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All Journal Dinamika Akuntansi Keuangan dan Perbankan Jurnal Paradigma Ekonomika Medula Midwifery Journal: Jurnal Kebidanan UM. Mataram Manuju : Malahayati Nursing Journal Jurnal Bidan Cerdas Lentera Acitya Journal Of Health Best Journal (Biology Education, Sains and Technology) INVEST : Jurnal Inovasi Bisnis dan Akuntansi Jurnal Kesehatan Tambusai Indo-MathEdu Intellectuals Journal Indonesian Journal of Nursing and Health Sciences (IJNHS) Innovative: Journal Of Social Science Research Molekul: Jurnal Ilmiah Kimia Jurnal Kesehatan Lentera Acitya JER Holistik Jurnal Kesehatan Journal of Asian-african Focus in Health Tirai Edukasi : Jurnal Pendidikan JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Adaptive Governance Research
Susianti, Susianti
Universitas Mega Buana Palopo
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Journal : Medula

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The Literatur Review: Hubungan Kadar Hemoglobin terhadap Lama Rawat Inap Pasien Laparotomi: - Buana, Faris Agung; Darwis, Iswandi; Marcellia, Selvi; Susianti, Susianti
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1432

Abstract

Hemoglobin is an important protein in the blood whose job is to transport oxygen to body tissues. Low hemoglobin levels (anemia) in laparotomy patients can affect postoperative recovery time, including the duration of hospitalization. This study aims to evaluate the relationship between pre-operative hemoglobin levels and length of stay in laparotomy patients. Data were obtained from medical records of patients who underwent laparotomy at the hospital, including hemoglobin levels before surgery, length of stay, and additional variables such as Body Mass Index (BMI) and Surgical Apgar Score (SAS). The analysis showed that patients with low hemoglobin levels had a greater risk of experiencing longer hospital stays. This is due to suboptimal oxygen supply to the tissue, thereby slowing wound healing and increasing the risk of complications, such as infection and organ failure. Treating anemia with blood transfusions or iron supplementation has proven effective in increasing hemoglobin levels and speeding up patient recovery, with the average length of stay reduced to less than four days. Apart from hemoglobin levels, factors such as BMI, SAS, level of complexity of surgery, and the patient's health condition also influence the length of treatment. These findings emphasize the importance of monitoring and correcting hemoglobin levels before surgery as a preventive measure to speed recovery, minimize complications, and reduce hospital operational burden, especially in health facilities with limited resources. Further research is needed to determine the most effective clinical interventions in managing anemia in preoperative patients.
Skrining Fitokimia Kualitatif Ekstrak Etanol 96% dan H-Heksana Kulit Batang Bakau Lindur (Bruguiera gymnorrhiza) Ismunanto, Aziza Regina Kinasih; Kurniawati, Evi; Putri, Giska Tri; Susianti, Susianti
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1253

Abstract

Lindur mangrove plants (Bruguiera gymnorrhiza) are known to contain secondary metabolite compounds which function as antibacterials. These secondary metabolite compounds include alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids. The design of this research was experimental, carried out to determine and compare the phytochemical components contained in 96% ethanol extract and n-hexane of Bruguiera gymnorrhiza mangrove bark. Bruguiera gymnorrhiza mangrove bark was taken at KPH Gunung Balak, East Lampung, then 4.5 kg of wet mangrove bark was obtained and dried for 7 days, then the extract was made using the maceration method for 3x24 hours using 2 types of solvents, namely 96% ethanol and n-hexane with a ratio of 1:10 between simplicia and solvent. Thick extracts were obtained from the two types of solvents which were then carried out qualitative phytochemical tests.  The results of this study showed that 96% ethanol extract and n-hexane of Bruguiera gymnorrhiza mangrove bark positively contained secondary metabolite compounds. The 96% ethanol extract of Bruguiera gymnorrhiza mangrove bark contains all types of secondary metabolite compounds, namely alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids, while the n-hexane extract contains secondary metabolite compounds, namely alkaloids, flavonoids, tannins, phenols, terpenoids, steroid but does not contain saponins. The conclusion of this research is that the 96% ethanol extract of Bruguiera gymnorrhiza mangrove bark contains more secondary metabolite compounds than the n-hexane extract of Bruguiera gymnorrhiza mangrove bark.
Eksplorasi Imunoterapi dan Terapi Gen dalam Pengobatan Tumor Otak: Literature Review Hana Muthi'a Putri; Windarti, Indri; Mayasari, Diana; Susianti, Susianti
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1378

