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All Journal Microbiology Indonesia Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Biotechnology JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Jurnal Penelitian Kesehatan Suara Forikes Health Notions ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Abdi Insani Indonesian Journal of Anesthesiology and Reanimation (IJAR) Indian Journal of Forensic Medicine & Toxicology Prosiding International Conference on Sustainable Innovation (ICoSI)
Cita Rosita Sigit Prakoeswa
Departemen Kesehatan Kulit Dan Kelamin, Fakultas Kedokteran, Universitas Airlangga, Surabaya; Departemen Ilmu Kesehatan Kulit Dan Kelamin, RSUD Dr. Soetomo, Surabaya
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The efficacy of fractional erbium:YAG laser (2940 nm) compared to Microneedling of topical amniotic membrane stem cell conditioned medium (AMSC-CM) for photoaging Cita Rosita Sigit Prakoeswa; Riyana Noor Oktaviyanti; Wisnu Triadi Nugroho; Febrina D Pratiwi; Luh Mas Rusyati; I G A A Praharsini; I G A A Elis Indira
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14694

Abstract

Background: Photoaging is a complex biologic process that affects various layers of the skin. Amnioticmembrane stem cell conditioned medium (AMSC-CM) that contain growth factors and have capability toimprove clinical picture of photoaged skin. Microneedling and laser devices are transdermal drug deliverymethods which shows promising results to improve photoaging .Objective: To investigate the efficacy of topical AMSC-CM after YAG erbium fractional laser compare tomicroneedling in photoaging.Method :A clinical study, 60 adult women with photoaging. Randomized into two groups A 30 womenreceived AMSC-CM after fractional erbium:YAG laser (2940nm) and group B 30 woman received AMSCCM after microneedling. Both groups received the treatment 3 times with 2 weeks interval. The improvementof pore, wrinkle, and UV spot as was evaluate before, after and post treatment using computer-stimulatedphotograph skin analyzer.Result: The evaluation of pore and UV spot showed greater improvement in the group of AMSC-CM withfractional erbium:YAG laser compare to AMSC-CM with microneedling group (pore p:0,00 and UV spotp:0,00). There was no significant different (p 0.43) of wrinkle improvement between both groups.Conclusion: The combination of AMSC-CM and fractional erbium:YAG laser have better efficacy in theimprovement in photoaged skins.
The Effect of Amniotic Membrane Stem Cell Metabolite Product (AMSP-MP) Combine with Vitamin E after Microneedling in Photoaging Progress Cita Rosita Sigit Prakoeswa; Agatha Anindhita Ayu Ardhaninggar; Riyana Noor Oktaviyanti; Irmadita Citrashanty; Maylita Sari; Menul Ayu Umborowati; Dwi Murtiastutik
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14695

Abstract

Introduction: The photoaging is a cumulative process. Amniotic Membrane Stem Cell Metabolite Products(AMSC-MP) that contain cytokines and growth factors that have a role in the skin’s rejuvenation process.Vitamin E is an antioxidant that has a photoprotective effect. Topical combination of AMSC-MP and VitaminE are expected to have an effect on clinical photoaging improvement.Objective: To evaluate the effect of topical combination of AMSC-MP with vitamin E after microneedlingcompared with AMSC metabolite products after microneedling.Methods: A total 60 photoaging women were included in this experimental analytic, controlled, matchingresearch. Each participant’s face was allocated to topical combination of AMSC-MP and vitamin E inintervention group and AMSC-MP only in control group. Microneedling modality was use to enhanceepidermal penetration. Three treatment sessions were repeated at two weeks’ interval.Results: From the comparison of the two groups showed there were significant different of mean value inwrinkle, skin tone and UV spots with p-value < 0,005 in the intervention grup. While pore and polarized spotdo not show significant differences between two groups.Conclusion: The administration of a topical combination of MP-AMSC and vitamin E after microneedlingprovides clinical improvement in photoaging.
Immune Dysregulation in Childhood Leprosy Flora Ramona Sigit Prakoeswa; Budi Prasetyo; Santi Martini; Hardyanto Soebono; Muhammad Yulianto Listiawan; Anang Endaryanto; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14725

