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All Journal Microbiology Indonesia Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Biotechnology JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Jurnal Penelitian Kesehatan Suara Forikes Health Notions ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Abdi Insani Indonesian Journal of Anesthesiology and Reanimation (IJAR) Indian Journal of Forensic Medicine & Toxicology Prosiding International Conference on Sustainable Innovation (ICoSI)
Cita Rosita Sigit Prakoeswa
Departemen Kesehatan Kulit Dan Kelamin, Fakultas Kedokteran, Universitas Airlangga, Surabaya; Departemen Ilmu Kesehatan Kulit Dan Kelamin, RSUD Dr. Soetomo, Surabaya
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Profile of Transepidermal Water Loss in Non-Atopic Dermatitis and Atopic Dermatitis in Indonesian Adults Damayanti; Anggraeni, Sylvia; Ayu Umborowati, Menul; Farah Adiba, Asmahan; Prakoeswa, Cita Rosita Sigit
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 1 (2025): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V37.1.2025.28-33

Abstract

Background: Atopic dermatitis (AD) is a recurrent and chronic inflammatory skin disease affecting the quality of life and productivity of individuals. Several studies have reported the profile of transepidermal water loss (TEWL) in AD patients, however, there is either no data or very limited data on TEWL values in normal skin or in non-atopic individuals. Purpose: This study aims to update of the available evidence about TEWL values in healthy (non-AD) adults and AD patients, especially in Indonesia. Methods: This analytic study involved 37 non-AD subjects and 37 subjects with AD. TEWL measurements were assessed on the volar side of the left forearm. Result: The mean values in the non-AD group were 5.61 ± 3.85, while the mean values in the AD group were 18.07 ± 4.88. There is a significant difference in TEWL ​​values between the groups with non-atopic dermatitis and atopic dermatitis (p<0.001). Conclusion: TEWL value is significantly higher in AD patients compared to non-AD  individuals, indicating a compromised skin barrier function in AD. The consistent results across populations and geographic regions support the utility of TEWS as a reliable measure of AD severity, which can help clinicians customize treatment plans to meet the needs of each patient.
PEMANFAATAN MEDIA DARING AUDIOVISUAL SEBAGAI SARANA EDUKASI PERAN GENETIKA MANUSIA PADA PENYAKIT INFEKSI Hamidah, Berliana; Pakpahan, Cennikon; Puteri, Rr. Astrid Aulia Artiono; Farahannisaa, Kintan Adelia; Wulandari, Laksmi; Wibawa, Tri; Prakoeswa, Cita Rosita Sigit
Jurnal Abdi Insani Vol 12 No 3 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i3.2386

Abstract

Penyakit infeksi merupakan penyakit dengan insidensi tinggi di Indonesia sebagai negara tropis. Dewasa ini, berbagai penelitian tidak hanya seputar agen penyebab (bakteri, virus, parasit) ataupun faktor lingkungan saja, namun juga banyak melibatkan inang, termasuk genetika manusia. Pengabdian masyarakat ini bertujuan mengedukasi sasaran terbatas yaitu akademisi, mahasiswa, peneliti, dan klinisi di bidang kedokteran dan kesehatan di Indonesia tentang peran genetika manusia dalam penyakit infeksi. Pengabdian masyarakat dilakukan dengan membuat media daring audiovisual berupa tanya jawab bersama pakar dengan evaluasi setelah satu bulan dari pengunggahan video. Hasil pengabdian masyarakat menunjukkan bahwa penggunaan media daring audiovisual efektif dalam meningkatkan pemahaman akademisi, mahasiswa, peneliti, dan klinisi mengenai peran genetika manusia dalam penyakit infeksi. Diskusi dengan responden menghasilkan daftar pertanyaan yang relevan, yang kemudian dijawab oleh pakar melalui video edukatif. Video ini diunggah dan dibagikan kepada sasaran terbatas, memperoleh 48 penayangan serta respon positif dalam satu bulan. Evaluasi menunjukkan perlunya distribusi lebih luas untuk meningkatkan dampak edukasi. Model serupa dapat dikembangkan untuk memperluas jangkauan edukasi kedokteran berbasis daring. Pemanfaatan media daring audiovisual dalam pengabdian masyarakat bagi akademisi, mahasiswa, peneliti, dan klinisi di bidang kedokteran dan kesehatan meningkatkan pemahaman tentang peran genetika manusia pada penyakit infeksi. Untuk memperluas dampaknya, distribusi konten perlu diperluas. Model edukasi serupa dapat dikembangkan lebih lanjut untuk menjangkau masyarakat luas, seiring dengan kemajuan teknologi dan kebutuhan informasi kesehatan yang terus berkembang.
Lactiplantibacillus plantarum IS-10506 Enhances Tight Junction Integrity in Bronchial Epithelium: An Experimental Study Fetarayani, Deasy; Soegiarto, Gatot; Surono, Ingrid Suryanti; Endaryanto, Anang; Athiyyah, Alpha Fardah; Hernaningsih, Yetti; Fauziah, Dyah; Sudiana, I Ketut; Utomo, Budi; Prakoeswa, Cita Rosita Sigit
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2995