Abstract

Brain tumors are a significant neurological disorder with a high mortality rate, especially in cases of glioblastoma, which is highly aggressive and difficult to treat. Conventional treatment methods, such as surgery, radiation therapy, and chemotherapy, are often not effective enough, particularly in advanced stages. This study aims to explore two innovative approaches, namely immunotherapy and gene therapy, as alternative treatments for brain tumors. Immunotherapy works by enhancing the immune system's ability to fight cancer cells through methods such as checkpoint inhibitors, cancer vaccines, and CAR-T therapy. However, the success of immunotherapy is often hindered by the blood-brain barrier (BBB), which limits the delivery of therapy to the brain. On the other hand, gene therapy offers a solution by modifying genetic material, either to repair damaged genes or to directly destroy cancer cells. Approaches such as the use of oncolytic viruses, CRISPR technology, and nanoparticles have shown promising results in preclinical research and early clinical trials, particularly for glioblastoma. The combination of immunotherapy and gene therapy opens new opportunities to enhance treatment effectiveness by strengthening the immune response and targeting tumors more specifically. However, challenges remain, including treatment resistance, side effects, and limitations in brain delivery methods. Further research is needed to ensure the safety, efficacy, and widespread application of this combination therapy. Immunotherapy and gene therapy have great potential as breakthroughs in the future treatment of brain tumors. Relevant literature, including articles and journals from both national and international sources, were gathered through online searches in various databases, such as Google Scholar, PubMed, and NCBI, and used to compile this article.
Pengaruh Pemberian Ekstrak Etanol Buah Pare (Momordica Charantia L) Terhadap Gambaran Histopatolgi Arteri Koronaria Tikus Putih (Rattus Norvegicus) Jantan Galur Sprague Dawley Yang Diinduksikan Minyak Jelant Joni, Agnesia Priskila; Windarti, Indri; Oktarlina, Rasmi Zakiah; Susianti, Susianti
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1392

Abstract

Coronary heart disease is one of the main causes of death in the world, with more than 17 million deaths every year due to heart and blood vessel diseases, with around 8.7 million of them caused by coronary heart disease and around 15 out of 1000 residents in Indonesia which is equivalent to around 2,78,064 people suffer from coronary heart disease. The high frequency of use of cooking oil means that cooking oil is often used repeatedly. Repeated use of cooking oil can cause damage to various body organs such as the liver, heart, kidneys and arteries. Exposure to free radicals and free fatty acids obtained from used cooking oil if it enters the body will result in oxidative stress. The atherosclerosis process is characterized by the change of k-LDL to Ox-LDL which triggers endothelial dysfunction and the formation of atherosclerotic plaque on the walls of blood vessels. The high fatty acid content in used cooking oil can easily stick to the walls of blood vessels, so that it will accumulate and form atherosclerotic plaque. One of the alternative antioxidants that comes from herbs is bitter melon (Momordica Charantia L). Bitter melon contains flavonoid compounds. Flavonoids are secondary metabolites which are antioxidants that can inhibit free radical activity and can prevent atherosclerosis. Antioxidant compounds can reduce atherosclerosis by inhibiting LDL metabolism in secondary atherosclerotic lesions to prevent LDL oxidation in these lesions.
Peran Flavonoid Sebagai Antiulser dan Antioksidan pada Ulkus Duodenum Zahra, Aulia Jannatuz; Susianti, Susianti; Happy, Terza Aflika; Soleha, Tri Umiana
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1415

