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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Klinik Indonesia Pharmascience Biomedical Journal of Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Ulul Albab SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Lumbung Farmasi : Jurnal Ilmu Kefarmasian Narra J Jurnal Ilmiah Kesehatan (JIKA) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Media Farmasi Indonesia Jurnal Farmasi Klinik dan Sains IJRETINA - International Journal of Retina Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Wirawan Adikusuma
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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EFEK HEPATOPROTEKTIF SERBUK AKAR PASAK BUMI (Eurycoma longifolia Jack.) DILIHAT DARI AKTIVITAS SGPTSGOT TIKUS JANTAN YANG DIINDUKSI CCl4 Adikusuma, Wirawan; Bachri, Moch. Saiful
Pharmaciana Vol. 4 No. 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v4i2.1574

Abstract

This study was designed to evaluate the hepatoprotective effect of the powder Eurycomalongifolia Jack. From the activity level of SGPT-SGOT on CCl4-induced in male rats. Twentyfive male rats (150-250 g) divide in to 5 groups. Group I treated with aquadest was kept asnormal, group II treated with a single dose of CCl4 (1 ml/ kg BW i.p), group III and IV weretreated with Eurycoma longifolia Jack. (100 mg/kg BW and 200 mg/kg BW p.o) respectivelyand CCl4 (1 ml/kg BW i.p), group V treated with a single dose of curcumin (100 mg/kg BWp.o) and CCl4 (1 ml/kg BW i.p). Blood was collected from vena porta for determination ofSGPT-SGOT. The study showed the activity level of SGPT from the rats was treated byEurycoma longifolia Jack. 100 mg/kg BW and 200 mg/kg BW, Curcumin, and control groupsare 150.0±5.099 U/L; 113.6±5.508 U/L; 60.5±2.887 U/L; and 129.0±6.055 U/L respectively. Mean while the activity level of SGOT from the rats was treated by Eurycoma longifolia Jack.100 mg/ kg BW and 200 mg/ kg BW, Curcumin, and control groups are 369.4±11.165;263.0±1.803; 194.5±7.448; and 451.5±16.759 U/L respectively. The Eurycoma longifoliaJack. powder and Curcumin significantly (p < 0.05) declines two enzymes (SGPT and SGOT)than control group. The results concluded that Eurycoma longifolia Jack. powder hashepatoprotective effect.
Repurposing drugs in endometrial cancer using genomic variants database Darmawi, Darmawi; S, Donel; Suhandri, Wiwin; Winarto, Winarto; Adikusuma, Wirawan; Irham, Lalu Muhammad; Fidiawati, Wiwit Ade; Razali, Renardy Reza; Nathania, Auren; Zahra, Leina Putri
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
EKSPLORASI HAMBATAN KEPATUHAN PENGOBATAN PASIEN DIABETES MELITUS DI PUSKESMAS: STUDI KUALITATIF Alfian, Riza; Fawwazi, Muhammad Hafizh Abiyyu Fathin; Faqih, Muhammad; Adikusuma, Wirawan
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2789

Abstract

Medication adherence is a crucial factor in the successful management of diabetes mellitus, yet many studies show that adherence remains low and is shaped by multidimensional influences. This study aimed to explore barriers to medication adherence among patients with diabetes mellitus in primary health centers (Puskesmas) using the WHO five-domain adherence framework. A qualitative descriptive-exploratory design was applied. Data were collected through in-depth interviews with ten patients undergoing routine treatment at Puskesmas in Banjarmasin City, recruited through purposive sampling. Thematic analysis was performed guided by the WHO adherence model. Five major themes emerged. Social and economic factors included limited transportation costs, distance to the health center, and lack of family support. Health system and provider factors involved brief consultations, insufficient patient education, and long queues. Condition-related factors comprised the absence of immediate symptoms, fatigue from chronic illness, comorbidities, and psychological distress. Therapy-related factors included complex regimens, side effects, and discontinuation of therapy without consultation. Patient-related factors were characterized by forgetfulness, reliance on alternative medicine, fluctuating motivation, and feelings of boredom. These findings highlight that adherence barriers are multidimensional and result from the interaction of individual, social, and system-level determinants. Addressing adherence requires holistic and continuous interventions at the primary care level, with emphasis on patient education, family involvement, and strengthening the role of healthcare providers.
THE TREND OF STUDIES RELATED TO MYASTHENIA GRAVIS AND GENETICS IN VARIOUS POPULATIONS AROUND THE WORLD Fitri, Dwiki; Irham, Lalu Muhammad; Sulistyani, Nanik; Adikusuma, Wirawan; Sianu, Rahman S; Ma’ruf, Muhammad
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1944