Abstract

Leprosy is a chronic infection which is caused by Mycobacterium leprae. Leprosy has long been considereda complex disease, in which host and environmental characteristics are as important as the pathogen todetermine disease outcome. Leprosy is an excellent model for examining the immunoregulatory functions.Children are believed to be the most vulnerable group to leprosy infection due to their immature immunity.This review is aimed to summarize the findings of previous studies about immune dysregulation in childhoodleprosy. This study highlighted the plausible maternal-fetal connection which are related in immunedysregulation in childhood leprosy.
Environmental Factors and Leprosy in Mother and Child: A Study in Endemic Areas in East Java, Indonesia Flora Ramona Sigit Prakoeswa; Hardyanto Soebono; Dominicus Husada; Hari Basuki Notobroto; Muhammad Yulianto Listiawan; Anang Endaryanto; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14726

Abstract

Background: Leprosy is a chronic infection caused by Mycobacterium leprae. In endemic locations,children become vulnerable as a result of being continuously exposed to foci of active transmission from avery young age, especially from their mothers. This study aims to find association between environmentalrisk factors and leprosy in mothers and children in endemic areas.Methods: This study is a case-control study in endemic areas in Tuban Regency, East Java Province,Indonesia. Retrieval of data was done using structured questionnaire and direct measurement. Chi-squarewas used to assess the association between environmental factors and leprosy in mothers and children groups.Results: 22 pairs of cases and 57 pairs of controls were examined. It is found that access to clean wateris associated with leprosy in mothers in endemic areas (p value = 0.047, OR 3.080, CI 95% 2.232-4.251).Environmental factors are not associated with pediatric leprosy in endemic areas.Conclusion: The results of our study show that environmental factors are not associated with pediatricleprosy in endemic areas. Access to clean water is associated with leprosy in mothers in endemic areas.
Role of Preconditioning Adipose Mesenchymal Stem Cells in Regeneration Disk: a Review Article Romaniyanto; Hari Basuki Notobroto; Cita Rosita Sigit Prakoeswa; Fedik Abdul Rantam; Dwikora Novembri Utomo; Heri Suroto; Ferdiansyah
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14892

Abstract

Intervertebral disk (IVD) degeneration (IDD) is a degenerative disease and often found in daily practice.The managements that were used so far are only symptomatic and have not been able to solve the diseasecompletely. The use of mesenchymal stem cells (MSCs) has been widely tested as a solution for theregeneration of IVD in IDD. Adipose-derived mesenchymal stem cells (ASCs) are one of the sources ofMSCs which were widely studied as an alternative. One of the factors that can influence the efficiency andcapacity of ASCs in IDD cases is preconditioning. Generally, there were three pre-conditioning strategies ofASCs before being used as therapy, (1) modifying the environment, (2) using Growth Factors, Cytokines,Chemokines, Hormones, (3) using pharmacological and chemical agents. Preconditioning on ASCs canchange its function in various ways. We tried to link all these things together so that we could know the roleof pre-conditioning ASCs in the regeneration disk.
Probiotics Intake as Adjunct Therapy for Infected Health-Care with SARS COV-2 Anna Surgean Veterini; Eighty Mardiyan Kurniawati; Hamzah; Subijanto Marto Soedarmo; Cita Rosita Sigit Prakoeswa; Damayanti Tinduh
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.15003

Abstract

Objectives: We performed this case-control observational study to evaluate the comparison of the length ofduration of SARS COV-2 infection and the cycle threshold (Ct) value of reverse-transcriptase polymerasechain reaction (RT-PCR) nasopharynx swab between the probiotics intake (case) group and the nonprobiotics intake (control) group.Materials and Methods: Our study was a case-control study involving 15 cases and 15 controls matchfor RT-PCR positive results. The participants were healthcare consisted of registrars, consultants, andnurses. Each participant was interviewed by google forms using a structured questionnaire to collect sociodemographic characteristics, diet, therapy from a pulmonologist, and adjunct therapy.Results: The total participants consisted of 15 males and 15 females. 4 participants in the case group hadfebrile, 1 participant with anosmia, 1 participant with febrile, nausea, and vomit before they consumedprobiotics, and 9 participants without clinical complaints. One participant in the control group had feveredand cough, 14 participants without clinical complaints—1 participant with co-morbidities in the controlgroup. The data of age, duration of infection, and cycle threshold (Ct) value were in the normal distribution.Analysis results using SPSS 21.00 show no significant differences in the course of disease between the casegroup and the control group. We found 2 participants in the control group had re-infection, while there wasno re-infection in the case group.Conclusion: The present study’s finding may imply future care for the viral infection through theimmunomodulation mechanism by probiotics consumption.
The Role of Aloe vera and Centella asiatica to the Improvement of Skin Barrier Function in Indonesian Batik Workers Damayanti; Menul Ayu Umborowati; Sylvia Anggraeni2; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15731

