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Repurposing drugs in endometrial cancer using genomic variants database Darmawi, Darmawi; S, Donel; Suhandri, Wiwin; Winarto, Winarto; Adikusuma, Wirawan; Irham, Lalu Muhammad; Fidiawati, Wiwit Ade; Razali, Renardy Reza; Nathania, Auren; Zahra, Leina Putri
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

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Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
EKSPLORASI HAMBATAN KEPATUHAN PENGOBATAN PASIEN DIABETES MELITUS DI PUSKESMAS: STUDI KUALITATIF Alfian, Riza; Fawwazi, Muhammad Hafizh Abiyyu Fathin; Faqih, Muhammad; Adikusuma, Wirawan
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2789

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Medication adherence is a crucial factor in the successful management of diabetes mellitus, yet many studies show that adherence remains low and is shaped by multidimensional influences. This study aimed to explore barriers to medication adherence among patients with diabetes mellitus in primary health centers (Puskesmas) using the WHO five-domain adherence framework. A qualitative descriptive-exploratory design was applied. Data were collected through in-depth interviews with ten patients undergoing routine treatment at Puskesmas in Banjarmasin City, recruited through purposive sampling. Thematic analysis was performed guided by the WHO adherence model. Five major themes emerged. Social and economic factors included limited transportation costs, distance to the health center, and lack of family support. Health system and provider factors involved brief consultations, insufficient patient education, and long queues. Condition-related factors comprised the absence of immediate symptoms, fatigue from chronic illness, comorbidities, and psychological distress. Therapy-related factors included complex regimens, side effects, and discontinuation of therapy without consultation. Patient-related factors were characterized by forgetfulness, reliance on alternative medicine, fluctuating motivation, and feelings of boredom. These findings highlight that adherence barriers are multidimensional and result from the interaction of individual, social, and system-level determinants. Addressing adherence requires holistic and continuous interventions at the primary care level, with emphasis on patient education, family involvement, and strengthening the role of healthcare providers.
THE TREND OF STUDIES RELATED TO MYASTHENIA GRAVIS AND GENETICS IN VARIOUS POPULATIONS AROUND THE WORLD Fitri, Dwiki; Irham, Lalu Muhammad; Sulistyani, Nanik; Adikusuma, Wirawan; Sianu, Rahman S; Ma’ruf, Muhammad
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1944

Abstract

Myasthenia gravis (MG) is an autoimmune disease involving the neuromuscular junction, mainly influenced by antibodies to acetylcholine receptors. In addition, antibodies to Muscle-Specific Kinase (MUSK), Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4). It is essential to determine publication trends regarding Myasthenia gravis because, currently, there are no studies that describe Myasthenia gravis publication trends related to genes in this field of study. Bibliometric analysis is used to see research trends, including frequently used keywords, most published journals, most cited publishers, author agencies, and collaboration between authors depicted in visualization using the VOSViewer application. Bibliometric analysis shows that the research trend is increasing from 1969 to 2023. The most frequently used keywords are myasthenia gravis, human, autoimmune disease, genetics, and article. The leading information related to the data is that the average annual publication is 5.89%, and the average citation for documents is 13.9%. Indonesia, as one of the countries experiencing Myasthenia gravis, has excellent potential to increase the number of research articles, which can be a means of exchanging knowledge, ideas, and technology and also has the potential for collaboration with other countries
RETINAL REATTACHMENT OF SCLERAL BUCKLING WITH OR WITHOUT SUTURES FOR RHEGMATOGENOUS RETINAL DETACHMENT AT CIPTO MANGUNKUSUMO NATIONAL GENERAL HOSPITAL IN INDONESIA Adikusuma, Wirawan; Adriono, Gitalisa Andayani; Victor, Andi Arus; Djatikusumo, Ari; Yudantha, Anggun Rama; Hutapea, Mario Marbungaran; Ayuningtyas, Sita Paramita; Harlena, Filza Amara Kamila
International Journal of Retina Vol 9 No 1 (2026): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2026.vol009.iss001.346