Abstract

Myasthenia gravis (MG) is an autoimmune disease involving the neuromuscular junction, mainly influenced by antibodies to acetylcholine receptors. In addition, antibodies to Muscle-Specific Kinase (MUSK), Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4). It is essential to determine publication trends regarding Myasthenia gravis because, currently, there are no studies that describe Myasthenia gravis publication trends related to genes in this field of study. Bibliometric analysis is used to see research trends, including frequently used keywords, most published journals, most cited publishers, author agencies, and collaboration between authors depicted in visualization using the VOSViewer application. Bibliometric analysis shows that the research trend is increasing from 1969 to 2023. The most frequently used keywords are myasthenia gravis, human, autoimmune disease, genetics, and article. The leading information related to the data is that the average annual publication is 5.89%, and the average citation for documents is 13.9%. Indonesia, as one of the countries experiencing Myasthenia gravis, has excellent potential to increase the number of research articles, which can be a means of exchanging knowledge, ideas, and technology and also has the potential for collaboration with other countries
RETINAL REATTACHMENT OF SCLERAL BUCKLING WITH OR WITHOUT SUTURES FOR RHEGMATOGENOUS RETINAL DETACHMENT AT CIPTO MANGUNKUSUMO NATIONAL GENERAL HOSPITAL IN INDONESIA Adikusuma, Wirawan; Adriono, Gitalisa Andayani; Victor, Andi Arus; Djatikusumo, Ari; Yudantha, Anggun Rama; Hutapea, Mario Marbungaran; Ayuningtyas, Sita Paramita; Harlena, Filza Amara Kamila
International Journal of Retina Vol 9 No 1 (2026): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2026.vol009.iss001.346

Abstract

Introduction: Rhegmatogenous Retinal Detachment (RRD) is a common, vision-threatening condition traditionally managed by Scleral Buckling (SB), Pars Plana Vitrectomy (PPV), or Pneumatic Retinopexy. SB is effective, however, it carries risks such as strabismus and buckle extrusion, often linked to the use of sutures. This study aimed to determine the outcomes and compare complications of SB with and without sutures for primary RRD cases. Methods: This was a retrospective, analytical cross-sectional study of 65 patients who underwent primary SB (alone or combined with PPV) at Cipto Mangunkusumo National General Hospital (RSCM) from January 2023 to December 2024. Data on demographics, clinical factors, anatomical success (retinal reattachment), functional success (BCVA), and complications were collected and analyzed using descriptive statistics and comparative tests (Chi-square, t-test/Mann-Whitney). Result: During the period, 65 RRD patients underwent the SB procedure. Subjects included 28 cases with sutures and 37 cases without. The mean age was 32.88 years, with a majority of male patients (73.8%) with a mean RRD duration of 17.82 weeks. Preoperative clinical findings showed a high rate of myopia, phakic status, RRD extent in 1 and 4 quadrants, single tear, macula-on, and PVR grade A, with preoperative visual acuity of 1.49 logMAR. The overall anatomical success rate was 76.9%. Statistically, there was no significant difference in retinal reattachment success between SB without sutures (75.7%) and SB with sutures (78.6%) (p=0.784). No demographic or clinical factors was found to significantly predict reattachment success. Postoperative complications included cataract (24.6%) and glaucoma (21.5%). Strabismus (4.61%) was only found in the SB with sutures group. No buckle extrusion occurred in either group. Conclusion: Scleral buckling provides a high enough anatomical success rate for RRD. The SB without sutures technique is equally effective in achieving retinal reattachment and shows a lower incidence of strabismus compared to SB with sutures, making it a viable option for RRD management.
ANALYSIS OF RISK FACTORS AND TREATMENT PHASES ON THE SEVERITY OF HEPATOTOXICITY DUE TO ANTI-TUBERCULOSIS DRUGS Isnani, Nazhipah; hadi, Samsul; Sandi, Dita Aulia Dwi; Rahmatullah, Satrio Wibowo; Adikusuma, Wirawan; Saksono, Reni Yustiati; Auralia, Najma; Maulida, Khelda; Setiawan, Feri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2911

