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Journal : Indonesian Journal of Biotechnology

The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article Romaniyanto Romaniyanto; Cita Rosita Sigit Prakoeswa; Damayanti Tinduh; Hari Basuki Notobroto; Fedik Abdul Rantam; Dwikora Novembri Utomo; Heri Suroto; Ferdiansyah Ferdiansyah
Indonesian Journal of Biotechnology Vol 26, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.63318

Abstract

Low back pain is a crucial public health problem that is commonly associated with intervertebral disc de‐ generation and has vast socio‐economic impact worldwide. Current treatments for disc degeneration are conservative, non‐surgical, or surgical interventions, and there is no current clinical therapy aimed at directly reversing the degeneration. Given the limited capacity of intervertebral disc (IVD) cells to self‐repair, treatment aiming to regenerate IVDs is a topic of interest and mesenchymal stem cells (MSCs) have been identified as having potential in this regeneration. Recent studies have revealed that the benefits of MSC therapy could result from the molecules the cells secrete and that play principal roles in regulating essential biologic processes, rather than from the implanted cells themselves. Therefore, the objective of this study is to review the potential use of the MSC secretome to regenerate IVDs. Current evidence shows that the secretome may regenerate IVDs by modulating the gene expressions of nucleus pulposus cells (upregulation of keratin 19 and downregulation of matrix metalloproteinase 12 and matrix Gla protein) and stimulating IVD progenitor cells to repair the degenerated disc.
Co-Authors Abdul Karim Abdullah, Salsabilla Putri Kinanti Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Agatha Anindhita Ardhaninggar Agatha Anindhita Ayu Ardhaninggar Agnes Sri Siswati Agung, Jeffrey Agus Aan Adriansyah Agus Sri Wardoyo Alpha Fardah Athiyyah Amak M. Yaqub Anang Endaryanto Anang Endaryanto Anggraen, Sylvia Anggraeni Noviandini Anggraeni Noviandini, Anggraeni Anggraeni, Sylvia Anna Surgean Veterini Antoni Miftah Antoni Miftah, Antoni Anum, Qaira Arifin Saiboo, Alvian Arlina Dewi Arlina Dewi Astindari Astindari Astindari, Astindari Ayu Umborowati, Menul Bagus Bagus Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra, Bagus Haryo Bella Ayu Paramitha Bintanjoyo, Lunardi Budi Prasetyo Budi Utomo Budi Utomo Budiono Budiono Chesia Christiani Liuwan Christina Avanti Cindy Fransisca, Cindy Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Tinduh Deasy Fetarayani Devi, Aprilin Krista Dewi Nurasrifah Dewi Puspitorini Dhelya Widasmara Dhyah Aksarani Handamari Diah Mira Indramaya Diana Kartika Sari Diana Kartika Sari, Diana Kartika DINAR ADRIATY Dominicus Husada Dwi Murtiastutik Dwikora Novembri Utomo Dyah Ayu Pitasari DYAH FAUZIAH, DYAH Dyah Ratri Anggarini Dyah Ratri Anggarini, Dyah Ratri Eighty Mardiyan K, Eighty Eliza, Frizka Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Evy Ervianti Evy Ervianty, Evy Fajrin, Farah Meriana Farah Adiba, Asmahan Farahannisaa, Kintan Adelia Farhat Surya Ningrat Febrina D Pratiwi Febrina Dewi Pratiwi Fedik Abdul Rantam Ferdiansyah Ferdiansyah Mahyudin Ferriastuti, Widiana Fifa Argentina Flora Ramona Sigit Prakoeswa Gatot Soegiarto Geani, Silvani Gede Wirya Kusuma Duarsa Hamidah, Berliana Hamzah Handamari, Dhyah Aksarani Hardyanto Soebono Hari Basuki Notobroto Hari Sukanto, Hari Hartanto, Felix Hasna, Iffa Halimah Heri Suroto I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Nyoman Darmaputra Indah Purnamasari Indah Purnamasari Indira, Regitta INDROPO AGUSNI INGRID SURYANTI SURONO Ingrid Suryanti Suryono Intan Primasari Irma Tarida Listiyawati Irma Tarida Listiyawati, Irma Tarida Irmadita Citrashanty Irmadita Citrashanty Irmadita Citrashanty, Irmadita Iskandar Zulkarnain Iskandar Zulkarnain Isnaniyanti Fajrin Arifin Iswahyudi Iswahyudi Iswahyudi Izzatul Fithriyah Jastika, Faradistiani Rakhmawati Jayawarsa, A.A. Ketut Kartika Paramita Komaratih, Evelyn Kurniati Kurniati KUSUMASTUTI, ETTY HARY laissa Bonita Laksmi Wulandari Laura Navika Yamani Linda Astari, Linda Lubis, Ramona Sari Luh Made Mas Rusyati Lutvia Hidayati M. Yulianto Listiawan Made Putri Hendaria Mamuaja, Enricco Hendra Mappamasing, Hasnikmah Marissa Astari Rubianti Marsudi Hutomo Marsudi Hutomo Maya Weka Santi Maylita Sari Maylita Sari, Maylita Medhi Denisa Alinda, Medhi Denisa Medisika, Dhea Meita Ardini Pratamasari, Meita Ardini Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Muchtar, Vitayani Mulianto, Nur Rachmat Nadia Wirantari Nadia Wirantari, Nadia Nadya Divina Baihaqi Ni Made Inten Lestari Nisa Qurrota Ayun Novianti Rizky Reza Nugroho, Wisnu Triadi Nur Hidayah Nur Hidayah Nyoman Suryawati Oki Wihardiyanto Pakpahan, Cennikon Pepy D. Endraswari Pepy Dwi Endraswari, Pepy Dwi Pradiptha, I Nyoman Tri Prajitno, Subur Prameswari, Faida Ufaira Pratiwi, Karina Dyahtantri Puput Ade Wahyuningtyas Puteri, Rr. Astrid Aulia Artiono Rahmadewi Rahmadewi Rahmadewi RATNA WAHYUNI Ratna Wahyuni Regitta Indira Agusni Renata Prameswari Renni Yuniati Retha Retha Ria Hanistya Ridha Ramadina Widiatma Ridha Ramadina Widiatma Rina Mutya Suzliana Riyana Noor Oktaviyanti Riyana Noor Oktaviyanti Romaniyanto Romaniyanto Romaniyanto Rubianti, Marissa Astari S.Pd. M Kes I Ketut Sudiana . Santi Martini Santoso, Kohar Hari Santoso Hari Sari, Desiana Widityaning Sari, Vida Cahlia Novita Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri Semedi, Bambang Pujo SHINZO IZUMI Silvani Geani Sri Awalia Febriana Sri L. Menaldi Subijanto Marto Soedarmo Sugianto, Ronald Sunarso Suyoso Tanojo, Natalia Tengku Riza Zarzani N Thinni Nurul Rochmah Tjokorda Gde Bagus Mahadewa Tri Wibawa Trias Mahmudiono Trisniartami Setyaningrum Tristiana Erawati Troef Soemarno Troef Soemarno, Troef Widji Soeratri Willy Sandhika Wisnu Triadi Nugroho Wisnu Triadi Nugroho Wisnu Triadi Nugroho Yaqub, Amak M. Yetti Hernaningsih Yohanes Aditya Adhi Satria Yuindartanto, Andre Yuri Widya Yusuf Wibisono Yuyun Rindiastuti