Abstract

Duodenal ulcer is a pathological condition characterized by damage to the duodenal mucosa due to an imbalance between protective and aggressive factors, such as gastric acid and pepsin. The primary factors contributing to the development of this ulcer include Helicobacter pylori infection. Additionally, prolonged use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) is also a significant factor in the occurrence of duodenal ulcers, as these drugs inhibit prostaglandin synthesis, which plays a crucial role in mucosal protection. In Indonesia, the prevalence of duodenal ulcers is estimated to be around 11–14%. Flavonoids, as bioactive compounds with antioxidant, anti-inflammatory, and anti-ulcer properties, have been widely studied for their potential in the management of peptic ulcers, including duodenal ulcers. Flavonoids have been shown to inhibit gastric acid secretion, stimulate mucus production, and protect the gastrointestinal mucosa through cytoprotective and antioxidative mechanisms, specifically by inhibiting reactive oxygen species (ROS). Furthermore, flavonoids have the ability to suppress H. pylori growth, thereby contributing to the prevention of ulcer pathogenesis caused by this bacterium. Flavonoids also enhance blood flow to the gastric mucosa and modulate enzymes involved in epithelial defense. Despite these benefits, the main challenges in utilizing flavonoids are their low bioavailability and potential toxicity at high doses. Therefore, further studies are essential to evaluate the efficacy, safety, and formulation optimization of flavonoids to enhance their availability as a natural therapeutic alternative and their application in the clinical treatment of peptic ulcers.
Potensi Daun Jambu Air (Syzygium aquem) sebagai Fitofarmaka : Literature Review Febrianti, Arlin; Susianti, Susianti; Kusumaningtyas, Intan; Mustofa, Syazili
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1456

Abstract

Traditional medicine widely utilizes plant extracts from various parts of plants due to their secondary metabolite content, which possesses therapeutic effects. One plant with high pharmacological potential is the water apple leaf (*Syzygium aqueum*), belonging to the Myrtaceae family and commonly found in tropical regions such as Indonesia, Malaysia, and India. Water apple leaves have been used as phytopharmaceuticals because they contain various bioactive compounds that can be extracted and utilized for treating different diseases. The active compounds commonly found in water apple leaves include alkaloids, flavonoids, steroids, triterpenoids, and coumarins. Studies have shown that water apple leaf extracts exhibit various pharmacological activities, including antibacterial, antioxidant, anti-inflammatory, anticancer, antimicrobial, and antidiabetic properties. Additionally, the bioactive compounds in water apple leaves have the potential to be further developed as natural therapeutic agents for treating degenerative diseases and infections. This pharmacological potential positions water apple leaves as a promising phytopharmaceutical candidate for development in the pharmaceutical and healthcare industries. However, further research is required to explore the mechanisms of action, efficacy, and potential toxicity of the active compounds in water apple leaves. A comprehensive study in this area will enable the optimization of water apple leaves as a safe and effective natural therapy for various diseases.
Pengaruh Pemberian Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp) Terhadap Gambaran Sel Hepatosit Tikus Putih Jantan Galur Sprague-Dawley Ruslani, Nada Oktista; Susianti, Susianti; Graharti, Risti; Rudianto, Waluyo
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1693

