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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Klinik Indonesia Biomedical Journal of Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Ulul Albab SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Lumbung Farmasi : Jurnal Ilmu Kefarmasian Narra J Jurnal Ilmiah Kesehatan (JIKA) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Media Farmasi Indonesia Jurnal Farmasi Klinik dan Sains Jurnal Kesehatan Reproduksi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kesehatan Journal of Pharmascience
Wirawan Adikusuma
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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EKSPLORASI HAMBATAN KEPATUHAN PENGOBATAN PASIEN DIABETES MELITUS DI PUSKESMAS: STUDI KUALITATIF Alfian, Riza; Fawwazi, Muhammad Hafizh Abiyyu Fathin; Faqih, Muhammad; Adikusuma, Wirawan
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2789

Abstract

Medication adherence is a crucial factor in the successful management of diabetes mellitus, yet many studies show that adherence remains low and is shaped by multidimensional influences. This study aimed to explore barriers to medication adherence among patients with diabetes mellitus in primary health centers (Puskesmas) using the WHO five-domain adherence framework. A qualitative descriptive-exploratory design was applied. Data were collected through in-depth interviews with ten patients undergoing routine treatment at Puskesmas in Banjarmasin City, recruited through purposive sampling. Thematic analysis was performed guided by the WHO adherence model. Five major themes emerged. Social and economic factors included limited transportation costs, distance to the health center, and lack of family support. Health system and provider factors involved brief consultations, insufficient patient education, and long queues. Condition-related factors comprised the absence of immediate symptoms, fatigue from chronic illness, comorbidities, and psychological distress. Therapy-related factors included complex regimens, side effects, and discontinuation of therapy without consultation. Patient-related factors were characterized by forgetfulness, reliance on alternative medicine, fluctuating motivation, and feelings of boredom. These findings highlight that adherence barriers are multidimensional and result from the interaction of individual, social, and system-level determinants. Addressing adherence requires holistic and continuous interventions at the primary care level, with emphasis on patient education, family involvement, and strengthening the role of healthcare providers.
THE TREND OF STUDIES RELATED TO MYASTHENIA GRAVIS AND GENETICS IN VARIOUS POPULATIONS AROUND THE WORLD Fitri, Dwiki; Irham, Lalu Muhammad; Sulistyani, Nanik; Adikusuma, Wirawan; Sianu, Rahman S; Ma’ruf, Muhammad
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1944

Abstract

Myasthenia gravis (MG) is an autoimmune disease involving the neuromuscular junction, mainly influenced by antibodies to acetylcholine receptors. In addition, antibodies to Muscle-Specific Kinase (MUSK), Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4). It is essential to determine publication trends regarding Myasthenia gravis because, currently, there are no studies that describe Myasthenia gravis publication trends related to genes in this field of study. Bibliometric analysis is used to see research trends, including frequently used keywords, most published journals, most cited publishers, author agencies, and collaboration between authors depicted in visualization using the VOSViewer application. Bibliometric analysis shows that the research trend is increasing from 1969 to 2023. The most frequently used keywords are myasthenia gravis, human, autoimmune disease, genetics, and article. The leading information related to the data is that the average annual publication is 5.89%, and the average citation for documents is 13.9%. Indonesia, as one of the countries experiencing Myasthenia gravis, has excellent potential to increase the number of research articles, which can be a means of exchanging knowledge, ideas, and technology and also has the potential for collaboration with other countries
UNCOVERING PATHOGENIC MISSENSE VARIANTS IN ENDOMETRIOSIS USING A GENOME-WIDE ASSOCIATION STUDY Nurullita Santri, Ichtiarini; Adikusuma, Wirawan; Theda Philothra, Petrina; Fadhliati Maulida, Nurul; Chong, Rockie; Ates, Ilker; Vincent Abero Phiri, Yohane; Muhammad Irham, Lalu
JURNAL KESEHATAN REPRODUKSI Vol 16 No 2 (2025): JURNAL KESEHATAN REPRODUKSI VOLUME 16 NOMOR 2 TAHUN 2025
Publisher : IAKMI South Tangerang Branch

