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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Syntax Literate: Jurnal Ilmiah Indonesia Majalah Farmaseutik Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Holistik Jurnal Kesehatan Jurnal Farmasi Indonesia JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Biomedika dan Kesehatan Poltekita : Jurnal Ilmu Kesehatan Majalah Farmasetika To Maega: Jurnal Pengabdian Masyarakat Jurnal Farmamedika (Pharmamedica Journal) SULUH: Jurnal Abdimas Health Information : Jurnal Penelitian Jurnal Kesehatan Poltekkes Kemenkes RI Pangkalpinang Jurnal Kefarmasian AKFARINDO Jurnal Kesehatan Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Farmagazine Jurnal Buana Farma Binawan Student Journal Journal of Social Research East Asian Journal of Multidisciplinary Research (EAJMR) International Journal of Health and Pharmaceutical (IJHP) Sciences of Pharmacy Jurnal Farmasi Indonesia Kartika : Jurnal Ilmiah Farmasi Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan Journal of Natural Product for Degenerative Diseases Akurasi Jurnal Kesehatan
Dian Ratih Laksmitawati
Universitas Pancasila
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pengaruh pelatihan pembuatan minuman probiotik serta efikasi diri terhadap minat usaha kelompok masyarakat pendiri bank sampah di kota Depok Umi Marwati; Laili Savitri Noor; Dian Ratih Laksmitawati; Liliek Nurhidayati
AKURASI: Jurnal Riset Akuntansi dan Keuangan Vol 4 No 2 (2022)
Publisher : LPMP Imperium

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36407/akurasi.v4i2.491

Abstract

This study aimed to determine the effect of counseling and training on the manufacture of probiotic-based health drinks as well as the self-efficacy ability of members of the community group waste management in the city of Depok on the interest in the probiotic beverage business. The 68 respondents included members of the Dahlia Pirus waste bank group (Pondokjaya Village, Cipayung District), Mekar Peduli waste bank (Krukut Sub-district, Limo District) and the Villa Tanah Baru waste bank (Tanah Baru, Beji). This activity involves students. The research method uses multiple regression analysis. The research results show that training has a positive and significant effect on business interest, but self-efficacy has a negative and insignificant effect on business interest.
Pengaruh Pemberian Antibiotik terhadap Tanda Infeksi Daerah Operasi Superfisial dan Lama Tinggal Pasien Sectio Caesaria Teulis Sumiartini; Dian Ratih Laksmitawati; Hesti Utami Ramadaniati; Ronald Irwanto Natadidjaja; Rudi Asmajaya
Jurnal Biomedika dan Kesehatan Vol 4 No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2021.v4.5-11

Abstract

LATAR BELAKANGStandar Nasional Akreditasi Rumah Sakit (SNARS) edisi 1/2018 menjadikan kejadian Infeksi Daerah Operasi (IDO) sebagai salah satu indikator mutu untuk menilai kinerja pengendalian infeksi di rumah sakit. Pemberian antibiotik lanjutan pascaoperasi sectio caesaria (SC) menjadi isu yang penting untuk dikaji, mengingat operasi ini pada dasarnya tidak membutuhkan pemberian antibiotik lanjut pascaoperasinya. Penelitian ini bertujuan untuk melihat apakah pemberian antibiotik lanjutan pascaoperasi SC berpengaruh terhadap penurunan IDO superfisial dan Length of Stay (LOS) pasien. METODEPasien dibagi menjadi 2 kelompok dengan jumlah masing-masing sebesar 49 subjek. Kelompok pertama adalah kelompok subjek yang diberikan antibiotik lanjut pascaoperasi SC dan kelompok kedua adalah kelompok subjek yang tidak diberikan antibiotik lanjutan pascaoperasi SC, kemudian dari masing-masing kelompok dikaji kemungkinan munculnya tanda IDO superfisial dan LOS pasien. Desain penelitian ini adalah kohort retrospektif dengan data sekunder dari rekam medis pasien Januari 2019-Desember 2019. Uji analisa dengan Chi-square. HASILSetelah mengontrol variabel perancu, pemberian antibiotik lanjut pascaoperasi SC tidak signifikan berpengaruh menurunkan kemungkinan munculnya tanda IDO superfisial (OR=0.157;p=0.098; 0.02-1.41 IK 95%), juga tidak memiliki pengaruh terhadap LOS pasien (OR=1.73; p=0.562; 0.27-10.85 IK 95%). KESIMPULANTidak terdapat pengaruh dari pemberian antibiotik lanjutan terhadap tanda kejadian IDO superfisial dan LOS pada pasien post SC. Pemberian antibiotik lanjutan pascaoperasi SC merupakan pemberian antibiotik yang tidak bijak.
LITERATURE REVIEW: POTENSI OBAT BAHAN ALAM DARI TANAMAN SEMANGGI AIR (Marsilea crenata) Chandra, Pra Panca Bayu; Laksmitawati, Dian Ratih
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1383