Abstract

Syzygium myrtifolium Walp., commonly known as red shoot leaves, is an ornamental plant rich in bioactive compounds such as flavonoids, tannins, and terpenoids, which exhibit antioxidant, anticancer, and antibacterial properties. However, administration at high doses may lead to hepatotoxic effects. The liver plays a central role in drug metabolism and is the first organ exposed to toxic agents, making it highly susceptible to hepatocyte necrosis. This study aimed to evaluate the effect of ethanol extract of Syzygium myrtifolium leaves on liver histopathology in male white rats (Rattus norvegicus). This experimental study employed a post-test only control group design with three groups: control, 2000 mg/kgBW, and 5000 mg/kgBW. The extract was administered orally, and hepatocyte necrosis was assessed using a histopathological scoring system. Statistical analysis included Shapiro-Wilk, Levene’s Test, One Way ANOVA, and post hoc LSD. Histopathological examination revealed normal hepatocytes in the control group, focal necrosis in the 2000 mg/kgBW group, and extensive necrosis in the 5000 mg/kgBW group. Statistical analysis confirmed normally distributed and homogeneous data, while ANOVA indicated significant differences among groups (p=0.001). Post hoc LSD test further demonstrated significant differences between the control and treatment groups as well as between both treatment doses. In conclusion, oral administration of ethanol extract of Syzygium myrtifolium leaves induces hepatocyte necrosis in male white rats, with the severity of liver damage increasing in a dose-dependent manner.
Co-Authors Ace Tatang Hidayat Agustyas Tjiptaningrum Ajabar, Ajabar Akram, Musfira Azizah Ambarwati, Yuli Anggraeni Janar Wulan, Anggraeni Janar Arfah, Arfah Ayu Irawati Azis, Sukmawati Bahri. S, Andi Bayu Anggileo Pramesona Betta Kurniawan, Betta Buana, Faris Agung DAMIRAH DAMIRAH, DAMIRAH Djamir, A. Fatimah Dyah Wulan Sumekar Rengganis Wardani Endro Prasetyo Wahono Ety Apriliana Eva Lusina, Septia Evi Kurniawati, Evi Faisal Rahman, Faisal Fatriyadi Suwandi, Jhons Fausyiah, Nurul Febrianti, Arlin Fitria Saftarina Gemayangsura, Gemayangsura Giska Tri Putri Hana Muthi'a Putri Hanif Kurniadi Hanna Mutiara, Hanna Happy, Terza Aflika Hardiansyah, Ridwan Haryono, Iranita Hasbilla, Raihan Fathurrahman Helmi Rahmawati Hendri Busman Herlina Herlina Imron, Nadi Indri Windarti Intan Kusumaningtyas Intanri Kurniati Iranita Haryono Irfandi Ismunanto, Aziza Regina Kinasih Iswandi Darwis Jamir, Fatimah Janar Wulan, Anggraini Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Joni, Agnesia Priskila Justisia, Adilla Khairun Nisa Landoni, Fira M. Ridho Ulya Mansur, Narti Marcellia, Selvi Marhani Marhani Mayasari, Diana Muhamad Stiadi Novianty, Detty Nurdin K, Nurdin Oktadoni Saputra, Oktadoni Oktaviani, Indri Ovalia, Nora Wilya Padli, Saiful Rahmadani, Ervi Ramadhana Komala Rasmi Zakiah Oktarlina Ratna, Maya Ganda Reni Zuraida Rianto, Muhamad Arif Risti Graharti Rizki Hanriko Rodiani, Rodiani Ronny Lesmana Rosdiana Rosdiana Rudianto, Waluyo Rudiyanto, Waluyo Rurini Retnowati Ruslani, Nada Oktista Safriansyah, Wahyu Salam, Supriyanto Sandra Amalia Riyadi Septia Eva Lusina Septiani, Linda Solihah, Fatimatus Soraya, Yeni Suharmanto Surriandari, Latifah Dwi Suryadi Islami Sutarto Sutarto Sutyarso Sutyarso Syahdewa, Budi Indra Syahriyah Semaun, Syahriyah SYAIFUL BAHRI Syazili Mustofa Tri Umiana Soleha Tuasikal, Moh. Irfan Tutik Ernawati Unang Supratman Usman, Arifa W, Dyah Wulan Sumekar R. W., Dyah Wulan Sumekar R. Wardani, Dyah Wulan Wati, Imelda Fera Yudho Prabowo, Arif Zahra, Aulia Jannatuz