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All Journal Jurnal Anestesi Perioperatif Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Global Medical and Health Communication JPSriwijaya Sari Pediatri Biomedical Journal of Indonesia Syntax Literate: Jurnal Ilmiah Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) International Journal of Retina SRIWIJAYA JOURNAL OF MEDICINE Economics and Finance in Indonesia Oto Rhino Laryngologica Indonesiana Majalah Anestesia dan Critical Care Majalah Kedokteran Andalas Majalah Patologi Indonesia Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health) Jurnal Aisyah : Jurnal Ilmu Kesehatan Sriwijaya Journal of Surgery Indonesian Journal of Global Health research Eureka Herba Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal Of World Science Jurnal Penyakit Dalam Indonesia IJRETINA - International Journal of Retina
Muhammad Irsan Saleh
Bagian Farmakologi, Fakultas Kedokteran, Universitas Sriwijaya, Palembang, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Terapi Bekam: Efek Anti Peradangan dalam Pengobatan Tradisional Wahyuni, Dian; Legiran, Legiran; Saleh, Irsan; Salim, Eddy Mart
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.374-390

Abstract

This comprehensive literature review consolidates findings from 11 diverse scholarly articles exploring the efficacy of cupping therapy as an anti-inflammatory intervention. The review encompasses studies investigating various clinical applications and experimental models to delineate the therapy's anti-inflammatory effects. The research method utilized the Publish or Perish application to access databases such as PubMed, Scopus, and Google Scholar. The screening process was based on predetermined inclusion and exclusion criteria. Article quality was assessed using the Crowe Critical Appraisal Tool (CCAT). Standard forms were used to extract important information from articles: Authors’ name, Year; Research title; Population; data; Findings. Data were analyzed narratively to generate thematic synthesis. The reviewed studies revealed significant outcomes across multiple domains. Clinical trials demonstrated the efficacy of cupping therapy in managing pain in osteoarthritis and idiopathic menorrhagia. Narrative reviews and experimental studies highlighted its potential in sports injury management and its influence on changes in local blood flow. Additionally, investigations provided insights into its immunomodulatory effects in cancer patients, allergic asthma models, and inflammatory conditions like acute herpes zoster. Synthesizing these findings emphasized the diverse anti-inflammatory effects of cupping therapy across various health conditions, elucidating its mechanisms and potential applications. The therapy exhibited promising outcomes in pain management, inflammation reduction, and modulation of immune responses.
Effect of Garlic (Allium Sativum) Extract on Hemoglobin Levels in Chronic Hemodialysis Patients Ramadhan, Philosophia; Alif Fathur Rachman, Muhammad; Ali, Zulkhair; Effendi, Ian; Novadian, Novadian; Suprapti, Suprapti; Saleh, Irsan
Journal of World Science Vol. 2 No. 1 (2023): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v2i1.129

Abstract

CKD patients undergoing hemodialysis have increased inflammatory biomarkers. Anemia in CKD is associated with an advanced degree of inflammation while undergoing chronic hemodialysis. Garlic (Allium sativum) has anti-inflammatory and antioxidant effects, which are expected to improve the degree of inflammation in CKD patients. This study aims to assess the effect of garlic extract on hemoglobin levels in patients undergoing chronic hemodialysis. This study was an experimental study with a double-blind, randomized clinical trial design. This study was a crossover, randomized, placebo-controlled, double-blind trial. The study subjects were 40 stages 5 CKD patients undergoing chronic hemodialysis, randomly divided into two groups, namely the group that received 1000 mg of garlic extract per day (2x500 mg) for six weeks and the group that received a placebo, then a 2-week wash-out period. And after that, the two groups were given alternate treatment. Statistical analysis was carried out using the SPSS version 25.0 program. A total of 40 subjects participated in the study, 57.5% male. The mean age of the subjects was 48.6 (26-59) years. The results showed that there was a significant difference in Hb levels in the garlic group (p = 0.047), where the increase in Hb was from 10.2 (9.2–11.8) mg/dl to 10.23 (8.9–11.6) mg/dl while in the placebo group, there was a decrease in Hb from 10.18 (9.6 – 11.2) mg/dl to 10.05 ± 0.52 mg/dl. Garlic extract can reduce levels of inflammation which can then increase hemoglobin levels.
Correlation of Vitamin D and Antimullerian Hormone Level in Infertile Women with Polycystic Ovary Syndrome and Obesity Usman, Fatimah; Saleh, Irsan; Effendi, Kms. Yusuf; Putra, Hadrians Kesuma; Abadi, Adnan; Siahaan, Salmon Charles Pardomuan Tua; Kesty, Cindy; Rizda, Dian Permata; Stevanny, Bella; Lestari, Peby Maulina
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.723

