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All Journal Indonesian Journal of Tropical and Infectious Disease SEL Jurnal Penelitian Kesehatan JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Jurnal Manajemen Kesehatan Indonesia Jurnal Penelitian Kesehatan Suara Forikes Jukema (Jurnal Kesehatan Masyarakat Aceh) Jurnal Surya Masyarakat JURNAL PENDIDIKAN TAMBUSAI Jurnal Ilmu Kedokteran dan Kesehatan Journal of Midwifery and Nursing Jurnal Medika Malahayati Jambura Health and Sport Journal Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Ilmu Kesehatan Bhakti Husada: Health Sciences Journal Jurnal Bidang Ilmu Kesehatan J-KESMAS: Jurnal Kesehatan Masyarakat Afiasi : Jurnal Kesehatan Masyarakat Jurnal Kesehatan Ilmiah Indonesia / Indonesian Health Scientific Journal Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health) Jurnal Sains Riset PREPOTIF : Jurnal Kesehatan Masyarakat BALABA (JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA) Journal of Nursing and Public Health (JNPH) Indonesian Journal of Global Health research Jurnal Surya Masyarakat Jurnal Pengabdian Masyarakat dalam Kesehatan Jurnal Promotif Preventif Journal SAGO Gizi dan Kesehatan Jurnal Kebidanan Muhammadiyah GEULIMA Jurnal Kesehatan Tambusai Jurnal Kesmas Jambi Journal of Public Health Innovation (JPHI) Narra J GANESHA: Jurnal Pengabdian Masyarakat Journal of Health Research Science Jurnal Ilmu Kesehatan Insan Sehat SEHATI: Jurnal Kesehatan Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Al-Khidmah Jurnal Pengabdian Masyarakat Jurnal Sains dan Teknologi Sehat Rakyat: Jurnal Kesehatan Masyarakat JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Journal of Health and Medical Science Journal of Public Health Concerns Narra X International Journal of Applied Research and Sustainable Sciences (IJARSS) Journal of Public Health and Pharmacy Medika: Jurnal Ilmiah Kesehatan Holistik Jurnal Kesehatan Joong-Ki Jurnal Berkawan
Farrah Fahdhienie
Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Aceh, Banda Aceh
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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PEMBERDAYAAN MASYARAKAT SEKOLAH MELALUI SOSIALISASI MANFAAT MENGKONSUMSI BUAH DAN SAYUR DI MADRASAH IBTIDAIYAH SWASTA AL ISTIQAMAH, KUEH LHOKNGA, ACEH BESAR Farrah Fahdhienie; Tahara Dilla Santi
Jurnal Berkawan: Jurnal Pengabdian kepada Masyarakat Vol. 1, No. 1, Januari 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/berkawan.v1i1.3141

Abstract

Elementary school children are in a critical period of growth and development. Proper nutritional intake, especially from vegetables and fruit, is very important to support their health, strengthen the immune system, and prevent disease. Increasing knowledge about the benefits of consuming fruit and vegetables needs to be done in order to prevent various diseases related to nutrition and optimize growth and development. The method used was health education for 31 Mis students. This activity begins with distributing pre-test questionnaires, counseling and ends with distributing post-test questionnaires. The results of this activity show that the outreach activities related to the benefits of consuming fruit and vegetables were carried out well and almost 70% experienced an increase in knowledge. In conclusion, there was an increase in knowledge after counseling was carried out through presentations and screening of educational videos.
Random forest-based QSAR modeling for predicting the potency of neprilysin inhibitors using Mordred molecular descriptors Albar, Nizam; Rampengan, Derren DCH.; Azhari, Saiful; Mahmudi, Mahmudi; Fahdhienie, Farrah; Susilawati, Anggi; Habiburrahman, Muhammad
Narra X Vol. 4 No. 1 (2026): April 2026 (In Press)
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v4i1.242

