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All Journal VALENSI Teknologi dan Kejuruan: Jurnal teknologi, Kejuruan dan Pengajarannya JURNAL KIMIA SAINS DAN APLIKASI Jurnal Pendidikan Teknologi dan Kejuruan Al-Manahij: Jurnal Kajian Hukum Islam Media Penelitian dan Pengembangan Kesehatan agriTECH Jurnal Pendidikan Ilmu Sosial R.E.M (Rekyasa Energi Manufaktur) Jurnal Manajemen Pendidikan BERITA BIOLOGI E-Dimas: Jurnal Pengabdian kepada Masyarakat Edukasi: Jurnal Pendidikan Jurnal Pengembangan Teknologi Informasi dan Ilmu Komputer AL-IDARAH: JURNAL KEPENDIDIKAN ISLAM ANNALES BOGORIENSES Jurnal Agrotek UMMat SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Teknik Pertanian Lampung (Journal of Agricultural Engineering) Journal of Tropical Crop Science IZDIHAR Jurnal Pro Hukum : Jurnal Penelitian Bidang Hukum Universitas Gresik Al - Tadabbur: Jurnal Ilmu Al-Qur'an dan Tafsir GERVASI: Jurnal Pengabdian kepada Masyarakat Teknologi Indonesia JURNAL PANGAN Musamus Journal of Physical Education and Sport (MJPES) APTEK Rayah Al Islam : Jurnal Ilmu Islam Jurnal PORKES Community Development Journal: Jurnal Pengabdian Masyarakat SUHUF: Jurnal Pengkajian Al-Qur'an dan Budaya International Journal of Social Learning (IJSL) Journal La Lifesci International Journal of Progressive Mathematics Education JUSTIN (Jurnal Sistem dan Teknologi Informasi) Jurnal Agro Dedikasi Masyarakat (JADM) Journal of Office Administration : Education and Practice Jurnal Energi dan Inovasi Teknologi Indonesian Health Issue Tsaqofah: Jurnal Penelitian Guru Indonesia Jurnal Magister Akuntansi Trisakti Jurnal: International Journal of Engineering and Computer Science Applications (IJECSA) Journal of Educational Management Research PANDU: Jurnal Pendidikan Anak dan Pendidikan Umum Pengabdian Jurnal Abdimas JPMAT Prosiding Seminar Nasional Keperawatan Universitas Muhammadiyah Surakarta Al-Qudwah: Jurnal Studi Al-Qur'an dan Hadis El-Mujtama: Jurnal Pengabdian Masyarakat Cocos Bio Protech Biosystems Journal Journal of Multidisciplinary Inquiry in Science, Technology and Educational Research Jurnal Pengabdian Dosen Republik Indonesia (JPDRI) Jurnal Ilmiah Cano Ekonomos Annales Bogorienses Berita Biologi
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Journal : VALENSI

Halal Authentication and Metabolite Mapping of Kombucha Products via Gas Chromatography-Mass Spectrometry (GC-MS) and Chemometric Analysis Hermanto, Sandra; Arginia, Della; Mustafidah, Mabrurotul; Fathoni, Ahmad
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.44602

Abstract

The presence of ethanol in fermented beverages is a critical factor in the halal certification process. One of the key parameters for verifying the halal status of such products is the quantification of ethanol content. Kombucha tea, a fermented beverage produced from sugared tea and a Symbiotic Culture of Bacteria and Yeast (SCOBY), naturally contains ethanol as a byproduct of fermentation. This study aims to determine the ethanol content and differentiate the metabolite profiles of kombucha tea using a non-targeted metabolomics approach, based on variations in tea type, storage temperature, and duration. Ethanol levels were measured by gas chromatography, and metabolite profiling was conducted by gas chromatography–Mass Spectrometry (GC-MS), followed by Principal Component Analysis (PCA) to visualize compositional differences and identify characteristic compounds. The results indicated that tea type significantly influenced ethanol production. The ethanol content of kombucha prepared with black tea, green tea, and white tea was 0.1126% w/w ± 0.0003 v/v, 0.1708% w/w ± 0.0053 v/v, and 0.1301% w/w ± 0.0043 v/v, respectively. Green tea kombucha, which exhibited the highest ethanol content, was selected for storage analysis. During storage, ethanol levels increased slightly to 0.1789% w/w ± 0.0008 v/v in the first week, followed by a gradual decline to 0.1478% w/w ± 0.0071 v/v by the fourth week. Metabolomic profiling revealed distinct differences in secondary metabolite composition among the three tea variants, as evidenced by non-overlapping PCA groupings. Key discriminant compounds identified included ethyl acetate, ethyl octanoate, ethylamine, and (E)-2-decenal, which are proposed as characteristic markers for kombucha derived from black, green, and white teas. These findings contribute to understanding kombucha’s biochemical diversity and support halal verification through ethanol quantification and metabolite-based authentication.
In-Silico Studies of Potential Anti-Alzheimer Compounds from Spondias dulcis Fathoni, Ahmad; Salma, Aninda; Amilia, Nurul; Rudiana, Tarso
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46175