Abstract

Introduction: Rhegmatogenous Retinal Detachment (RRD) is a common, vision-threatening condition traditionally managed by Scleral Buckling (SB), Pars Plana Vitrectomy (PPV), or Pneumatic Retinopexy. SB is effective, however, it carries risks such as strabismus and buckle extrusion, often linked to the use of sutures. This study aimed to determine the outcomes and compare complications of SB with and without sutures for primary RRD cases. Methods: This was a retrospective, analytical cross-sectional study of 65 patients who underwent primary SB (alone or combined with PPV) at Cipto Mangunkusumo National General Hospital (RSCM) from January 2023 to December 2024. Data on demographics, clinical factors, anatomical success (retinal reattachment), functional success (BCVA), and complications were collected and analyzed using descriptive statistics and comparative tests (Chi-square, t-test/Mann-Whitney). Result: During the period, 65 RRD patients underwent the SB procedure. Subjects included 28 cases with sutures and 37 cases without. The mean age was 32.88 years, with a majority of male patients (73.8%) with a mean RRD duration of 17.82 weeks. Preoperative clinical findings showed a high rate of myopia, phakic status, RRD extent in 1 and 4 quadrants, single tear, macula-on, and PVR grade A, with preoperative visual acuity of 1.49 logMAR. The overall anatomical success rate was 76.9%. Statistically, there was no significant difference in retinal reattachment success between SB without sutures (75.7%) and SB with sutures (78.6%) (p=0.784). No demographic or clinical factors was found to significantly predict reattachment success. Postoperative complications included cataract (24.6%) and glaucoma (21.5%). Strabismus (4.61%) was only found in the SB with sutures group. No buckle extrusion occurred in either group. Conclusion: Scleral buckling provides a high enough anatomical success rate for RRD. The SB without sutures technique is equally effective in achieving retinal reattachment and shows a lower incidence of strabismus compared to SB with sutures, making it a viable option for RRD management.
ANALYSIS OF RISK FACTORS AND TREATMENT PHASES ON THE SEVERITY OF HEPATOTOXICITY DUE TO ANTI-TUBERCULOSIS DRUGS Isnani, Nazhipah; hadi, Samsul; Sandi, Dita Aulia Dwi; Rahmatullah, Satrio Wibowo; Adikusuma, Wirawan; Saksono, Reni Yustiati; Auralia, Najma; Maulida, Khelda; Setiawan, Feri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2911

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Hepatotoxicity caused by anti-tuberculosis drugs (OAT) is one of the adverse effects of tuberculosis therapy and may lead to liver dysfunction. This study aimed to analyze the relationship between age, gender, and treatment phase with the severity of OAT induced hepatotoxicity, as well as to assess factors influencing the increase in hepatotoxicity grade. This research employed a retrospective cross-sectional design and was conducted at Ulin Regional Hospital Banjarmasin using a total sampling method involving 45 tuberculosis patients. Secondary data were obtained from medical records of TB patients in 2024–2025. The results showed that 62.2% of patients were under 60 years old and 37.8% were over 60 years old. Male patients accounted for 75.6%, while females accounted for 24.4%. The distribution of hepatotoxicity grades was 40% normal, 28.9% grade 1, 20% grade 2, and 11.1% grade 3. Based on the treatment phase, 91.1% of patients were in the intensive phase and 8.9% were in the continuation phase. The Chi square test revealed no significant association between age, gender, or treatment phase and the severity of hepatotoxicity.
Bioinformatics Analysis of Potential Targets of Betulinic Acid Against Virulence Factors of Chlamydia trachomatis Nurani, Erla; Roza, Putri Diana; Darmawi, Darmawi; Irham, Lalu Muhammad; Adikusuma, Wirawan; Anggraini, Dewi
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1465

