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Gunawan Pamudji Widodo
Universitas Setia Budi
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Aktivitas Antidiabetika Kombinasi Fraksi Etil Asetat Buah Pare (Momordica charantia L.) dan Rimpang Zamzani, Irfan; Nugroho, Agung Endro; Widodo, Gunawan Pamudji
Jurnal Farmasi Indonesia Vol 9, No 2 (2017)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v9i2.575

Abstract

Diabetes Mellitus type 2 can be caused by the resistance of tissue towards insulin accompanied by relative deficiency in insulin secretion. Insulin resistance factor can result from obesity. This research aims to investigate anti- diabetic activity of the compound of FEA of curcuma (Curcuma domestica Val) and bitter melon (Momordica charantia L.). Subjects of this research were 40 albino Wistar rats (Rattus norvegicus) aged 5-8 weeks. The rats were randomly grouped into 8 experimental groups in which each group consisted of'5 rats. The tested animals were divided into 6 groups, KG) metformin 45 mg/Kg BB, P1: FEA curcuma 10 mg/ 200g BB, P2: FEA bitter melon 04 mg/ 200g BB, P3: Compound of FEA curcuma : FEA bitter melon 5 : 0,8 mg/200g BB, P4: Compound of FEA curcuma : FEA bitter melon 10 : 04 mg/200g BB, and P5: Compound of FEA curcuma : FEA bitter melon (20 : 02mg9/200g BB). The animals were inducted with insulin resistance with the giving of HFD-fructose. Result showed that the compound of FEA of curcuma (Curcuma domestica Val) and FEA of bitter melon (Momordica charantia L.) had the activity of lowering blood glucose level: the best anti-diabetic activity was identified in the compound of FEA of curcuma and FEA of bitter melon at the dose of 20: 0,2m9g/200g BB in the rats with HFD- fructose.Diabetes Mellitus type 2 can be caused by the resistance of tissue towards insulin accompanied by relative deficiency in insulin secretion. Insulin resistance factor can result from obesity. This research aims to investigate anti- diabetic activity of the compound of FEA of curcuma (Curcuma domestica Val) and bitter melon (Momordica charantia L.). Subjects of this research were 40 albino Wistar rats (Rattus norvegicus) aged 5-8 weeks. The rats were randomly grouped into 8 experimental groups in which each group consisted of'5 rats. The tested animals were divided into 6 groups, KG) metformin 45 mg/Kg BB, P1: FEA curcuma 10 mg/ 200g BB, P2: FEA bitter melon 04 mg/ 200g BB, P3: Compound of FEA curcuma : FEA bitter melon 5 : 0,8 mg/200g BB, P4: Compound of FEA curcuma : FEA bitter melon 10 : 04 mg/200g BB, and P5: Compound of FEA curcuma : FEA bitter melon (20 : 02mg9/200g BB). The animals were inducted with insulin resistance with the giving of HFD-fructose. Result showed that the compound of FEA of curcuma (Curcuma domestica Val) and FEA of bitter melon (Momordica charantia L.) had the activity of lowering blood glucose level: the best anti-diabetic activity was identified in the compound of FEA of curcuma and FEA of bitter melon at the dose of 20: 0,2m9g/200g BB in the rats with HFD- fructose.Diabetes Mellitus type 2 can be caused by the resistance of tissue towards insulin accompanied by relative deficiency in insulin secretion. Insulin resistance factor can result from obesity. This research aims to investigate anti- diabetic activity of the compound of FEA of curcuma (Curcuma domestica Val) and bitter melon (Momordica charantia L.). Subjects of this research were 40 albino Wistar rats (Rattus norvegicus) aged 5-8 weeks. The rats were randomly grouped into 8 experimental groups in which each group consisted of'5 rats. The tested animals were divided into 6 groups, KG) metformin 45 mg/Kg BB, P1: FEA curcuma 10 mg/ 200g BB, P2: FEA bitter melon 04 mg/ 200g BB, P3: Compound of FEA curcuma : FEA bitter melon 5 : 0,8 mg/200g BB, P4: Compound of FEA curcuma : FEA bitter melon 10 : 04 mg/200g BB, and P5: Compound of FEA curcuma : FEA bitter melon (20 : 02mg9/200g BB). The animals were inducted with insulin resistance with the giving of HFD-fructose. Result showed that the compound of FEA of curcuma (Curcuma domestica Val) and FEA of bitter melon (Momordica charantia L.) had the activity of lowering blood glucose level: the best anti-diabetic activity was identified in the compound of FEA of curcuma and FEA of bitter melon at the dose of 20: 0,2m9g/200g BB in the rats with HFD- fructose.