Abstract

Hepatotoxicity caused by anti-tuberculosis drugs (OAT) is one of the adverse effects of tuberculosis therapy and may lead to liver dysfunction. This study aimed to analyze the relationship between age, gender, and treatment phase with the severity of OAT induced hepatotoxicity, as well as to assess factors influencing the increase in hepatotoxicity grade. This research employed a retrospective cross-sectional design and was conducted at Ulin Regional Hospital Banjarmasin using a total sampling method involving 45 tuberculosis patients. Secondary data were obtained from medical records of TB patients in 2024–2025. The results showed that 62.2% of patients were under 60 years old and 37.8% were over 60 years old. Male patients accounted for 75.6%, while females accounted for 24.4%. The distribution of hepatotoxicity grades was 40% normal, 28.9% grade 1, 20% grade 2, and 11.1% grade 3. Based on the treatment phase, 91.1% of patients were in the intensive phase and 8.9% were in the continuation phase. The Chi square test revealed no significant association between age, gender, or treatment phase and the severity of hepatotoxicity.
Integrative PharmGKB and GTEx Analysis Identifies Candidate Pharmacogenomic Biomarkers of Toxicity in Thyroid Cancer Therapy Rahmawati, Desti; Muhammad Irham, Lalu; Adikusuma, Wirawan; Lolita, Lolita; Gustinanda, Rizky; Chong, Rockie; Ates, Ilker; Dewi Tamayanti, Wahyu; Dani Satria, Rahmat
Media Farmasi: Jurnal Ilmu Farmasi Vol. 23 No. 1 (2026): March 2026
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v23i1.31952

Abstract

Systemic therapies such as Lenvatinib and radioiodine in thyroid cancer (TC) show promising clinical efficacy, but often cause significant toxicity. Interindividual variability in response to this toxicity is largely influenced by genetic factors, requiring a pharmacogenomic approach to accurately identify predictive biomarkers. This study aims to integrate pharmacogenomic and bioinformatics strategies in identifying genetic variants associated with the risk of TC therapy toxicity. The research method involved a systematic search of the PharmGKB database using the keyword “Thyroid Cancer.” The selection results were filtered based on clinical pharmacogenomic relevance and ESMO therapy guidelines. Only gene-drug pairs with Level of Evidence (LOE) 1A to 3 were included. Furthermore, genetic variant data were analyzed bioinformatically based on tissue expression profiles and biological relevance. The results of the study of three main systemic therapies (lenvatinib, sorafenib, and radioiodine) identified two biomarkers with LOE level 3: the rs776746 (CYP3A5) variant associated with lenvatinib toxicity, and rs620815 (ATM) associated with gastrointestinal toxicity due to radioiodine. Tissue expression analysis showed CYP3A5 to be dominant in the liver and intestines, supporting its role in drug metabolism, while ATM was widely expressed and involved in DNA repair. Both genes have potential as predictive biomarkers of TC therapy toxicity. This study demonstrates that the integration of pharmacogenomic and bioinformatics approaches can identify potential genetic biomarkers contributing to the risk of TC therapy toxicity. These findings strengthen the basis for the application of genetic-based precision medicine in optimizing the safety and individualization of TC therapy.
Bioinformatics Analysis of Potential Targets of Betulinic Acid Against Virulence Factors of Chlamydia trachomatis Nurani, Erla; Roza, Putri Diana; Darmawi, Darmawi; Irham, Lalu Muhammad; Adikusuma, Wirawan; Anggraini, Dewi
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1465