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Chlamydia trachomatis is an obligate intracellular pathogen responsible for trachoma and sexually transmitted infections, with rising antibiotic resistance posing a major therapeutic challenge. Natural compounds such as betulinic acid, a pentacyclic triterpenoid with broad-spectrum antimicrobial and anti-inflammatory properties, offer potential as alternative therapeutic agents. This study aimed to analyze the potential targets of betulinic acid against C. trachomatis virulence factors using bioinformatics approaches. Protein–compound interaction prediction was performed using STITCH v5.0, while virulence classification was analyzed through VICMpred and VirulentPred. BepiPred v2.0 was employed to identify B-cell epitopes, and PSORTb v3.0 was used to predict subcellular localization. The results identified five proteins targeted by betulinic acid, including DNA topoisomerase IV subunit B (parE), DNA topoisomerase IV subunit A (parC), DNA gyrase subunits (gyrA and gyrB), and sulfite reductase (cysJ). Among these, three were classified as virulence factors: parE (0,2959), parC (0,1754), and cysJ (0,4018). Subcellular localization analysis showed that parE and parC are cytoplasmic proteins essential for DNA replication, while cysJ is associated with the cytoplasmic membrane and metabolic processes. Betulinic acid showed strong potential as an antimicrobial compound targeting key virulence proteins of C. trachomatis. These findings provide foundational insight for further experimental studies to develop betulinic acid–based therapeutic strategies against chlamydial infections.
UNCOVERING PATHOGENIC MISSENSE VARIANTS IN ENDOMETRIOSIS USING A GENOME-WIDE ASSOCIATION STUDY Nurullita Santri, Ichtiarini; Adikusuma, Wirawan; Theda Philothra, Petrina; Fadhliati Maulida, Nurul; Chong, Rockie; Ates, Ilker; Vincent Abero Phiri, Yohane; Muhammad Irham, Lalu
JURNAL KESEHATAN REPRODUKSI Vol 16 No 2 (2025): JURNAL KESEHATAN REPRODUKSI VOLUME 16 NOMOR 2 TAHUN 2025
Publisher : IAKMI South Tangerang Branch

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58185/jkr.v16i2.407

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Background: Endometriosis is a complex gynecological disorder with a strong genetic component. Although genome-wide association studies (GWAS) have identified numerous risk loci, the functional interpretation of protein-altering missense variants remains limited. Objective: This study identified pathogenic missense variants linked to endometriosis risk using publicly available GWAS data and explored implications for genetic risk detection, particularly in underrepresented populations such as Indonesia. Methods: Endometriosis-associated missense single nucleotide polymorphisms (SNPs) were identified from GWAS data, and a total of eight missense SNPs were analyzed. Functional effects were evaluated in silico using PolyPhen-2 and SIFT. Allele frequency distributions were assessed across global populations, and pathway enrichment analysis was conducted using the Reactome database. Results: Several missense variants were significantly associated with increased endometriosis risk (e.g., rs75801644, OR = 3.88; rs144824657, OR = 3.52), while rs2341097 showed a potential protective effect. Functional prediction prioritized variants in genes such as KCNG2 and BSG as potentially damaging. Population analyses revealed marked allele frequency differences, and enriched pathways were related to potassium channel activity, metabolism, extracellular matrix organization, and signal transduction. Conclusion: This study identifies missense variants contributing to endometriosis susceptibility and provides insight into biological pathways. Further experimental validation and clinical studies are warranted.
Identification Target Genes for Potential Biomarkers in Endometriosis from Transcriptomics Database Zahlina, Dian; Iskandar, Benni; Adikusuma, Wirawan; Yusuf, Muhammad; Tiara Fani, Rifia; Ocktariyana, Ocktariyana; Darmawi, Darmawi
Jurnal Kesehatan - STIKes Prima Nusantara Vol 17 No 1 (2026): Jurnal Kesehatan Volume 17 Nomor 1 Tahun 2026 (on progress)
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v17i1.1281

Abstract

Endometriosis is a common benign gynecological disease characterized by the ectopic growth of endometrial tissue. Its pathogenesis is influenced by complex genetic and epigenetic factors, making diagnosis and treatment challenging. This study aimed to identify molecular pathways and candidate genes associated with endometriosis using transcriptomic data. Three datasets (GSE7307, GSE23339, and GSE25628) were retrieved from the Gene Expression Omnibus (GEO) database and analyzed to identify differentially expressed genes (DEGs). A total of 339 intersecting DEGs were obtained and subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. The results indicated enrichment in biological processes related to epithelial cell proliferation and angiogenesis, cellular components associated with the lysosomal lumen and extracellular matrix, and molecular functions involving Wnt-activated receptor activity and low-density lipoprotein particle binding. Ten genes (TAGLN, C7, TCF21, GATA6, GPC3, FZD7, TCEAL2, KLF2, FMO1, and HOXC6) were identified as potential candidate biomarkers. These findings provide preliminary molecular insights into endometriosis and may support future experimental and clinical studies for biomarker development.
BIBLIOMETRIC ANALYSIS OF AIR POLLUTION'S IMPACT ON CHILDREN WITH ASTHMA: INSIGHTS FROM A DECADE OF RESEARCH (2012-2022) Santri, Ichtiarini Nurullita; Irham, Lalu Muhammad; Musfirah, Musfirah; Wardani, Yuniar; Isni, Khoiriyah; Phiri, Yohane Vincent Abero; Rangkuti, Ahmad Faizal; Ekadinata, Nopryan; Adikusuma, Wirawan
The Indonesian Journal of Public Health Vol. 21 No. 1 (2026): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v21i1.2026.140-152

