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Journal : PROFESSIONAL HEALTH JOURNAL

The Effect of CYP3A4, CYP3A5 and ABCB1 Polymorphisms on Tacrolimus Dose Requirements in Adult Kidney Transplant Patients Khusnul Khotimah; Lolita; Lalu Muhammad Irham
PROFESSIONAL HEALTH JOURNAL Vol. 8 No. 1 (2026)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v8i1.1371

Abstract

Introduction: Polymorphisms in the CYP3A4, CYP3A5, and ABCB1 genes play a significant role in the response to tacrolimus therapy in kidney transplant patients. Tacrolimus, a commonly used immunosuppressant, has a narrow therapeutic index and is highly influenced by individual genetic variation. These genetic polymorphisms significantly affect the response to tacrolimus therapy in patients undergoing kidney transplantation. Inaccurate dosing can lead to serious consequences: a tacrolimus dose that is too low increases the risk of acute rejection, while a dose that is too high can cause nephrotoxicity and other serious side effects. Therefore, accurate initial dosing of tacrolimus is critical in the clinical practice of kidney transplantation.. Methods: The article search was conducted using the CrossRef database, which provided access to various scientific journals. The focus was on research published in the last five years, ensuring that only studies exploring polymorphisms related to the CYP3A4, CYP3A5, and ABCB1 genes in the context of tacrolimus were used. Results: Previous analysis revealed that CYP3A5 polymorphisms were the most consistent genetic factors influencing tacrolimus metabolism; expressors with the *1/*1 and *1/*3 genotypes required higher doses to reach target levels, while non-expressors with the *3/*3 genotypes experienced a greater risk of toxicity with elevated trough levels, although contributions from CYP3A4 and ABCB1 varied based on ethnicity and transplantation stage. Conclusions: From the results of this review, it can be concluded that CYP3A5 gene polymorphisms are the primary predictors of tacrolimus dose requirements. Recommendations for implementing CYP3A5 genotyping before transplantation may enhance the efficacy of immunosuppression and reduce the risk of toxicity. Further research is necessary to develop more adaptive, pharmacogenetic-based dosing models and to evaluate the clinical factors influencing tacrolimus pharmacokinetics.
Co-Authors Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Adi Wira Septama Adnan Adnan Afief, Arief Rahman Ageng Brahmadhi Akrom, Akrom Ana Hidayati Anisa Devi Kharisma Wibowo Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Anita Silas La’ah Any Guntarti Arief Rahman Afief Arief Rahman Afief Arief Rahman Afief Auren Nathania Ayu Lifia Nur Kartikasari Azzahra, Fara Barkah Djaka Purwanto Barkah Djaka Purwanto Bramadi Arya Cheung, Rocky Chita Widia Chong, Rockie Citra Ariani Edityaningrum, Citra Danang Prasetyaning Amukti Darmawi . Darmawi Darmawi Daud, Intan Delfi Iskardyani Denys Chichi Kusumastuti Didik Setiawan Donel S Dyah Aryani Perwitasari Eko Mugiyanto Faridah, Imaniar Febriana Astuti Firdayani Firdayani Firdayani Firdayani, Firdayani Firman Firman Fitri, Dwiki Fredrick Dermawan Purba Galuh, Tiwi Gina Noor Djalilah Gustinanda, Rizky Haafizah Dania Haafizah Dania Haafizah Dania Handayani, Eka Wuri Hanisari, Putri Henry Budiawan Prasetya Herjanti Ratnawiningsih Herlina, Tetie Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Ilham alifiar Ilham Alifiar Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Iwan Santoso, Iwan Kartikasari, Ayu Lifia Nur Khair, Riat Khairi, Sabiah Khairurrizki, Amanda Khusnul Khotimah La Malihi Laela Hayu Nurani La’ah, Anita Silas Leina Putri Zahra Lisza Niarisessa Lolita Made Ary Sarasmita Maliza, Rita MARIA BINTANG Maulida Mazaya Ma’ruf, Muhammad Medi Sushanti, Nining Melodia Rezadhini Melodia Rezadhini Menit Ardhiani Menit Ardhiani Muh. Deni Kurniawan Muhammad Fathurrahman Muhammad Yusron Maulana El-Yunusi Mutmainnah Siradjuddin Nanik Sulistyani Nathania, Auren Ni Made Ary Sarasmita Nining Medi Sushanti Nining Medi Sushanti Nining Sugihartini Novi Febrianti Nugraha, Media Fitri Isma Isma Nur Ismiyati Nur Rahayuningsih Pendicho Eko Yuliyanto Pradika, Jaka Pranata, Satria Pratama, Kharisma Puriyanto, Riky Dwi Purwanto, Barkah Djaka Puspitaningrum, Anisa Nova Rafiastiana Capritasari Rahmat Dani Satria Razali, Renardy Reza Renardy Reza Razali Rezadhini, Melodia Ria Indah Pratami Riat El Khair Riat Khair Rizka Novia Atmadani Rockie Chong Rocky Cheung Rocky Cheung Rocky Cheung Rudi, Nyoman S, Donel S, Yuni Salamah, Siti Hajar Sany Sapto Yuliani Saputri, Septiana Satria, Rahmat Dani Sianu, Rahman Sianu, Rahman S Simanjuntak, LB Siswandi Siswandi, Siswandi Siswanto, Lalu Muhammad Harmain Siti Rofida Siti Urbayatun Solikhah Solikhah, EfA Wakhidatus Sugiyanto - Suhandri, Wiwin Suhendra, Gugun Sulistiyani, Nanik Susan Fitria Candradewi Triantoro Safaria Triantoro Safaria Uswatun Chasanah Wahyu Rahmatulloh Wahyu Widyaningsih Wahyu Widyaningsih Wibowo, Anisa Devi Karisma Widyastuti, Lina Wigka Pawestri, Novianti Winarto Winarto Winarto Winarto Wirawan Adikusuma Wiwin Suhandri Wiwit Ade Fidiawati Wiwit Ade Fidiawati Woro Supadmi Woro Supadmi Wulandari, D Yudha Rizky Nuari Zahra, Leina Putri Zainul Amiruddin Zakaria Zakaria, Zainul Amiruddin Zukhruf Saputri, Ginanjar