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58185/jkr.v16i2.407

Abstract

Background: Endometriosis is a complex gynecological disorder with a strong genetic component. Although genome-wide association studies (GWAS) have identified numerous risk loci, the functional interpretation of protein-altering missense variants remains limited. Objective: This study identified pathogenic missense variants linked to endometriosis risk using publicly available GWAS data and explored implications for genetic risk detection, particularly in underrepresented populations such as Indonesia. Methods: Endometriosis-associated missense single nucleotide polymorphisms (SNPs) were identified from GWAS data, and a total of eight missense SNPs were analyzed. Functional effects were evaluated in silico using PolyPhen-2 and SIFT. Allele frequency distributions were assessed across global populations, and pathway enrichment analysis was conducted using the Reactome database. Results: Several missense variants were significantly associated with increased endometriosis risk (e.g., rs75801644, OR = 3.88; rs144824657, OR = 3.52), while rs2341097 showed a potential protective effect. Functional prediction prioritized variants in genes such as KCNG2 and BSG as potentially damaging. Population analyses revealed marked allele frequency differences, and enriched pathways were related to potassium channel activity, metabolism, extracellular matrix organization, and signal transduction. Conclusion: This study identifies missense variants contributing to endometriosis susceptibility and provides insight into biological pathways. Further experimental validation and clinical studies are warranted.
Identification Target Genes for Potential Biomarkers in Endometriosis from Transcriptomics Database Zahlina, Dian; Iskandar, Benni; Adikusuma, Wirawan; Yusuf, Muhammad; Tiara Fani, Rifia; Ocktariyana, Ocktariyana; Darmawi, Darmawi
Jurnal Kesehatan - STIKes Prima Nusantara Vol 17 No 1 (2026): Jurnal Kesehatan Volume 17 Nomor 1 Tahun 2026
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v17i1.1281

Abstract

Endometriosis is a common benign gynecological disease characterized by the ectopic growth of endometrial tissue. Its pathogenesis is influenced by complex genetic and epigenetic factors, making diagnosis and treatment challenging. This study aimed to identify molecular pathways and candidate genes associated with endometriosis using transcriptomic data. Three datasets (GSE7307, GSE23339, and GSE25628) were retrieved from the Gene Expression Omnibus (GEO) database and analyzed to identify differentially expressed genes (DEGs). A total of 339 intersecting DEGs were obtained and subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. The results indicated enrichment in biological processes related to epithelial cell proliferation and angiogenesis, cellular components associated with the lysosomal lumen and extracellular matrix, and molecular functions involving Wnt-activated receptor activity and low-density lipoprotein particle binding. Ten genes (TAGLN, C7, TCF21, GATA6, GPC3, FZD7, TCEAL2, KLF2, FMO1, and HOXC6) were identified as potential candidate biomarkers. These findings provide preliminary molecular insights into endometriosis and may support future experimental and clinical studies for biomarker development.
Kepatuhan Penggunaan Obat Antihipertensi di Puskesmas Pagesangan Mataram Wirawan Adikusuma; Nurul Qiyaam; Fita Yuliana
Journal of Pharmascience Vol. 2 No. 2 (2015): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v2i2.5823