Abstract

The use of plants as natural medicine is used because Indonesia has a wealth of natural resources. One of the plants used is water clover (Marsilea crenata). This plant is used as food and medicine. This study aims to identify the potential of natural medicine from water clover (Marsilea crenata). The research method in the literature study is to apply journal searches to the Google Scholar, Science Direct, and Pubmed databases with the keywords water clover (Marsilea crenata) and pharmacological activity. The journals used are national and international journals published from 2012 to 2025. The journals used are research on the potential of water clover as a natural medicine in silico, in vitro and in vivo. From the results of the literature study, 9 journals were obtained. After obtaining research data from journals, they were then combined and studied, then explained and explained systematically. The results of the study showed that water clover leaves in both extract and fraction forms have pharmacological activities including anticholesterolemia, antihyperglycemia, antioxidant, anti-inflammatory, HMG-CoA reductase enzyme inhibitory activity, sperm quality improvement activity in hyperglycemic mice, anti-neuroinflammatory serum. The content of secondary metabolites found in Marsilea crenata is a bioactive compound that is responsible for providing pharmacological activity.
Antioxidant Activity Cultivated of Soursop (Annona muricata L.) Leaves Extract in Jayasari Village, Pangandaran District, West Java Zahara, Indah; Anwar, Effionora; Laksmitawati, Dian Ratih; Rahmat, Deni
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.5317

Abstract

Indonesia is a source of raw materials for tropical medicines that treat various diseases. One of the places to plant soursop leaves in West Java is Jayasari Village, Pangandaran District. Annona muricata Linn (Soursop) leaves is a medicinal plant widely used as an anti-diabetic, anti-inflammatory, insecticide, antimalarial, anticancer, antibacterial, and antioxidant. Soursop leaves have many benefits because they contain phytochemical compounds. This study aims to determine the phytochemical content, total flavonoid content, and antioxidant activity of A. muricata leaves. This research was carried out in several steps, including extraction, evaporation, phytochemical testing, total flavonoid content, and antioxidant activity. Phytochemicals were extracted with 96% ethanol by maceration. Measurement of flavonoids in extracts was determined using standard quercetin and UV-Vis spectrophotometry method. Antioxidant activity was carried out through a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical removal test. The results showed that the ethanol extract of soursop leaves contained alkaloids, flavonoids, phenolics, saponins, and tannins. The results of measurements of flavonoids from the ethanol extract of soursop leaves showed that 1 g of the extract contained 8.32 mg of quercetin equivalent. The ethanol extract of soursop leaves has antioxidant activity, as indicated by the scavenging of DPPH radicals with an IC50 of 56.73 ppm.
Anti-inflammatory Activity of Glucomannan Resulting from β-mannanase Enzyme Hydrolysis in RAW 264.7 Cells Nuraini, Nuraini; Effionora Anwar; Dian Ratih Laksmitawati; Hendig Winarno; Siti Irma Rahmawati
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 2 (2025): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i2.7797