Abstract

Introduction: Asthma, a prevalent chronic inflammatory respiratory ailment, affects approximately 8% of children worldwide, with urban air pollution, particularly traffic-related pollutants, recognized as a significant contributor to its incidence. The heightened vulnerability of children due to their immature respiratory and immune systems accentuates the importance of addressing this issue. Aims: This study aims to explore the relationship between air pollution and children with asthma incidence and map the trends. Methods: We conducted a thorough bibliometric analysis, meticulously selecting 4,420 articles from the Scopus database based on specific inclusion criteria. These criteria included papers published between 2012 and 2022, with a particular emphasis on the keywords "air pollution," "asthma," and "children." Diverse bibliometric analyses, including performance analysis (citation analysis) and science mapping, were facilitated using specialized software. Keyword network construction and clustering analyses utilized data extracted from Bibtex, RIS, and CVS files with VOSviewer software. Results: The study uncovered 4,420 research documents, primarily categorized as "Research Article" (3,726 articles) and "Review Article" (618 articles), with the United States leading in citations (50,169), followed by China (13,187) and the United Kingdom (8,095). Conclusion: This bibliometric study delves into the intricate relationship between air pollution and children with asthma, illuminating extensive literature trends and influential countries. It enriches the understanding of children with asthma and informs future research aimed at mitigating air pollution's impact on this vulnerable population.
Kepatuhan Penggunaan Obat Antihipertensi di Puskesmas Pagesangan Mataram Wirawan Adikusuma; Nurul Qiyaam; Fita Yuliana
Journal of Pharmascience Vol. 2 No. 2 (2015): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v2i2.5823

