and trifolin (kaempferol-3-O-β-D-galactoside) have been successfully isolated from Blechnum orientale. Further in silico study was performed to explain the binding mode between flavonoid pyranoside or galactoside and flavonoid aglycone in the 15-LOX cavity and their amino acid residues interaction. Isoquercitrin binds with Ile663, Ile400, Leu408, Leu597, Ala404, and Arg403 in the 15-LOX cavity as a lipoxygenase inhibitor. Trifolin binds the same amino acids as isoquercetin with addition His366, Gln596, and Phe175. Both isoquercitrin and trifolin act as competitive inhibitors against lipoxygenase enzymes.
Secondary Metabolite Compounds from Alpinia monopleura Extract and Evaluation of Anti-Inflammatory Activity based on In Vitro and In Silico Studies Yodha, Agung Wibawa Mahatva; Badia, Esti; Musdalipah; Reymon; Fauziah, Yulianti; Fusvita, Angriani; Arfan; Wahyuni; Sahidin
HAYATI Journal of Biosciences Vol. 31 No. 6 (2024): November 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.6.1154-1164

Abstract

Alpinia monopleura is one of the endemic plants of Sulawesi, and it has an extensive distribution in the region. Research on chemical compounds and biological activities of A. monopleura is essential to continue as an effort to support the utilization of native plants for medicine. The extract was obtained using the maceration method. The chemical compounds in the extract were identified using Liquid Chromatography Mass Spectrometry (LCMS). Bovine Serum Albumin (BSA) and molecular docking methods were used to evaluate the anti-inflammatory activity. Ten compounds contained in the extract were successfully identified, E-para-coumaric acid (1), trans-ferulaldehyde (2), 3,5,6-trihydroxy-4',7-dimethoxyflavone (3), nevadensin (4), malvalic acid (5), ent-16α,17-hydroxy-19-kauranoic acid (6), 3′,5-dihydroxy-7,4'-dimethoxy flavone (7), saurufuran B (8), 5-hydroxy-7,8,2'-trimethoxyflavanone (9) and dehydroabietic acid (10). The anti-inflammatory activity of extracts from rhizomes and stems of A. monopleura were 8.62 and 10.59 mg/L, respectively. Some flavonoids (9 and 7) can bind strongly to specific residues around the COX-2 active site, such as Ser530, thereby interfering with the function of the COX-2 enzyme and reducing the production of pro-inflammatory prostaglandins. Thus, A. monopleura extract has the potential to inhibit inflammatory responses through molecular regulation of the COX-2 enzyme.
Co-Authors Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Agustini Andini Sundowo Andini Sundowo Andini Sundowo Angriani Fusvita Anwar, Irvan Arba, Muhammad Arfan Arfan Arfan Arfan Arfan Asasutjarit, Rathapon Asnani Asnani Astrid Indalifiany Austin Tee, Selfyana Azdar Setiawan, Muh. Badia, Esti Bafadal, Mentarry Baharum, Syarul Nataqain Baru Sadarun Baru Sadarun Budipramana, Krisyanti Daud, Nur Saadah Dhea, Alisha Dian Munasari Elfahmi Elfahmi, Elfahmi Eny Nurhikma Esti Badia Esti Badia Fadhliyah Malik Fauziah, Yulianti Firasmi Sangadji Firdayanti, Firdayanti Fitrawan, La Ode Muhammad Fitrawan, La Ode Muhammad Fitria Nurcahyani Frangky Sangande Fristiohady, Adryan Fusvita, Angriani Gusti Ayu Kade Sutariati Gusti Ray Sadimantara Hariana Hariana, Hariana Harnita, Wa Ode Haruna, Lidya Agriningsih Haslianti Haslianti, Haslianti I Sahidin I. Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin, Sahidin Idris, Sri Aprilianti Ilyas Y, Muhammad Irnawati Irnawati Irnawati Irvan Anwar Jafriati Jumadil Junli Hong Karmilah Karmilah Karmilah Karmilah, Karmilah La Ode Muh. Fitrawan La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama Lisa Wulansari Siregar Loly Subhiaty Idrus Loly Subhiaty Idrus Malaka, Muh. Hajrul Malaka, Muhammad Hajrul Malaka, Muhammad Hajrul Muamar Abdillah Muh. Arnas Muh. Azdar Setiawan Muhammad Azhar Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Israwan Azis Munasari, Dian Murtafia Murtafia Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah, Musdalipah NASRUDIN Nirwati Rusli Nur Af’idah Anas Nur Illiyyin Akib Nur Saadah Daud Nur Saadah Daud Nur Syifa Rahmatika Nur Syifa Rahmatika Nurcahyani, Fitria Nurpajriani, Nurpajriani Nurramadhani A. Sida Nursaadah Daud Pascayantri, Asniar Pryangan, Wulandari Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian RAHMAT MULIADI, RAHMAT Randa Wulaisfan Reymon Reymon Rina Andryani Rini Hamsidi Rissyelly Rissyelly Sahidin Sahidin . Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin, Idin Santi Oktaviani, Santi Saripuddin Selfyana Austin Tee Sernita Sernita Setiawan, Muh. Azdar Sitti Raodah Nurul Jannah Solo, Dian Munasari Sukrasno Sukrasno SURYANI Susanti Susanti Syaikhul Aziz Syamsu Alam Syarul Nataqain Baharum Tee, Selfyana Austin WAHYUNI Wahyuni Wahyuni wahyuni wahyuni Wenty, Darmayanita Yulianti Fauziah Zeptiano, Zeptiano