Aktivitas Antidiabetika Kombinasi Fraksi Etil Asetat Buah Pare (Momordica charantia L.) dan Rimpang Zamzani, Irfan; Nugroho, Agung Endro; Widodo, Gunawan Pamudji
Jurnal Farmasi Indonesia Vol 9, No 2 (2017)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (953.194 KB) | DOI: 10.35617/jfi.v9i2.575

Abstract

Diabetes Mellitus type 2 can be caused by the resistance of tissue towards insulin accompanied by relative deficiency in insulin secretion. Insulin resistance factor can result from obesity. This research aims to investigate anti- diabetic activity of the compound of FEA of curcuma (Curcuma domestica Val) and bitter melon (Momordica charantia L.). Subjects of this research were 40 albino Wistar rats (Rattus norvegicus) aged 5-8 weeks. The rats were randomly grouped into 8 experimental groups in which each group consisted of'5 rats. The tested animals were divided into 6 groups, KG) metformin 45 mg/Kg BB, P1: FEA curcuma 10 mg/ 200g BB, P2: FEA bitter melon 04 mg/ 200g BB, P3: Compound of FEA curcuma : FEA bitter melon 5 : 0,8 mg/200g BB, P4: Compound of FEA curcuma : FEA bitter melon 10 : 04 mg/200g BB, and P5: Compound of FEA curcuma : FEA bitter melon (20 : 02mg9/200g BB). The animals were inducted with insulin resistance with the giving of HFD-fructose. Result showed that the compound of FEA of curcuma (Curcuma domestica Val) and FEA of bitter melon (Momordica charantia L.) had the activity of lowering blood glucose level: the best anti-diabetic activity was identified in the compound of FEA of curcuma and FEA of bitter melon at the dose of 20: 0,2m9g/200g BB in the rats with HFD- fructose.Diabetes Mellitus type 2 can be caused by the resistance of tissue towards insulin accompanied by relative deficiency in insulin secretion. Insulin resistance factor can result from obesity. This research aims to investigate anti- diabetic activity of the compound of FEA of curcuma (Curcuma domestica Val) and bitter melon (Momordica charantia L.). Subjects of this research were 40 albino Wistar rats (Rattus norvegicus) aged 5-8 weeks. The rats were randomly grouped into 8 experimental groups in which each group consisted of'5 rats. The tested animals were divided into 6 groups, KG) metformin 45 mg/Kg BB, P1: FEA curcuma 10 mg/ 200g BB, P2: FEA bitter melon 04 mg/ 200g BB, P3: Compound of FEA curcuma : FEA bitter melon 5 : 0,8 mg/200g BB, P4: Compound of FEA curcuma : FEA bitter melon 10 : 04 mg/200g BB, and P5: Compound of FEA curcuma : FEA bitter melon (20 : 02mg9/200g BB). The animals were inducted with insulin resistance with the giving of HFD-fructose. Result showed that the compound of FEA of curcuma (Curcuma domestica Val) and FEA of bitter melon (Momordica charantia L.) had the activity of lowering blood glucose level: the best anti-diabetic activity was identified in the compound of FEA of curcuma and FEA of bitter melon at the dose of 20: 0,2m9g/200g BB in the rats with HFD- fructose.Diabetes Mellitus type 2 can be caused by the resistance of tissue towards insulin accompanied by relative deficiency in insulin secretion. Insulin resistance factor can result from obesity. This research aims to investigate anti- diabetic activity of the compound of FEA of curcuma (Curcuma domestica Val) and bitter melon (Momordica charantia L.). Subjects of this research were 40 albino Wistar rats (Rattus norvegicus) aged 5-8 weeks. The rats were randomly grouped into 8 experimental groups in which each group consisted of'5 rats. The tested animals were divided into 6 groups, KG) metformin 45 mg/Kg BB, P1: FEA curcuma 10 mg/ 200g BB, P2: FEA bitter melon 04 mg/ 200g BB, P3: Compound of FEA curcuma : FEA bitter melon 5 : 0,8 mg/200g BB, P4: Compound of FEA curcuma : FEA bitter melon 10 : 04 mg/200g BB, and P5: Compound of FEA curcuma : FEA bitter melon (20 : 02mg9/200g BB). The animals were inducted with insulin resistance with the giving of HFD-fructose. Result showed that the compound of FEA of curcuma (Curcuma domestica Val) and FEA of bitter melon (Momordica charantia L.) had the activity of lowering blood glucose level: the best anti-diabetic activity was identified in the compound of FEA of curcuma and FEA of bitter melon at the dose of 20: 0,2m9g/200g BB in the rats with HFD- fructose.