Abstract

Glucomannan is a polysaccharide of the hemicellulose type, composed of glucose and mannose chains. It has the ability to form solutions that expand and thicken. The bioactivity of carbohydrates is influenced by the length of their saccharide chains. Hydrolysis can alter the structural dimensions of polysaccharides, including molecular weight, type, number, and position of substituent groups, which in turn impacts their biological activity. Various methods can modify carbohydrate structures to enhance their value, with degradation being one such method. Enzymatic degradation is particularly advantageous due to its high specificity, efficiency, and minimal side effects. Numerous studies have identified glucomannan as having immunomodulatory effects on macrophage cells. When stimulated with lipopolysaccharides, macrophages release various cytokines and inflammatory mediators, such as TNF-α, iNOS, and NO. This study explored the potential anti-inflammatory effects of glucomannan (GM) and its enzymatically hydrolyzed form (Enz-GM) on RAW 264.7 cells. The research involved degrading glucomannan using the β-mannanase enzyme, followed by in vitro testing of the degradation product (Enz-GM) for anti-inflammatory activity. This was achieved using an ELISA kit to measure the expression of IL-6, TNF-α, and iNOS. The results showed that Enz-GM at pH 9 (Mw 1.24 kDa) significantly reduced the pro-inflammatory cytokines IL-6 and iNOS (p ≤ 0.05) compared to GM, while TNF-α expression did not show a significant difference between Enz-GM and GM.
Study Of The Anti-Obesity Potential Of Chlorogenic Acid Through Molecular Docking Faridah, Faridah; Mumpuni, Esti; Purnomo, Hari; Laksmitawati, Dian Ratih; Simanjuntak, Partomuan
Journal of Social Research Vol. 3 No. 2 (2024): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v3i2.1910

Abstract

Chlorogenic acid, the primary constituent found in green coffee, is believed to possess anti-obesity properties. Numerous studies have indicated that the etiology of obesity is predominantly influenced by genetic factors. This study employs molecular docking techniques to estimate the effectiveness and toxicity of chlorogenic acid as an anti-obesity agent, focusing on its interaction with PLANTS. Initially, the validation process involved confirming the target cell or receptor (PDB code) which included PPAR-? (3NOA, 2ATH), pancreatic lipase (5ZUN), ghrelin (6ZYF), leptin (3V6O), and melanocortin (6W25, 7F58) through the utilization of YASARA software. In addition, the process of docking chlorogenic acid compounds and a positive control (for comparative purposes) was conducted on target cells utilizing the PLANTS program. The toxicity test and prediction of lethal dose (LD 50) were conducted on active substances and positive controls using the ProTox-II program. Chlorogenic acid exhibits anti-obesity properties by acting as an inhibitor of the ghrelin hormone, as seen by its activity at PDB code 6ZYF with a docking score of -19.7099 higher than the positive controls bupropion -18.5269 and naltrexone -18.5871. Furthermore, it has been determined to possess a generally safe profile, with an LD50 value of 5000 mg/kg body weight. The docking studies indicate that chlorogenic acid exhibits anti-obesity activity specifically at PDB code 6ZYF, where it functions as an inhibitor of the ghrelin hormone. Chlorogenic acid typically exhibits modest efficacy as an anti-obesity agent, hence presenting potential avenues for enhancing its effectiveness by structural modifications
Effect of Combination of Porang and Moringa Flour on Blood Glucose Levels and Body Weight in Rats Laksmitawati, Dian Ratih; Marwati, Umi; Okta, Fauzia Noprima; Partana, Citra Prastuti
Sciences of Pharmacy Volume 3 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0302215

Abstract

Porang tuber is rich in fiber and low in calories of carbohydrates. Moringa oleifera leaf has a high protein and a low content of lipids. Obesity and diabetes mellitus are the risk factors of cardiovascular disease, also known as cardiovascular disease risk factors. Combining of porang and moringa as feed can increase nutrition without causing weight gain. This study aims to determine these two materials as antidiabetic and antiobesity agents. The samples are porang tuber, a combination of porang tuber and M. oleifera leaves, a combination of M. oleifera leaves and wheat flour, wheat flour, and standard feed of mice. The parameters tested in this study are analysis of macronutrients of feed, loss of weight of mice, average consuming feed in 28 days, and reduction of blood glucose with a glucometer. The results obtained are a combination of porang tuber and moringa had a low contain carbohydrates and a high contain lipids and protein, can reduction in body weight of 21%, the lowest consumption of feed, and the lowest fasting and postprandial blood glucose levels compared to the other feeds. A combination of porang and moringa can be an antidiabetic and antiobesity agent.
ANALISIS KLAIM PEMBIAYAAN KEMENKES DAN BIAYA RIIL RS PADA COVID-19 DI RSUD CEMPAKA PUTIH JAKARTA Ana Yupita Liza; Dian Ratih Laksmitawati; Prih Sarnianto; Selvy Devita Anggeraini
Jurnal Kesehatan Vol. 13 No. 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan (STIKes) Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38165/jk.v13i2.323