Abstract

ABSTRAK Keberhasilan suatu pengobatan tidak hanya dipengaruhi oleh kualitas pelayanan kesehatan, sikap, dan keterampilan petugasnya, tetapi juga dipengaruhi oleh kepatuhan pasien. Penelitian ini bertujuan untuk mengetahui kepatuhan penggunaan obat hipertensi dan beberapa variabel karakteristik pasien yang berpengaruh terhadap kepatuhan pasien hipertensi di Puskesmas Pagesangan, Mataram. Penelitian ini dilakukan dengan metode observasional crossectional dengan mengambil data secara prospektif selama periode Februari – Maret 2015. Pengukuran kepatuhan dilakukan dengan menggunakan kuesioner MMAS (Morisky Medication Adherence Scale) yang berisi 8 pertanyaan. Persentase tingkat kepatuhan berdasarkan kuesioner MMAS adalah kepatuhan tinggi 75 % dan kepatuhan rendah 25 %. Berdasarkan analisis Chi Square tidak ada karakteristik subyek penelitian yang berpengaruh terhadap kepatuhan (P>0,05).Kata kunci: Hipertensi, kepatuhan, MMAS ABSTRACTThe success of a treatment is not only influenced by the quality of health services, attitudes and skills of its health workes, but also influenced by patient adherence. This research is aimed to measure adherence to antihypertensive therapy in hypertensive patients at primary health center Mataram, and to investigate patient’s characteristic associated with such adherence. This research was carried out by observational cross-sectional design with prospective data collection during February – March  2015. The measurement of adherence is done by using a questionnaire MMAS (Morisky Medication Adherence Scale) which contains 8 questions. The percentage of the level of adherence by questionnaire MMAS is a high adherence 75% and 25% lower adherence. Based on the analysis of Chi-Square no characteristic of the study subjects that affect adherence (P>0,05).Key word : Hipertensive, Adherence, MMAS
Evaluasi Kualitas Hidup Pasien Diabetes Mellitus Tipe 2 Dengan Kombinasi Anti Diabetik Oral-Oral Di RSUD Provinsi NTB Baiq Lenysia Puspita Puspita Anjani; Nadia Sierly; Wirawan Adikusuma; Nurul Qiyaam; Nur Furqani; Cyntiya Rahmawati
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 2 (2024): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i2.23492

Abstract

Background: based on data from the Ministry of Health NTB, the prevalence of Diabetes Mellitus in West Nusa Tenggara in 2020 is around 59,606 people divided into 10 regencies and cities. The highest prevalence of diabetes is type 2 diabetes mellitus (DMT2). One way to assess the success of T2DM therapy is to measure quality of life using Quessionnair's Diabetic Quality Of Life Clinical Trial (DQLCTQ) questionnaire. The purpose of the study: to evaluate the quality of life of DMT2 patients who received oral-oral antidiabetic combination at West Nusa Tenggara Provincial Hospital. Method: observational  analytic with Cross Sectional design with  Concurrent patient data collection. Samples: 56 T2DM patients. The results of the study: on  the characteristics of respondents there was no difference in quality of life on gender, age, occupation and length of suffering from T2DM. Patients who received the combination of metformin and glimepiride had a quality of life score of 71.84, while patients who received the combination of metformin and glimepiride 74.77. Research conclusion: statistical test  with independent sample t-test showed no significant difference between the two groups (p = 0.268).
Bioinformatics Analysis of Potential Targets of Betulinic Acid Against Virulence Factors of Chlamydia trachomatis Erla Nurani; Putri Diana Roza; Darmawi Darmawi; Lalu Muhammad Irham; Wirawan Adikusuma; Dewi Anggraini
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1465