Abstract

Introduction: Increasing amount of research indicates that women with PCOS are more likely to have a shortage in vitamin D with abnormally high anti-Müllerian hormone (AMH) levels. This study aims to assess the correlation between vitamin D and Anti-Mullerian Hormone (AMH) levels in infertile women with polycystic ovarian syndrome (PCOS) and obesity. Method: This observational cross-sectional study examined all obese women with PCOS who sought infertility treatment at Dr. Mohammad Hoesin Hospital Palembang from August 2021 to November 2021. PCOS diagnosis was determined using the Rotterdam criteria. All research subjects underwent a physical examination and transvaginal ultrasound to evaluate body mass index (BMI) and polycystic ovary morphology. Blood samples were collected to evaluate their testosterone, AMH, and vitamin D levels. Statistical analysis was performed using the Spearman correlation test with IBM® SPSS Statistics version 24. Results: Thirty infertile women with PCOS and obesity were included in the study, with average age of 31.17±4.48 years and average BMI of 33.45±2.67 kg/m2. The majority of the subjects had polycystic ovary morphology (86.7%) and oligomenorrhea (76.7%). No correlation between BMI and vitamin D as well as AMH levels was found in infertile women with PCOS and obesity. The Spearman test showed moderate negative correlation (p = 0.011. r = -0.458) between vitamin D and AMH levels in infertile women with PCOS and obesity. Conclusion: There is a moderate negative correlation between vitamin D and AMH levels among infertile women with PCOS and obesity. Further research is required to comprehend the role of vitamin D in female fertility.Korelasi Vitamin D dan Kadar Hormon Anti-Müllerian pada Wanita Infertil dengan Sindrom Ovarium Polikistik dan ObesitasAbstrakPendahuluan: Semakin banyak penelitian melaporkan bahwa wanita dengan PCOS cenderung mengalami defisiensi vitamin D dengan penignkatan kadar hormon anti-Müllerian (AMH). Penelitian ini bertujuan untuk mengkaji hubungan vitamin D dan kadar AMH pada wanita infertil dengan sindrom ovarium polikistik (SOPK) dan obesitas.Metode: Penelitian ini merupakan studi observasional potong lintang terhadap seluruh wanita infertil dengan SPOK dan obesitas yang di RSUP Dr. Mohammad Hoesin Palembang pada bulan Agustus 2021 hingga November 2021. Diagnosis SOPK ditegakkan berdasarkan kriteria Rotterdam. Seluruh subjek penelitian menjalani pemeriksaan fisik dan ultrasonografi transvaginal untuk menilai indeks massa tubuh (IMT) dan morfologi ovarium polikistik. Sampel darah dikumpulkan dari semua wanita untuk mengukur kadar testosteron, AMH, dan vitamin D. Analisis statistik dilakukan dengan menggunakan uji korelasi Spearman menggunakan IBM® SPSS Statistics versi 24.Hasil: Tiga puluh wanita infertil dengan SOPK dan obesitas dilibatkan dalam penelitian ini dengan usia rata-rata 31,17±4,48 tahun dan rata-rata IMT 33,45±2,67 kg/m2. Mayoritas subjek memiliki morfologi ovarium polikistik (86,7%) dan oligomenore (76,7%). Tidak ada korelasi antara IMT dan vitamin D maupun kadar AMH pada wanita infertil dengan SOPK dan obesitas. Uji Spearman menunjukkan korelasi negatif sedang (p=0.011.r=-0.458) antara kadar vitamin D dan AMH pada wanita infertil dengan SOPK dan obesitas. Kesimpulan: Kadar vitamin D berkorelasi negatif dengan kadar AMH pada wanita infertil dengan SOPK dan obesitas. Penelitian lebih lanjut diperlukan untuk memahami peran vitamin D pada kesuburan wanita.Kata kunci: Anti-Müllerian Hormone, Indeks Massa Tubuh, Obesitas, Sindrom Ovarium Polikistik, Vitamin D
MicroRNA-21 Expression in Prostate Cancer: A Systematic Review Ulfa, Maria; Murti, Krisna; Saleh, Irsan; Handayati, Debby
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6042