Abstract

Coronavirus Disease 2019 (COVID-19) merupakan penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Kasus COVID-19 diperparah oleh beragam komorbid, menyebabkan biaya per pasien menjadi bervariasi. Pemerintah mengalokasikan dana yang tinggi sebagai strategi dalam upaya percepatan penanggulangan wabah COVID-19 yang teknis pengajuan klaimnya merujuk pada Keputusan Menteri Kesehatan 446/2020 dan 4344/2021. Penelitian ini bertujuan untuk mengetahui selisih biaya yang diterima oleh rumah sakit dari Kementerian Kesehatan (Kemenkes) dengan biaya riil rumah sakit. Pada penelitian observasional ini, sampel (236 responden) diambil secara acak dari populasi pasien rawat inap COVID-19 derajat sedang periode Januari–Juni 2021 (597 pasien) menggunakan tabel Krejcie dan Morgan. Data restrospektif diambil dari rekam medis, casemix, dan penagihan (billing), secara potong-lintang. Hasil analisis deskriptif yang dilakukan menunjukkan bahwa pasien COVID-19 dalam penelitian ini sebagian besar adalah perempuan (139 orang, 58,9%), rentang usia 18–82 tahun dan sebagian besar dari kelompok usia 26–45 tahun (102 orang, 43,2%), tidak memiliki komorbiditas (121 orang, 51,3%), dengan rerata lama rawat-inap (LoS) 10 hari. Terkait biaya, total realisasi klaim pembiayaan periode Januari–Juni 2021 yang diterima dari Kemenkes mencapai Rp18.659.815, atau lebih tinggi secara signifikan dibanding total biaya riil rumah sakit (Mann-Whitney, p <0,05). Dari biaya riil rumah sakit Rp2.286.282.430, komponen terbesar adalah obat Rp557.193.006 (24,37%). Rerata selisih antara klaim dan biaya riil yang cukup tinggi, Rp57.860.630 -Rp76.870.587 per pasien tersebut belum memperhitungkan biaya investasi yang dikeluarkan rumah sakit dalam bentuk berbagai peralatan (seperti ventilator) dan fasilitas lainnya (ruang isolasi bertekanan negatif, penambahan ruangan ICU dan HCU) yang belum tentu produktif setelah pandemi berlalu, sehingga dapat dikatakan wajar. Selisih positif tersebut menurun setelah diberlakukannya Keputusan Menteri Kesehatan Nomer 4344/2021 untuk periode 20 April 2021 sampai 30 Juni 2021 sebagai bentuk evaluasi secara berkesinambungan dari pemerintah terhadap pembiayaan COVID-19.Kata Kunci: COVID-19; analisis biaya; realisasi klaim; biaya riil; selisih biaya AbstractCoronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Cases of COVID-19 are exacerbated by various comorbidities which lead to various per patient costs. The government allocates high funds as a strategy to accelerate the management of the COVID-19 outbreak, wherein the technical claims refer to the Decree of the Minister of Health number 446/2020 and 4344/2021. This study aims to determine the difference between costs received by hospitals from the Ministry of Health and the real costs incurred by the hospitals. This was an observational study which involved 236 respondents who were randomly selected from the population of moderate-degree COVID-19 inpatients for the period January–June 2021 (597 patients) by using Krejcie and Morgan table. Retrospective data were taken from medical records, casemix, and billing, cross-sectionally. The results of the descriptive analysis conducted showed that most of COVID-19 patients in this study were women (139 respondents or 58.9%). Age of respondents ranged from 18–82 years old and most of respondents were involved in the age group of 26–45 years (102 respondents or 43, 2%). Furthermore, most of respondents had no comorbidities (121 respondents or 51.3%), with the mean length of stay (LoS) of 10 days. Regarding costs, the total realization of financing claims for the period January–June 2021 from the Ministry of Health was IDR 18,659,815, or significantly higher than the total real hospital costs (Mann-Whitney, p < 0.05). Of the real hospital costs of IDR 2,286,282,430, the largest component was medicine by IDR 57,193,006 (24.37%). The mean difference between claims and real costs was quite high by IDR 57,860,630 – IDR 76,870,587 per patient, by not considering the investment costs incurred by the hospital in the form of various equipment (such as ventilators) and other facilities (negative pressure isolation rooms, as well as additional ICU and HCU wards) which are not necessarily productive after the pandemic has passed. Thus, it can be said that such difference was natural. The positive difference decreased after the enactment of Decree of the Minister of Health No. 4344/2021 for the period April 20, 2021 to June 30, 2021 as a form of continuous evaluation provided by the government towards COVID-19 financing.Keywords: COVID-19; cost analysis; claim realization; real cost; difference in cost
Co-Authors . Syamsudin Ahmad Faried Ana Yupita Liza Andayani, Nurita Andreas Infianto Ani Retno Prijanti Annisa Septyana Putri Ayu Werawati Bagus Bahtiar Bambang Ponco Priosoeryanto Cahyaning Riski Wijayanti Caroline Tan Sardjono CAROLINE TAN SARDJONO Chandra, Pra Panca Bayu Claudia Tiffani Dedy Kurniawan Deni Rahmat Deni Rahmat Devina Harti Syaputri Diah Kartika Pratami Diar Gustianti Istita Edwin Tomasoa Effionora Anwar Effionora Anwar Elisabeth Ninung Yuliarti Esti Mumpuni Esti Mumpuni Esti Mumpuni Esti Mumpuni, Esti Faradiba Faradiba Faridah Faridah Ferry Sandra Hanna Sari W Kusuma Hanna Sari Widya Kusuma HARI PURNOMO Hendig Winarno Hendig Winarno Hesti Utami Ramadaniati Hesti Utami Ramadaniati Hikariastri, Pangartika Indah Zahara Ivans Panduwiguna James Ibrahim Jayati, Turpuk Mannaria Jeanette Mangiwa Jeanne A. Pawitan JEANNE ADIWINATA PAWITAN Juliana Irem Adriana Purukan Katharina Aditya Candra Utukaman Kusmardi Kusmardi Kusmardi Kusmardi Laili Savitri Noor Laksono Trisnantoro Larasinta, Nadia Lia Warti Liliek Nurhidayati Magdalena Niken Oktovina Marwati, Umi Marybet Tri Retno Handayani Meilda Ayu Bathini Mita Restina Moch Futuchul Arifin Mohamad Sadikin Mohammad Sadikin Mokhamad mahroji Muhammad Hanafi Mulatsari, Esti Noor, Laili Savitri Novia Maulina Novia Maulina Nuraini Nuraini Nurita Andayani Okta, Fauzia Noprima Oriza Safrini Oriza Safrini Panca, Pra Panca Bayu Chandra Pangartika Hikariastri Partana, Citra Prastuti Partomuan Simanjuntak Patminingsih, Nanik Pra Panca Bayu Chandra Pra Panca Bayu Chandra Prasasta Sutedjo Prih Sarnianto Prih Sarnianto Prih Sarnianto Prilasari, Sharon Alia Rachmawati Noverina RAHMAT, DENI Rahmawati, Siti Irma Ramadaniati, Hesty Utami Ranald Irwanto Ratih Rinendyaputri Renni Septini Rikkit Sihombing Rilianawati Rilianawati Riska Eka Putri, Riska Eka Rizal Rizal Rizal Rizal Ronald Irwanto Ronald Irwanto Natadidjaja Ros Sumarny ROS SUMARNY Ros Sumarny Rudi Asmajaya Sahat Saragi Sampurno Sampurno Sampurno Sampurno Sarwono Waspadji Seila Arumwardana Selvy Devita Anggeraini Shelly Taurhesia Simbolon, Roslan Simbolon, Roslan Siti Umroh Noor Sutarno Syamsudin Abdillah Teulis Sumiartini Tomasoa, Edwin Trisna Lestari Umi Marwati Utukaman, Katharina Aditya Candra Vergie Indriani Wahono Sumaryono Wahyu Widowati Wahyu Widowati Wireni Ayuningtyas Yoppy Mayrosa Yudha Sukowati Yusi Anggraini Yusi Anggriani Yusi Anggriani Zahara, Indah