Abstract

Background: The batik industry uses dyes and candles, that can disrupt the skin barrier function and may precipitate skin disease. Objective: To determine the role of Aloe vera and Centella asiatica to the improvement of the skin barrier function in Indonesian batik workersMethods: This was a double blind clinical trial of 30 Indonesian batik workers were divided into 2 group and given Aloe vera or Centella asiatica topical randomly was applied twice a day. Transepidermal water loss (TEWL) level, stratum corneum hydration level, and pH level, were examined using Cutometer dual MP-580. Result: Sensitivity (Sn) of new local compared with imported allergen extracts in this study was between 15.38%-84.61%, the highest point was house dust mite extract. Specificity (Sp) was ranged from 81.48%-93.75%, the highest rank was shrimp extract. Compared with IgE results, the Sn of new local and imported house dust mite extracts was good (85.7%; 92.9%). The Sp was good for egg white and cow’s milk new local extracts (86.4%; 84.4%). Conclusion: Aloe vera topical gave significant improvement on palm area of TEWL level (P=0.033; CI 95%), stratum corneum hydration (P=0.000; CI 95%), and pH level (P=0.004; CI 95%); while on dorsal hand area of stratum corneum hydration (P=0.002; CI 95%). Centella asiatica topical gave significant improvement on palm area of stratum corneum hydration (P=0.007; CI 95%); while on dorsal hand area of stratum corneum hydration (P=0.001; CI 95%) and pH level (P=0.17; CI 95%). No significant differences of Aloe vera compared to Centella asiatica in the improvement of skin barrier function.
Drug Patch Test as a Diagnostic Test to Determine the Culprit Drug of Cutaneous Adverse Drug Reaction (CADR) Damayanti; Hari Sukanto; Marsudi Hutomo; Sylvia Anggraeni; Menul Ayu Umborowati; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15739

Abstract

Background: Cutaneous Adverse Drug Reaction (CADR) is a frequent problem in clinical practice since there were new drugs or drug misuse, which leads to high morbidity and mortality rate. It is often difficult to determine the offending drug only from the history. Provocation test, intradermal test or skin prick test are of significant value, but having higher risk to re-precipitate life-threatening reaction. Drug patch test (DPT) is a test, which is performed to CADR patient to determine the culprit drug. The main advantages of DPT are, it gives rarely adverse reaction and any commercialized form of drugs can be used.Methods: This is a retrospective study, aimed to analize the clinical relevance between anamnesis and DPT result in patient with history of CADR. All patient, who were performed with DPT in one year period in Dr. Soetomo General Academic Hospital Surabaya Indonesia, were evaluated in this study. Results: There were 14 patients with history of CADR, who performed DPT; consist of 7 maculopapular eruption cases, 4 Stevens-Johnson Syndrome (SJS) cases, 1 Fixed Drug Eruption (FDE) case, 1 Acute Generalized Exanthematous Pustulosis (AGEP) case and 1 Drug Reaction with Eosinophilia and Systemic Reaction (DRESS) case. There were 9 patients (64.3 %), who got positive result of DPT. The relevance between anamnesis and positive result of DPT were shown in 8 patient (88.9%) of 9 patient with positive DPT result. Conclusion: DPT has important role in identifying the culprit drug in CADR, especially when multiple drugs are involved.
Nutritional Status and Blood Profile amongst Patient withChildand Maternal Leprosy in Endemic and Non-Endemic Area of Indonesia Flora Ramona Sigit Prakoeswa; Yohanes Aditya Adhi Satria; Budi Prasetyo; Santi Martini; Muhammad Yulianto Listiawan; Anang Endaryanto; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15761