Abstract

ABSTRAK Keberhasilan suatu pengobatan tidak hanya dipengaruhi oleh kualitas pelayanan kesehatan, sikap, dan keterampilan petugasnya, tetapi juga dipengaruhi oleh kepatuhan pasien. Penelitian ini bertujuan untuk mengetahui kepatuhan penggunaan obat hipertensi dan beberapa variabel karakteristik pasien yang berpengaruh terhadap kepatuhan pasien hipertensi di Puskesmas Pagesangan, Mataram. Penelitian ini dilakukan dengan metode observasional crossectional dengan mengambil data secara prospektif selama periode Februari – Maret 2015. Pengukuran kepatuhan dilakukan dengan menggunakan kuesioner MMAS (Morisky Medication Adherence Scale) yang berisi 8 pertanyaan. Persentase tingkat kepatuhan berdasarkan kuesioner MMAS adalah kepatuhan tinggi 75 % dan kepatuhan rendah 25 %. Berdasarkan analisis Chi Square tidak ada karakteristik subyek penelitian yang berpengaruh terhadap kepatuhan (P>0,05).Kata kunci: Hipertensi, kepatuhan, MMAS ABSTRACTThe success of a treatment is not only influenced by the quality of health services, attitudes and skills of its health workes, but also influenced by patient adherence. This research is aimed to measure adherence to antihypertensive therapy in hypertensive patients at primary health center Mataram, and to investigate patient’s characteristic associated with such adherence. This research was carried out by observational cross-sectional design with prospective data collection during February – March  2015. The measurement of adherence is done by using a questionnaire MMAS (Morisky Medication Adherence Scale) which contains 8 questions. The percentage of the level of adherence by questionnaire MMAS is a high adherence 75% and 25% lower adherence. Based on the analysis of Chi-Square no characteristic of the study subjects that affect adherence (P>0,05).Key word : Hipertensive, Adherence, MMAS
Co-Authors Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Adi Wira Septama Adrian A. Kaptein Afief, Arief R. Afief, Arief Rahman Ageng Brahmadhi Anak Agung Gede Sugianthara Ananda, Dwi Rizki Andayani, Gitalisa Andi Arus Victor Anisa Devi Kharisma Wibowo Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Anita Silas La’ah Anna Pradiningsih Anna Pradiningsih Annisa Abdi Ghifari Arfianti Arfianti Arief Rahman Afief Arief Rahman Afief Arief Rahman Afief Asamuni, GJ Rahma Dewi Ates, Ilker Auralia, Najma Auren Nathania Ayu Fatmala Ayu Lifia Nur Kartikasari Ayuningtyas, Sita Paramita Baiq Leny Nopitasari Baiq Lenysia Puspita Anjani Baiq Nurbaety Barkah Djaka Purwanto Barkah Djaka Purwanto BENNI ISKANDAR Cheung, Rocky Chong, Rockie Cyntiya Rahmawati Danang Prasetyaning Amukti Darmawi Darmawi . Darmawi Darmawi Dewi Anggraini Djatikusumo, Ari Donel S Dyah A. Perwitasari Dyah Aryani Perwitasari Ekadinata, Nopryan Eko Mugiyanto Eko Satria Putra Fadhliati Maulida, Nurul Firdayani Firdayani Firdayani Firdayani, Firdayani Firman Firman Fita Yuliana Fitri, Dwiki Furqani, Nur Gina Noor Djalilah GJ Rahma Dewi Asamuni Haafizah Dania Haafizah Dania Haafizah Dania Hamidy, Muhammad Y. Harlena, Filza Amara Kamila Henry Budiawan Prasetya Herjanti Ratnawiningsih Hutapea, Mario Marbungaran Imaniar Noor Faridah Imaniar Noor Faridah Indri Istiqomah Irham, Lalu M. Irmatika Hendriyani Kartikasari, Ayu Lifia Nur Kemal, Rahmat A. Khair, Riat Khairi, Sabiah Khoiriyah Isni La Malihi Lalu Muhammad Irham La’ah, Anita Silas Leina Putri Zahra Lisza Niarisessa Made Ary Sarasmita Maliza, Rita MARIA BINTANG Maulida Mazaya Maulida, Khelda Maya Savira Ma’ruf, Muhammad Medi Sushanti, Nining Melodia Rezadhini Melodia Rezadhini Moch. Saiful Bachri Muhammad Faqih Muhammad Hafizh Abiyyu Fathin Fawwazi Muhammad Ma'ruf Muhammad Yulis Hamidy Muhammad Yusuf Musfirah Musfirah Nanik Sulistyani Nathania, Auren Nazhipah Isnani Ni Made Ary Sarasmita Nining Medi Sushanti Nining Medi Sushanti Nopitasari, Baiq Leny Nugraha, Media Fitri Isma Isma Nur Furqani Nurani, Erla Nurfi Pratiwi, Nurfi NURUL AZIZAH Nurul Hidayatullah Nurul Qiyaam, Nurul Nurullita Santri, Ichtiarini Ocktariyana, Ocktariyana Pendicho Eko Yuliyanto Phiri, Yohane Vincent Abero Pranata, Satria Purwanto, Barkah Djaka Puspita Anjani, Baiq Lenysia Puspita Puspitaningrum, Anisa Nova Putu Gede Suriya Gunawan Rachmadina, Rachmadina Rahmat Dani Satria Rahmatullah, Satrio Wibowo Rahmawati, Cyntiya Rangkuti, Ahmad Faizal Rangkuti, Ina F. Razali, Renardy Reza Renardy Reza Razali Rezadhini, Melodia Ria Indah Pratami Riat El Khair Riat Khair Rihhadatul Aisy Risma Widia Ningsih Riza Alfian Rockie Chong Rocky Cheung Rocky Cheung Rocky Cheung Roza, Putri Diana S, Donel Safwan Safwan Safwan Safwan Saksono, Reni Yustiati Samsul Hadi Sandi, Dita Aulia Dwi Santri, Ichtiarini Nurullita Satria, Rahmat Dani Setiawan, Feri Shoma Rikifani Sianu, Rahman S Sierly, Nadia Siswanto, Lalu Muhammad Harmain Soraya Soraya Suhandri, Wiwin Theda Philothra, Petrina Tiara Fani, Rifia Tien Partini Tri Murti Andayani Ulfah, Aida J. Uswaton Hasanah Vincent Abero Phiri, Yohane Winarto Winarto Winarto Winarto Wiwin Suhandri Wiwit Ade Fidiawati Wiwit Ade Fidiawati Woro Supadmi Woro Supadmi Yudantha, Anggun Rama Yudha Rizky Nuari Yuniar Wardani Zahlina, Dian Zahra, Leina Putri Zainul Amiruddin Zakaria Zakaria, Zainul Amiruddin