Abstract

Chlamydia trachomatis is an obligate intracellular pathogen responsible for trachoma and sexually transmitted infections, with rising antibiotic resistance posing a major therapeutic challenge. Natural compounds such as betulinic acid, a pentacyclic triterpenoid with broad-spectrum antimicrobial and anti-inflammatory properties, offer potential as alternative therapeutic agents. This study aimed to analyze the potential targets of betulinic acid against C. trachomatis virulence factors using bioinformatics approaches. Protein–compound interaction prediction was performed using STITCH v5.0, while virulence classification was analyzed through VICMpred and VirulentPred. BepiPred v2.0 was employed to identify B-cell epitopes, and PSORTb v3.0 was used to predict subcellular localization. The results identified five proteins targeted by betulinic acid, including DNA topoisomerase IV subunit B (parE), DNA topoisomerase IV subunit A (parC), DNA gyrase subunits (gyrA and gyrB), and sulfite reductase (cysJ). Among these, three were classified as virulence factors: parE (0,2959), parC (0,1754), and cysJ (0,4018). Subcellular localization analysis showed that parE and parC are cytoplasmic proteins essential for DNA replication, while cysJ is associated with the cytoplasmic membrane and metabolic processes. Betulinic acid showed strong potential as an antimicrobial compound targeting key virulence proteins of C. trachomatis. These findings provide foundational insight for further experimental studies to develop betulinic acid–based therapeutic strategies against chlamydial infections.
Co-Authors Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Adi Wira Septama Adrian A. Kaptein Afief, Arief R. Afief, Arief Rahman Ageng Brahmadhi Anak Agung Gede Sugianthara Ananda, Dwi Rizki Andayani, Gitalisa Andi Arus Victor Anisa Devi Kharisma Wibowo Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Anita Silas La’ah Anna Pradiningsih Anna Pradiningsih Annisa Abdi Ghifari Arfianti Arfianti Arief Rahman Afief Arief Rahman Afief Arief Rahman Afief Asamuni, GJ Rahma Dewi Ates, Ilker Auralia, Najma Auren Nathania Ayu Fatmala Ayu Lifia Nur Kartikasari Ayuningtyas, Sita Paramita Baiq Leny Nopitasari Baiq Lenysia Puspita Anjani Baiq Nurbaety Barkah Djaka Purwanto Barkah Djaka Purwanto Cheung, Rocky Chong, Rockie Cyntiya Rahmawati Danang Prasetyaning Amukti Dani Satria, Rahmat Darmawi Darmawi . Darmawi Darmawi Dewi Anggraini Dewi Tamayanti, Wahyu Djatikusumo, Ari Donel S Dyah A. Perwitasari Dyah Aryani Perwitasari Eko Mugiyanto Eko Satria Putra Firdayani Firdayani Firdayani Firdayani, Firdayani Firman Firman Fita Yuliana Fitri, Dwiki Furqani, Nur Gina Noor Djalilah GJ Rahma Dewi Asamuni Gustinanda, Rizky Haafizah Dania Haafizah Dania Haafizah Dania Hamidy, Muhammad Y. Harlena, Filza Amara Kamila Henry Budiawan Prasetya Herjanti Ratnawiningsih Hutapea, Mario Marbungaran Imaniar Noor Faridah Imaniar Noor Faridah Indri Istiqomah Irham, Lalu M. Irmatika Hendriyani Kartikasari, Ayu Lifia Nur Kemal, Rahmat A. Khair, Riat Khairi, Sabiah La Malihi Lalu Muhammad Irham La’ah, Anita Silas Leina Putri Zahra Lisza Niarisessa Lolita Lolita Made Ary Sarasmita Maliza, Rita MARIA BINTANG Maulida Mazaya Maulida, Khelda Maya Savira Ma’ruf, Muhammad Medi Sushanti, Nining Melodia Rezadhini Melodia Rezadhini Moch. Saiful Bachri Muhammad Faqih Muhammad Hafizh Abiyyu Fathin Fawwazi Muhammad Yulis Hamidy Nanik Sulistyani Nathania, Auren Nazhipah Isnani Ni Made Ary Sarasmita Nining Medi Sushanti Nining Medi Sushanti Nopitasari, Baiq Leny Nugraha, Media Fitri Isma Isma Nur Furqani Nurani, Erla Nurfi Pratiwi, Nurfi NURUL AZIZAH Nurul Hidayatullah Nurul Qiyaam, Nurul Pendicho Eko Yuliyanto Pranata, Satria Purwanto, Barkah Djaka Puspita Anjani, Baiq Lenysia Puspita Puspitaningrum, Anisa Nova Putu Gede Suriya Gunawan Rachmadina, Rachmadina Rahmat Dani Satria Rahmatullah, Satrio Wibowo Rahmawati, Cyntiya Rahmawati, Desti Rangkuti, Ina F. Razali, Renardy Reza Renardy Reza Razali Rezadhini, Melodia Ria Indah Pratami Riat El Khair Riat Khair Rihhadatul Aisy Risma Widia Ningsih Riza Alfian Rockie Chong Rocky Cheung Rocky Cheung Rocky Cheung Roza, Putri Diana S, Donel Safwan Safwan Safwan Safwan Saksono, Reni Yustiati Samsul Hadi Sandi, Dita Aulia Dwi Santri, Ichtiarini Nurullita Satria, Rahmat Dani Setiawan, Feri Shoma Rikifani Sianu, Rahman S Sierly, Nadia Siswanto, Lalu Muhammad Harmain Soraya Soraya Suhandri, Wiwin Tien Partini Tri Murti Andayani Ulfah, Aida J. Uswaton Hasanah Winarto Winarto Winarto Winarto Wiwin Suhandri Wiwit Ade Fidiawati Wiwit Ade Fidiawati Woro Supadmi Woro Supadmi Yudantha, Anggun Rama Yudha Rizky Nuari Zahra, Leina Putri Zainul Amiruddin Zakaria Zakaria, Zainul Amiruddin