Abstract

BACKGROUND: Airway epithelium constitutes the initial structural defense against inhaled allergens, with its integrity primarily maintained through the formation of tight junctions (TJ) consisting of claudins, occludins, and zonula occludens (ZO). Currently, the effects of probiotics on airway TJ remain unclear. Therefore, this study was conducted to explore the impact of Lactiplantibacillus plantarum IS-10506, a native probiotic from Indonesia, on bronchial epithelial TJ in a mouse model of allergic airway inflammation.METHODS: Twenty-four BALB/c mice were randomly assigned to three groups: negative control, positive control subjected to Dermatophagoides pteryonissinus (Der p) sensitization and challenge, and treatment group exposed to Der p and administered L. plantarum IS-10506 since one week before sensitization up to three weeks after. The expression levels of claudin-18, occludin, and ZO-1 were investigated through immunohistochemistry analysis and quantified based on the immunoreactive score (IRS). RESULTS: The results of this study demonstrated that L. plantarum IS-10506 significantly enhanced the expressions of claudin-18, occludin, and ZO-1 (p<0.05).CONCLUSION: These findings underscore the probiotic's role in fortifying the integrity of airway TJ.KEYWORDS: allergic inflammation, probiotic Lactiplantibacillus plantarum, immunology, respiratory system, tight junction, occludin, claudin, zonula occludens
Lactiplantibacillus plantarum IS-10506 Supplementation Improves Clinical Outcome and Immunology Markers in Psoriasis Vulgaris Patients: A Randomized Controlled Trial Umborowati, Menul Ayu; Hasna, Iffa Halimah; Endaryanto, Anang; Surono, Ingrid Suryanti; Prakoeswa, Cita Rosita Sigit
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3155