Abstract

Leprosy remains endemic in several country, where the disease is still considered as a health burden. The development of the disease is determined by several factors, amongst which that play significant role are close household contact and impaired immunity. Maternal index case significantly associated with leprosy case in children and nutritional status plays a pivotal role in shaping the immune response against the bacteria Mycobacterium leprae. Thus, this paper aims to evaluatethe association between nutritional status and leprosy, especially in maternal and child leprosy. The study was conducted in Tuban, Indonesia. We foundsignificant difference in haemoglobin, red blood cells, and haematocrit levels in subject with maternal leprosy in the group of child without leprosy and leprous mother compared to the control group. The difference in haemoglobin and haematocrit level are also associated with child leprosy in the group of child with leprosy and mother with leprosy.In addition, although no significant association on BMI were observed, we found that the child whose mother contracted leprosy has a lower BMI compared to the other groups
Socioeconomic Factors and The Incidence of Maternal and Child Leprosy: A Study in Endemic Areas in East Java, Indonesia Hari Basuki Notobroto; Flora Ramona Sigit Prakoeswa; Anang Endaryanto; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15775

Abstract

Background: Leprosy is one of the neglected tropical disease caused by Mycobacterium leprae. Endemicareas are still found due to incapability of MDT regimen alone to eradicate leprosy. The good understandingof high-risk population characteristic to plan elimination strategy of leprosy is needed, especially invulnerable populations such as mothers and children population. This study aims to find association betweensocioeconomic factors and the incidence of leprosy in maternal and children leprosy in endemic areas.Methods: This is a case-control study in endemic areas in Tuban Regency, East Java Province, Indonesia.The obtained data was done using structured questionnaire and direct measurement. Chi-square, t-test/Mann-Whitney test was used to assess the association between socioeconomic factors and the incidence ofleprosy in maternal and children leprosy in endemic areas.Results: 22 pairs of cases and 57 pairs of controls were analyzed. This study found that education isassociated with the incidence of leprosy. Significant results were observed in father’s education (p value=0.023) with the incidence of maternal leprosy and mother’s education (p value= 0.003) education) andfather’s education (p value= 0.013) with the incidence of children leprosy. Family income also associatedwith the incidence of maternal (p value= 0.040) and children leprosy (p value= 0.036). Occupation is notassociated with the incidence of leprosy.Conclusion : The result of this study shows that education and family income are related with the incidenceof leprosy in both, mothers and children population.
Co-Authors Abdul Karim Abdullah, Salsabilla Putri Kinanti Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Agatha Anindhita Ardhaninggar Agatha Anindhita Ayu Ardhaninggar Agnes Sri Siswati Agung, Jeffrey Agus Aan Adriansyah Agus Sri Wardoyo Alpha Fardah Athiyyah Amak M. Yaqub Anang Endaryanto Anang Endaryanto Anggraen, Sylvia Anggraeni Noviandini Anggraeni Noviandini, Anggraeni Anggraeni, Sylvia Anna Surgean Veterini Antoni Miftah Antoni Miftah, Antoni Anum, Qaira Arifin Saiboo, Alvian Arlina Dewi Astindari Astindari Astindari, Astindari Ayu Umborowati, Menul Bagus