Co-Authors Abdul Mahmud Yumassik abdul rofiq Achmad Fudholi Achmad Fudholi Ade Sukma Hamdani Adrianto, Madyo Agnes Christina Budiwati Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Andayani, Tri Murti Aneng Ardiya Sukmawanti Anggun Setya Wibawa, Anggun Setya Arief Nurrochmad arikha ayu susilowati Arisma Nuri Pebryana Aslam, Astri Asri Laksmi Riani Asri Laksmi Riani Astri Aslam Aswandi Aswandi Ayu Wulandari Ayudia Cipta Khairani BETA K. PRAMUDYAWARDHANI Chairun Wiedyaningsih Chandra Arifin Clara Ritawany Sinaga Dan Mona Aprilia Daniel Maharai Daniel Maharai Dedent Eka Bimmaharyanto.s Dewi, Lucia VIta Inandha Dian Marlina Dini Okyaviani Dwi Ningsih Eko Yudha Prasetyo Elin Yulinah Sukandar Elina Endang Sulistyowati Endang Diyah Endang Diyah Endang Dyah Ikasari endey, joverly Ercis Ercis Ercis, Ercis Fauziyyah Al Hasanah Fendy Prasetyawan FEOLISTIN MIENCE POBAS Ferdinan Jalung Ferdinan Jalung Fitrianingsih, Sri Fridly Manawan Gunawan Firmansyah Gusti Ayu Rai Saputri Handayani, Sri Rejeki Handi Mukti Fahrizal Handi Mukti Fahrizal Haris Maspekeh Hartih, Nur Aeni Hartono Hartono Hasbrianti, Armayanti Rindiarko Hastuti, Nita Hasty Martha Wijaya Hierowat, Rina Humaidah, Daffa I Ketut Adnyana Ika Purwidyaningrum INDRAWATI FITRIANA Irmatika Hendriyani Islamiati , Utami Ismi Rahmawati Isna Nur Khasanah Iswandi Iswandi Iswandi Iswandi Ittiqo, Dzun Haryadi Iwan Yuwindry Jason Merari Peranginangin Junagsti Bermalam Kartini Nur Wulandari Latief, Aprilianti A. Lestari, Rizkia Putri Madyo Adrianto Madyo Adrianto Mamik Ponco Rahayu MARIA E.D.O. HUREK MAKING MARIA YANGSYE LENGGU Marlina, Dian Milda Rianty Lakoan Milda Rianty Lakoan Muhamad Aulia Putra Tawakal Muhammad Syukri Mukti, Yusuf Anggoro Naha Ndjurumbaha, Echa Malinda Noval Noval Noval Noval Nugroho , Agung Endro Nugroho Wisnu Putro Nur Aeni Hartih NURAINI HARMASTUTI Nuraini Harmastuti Nuraini Harmastuti Oetari Oetari Oetari Oetari Oklyan, Risny Pare, Nurdiana Tandi Poppy Dwi Citra Jaluri Puspitasari, Ismi R, Herowati R., Wirdah Wati R.A. Oetari R.A. Oetari R.A. Oetari, R.A. Rahmadani . Rahmawati, Ismi Ranowijaya Ranowijaya Recky Patala Rika Arfiana Safitri Rosa Juwita Hesturini Ruly Anggrayni Safwan Safwan, Safwan Santi Dwi Astuti Satibi Satibi . Satibi Satibi Satibi Satibi Satibi Satibi Siswanto, Didik Sri Fitrianingsih Srini, Dwi Sukrasno Sukrasno Suryono Suryono Teodhora, Teodhora Teuku Nanda Saifullah Sulaiman Theedens, Maria Theodora Toding, Ficanata Adhiguna Tri Murti Andayani Tri Murti Andayani Tri Wijayanti Tri Wijayanti Valiandri Puspadina Wahdah, Rismaul Wahid, Abdul Rahman Widayatul Khairi Widia Wati Widyasti, Jena Hayu Windi Astuti Wirdah Wati R. Yeli Trimayanti Yul Mariyah Yuwindry, Iwan Zamzani, Irfan