Abstract

Neprilysin (NEP) is a zinc-dependent metallopeptidase, considered a key therapeutic target in heart failure management. Efficient identification of potent NEP inhibitors remains a challenge in drug discovery. The aim of this study was to develop a quantitative structure–activity relationship (QSAR) model using 2D Mordred molecular descriptors and Random Forest algorithms to predict the inhibitory potency (pIC50) of drug candidates. A curated dataset of compounds with experimentally determined IC₅₀ values (in nM) against NEP was preprocessed and converted to pIC50. Mordred was used to calculate 2D molecular descriptors, and descriptors with missing values were excluded. The dataset was split into training, internal validation, and external test sets. A Random Forest regression model was trained using 500 estimators, and model performance was evaluated using R2, root mean square error (RMSE), mean absolute error (MAE), and concordance correlation coefficient (CCC), while a binary classification model was also constructed. Feature importance, residual analysis, and chemical space visualization were conducted to assess model interpretability and reliability. The regression model demonstrated moderate to strong predictive performance, with R2 of 0.286, RMSE of 0.949, MAE of 0.723, and CCC of 0.532 in the internal validation. External validation showed improved generalization, with R2=0.659, RMSE=0.858, MAE=0.630, and CCC=0.763. Binary classification revealed an accuracy of 0.953, precision of 1.000, recall of 0.943, and an F1-score of 0.971, indicating strong discriminative ability in classifying inhibitory versus non-inhibitory compounds. Top contributing descriptors included ATSC2p (feature importance=0.0505), GATS2p (0.0408), and SaasC (0.0317). Principal component analysis (PCA) and Williams plots confirmed that test compounds lie within the model’s applicability domain, with no major outliers in leverage or residual distribution. The developed Random Forest-based QSAR model demonstrates strong predictive power and interpretability for identifying NEP inhibitors. This study provides a valuable tool for virtual screening and highlights the relevance of 2D structural features in governing NEP inhibitory activity. It is the first dedicated QSAR analysis of neprilysin inhibition using Mordred descriptors with rigorous internal and external validation.
Perilaku Pencegahan Demam Berdarah Dengue di Wilayah Kerja Puskesmas Meuraxa Kota Banda Aceh Ainul Fadla; Farrah Fahdhienie; Vera Nazhira Arifin
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7576