Bagus Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra, Bagus Haryo Bella Ayu Paramitha Bintanjoyo, Lunardi Budi Prasetyo Budi Utomo Budi Utomo Budi Utomo Budiono Budiono Chesia Christiani Liuwan Christina Avanti Cindy Fransisca, Cindy Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Tinduh Deasy Fetarayani Devi, Aprilin Krista Dewi Nurasrifah Dewi Puspitorini Dhelya Widasmara Dhyah Aksarani Handamari Diah Mira Indramaya Diana Kartika Sari Diana Kartika Sari, Diana Kartika DINAR ADRIATY Dominicus Husada Dwi Murtiastutik Dwikora Novembri Utomo Dyah Ayu Pitasari DYAH FAUZIAH, DYAH Dyah Ratri Anggarini Dyah Ratri Anggarini, Dyah Ratri Eighty Mardiyan K, Eighty Eliza, Frizka Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Evy Ervianti Evy Ervianty, Evy Fajrin, Farah Meriana Farah Adiba, Asmahan Farahannisaa, Kintan Adelia Farhat Surya Ningrat Febrina D Pratiwi Febrina Dewi Pratiwi Fedik Abdul Rantam Ferdiansyah Ferdiansyah Mahyudin Ferriastuti, Widiana Fifa Argentina Flora Ramona Sigit Prakoeswa Gatot Soegiarto Geani, Silvani Hamidah, Berliana Hamzah Hardyanto Soebono Hari Basuki Notobroto Hari Sukanto Hari Sukanto Hari Sukanto, Hari Hartanto, Felix Heri Suroto I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Nyoman Darmaputra Indah Purnamasari Indah Purnamasari INDROPO AGUSNI Ingrid Suryanti Surono Ingrid Suryanti Suryono Intan Primasari Irma Tarida Listiyawati Irma Tarida Listiyawati, Irma Tarida Irmadita Citrashanty Irmadita Citrashanty Irmadita Citrashanty, Irmadita Iskandar Zulkarnain Iskandar Zulkarnain Isnaniyanti Fajrin Arifin Iswahyudi Iswahyudi Iswahyudi Izzatul Fithriyah Jastika, Faradistiani Rakhmawati Jayawarsa, A.A. Ketut Kartika Paramita Komaratih, Evelyn Kurniati Kurniati KUSUMASTUTI, ETTY HARY laissa Bonita Laksmi Wulandari Laura Navika Yamani Linda Astari, Linda Lubis, Ramona Sari Luh Made Mas Rusyati Lutvia Hidayati M. Yulianto Listiawan Made Putri Hendaria Mamuaja, Enricco Hendra Mappamasing, Hasnikmah Marissa Astari Rubianti Marsudi Hutomo Marsudi Hutomo Maya Weka Santi Maylita Sari Maylita Sari, Maylita Medhi Denisa Alinda, Medhi Denisa Medisika, Dhea Meita Ardini Pratamasari, Meita Ardini Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Muchtar, Vitayani Mulianto, Nur Rachmat Nadia Wirantari Nadia Wirantari, Nadia Nadya Divina Baihaqi Ni Made Inten Lestari Nisa Qurrota Ayun Novianti Rizky Reza Nugroho, Wisnu Triadi Nur Hidayah Nyoman Suryawati Oki Wihardiyanto Pakpahan, Cennikon Pepy D. Endraswari Pepy Dwi Endraswari, Pepy Dwi Prajitno, Subur Prameswari, Faida Ufaira Pratiwi, Karina Dyahtantri Puput Ade Wahyuningtyas Puteri, Rr. Astrid Aulia Artiono Rahmadewi Rahmadewi Rahmadewi Ratna Wahyuni RATNA WAHYUNI Regitta Indira Regitta Indira Agusni Renata Prameswari Renni Yuniati Retha Retha Ria Hanistya Ridha Ramadina Widiatma Ridha Ramadina Widiatma Rina Mutya Suzliana Riyana Noor Oktaviyanti Riyana Noor Oktaviyanti Romaniyanto Romaniyanto Romaniyanto Rubianti, Marissa Astari S.Pd. M Kes I Ketut Sudiana . Santi Martini Santoso, Kohar Hari Santoso Hari Sari, Desiana Widityaning Sari, Vida Cahlia Novita Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri Semedi, Bambang Pujo SHINZO IZUMI Silvani Geani Sri Awalia Febriana Sri L. Menaldi Subijanto Marto Soedarmo Sunarso Suyoso Tanojo, Natalia Tengku Riza Zarzani N Thinni Nurul Rochmah Tri Wibawa Trias Mahmudiono Trisniartami Setyaningrum Tristiana Erawati Troef Soemarno Troef Soemarno, Troef Widji Soeratri Willy Sandhika Wisnu Triadi Nugroho Wisnu Triadi Nugroho Wisnu Triadi Nugroho Yetti Hernaningsih Yohanes Aditya Adhi Satria Yuindartanto, Andre Yuri Widya Yusuf Wibisono Yuyun Rindiastuti