Abstract

Prostate cancer is the second most prevalent and fourth largest cause of death for men globally. Meanwhile, in Indonesia, prostate cancer ranks and is the fourth leading cause of death. Molecular studies continue to be conducted to understand the molecular heterogeneity, both genetic and epigenetic, that affects the progression of prostate cancer, one of which is the role of microRNA. This study aims to analyze the expression profile of microRNA-21 associated with the development and aggressiveness of prostate cancer. Comprehensive search into three databases; PubMed, Cochrane Library, and Science Direct was performed by authors. The study that best met the inclusion criteria was chosen from among duplicates. The QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies) tool was used to assess the risk of bias before the relevant data were retrieved for analysis. There were eleven studies that included a variety of sample sources, sample size and methods. Although a number of the studies had unclear standard reporting, the research overall quality was acceptable. For the results, Prostate cancer samples showed a significantly higher expression level of miR-21 than controls in ten of the studies, and was linked to cancer aggressiveness. In one study, the expression of miR-21 did not significantly increase, despite the use of extracellular vesicle isolation samples.
Co-Authors Abdi Wijaya Abdulwahab Hakimi Ade Suryaman Aditiawati Aditiawati Adnan Abadi, Adnan Adrian, Ronny Ahmad Rasyid ahmad rasyid, ahmad Ahmad, Zen AK Ansyori Akmal, Reza Ali Ghanie Ali Ghanie Ali Ghanie Alif Fathur Rachman, Muhammad Alvilusia, Alvilusia Alwi Shahab Amir Fauzi Amir Fauzi Andi Putra Siregar Anggeria, Septa Anita Tursia Ansyori, AK Anwar, Chairil Arlis Karlina Aseptianova Aseptianova Athiah, Medina Ayeshah A Rosdah Azhari Azhari Banun, Syahri Bastian Bastian Bastian Bintang Arroyantri Prananjaya Chairil Anwar Chakra, Aerul Dalillah Dalillah Dessy Adhriyani, Dessy Dian Wahyuni Dwi Handayani Dwi Handayani Dwirini Retno Gunarti Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim, Eddy Mart Eeng Yoneska Effendi, Ian Effendi, Kms. Yusuf Efman EU Manawan Efman Manawan Efrieni Yusuf Ella Amalia, Ella Emilia Eny Rahmawati, Eny Ernawati Sinaga Erwin Sukandi Erwin Sukandi Evi Lusiana Fatmawati Fatmawati Ferdi, Roni Ferry Usnizar Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fuad Bakry Gita Dwi Prasasty Hafizzanovian, Hafizzanovian Handayati, Debby Heni Maulani, Heni Herdana, Nova Hermansyah Hu, Owen Ian Effendi Iche Andriyani Liberty, Iche Andriyani Ika Kartika Imran Saleh Irfannuddin Irfannuddin Irfanuddin Irfanuddin Istiqomah, Amelia Izzah, Puspita Nurul Jayawarsa, A.A. Ketut Joko Marwoto Jusak Nugraha Kamaluddin Kamaluddin Kartini Wulan Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kendenan, Margaretha Kesty, Cindy Kms Yusuf Effendi Krisna Murti kurniati, nova Kusrini, Ida Kusuma Harimin, Kusuma Larasati, Veny Legiran Legiran Leni Wijaya, Leni Lubis, Fadhyl Zuhry Makbruri Amin Margaretha Kendenan Maria Ulfa Mediarty Medina Athiah Mega Sary Mezfi Unita Mudinillah, Adam Muhamad Ayus Astoni Muhammad Hadi Wijaya Muhammad Haryadi Ade Kurnadi Nadia Karimah Amalia Zulfadli Nita Parisa Nova Herdana Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Novadian Novadian Novadian, Novadian Nugroho, Suroso Adi Nur Riviati, Nur Nuswil Bernolian Oktariana, Desi Pahlawan, M Kaisar Patwa Amani, Patwa Peby Maulina Lestari, Peby Maulina Phey Liana Poedji Loekitowati Hariani Purwoko, Izazi Hari Puspa Zuleika, Puspa Putra, Hadrians Kesuma Rachmat Hidayat RACHMAT HIDAYAT Radiyati Umi Partan Rahadiyanto, Kemas Ya'Kub Rahadiyanto, Kemas Ya’kub Ramadhan, Philosophia Ramzi Amin Ramzi Amin, Ramzi Ratih Pratiwi Reza Akmal Riani Erna Rieke Cahyo Budi Utami Rizal Zainal Rizani Amran Rizda, Dian Permata Rizki Andini Nawawi Ronny Adrian Rostika Dewi Rukiah Chodilawati Rukiah Chodilawati Sabri Prihantika Safyudin Salmon Charles Pardomuan Tua Siahaan Salni Salni Salni Salutondok, Welly Sari, Febrina Sary, Mega Sastradinata, Irawan Shahab, Alwi Soenarto Kartowigno Sri Nita Sri Nita Sri Nita, Sri Stevanny, Bella Subandrate Sudarto Sudarto Sulfa Esi Warni Suprapti Suprapti Suprapti Suprapti Sutandar, Vivi Hendra Syamsu Indra Syifa Alkaf Tanoehardjo, Francisca Srioetami Tanoehardjo, Francisca Srioetami Tanzil, Iswadi Tati Lahmuddin, Tati Tatit Nurseta Taufik Indrajaya Taufik Indrajaya Taufik Indrajaya Taufik Indrajaya Taufik Indrajaya Tengku Arfi Sulaiman Theodarus, Theodarus Theodorus Theodorus Tiara Fatrin Triwani Triwani Triwani Triwani Tursia, Anita Usman Said, Usman Usman, Fatimah Widyastuti Wina Safutri Wresnindyatsih Wresnindyatsih, Wresnindyatsih Yeni Agustin Yenny Dian Andayani Yesi Astri Yudhie Tanta Yulia Farida Yahya Yundari, Yundari Zen Ahmad Zen Hafy Ziske Maritska Zulfadli, Nadia Karimah Amalia Zulfiawan, Zulfiawan Zulkarnain Musa, Zulkarnain Zulkhair Ali Zulkhair Ali Zulkhair Ali Zulkifli Zulkifli Zulkifli Zulkifli