Abstract

DHF is a health problem in tropical climates. This disease can disrupt the function of capillary blood vessels and the blood clotting system, thus increasing the risk of bleeding in sufferers. This study design was a case-control study with 31 cases and 31 controls, totaling 62 respondents. The sampling technique was total sampling, with data collected through questionnaires over 27 days. The results of the univariate analysis showed that most respondents sometimes empty landfills (43.5%), do not cover them properly (58.1%), and do not recycle used items (91.9%). In addition, 79% hang clothes indoors, 69.4% use mosquito repellent, and 79% consider the role of mosquito larvae control teams to be inadequate. Bivariate analysis showed that the behavior of draining (p = 0.001; OR = 13.3) and covering water reservoirs (p = 0.033; OR = 2.6) were significantly associated with the incidence of dengue fever, while recycling used goods (p = 0.162; OR = 0.225), hanging clothes (p = 0.755; OR = 1.215), the use of mosquito repellent (p = 0.409; OR = 1.581), and the role of jumantik (p = 0.119; OR = 2.761) did not show a statistical relationship. Community behavior in implementing 3M Plus plays a role in the incidence of DMF, especially the habit of not draining landfills regularly. Therefore, cross-sectoral cooperation and continuous education are needed between the government, health workers, and the community through mosquito nest eradication activities and routine counseling, so that compliance can be increased and the incidence of DMF can be suppressed.
Co-Authors Abdi, Naufal Abdullah, Asnawi Abidin, Taufik F. Achmad, Asmawati Afriliansyah Sihotang Afriliansyah, Afriliansyah Agustin, Rahmanda Amelia Agustina Agustina Agustina Agustina Agustina Ainul Fadla Akbar, Azrial Akbar, Fahrisal Akhmalnihar, Ulfa Albar, Nizam Amalia, Anasya Amara Rizal, Audia Amin, Fauzi Ali Andrean, Heppy Maulizar Andria, Dedi Anggi Susilawati Anggun Paramita Djati Arafani, Vilda Arbi, Anwar ARBIE, ANWAR Arifin, Vera Nazhira Arifin, Vera Nazira Arifin, Vera Nazirah Ariscasari, Putri Arlianti, Nopa Asnawi Abdullah Atira, Dhia Ayu Vinezia Situmeang Azhari, Saiful Azwar, Eddy Baharuddin , Dharina Baharuddin, Dharina Basri Aramico, Basri Bella, Natha Damayanti, Elok Darmawan, Aldi Darwis, Aryandi Dede Dessy Listyana Depa Raihan Desi Ari Apsari Devi Zulfika Dharina Baharuddin Diana, Mutia Eddy Azwar Elvira Nova Riany Erma Wina Erwiyanti, Sherly Nurfajri Fadhlullah Fadhlullah Fadhlullah, Fadhlullah Fahmi Ichwansyah Faisal Abdurahman fajri, izzarul fahmi Fathiariani, Liza febrianti, heni Febriyanti, Heni Fitri, Raihanil Hafnidar, Hafnidar Hamisah, Irma Handayani, Yusra Haris Ferdinal Setiawan Hasnaini, Cika Hayatunnufus Hayatunnufus Hermansyah Hermansyah Humaira, Adintya Ibrahim, Aisha Humaira Ichwamsyah, Fahmi Ihsan, Ahadun Ipah Riani Iqhrammullah, Muhammad Irma Hamisah Irma Linda Jabari, Jabari Julamnur, Ratifa Kamalurrijal, Kamalurrijal Kartini Kartini Kausar, Muhammad Anis AL Khairunnisa LB, ROSMAINI Lheena, Cut Putri Zaila M. Marthoenis Mahmudi Mahmudi Maidar, Maidar Maidar, Maidar Mainimar Mainimar Mairani, Tiara MAQFIRAH, MONA HILOKA Maqfirah, Rauzatul Marhamah Marhamah Marzuki Marzuki Maudi, Viranika Maulana, Aiga Maulinasari, Maulinasari Melania Hidayat Meutia Zahara Mhd. Nauval Ridha Mudatsir Mudatsir Muhammad Ghifari Karsa Muhammad Habiburrahman, Muhammad Muhammad Iqbal Muharani, Muharani Mulia, Syarifah Sulfira Mushaddiq, Muhammad Mutia, Sunnia Nahrisah, Putri Naila Sabila Nana Wildana Nauval, M. Dharma Nazri Fajrianda Nengsi, Poppy Sri Ningsih, Rima Wirayudha Nisak, Khairun Nisrina Nisrina Nova Septiana Puteri Nurjannah Nurjannah Nurjannah, Nurjannah Nurmaili Nurmaili Phossy Vionica Ramadhana Pratiwi, Agil Putri Balqis, Putri Putri Riza Yana Radhiah Zakaria Rahayu, Rauza Lestari Rahma Wati Rahmadhani, Syahri Rahmadhaniah Rahmadhaniah Rahmah, Fitri Mauliza Raiyan, Deka Ramadhana, Phossy Vionica Ramadhani, Putri Nur Ramadhani, Tiara Rampengan, Derren DCH. Rasmawati, Rasmawati Rawanita, Misdar Regina, Farin Rezeki, Tamara Riany, Elvira Nova Ricinta, Putroe Aliya Rihadah, Sofaa Risa Hajjatul Ula Riska Riska Rosaria Indah Saiful Kamal sainah, Nur Santika, Deva saputra, T. Yudha Sari, Herdinda Mutiara Sari, Putri Ardila Savitri, Hidayati Septiani, Riza Siska Riani Soleha, Rifa Sonia Bella Sanjaya Sugisni, Susi Syahriazi Tahara Dilla Santi Tahara Dilla Santi Tapa, Rd Baresi Sananda ULUL AZMI Utari, Nadia Vera Nazhira Arifin Vera Nazhira Arifin Vera Nazhira Arifin Vera Nazhira Arifin Vera Nazhira Arivin Waliyyuddin, Rajwa Wardiati, Wardiati Wartini, Sari Wiwit Aditama Yesi Yuliana Yesika Amananda Yusafrita, Yusafrita Zahara, Meutia Zakaria , Radhiah Zakaria, Radhiah Zuhriyyah, Azqia