Abstract

Chlamydia trachomatis is an obligate intracellular pathogen responsible for trachoma and sexually transmitted infections, with rising antibiotic resistance posing a major therapeutic challenge. Natural compounds such as betulinic acid, a pentacyclic triterpenoid with broad-spectrum antimicrobial and anti-inflammatory properties, offer potential as alternative therapeutic agents. This study aimed to analyze the potential targets of betulinic acid against C. trachomatis virulence factors using bioinformatics approaches. Protein–compound interaction prediction was performed using STITCH v5.0, while virulence classification was analyzed through VICMpred and VirulentPred. BepiPred v2.0 was employed to identify B-cell epitopes, and PSORTb v3.0 was used to predict subcellular localization. The results identified five proteins targeted by betulinic acid, including DNA topoisomerase IV subunit B (parE), DNA topoisomerase IV subunit A (parC), DNA gyrase subunits (gyrA and gyrB), and sulfite reductase (cysJ). Among these, three were classified as virulence factors: parE (0,2959), parC (0,1754), and cysJ (0,4018). Subcellular localization analysis showed that parE and parC are cytoplasmic proteins essential for DNA replication, while cysJ is associated with the cytoplasmic membrane and metabolic processes. Betulinic acid showed strong potential as an antimicrobial compound targeting key virulence proteins of C. trachomatis. These findings provide foundational insight for further experimental studies to develop betulinic acid–based therapeutic strategies against chlamydial infections.
Co-Authors Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Adi Wira Septama Adrian A. Kaptein Afief, Arief R. Afief, Arief Rahman Ageng Brahmadhi Anak Agung Gede Sugianthara Ananda, Dwi Rizki Anisa Devi Kharisma Wibowo Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Anisa Nova Puspitaningrum Anita Silas La’ah Anna Pradiningsih Anna Pradiningsih Annisa Abdi Ghifari Arfianti Arfianti Arief Rahman Afief Arief Rahman Afief Arief Rahman Afief Asamuni, GJ Rahma Dewi Ates, Ilker Auren Nathania Ayu Fatmala Ayu Lifia Nur Kartikasari Baiq Leny Nopitasari Baiq Lenysia Puspita Anjani Baiq Lenysia Puspita Puspita Anjani Baiq Nurbaety Barkah Djaka Purwanto Barkah Djaka Purwanto Benni Iskandar Cheung, Rocky Chong, Rockie Cyntiya Rahmawati Cyntiya Rahmawati Danang Prasetyaning Amukti Darmawi Darmawi . Darmawi Darmawi Darmawi Darmawi Dewi Anggraini Donel S Dyah A. Perwitasari Dyah Aryani Perwitasari Eko Mugiyanto Eko Satria Putra Erla Nurani Fadhliati Maulida, Nurul Firdayani Firdayani Firdayani Firdayani, Firdayani Firman Firman Fita Yuliana Fitri, Dwiki Gina Noor Djalilah GJ Rahma Dewi Asamuni Haafizah Dania Haafizah Dania Haafizah Dania Hamidy, Muhammad Y. Henry Budiawan Prasetya Herjanti Ratnawiningsih Imaniar Noor Faridah Imaniar Noor Faridah Indri Istiqomah Irham, Lalu M. Irmatika Hendriyani Kartikasari, Ayu Lifia Nur Kemal, Rahmat A. Khair, Riat Khairi, Sabiah La Malihi Lalu Muhammad Irham Lalu Muhammad Irham La’ah, Anita Silas Leina Putri Zahra Lisza Niarisessa Made Ary Sarasmita Maliza, Rita MARIA BINTANG Maulida Mazaya Maya Savira Ma’ruf, Muhammad Medi Sushanti, Nining Melodia Rezadhini Melodia Rezadhini Moch. Saiful Bachri Muhammad Faqih Muhammad Hafizh Abiyyu Fathin Fawwazi Muhammad Ma'ruf Muhammad Yulis Hamidy Muhammad Yusuf Nadia Sierly Nanik Sulistyani Nathania, Auren Ni Made Ary Sarasmita Nining Medi Sushanti Nining Medi Sushanti Nopitasari, Baiq Leny Nugraha, Media Fitri Isma Isma Nur Furqani Nur Furqani Nurfi Pratiwi, Nurfi NURUL AZIZAH Nurul Hidayatullah Nurul Qiyaam, Nurul Nurullita Santri, Ichtiarini Ocktariyana, Ocktariyana Pendicho Eko Yuliyanto Pranata, Satria Purwanto, Barkah Djaka Puspitaningrum, Anisa Nova Putri Diana Roza Putu Gede Suriya Gunawan Rachmadina, Rachmadina Rahmat Dani Satria Rangkuti, Ina F. Razali, Renardy Reza Renardy Reza Razali Rezadhini, Melodia Ria Indah Pratami Riat El Khair Riat Khair Rihhadatul Aisy Risma Widia Ningsih Riza Alfian Rockie Chong Rocky Cheung Rocky Cheung Rocky Cheung S, Donel Safwan Safwan Safwan Safwan Santri, Ichtiarini Nurullita Satria, Rahmat Dani Shoma Rikifani Sianu, Rahman S Siswanto, Lalu Muhammad Harmain Soraya Soraya Suhandri, Wiwin Theda Philothra, Petrina Tiara Fani, Rifia Tien Partini Tri Murti Andayani Ulfah, Aida J. Uswaton Hasanah Vincent Abero Phiri, Yohane Winarto Winarto Winarto Winarto Wiwin Suhandri Wiwit Ade Fidiawati Wiwit Ade Fidiawati Woro Supadmi Woro Supadmi Yudha Rizky Nuari Zahlina, Dian Zahra, Leina Putri Zainul Amiruddin Zakaria Zakaria, Zainul Amiruddin