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Albert Albert
Bina Nusantara University
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Journal : Medical Scope Journal (MSJ)

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Efficacy and Safety of Drug Elution Bead-Transarterial Chemoembolization in Advanced Soft Tissue Sarcoma Albert, Albert; Manginstar, Christian O.; Saleh, Denny; Merung, Marselus A.
Medical Scope Journal Vol. 7 No. 2 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i2.58794

Abstract

Abstract: Soft-tissue sarcomas (STS) are rare and heterogeneous tumors originating from mesenchymal tissues. While surgical resection remains the primary treatment, not all patients are eligible for surgery, particularly in advanced stages. Drug-eluting bead transarterial chemoemboli zation (DEB-TACE) is a promising therapeutic option for such cases. This retrospective study evaluated the efficacy and safety of DEB-TACE in 30 patients with advanced STS at Prof. Dr. R. D. Kandou Hospital, Manado, from 2020 to 2023. The overall response rate (ORR) was 76.7% (p<0.05), with five patients achieving complete response and 18 showing partial response. The main adverse reactions included post-embolization syndrome (fever, pain, nausea, vomiting) and grade II or higher bone marrow suppression. Despite a morbidity rate of 93.3%, no treatment-related mortality was observed. In conclusion, DEB-TACE is an effective and safe treatment for advanced STS, providing superior short-term efficacy compared to traditional systemic chemotherapy. Keywords: soft tissue sarcoma; drug eluting bead; transarterial chemoembolization
Co-Authors Abda Abda Achmad Noerkhaerin Putra Agus Susanto Alfarizy, Tomy Aminingtyas, Septi Andini Andayani, Lia H. Andini, Lilla Andyka Andyka, Andyka Angkasa, Marco Anita Damajanti Aprih Santoso Arman Husni Aurelia, Clarecia Bonnarty Steven Silalahi Budianto, Justin Chairisni Lubis Chandra, Felixco Chandriani, Casslyn Collins Willim, Zackrey Dewayani , Ery Dewi Apipah, Wulan Djohan, Deva Djohan, Stevannie Duti Volya Elbistian, Kevin Putra Emaya Kurniawati, Emaya Endah Dwi Kusumastuti, Endah Dwi Ermatita - Etty Widyastuti Gawei, Apria Brita Pandohop Girsang, Ermi Hairinsyah, Kesuma Halawa, Misdayanti Hamidjaja, Beverly C. Harahap, Zainy Kholis Muda Hariyanti , Tri Yuli Hartanto, Janssen Yohana Putri Hartati Hartati Hartoto, Witjaksono Eko Haryadi, Nicko Hassim, Affendy Abu Helmy Thendean Hutabarat, Chintya Yohana Putri Hwang, James IKA PUSPA SATRIANNY Indarto Indarto Iratutisisilia, Iratutisisilia Irmawati, B Irwandi Irwandi Ita Fionita Izza, Ainul Jacqueline, Jacqueline Jawari, Irvan Kosasih, Hengky Kridasusila, Andy Kuswardani, Dc Laoli, Tierlin Gustin Kristiani Lestari , Rohmini Indah Liana Susanto Lim, Jennifer Lowins, Leandro Maimori, Romi Male, Minarti Manginstar, Christian Manginstar, Christian O. Manik, Rifqa Yolandha Efreymind Marissa, Novaria Marselus A. Merung, Marselus A. Marselus Merung, Marselus Masduki Masduki Meliala, Juli Elisabet Mayen br Muhamad Fajri, Muhamad Mulyono, Jovan Naga , Dali Santun Nasib Nefianto, Tirton Nely Arif Nengsih, Widya Nesia, Yesha Nunung Fajaryani, Nunung Nurhayati Nurhayati Okta Jaya Harmaja Pasaribu, Ester YYN Pranata, Hamdi Pranyoto, Edi Prasetio, Meriyawaty Amelia Prastyaningsih, Nila Robin Robin, Robin Rochimah, Heni Rojuaniah Rojuaniah Rudi Waluyo SAFITRI, CANDRA Sagala, Lapiti Gokmatua Sahat Simbolon Saing, Fatmawati M Saleh, Denny SALMAN FARIS Santoso, Thomas Budi Santy Deasy Siregar Saragih, Saut Pintubipar Sari, Elna Sarumi, Rasniah Savitri, Fania Mutiara Sina, Wa Soelistiyono, Anitiyo Sucandra, I Made Agus Kresna Sulistiani Sulistiani, Sulistiani Sunario Megawan Surya Surya SUSANTI Sutanto, Fernando Thamrin Thamrin Tita Elfitasari Tjokorda Gde Agung Senapathi Tommy Setiawan Ruslim, Tommy Setiawan Trijani Suwandi Ugang, Yandi Valerie, Valerie Wahid, Ayi Wedra Aprison Wiguna, Teguh Nusa Wijaya, Elyzabeth William, Justin Sebastian Winda Rika Lestari Wizmar, Dickie A. Yani, Tri Endang Yohana Yohana Yuli Budiati Yusmei, Nining Zulfani Sesmiarni