Abstract

BACKGROUND: Probiotics may modify the gut microbiome and have been proven to improve psoriasis vulgaris. Lactiplantibacillus plantarum IS-10506 is a probiotic strain of Indonesian origin. It offers a safe and effective probiotic for psoriasis patients in Indonesia. This study was conducted to evaluate the effect of L. plantarum IS-10506 on clinical and immunology markers in psoriasis vulgaris.METHODS: This randomized, placebo-controlled, and double-blind trial compared L. plantarum IS-10506 (2×1010 CFU/day) and placebo in 49 patients mild-moderate psoriasis vulgaris, which were divided into intervention (n=24) and control groups (n=25). The interventions were given twice daily for 12 weeks. Both groups received topical corticosteroid and emollient as standard treatment. Psoriasis area and severity index (PASI), dermatology life quality index (DLQI), interleukin (IL)-10, IL-17, and forkhead box protein (Foxp3) were then assessed.RESULTS: Mean PASI score for the the subjects in probiotic group was significantly reduced compared to placebo at week-6 (p=0.024), and was sustained until week-12 (p=0.049). At week-12, DLQI scores in the probiotic group were lower than placebo (7.57±5.77 vs. 7.79±5.48). IL-17 level was significantly decreased (p=0.013), while the IL-10 and Foxp3 were significantly increased (p≤0.001 and p=0.048, respectively) in probiotic group. Six months after the completion of study, subjects in probiotic group had a lower probability of flares (52.2%) compared to placebo (79.2%). Two subjects receiving probiotics and one receiving placebo noticed changes in defecation frequency, while another subject in the placebo group complained of mild nausea.CONCLUSION: L. plantarum IS-10506 might effectively improve clinical outcomes and immune biomarkers in psoriasis vulgaris patients, potentially acting as an adjuvant therapy.KEYWORDS: psoriasis, probiotic, clinical severity, immune marker, human and health
Co-Authors Abdul Karim Abdullah, Salsabilla Putri Kinanti Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Agatha Anindhita Ardhaninggar Agatha Anindhita Ayu Ardhaninggar Agnes Sri Siswati Agung, Jeffrey Agus Aan Adriansyah Agus Sri Wardoyo Alpha Fardah Athiyyah Amak M. Yaqub Anang Endaryanto Anang Endaryanto Anggraen, Sylvia Anggraeni Noviandini Anggraeni Noviandini, Anggraeni Anggraeni, Sylvia Anna Surgean Veterini Antoni Miftah Antoni Miftah, Antoni Anum, Qaira Arifin Saiboo, Alvian Arlina Dewi Astindari Astindari Astindari, Astindari Ayu Umborowati, Menul Bagus Bagus Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra, Bagus Haryo Bella Ayu Paramitha Bintanjoyo, Lunardi Budi Prasetyo Budi Utomo Budi Utomo Budiono Budiono Chesia Christiani Liuwan Christina Avanti Cindy Fransisca, Cindy Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Tinduh Deasy Fetarayani Devi, Aprilin Krista Dewi Nurasrifah Dewi Puspitorini Dhelya Widasmara Dhyah Aksarani Handamari Diah Mira Indramaya Diana Kartika Sari Diana Kartika Sari, Diana Kartika DINAR ADRIATY Dominicus Husada Dwi Murtiastutik Dwikora Novembri Utomo Dyah Ayu Pitasari DYAH FAUZIAH, DYAH Dyah Ratri Anggarini Dyah Ratri Anggarini, Dyah Ratri Eighty Mardiyan K, Eighty Eliza, Frizka Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Evy Ervianti Evy Ervianty, Evy Fajrin, Farah Meriana Farah Adiba, Asmahan Farahannisaa, Kintan Adelia Farhat Surya Ningrat Febrina D Pratiwi Febrina Dewi Pratiwi Fedik Abdul Rantam Ferdiansyah Ferdiansyah Mahyudin Ferriastuti, Widiana Fifa Argentina Flora Ramona Sigit Prakoeswa Gatot Soegiarto Geani, Silvani Gede Wirya Kusuma Duarsa Hamidah, Berliana Hamzah Hardyanto Soebono Hari Basuki Notobroto Hari Sukanto, Hari Hartanto, Felix Hasna, Iffa Halimah Heri Suroto I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Nyoman Darmaputra Indah Purnamasari Indah Purnamasari INDROPO AGUSNI INGRID SURYANTI SURONO Ingrid Suryanti Suryono Intan Primasari Irma Tarida Listiyawati Irma Tarida Listiyawati, Irma Tarida Irmadita Citrashanty Irmadita Citrashanty Irmadita Citrashanty, Irmadita Iskandar Zulkarnain Iskandar Zulkarnain Isnaniyanti Fajrin Arifin Iswahyudi Iswahyudi Iswahyudi Izzatul Fithriyah Jastika, Faradistiani Rakhmawati Jayawarsa, A.A. Ketut Kartika Paramita Komaratih, Evelyn Kurniati Kurniati KUSUMASTUTI, ETTY HARY laissa Bonita Laksmi Wulandari Laura Navika Yamani Linda Astari, Linda Lubis, Ramona Sari Luh Made Mas Rusyati Lutvia Hidayati M. Yulianto Listiawan Made Putri Hendaria Mamuaja, Enricco Hendra Mappamasing, Hasnikmah Marissa Astari Rubianti Marsudi Hutomo Marsudi Hutomo Maya Weka Santi Maylita Sari Maylita Sari, Maylita Medhi Denisa Alinda, Medhi Denisa Medisika, Dhea Meita Ardini Pratamasari, Meita Ardini Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Muchtar, Vitayani Mulianto, Nur Rachmat Nadia Wirantari Nadia Wirantari, Nadia Nadya Divina Baihaqi Ni Made Inten Lestari Nisa Qurrota Ayun Novianti Rizky Reza Nugroho, Wisnu Triadi Nur Hidayah Nyoman Suryawati Oki Wihardiyanto Pakpahan, Cennikon Pepy D. Endraswari Pepy Dwi Endraswari, Pepy Dwi Pradiptha, I Nyoman Tri Prajitno, Subur Prameswari, Faida Ufaira Pratiwi, Karina Dyahtantri Puput Ade Wahyuningtyas Puteri, Rr. Astrid Aulia Artiono Rahmadewi Rahmadewi Rahmadewi Ratna Wahyuni RATNA WAHYUNI Regitta Indira Agusni Renata Prameswari Renni Yuniati Retha Retha Ria Hanistya Ridha Ramadina Widiatma Ridha Ramadina Widiatma Rina Mutya Suzliana Riyana Noor Oktaviyanti Riyana Noor Oktaviyanti Romaniyanto Romaniyanto Romaniyanto Rubianti, Marissa Astari S.Pd. M Kes I Ketut Sudiana . Santi Martini Santoso, Kohar Hari Santoso Hari Sari, Desiana Widityaning Sari, Vida Cahlia Novita Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri Semedi, Bambang Pujo SHINZO IZUMI Silvani Geani Sri Awalia Febriana Sri L. Menaldi Subijanto Marto Soedarmo Sugianto, Ronald Sunarso Suyoso Tanojo, Natalia Tengku Riza Zarzani N Thinni Nurul Rochmah Tjokorda Gde Bagus Mahadewa Tri Wibawa Trias Mahmudiono Trisniartami Setyaningrum Tristiana Erawati Troef Soemarno Troef Soemarno, Troef Widji Soeratri Willy Sandhika Wisnu Triadi Nugroho Wisnu Triadi Nugroho Wisnu Triadi Nugroho Yetti Hernaningsih Yohanes Aditya Adhi Satria Yuindartanto, Andre Yuri Widya Yusuf Wibisono Yuyun Rindiastuti