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Hamny Sofyan
Laboratorium Anatomi, Fakultas Kedokteran Hewan, Universitas Syiah Kuala, Banda Aceh
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Immunoexpression of aortic endothelial P-selectin and serum apolipoprotein A-1 levels after administration of arabica (Coffea arabica) and robusta (Coffea canephora) coffee bean extracts: In vivo study in atherosclerosis rat model Ekawati, Wahyu; Heriansyah, Teuku; Kamarlis, Reno K.; Purnawarman, Adi; Sofyan, Hamny; Enitan, Seyi S.
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.794

Abstract

Atherosclerosis is a leading cause of cardiovascular disease-related death worldwide. Some studies suggested that the natural ingredients in coffee may negatively affect cardiovascular diseases, while other studies indicated that coffee contains anti-inflammatory compounds that are beneficial for cardiovascular diseases. The aim of this study was to measure the expression of P-selectin in aortic endothelial cells and the level of serum apolipoprotein A-1 (ApoA-1) in an atherosclerosis rat model after the administration of arabica and robusta coffee bean extracts at mild-moderate and high doses. An experimental study was conducted with a complete randomized design using 36 adult male white rats (Rattus norvegicus) divided into six groups: negative control (NC), positive control (PC), arabica mild-moderate dose (A1), arabica high dose (A2), robusta mild-moderate dose (R1), and robusta high dose (R2). Animals were induced atherosclerosis with atherogenic feed and then were treated with arabica and robusta coffee bean extracts at two different doses for four weeks. The results showed that the expression of P-selectin in the group of rats treated with robusta coffee bean extract was lower than arabica coffee bean extract group. Rats with robusta coffee bean extract mild-moderate dose had the highest ApoA-1 levels compared to other groups significantly (p<0.05). The level of ApoA-1 was higher in both mild-moderate and high dose of robusta coffee groups compared to the negative control group (both with p<0.001). In conclusion, mild-moderate intake of robusta coffee bean extract could reduce aortic P-selectin immunoexpression and increase serum ApoA-1 levels in an atherosclerosis rat model.
Co-Authors . Nurliana . Zuchri ., Daniel Abdul Harris Abdullah Hamzah Adi Purnawarman, Adi Ahmad Azhari Nopiosi Alfajri Saputra Alfajri Saputra Ali, Ihfan Khaidir Aliman Irfandi Amalia Sutriana Amiruddin A Andi Novita Anugrah Septian Aris Junaidi Ayu Agita Ginting Azhari Azhari Bambang Pontjo Priosoeryanto Boni Anggara Budianto Panjaitan Budianto Panjaitan Chairun Nisa Chika Nahara Ramadhanty Chintya Desfariza Cut Dahlia Iskandar Daniel Daniel Darmawi Darmawi Debby Novita ayumi Dian Masyitha Dian Masyitha Dwinna Aliza Ekawati, Wahyu Enitan, Seyi S. Erdiansyah Rahmi Erdiansyah Rahmi Erdiansyah Rahmi Ezy Yulanda Rezki Fachrizal Ambia Fadli A Gani Fadli A. Gani Fadli A. Gani Fadli A. Gani Fadli. A. Gani Fahrezi, Muhammad Gilbran Faisal Jamin Faisal Mustafa Fakhrurrazi Fakhrurrazi Fakhrurrazi Fakhrurrazi Ferllya Adela Putri Fitriani Fitriani Fitriani Fitriani Frengki Frengki Gani, Fadli A Gani, Fadli A. Gholib Gholib Gholib Gholib, Gholib Hafizuddin Hafizuddin Hamdani Budiman Hasan, Hafidh Hasriati Hasriati Hendri Hermawan Adinugraha Herlina Dimiati, Herlina Herlina Yuliani Herrialfian Herrialfian I. Djuwita . I.Nasution . Idawati Nasution Idawati Nasution Idawati Nasution Idawati Nasution Isky, Saiful Ismail Ismail Ismail Ismail Ita Djuwita Ita Djuwita Joharsyah J Juli Melia Kamarlis, Reno K. Ketut Adnyane Mudite Khairun Nisa Kimmy Keisha Avrila Rozandi Kusdiantoro Mohamad Lailia Dwi Kusuma Wardhani Lailia Dwi Kusuma Wardhani Lexa Lady Syourin Lidya Elizabeth M. Manik M. Hasan M. Isa M. Isa M. Jalaluddin Mahdi Abrar Mahdi Abrar Mahdi Abrar Makmur, Ali Manfarizah Manfarizah Manfarizah Manfarizah Maryulia Dewi Mudatsir Mudatsir Mudhita Zikkrullah Ritonga MUHAMMAD AGIL Muhammad Hambal Muhammad Hambal Muhammad Iqbal Muhammad Jalaluddin Muhammad Jalaluddin Muhammad Jalaluddin Muhammad Jalaluddin, Muhammad Muhammad Resthu Muhammad Zulfan Mulyadi Adam Mulyadi Adam Mulyadi Adam Mulyadi Adam, Mulyadi Muslim Akmal Muslim Akmal Mustafa Sabri Mustafa Sabri Mustafa Sabri Muttaqien Muttaqien Nabila Latifa Hafizsha Nadia Hanifah Nanda Yulian Syah Nauval Gibran Lubis Noni Zakiah Nurhidayat, Nurhidayat Nuzul Asmilia Patrick Flaggellata Prabowo Purwono Putro Primaadhi Abimanyu Satrio Raharjo Rastina Rastina Razali Daud Rinidar R Rinidar Rinidar Ritonga, Mudhita Zikkrullah Ritonga, Mudhita Zikrullah Roslizawaty R Rosmaidar Rosmaidar S. Agungpriyono . Safni Kamal Saputra, Jefri Dwi Savitri Novelina Shinta Mutia RM Siti Aisyah Sri Haryani Sri Wahyuni Sri Wahyuni Sri Wahyuni Sri Wahyuni Sri Wahyuni Sri Wahyuni Sri Wahyuni Srihadi Agungpriyono Sugito Sugito Sugito Sugito Sulasmi Sulasmi Suriadi S Syafruddin S Syafruddin Syafruddin Syakur Syakur Syakur Syakur Syifa Aurelia Devina T. Armansyah T. Armansyah T. Armansyah, TR Tanjung, Fitri Aisah Taufan Hidayat Taufan Hidayat Taufan Hidayat Taufan Hidayat Taufan Hidayat Teti Arabia Teti Arabia Teuku Heriansyah, Teuku Teuku Reza Ferasyi Tongku Nizwan Siregar Triva Murtina Lubis Tuty L. Yusuf Tuty Laswardi Yusuf Tuty Laswardi Yusuf Ummu Balqis W.E. Prasetyaningtyas . Wahono Esthi Prasetyaningtyas Wahyu Eka Sari Wahyuni, Sri Wardhani, Lailia Dwi Kusuma Wasmen Manalu Yulisma, Rika Yusnizar Yusnizar Yusnizar Yusnizar Zainabun Zainabun Zainabun Zainabun Zainabun Zainabun Zainabun, Z Zainuddin Z Zainuddin Zainuddin Zainuddin Zainuddin Zainuddin Zainuddin Zuhrawati Zuhrawati Zuraidawati Zuraidawati