Abstract

Alzheimer's is a chronic neurodegenerative disease characterized by low levels of acetylcholine and the accumulation of abnormal neuritic plaques, leading to rapid memory decline and cognitive impairment. Compounds found in the kedondong plant (Spondias dulcis) have been reported to exhibit in vitro activity as acetylcholinesterase inhibitors. This study examines the potential of active compounds in Spondias dulcis in their interaction with acetylcholinesterase, an enzyme implicated in the pathogenesis of Alzheimer's disease. The enzyme was obtained from the Protein Data Bank (PDB ID: 4EY7). The test ligands were screened based on Lipinski's rule and docked with the receptor. The results of molecular docking which yielded the five best affinity energy values were followed by ADMET testing (absorption, distribution, metabolism, excretion, and toxicity). The test ligand ellagic acid deoxyhexoside showed binding energy at -11.213 kcal/mol. Molecular dynamics simulations were performed using YASARA with AMBER14 force fields for 50 ns. The test ligand ellagic acid eoxyhexoside showed an MM-PBSA value of -51.277 kcal/mol and exhibited good complex stability with an average total RMSD value of 2 Å and low inter-residue fluctuation values. These findings are consistent with the results obtained from the comparator ligand, donepezil. Therefore, compounds in Spondias dulcis have the potential to act as acetylcholinesterase inhibitors and can be considered for the development of therapies for Alzheimer's disease. 
Co-Authors -, Munoto Abdul Aziz Abdul Basid Abdul Hakim Abdul Malik Abdul Muhaimin, Abdul Abdul Wahab Rosyidi Adi Gunawan, Adi Adi Supratikto, Adi Ahmad Muhibbin Ahmad Zain Sarnoto Aini, Isnawatul Akbar, Muhammad Aminul Aldy, Aldy Alfi Rahmi, Alfi Alfiah, Lufita Nur Amilia, Nurul AMINUDIN ANDRIA AGUSTA Anjis Sapto Nugroho Anshori, Muhammad Helmi Anton Anton Antonius Herry Cahyana Aprilia, Aqsha Putri Arginia, Della Arif Nurkanto Arif Rahman Saleh Arip, Moh Astuti, Tri Dwi Ayuniyyah, Q Azhar, Fachri Azis, Sri Misykat Azmi Asra, Azmi Azmi, Aulul Baiq Desi Dwi Arianti Dewi Sukma DEWI WULANSARI Dian Kristiawan Nugroho Dody Pratama Marumpe Durinda Puspasari Efendy, Oscar Effendi, Oscar Eko Supriyanto Ema Damayanti Emilyani, Desty Eri Zuliarso Erik Estrada Erni Romansyah Euis Ismayati Faisal Mahmoud Adam Farooq, Omar Fatahillah, Ahmad Fathoni, Rois Fitriyanto, Arief Hafid, Lukman Haq, M. Ziyadul Hard, Rasyd Hariadi Hariadi Hariani, Listi Hariyanto Hengky Anra Heri Kuswanto Hidayatullah, Tobib Huda, Ade Naelul Huda, Ahmad Akromul Husni Tamim, Muhammad Ida Wahyuni Ikhsan Gunawan Indra Himayatul Asri Irdawati, I Irma Sari Ismatullah, Kholida Ismiyarto Ismitarto I’tishom Billah, Muhammad Qudwah Jamaludin . Jeong, Soo Kyoung Jeong, Soo Kyoung Jumesam, Jumesam Junaidi, Nurhikmah Sasna Junaidin, Junaidin Kamal, Andi Saptaji Kamaludin, Basori Kartika Dyah Palupi Karyanik, Karyanik Keim, Ary P Khairunnisa, Imma Jannati Khoirul Muhtadin Kholisho, Yosi Nur Kim, Joon Kyun Kim, Joong Kyun Legisnal Hakim lina marlina, lina Maksum, M. Syukron Maliq, Nina Marianah, Marianah Markhamah Mayasti, Nur Kartika Indah Mohammad Fathi Royyani, Mohammad Fathi Mohammad Irfan Molo, Hasanuddin Muhamad Arpan Muhammad Ilyas Muhammad Ramli Muliatiningsih Muliatiningsih Murry Harmawan Saputra Mustafidah, Mabrurotul Mu’iz Widayat, Walid N. Sri Hartati, N. Sri Naelul Huda, Ade Ngadiwiyana M.Si. S.Si. Nofriser, Nofriser Nunung Ariandani Nur Annisa Istiqamah Nur Halifa Nurhayati, Nurhayati Nurhikmah Sasna Junaidi Sasna Junaidi, Nurhikmah Sasna Junaidi Sasna Nurlaela, Lutfiyah Oktiva, Yayuk Dwi Pipit Irawati Prabowo, Ardian Adi Pramono Pramono Praptiwi Praptiwi Prastiwi, Erfa Kurnia Purwo Subekti Puspa, Rahma Putra, Aldho Pramana Putra, Reinaldo Dede Putri, Ade Lia Putu Sudira R. Haryo Bimo Setiarto, R. Haryo Bimo Raden Haryo Bimo Setiarto, Raden Haryo Bimo Rahmawati, Rika Sri Ridwan Sinurat Rina Nopiana Risna Rianti Sari Rois Fatoni Royani, M Fathi ryanjani lila anggraita Salma, Aninda Sandra Hermanto Saputra, Andra Sasna Junaidi, Nurhikmah Septiana, Nurwinda Sari Sintho Wahyuning Ardie Sudarsono Sudiyanto, I wayan Suhairin, Suhairin Supari Muslim Suryansah Suyitno Suyitno Syafri Edi Syamsiar, Syamsiar Syirril Ihromi, Syirril Tanjung, H Tarso Rudiana, Tarso Tiwi, Praptiwi Toman, Sarah Husain Tri Afirianto, Tri Tri Murningsih, Tri Tri Rijanto Tursina Tursina Uska, Muhammad Zamroni Visto, Yohanes Wahyudi Wahyudi Wariso Wariso, Wariso Wazni, M Khairul Wibawanti, Jeki Mediantari Wahyu Wijoyo, Moh. Noer Tondo Winna Dharmayanti Yeza Febriani Yose Rizal Yuhendri, Muhammad Yuliasri Jamal Zaki Al Fatih, Moh Zakiy, Ahmad Zuliawan, Ikbal Zulkarnain, Lalu Iskandar