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The Effect of Giving Vitamin D Supplements on Improving Ejection Fraction in Heart Failure Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Andi Putra Siregar; Rukiah Chodilawati; Mgs. Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.869

Background: The role of vitamin D as an inflammation modulator, regulation system renin-angiotensin-aldosterone (RAAS), inhibits the production of parathyroid hormone (PTH), thereby causing left ventricular hypertrophy, causing hypocalcemia which induces hypertrophy in cardiac myocytes and can reduce cardiac contractility. This study aimed to determine the effect of giving vitamin D supplements on improving ejection fraction in heart failure patients at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang, Indonesia. Methods: This study is an experimental study with a double-blind, randomized clinical trial design and uses primary data obtained from clinical examinations and supporting examinations of research subjects. A total of 40 research subjects participated in this study. Results: In this study, the median vitamin D level in the vitamin D supplementation group before treatment was 19.92 ng/dl (18.65-20.22), and in the placebo group was 19.74 ng/dl (18.14 - 20.13). After treatment with 1000 iu of vitamin D given for 3 months, the results showed that in the vitamin D supplementation group, there was an increase in vitamin D levels to 33.06 ng/dl (an increase of 13.14) with statistically significant results (p < 0 .05). In the vitamin D supplementation group, there was an increase in ejection fraction to 37.9% (an increase of 3.65%) with statistically significant results (p<0.05). Contrasting results were shown in the group that received a placebo, where there was a decrease in ejection fraction to 33.15% (2.25% decrease). Conclusion: There is an improving effect of giving vitamin D supplements on increasing ejection fraction in heart failure patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

The Relationship between Skeletal Muscle Strength and Cardiac Senescence Performance in the Elderly at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Muhammad Haryadi Ade Kurnadi; Nur Riviati; Taufik Indrajaya; Mgs. Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.873

Background: The aging process is physiological, but the onset, rate, and extent of the progression of aging at the cell, tissue, organ, and system level are very heterogeneous because they are influenced by genetic and environmental factors. The aging process is known to involve the entire body, including musculoskeletal and cardiovascular components. Several theories explain this association, including reduced muscle mass associated with chronic heart failure, decreased serum myostatin, and cross-talk between skeletal and cardiac muscle mediated by inflammatory cytokines. This study aimed to determine the relationship between skeletal muscle strength and cardiac performance in elderly patients at Dr. Mohammad Hoesin General Hospital, Palembang. Methods: This research is an analytical observational study with a cross-sectional design. The total sample size was 65 individuals who met the inclusion and exclusion criteria. Data analysis was carried out using the SPSS 25 for Windows program. Results: Handgrip strength has a significant relationship with diastolic dysfunction on a numerical scale (p=0.009). Low handgrip strength has a 3 times greater risk of experiencing diastolic dysfunction than patients with Normal Handgrip Strength. Conclusion: Skeletal muscle strength has a relationship with cardiac senescence performance in elderly patients at Dr. Mohammad Hoesin General Hospital, Palembang.

The Relationship Between High-Sensitivity C-Reactive Protein (hs-CRP) and Diastolic Dysfunction in Geriatrics Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Muhammad Hadi Wijaya; Ali Ghanie; Nur Riviati; Mgs. Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.879

Background: Systemic inflammation associated with high hs-CRP levels constitutes one pathway through which diastolic dysfunction develops in older adults. This study aims to determine the relationship between high-sensitivity c-reactive protein (hs-CRP) and diastolic dysfunction in older adults at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This research is an observational analytical study using a cross sectional design. The research was conducted at the geriatrics polyclinic at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia from June to August 2023. A total of 65 people took part in this study. The relationship between hs-CRP and diastolic dysfunction was analyzed using SPSS version 25, univariate and bivariate. Results: Hs-CRP had a significant relationship with diastolic dysfunction on a numerical scale (p=0.012), with a median value of 1.6 mg/dL in subjects with diastolic dysfunction and 0.9 mg/dL in subjects without diastolic dysfunction. On the categorical scale, the hsCRP less than 1 mg/dL group found nine subjects (23.7%) with diastolic dysfunction and 14 subjects (51.9%) without diastolic dysfunction, the hsCRP 1-3 mg/dL group found 21 subjects (55.3%) with diastolic dysfunction and 12 subjects (44.9%) without diastolic dysfunction, in the hsCRP more than 3 mg/dL group (p=0.026) there were eight subjects (21.1%) with diastolic dysfunction and one subject (3.7%) without dysfunction diastolic. Conclusion: There is a significant relationship between hsCRP and left ventricular diastolic dysfunction in geriatrics patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

Competition Test Veteran Affairs Medical Centre (VAMC) Score And KIMS-14 For Predicting the Dehiscence of Abdoment Post Laparotomy Operating Wounds Reza Akmal; Efman EU Manawan; Mgs Irsan Saleh
Sriwijaya Journal of Surgery Vol. 3 No. 1 (2020): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v3i1.24

Introduction: Abdominal wound dehiscence (AWD) is a complication of severe postoperative abdominal surgery, with reported death rates ranging from 10% to 45%. Significant mortality, prolonged hospitalization, increased incidence of incisional hernias and reoperations for ruptured stomachs, with costs associated with the community, emphasize the severity of these complications. The VAMC score and KIMS-14 can be used as screening in predicting surgical injury dehiscence Method: This study is a diagnostic test study to assess the sensitivity and specificity of VAMC and KIMS-14 scoring in predicting the occurrence of abdominal wound dehiscence to be performed in surgery outpatient and digestive surgery ward at the General Hospital, Dr. Mohammad Hoesin Palembang in the period March to May 2019. Results: There were 44 subjects that participated in this study. VAMC has a sensitivity value of 87.5% and specificity of 97.2 with an area under curve value of 0.958 with a cut-off of > 10. KIMS 14 has a sensitivity value of 100% and a specificity of 94.4% with an area under curve value of 0.944 with a cut-off of > 5. Conclusion: KIMS-14 is better in sensitivity, but VAMC is more specific to predict dehiscence licensing in patients undergoing intraabdominal surgery.

The Effect of Giving Vitamin D Supplements on Improving Ejection Fraction in Heart Failure Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Andi Putra Siregar; Rukiah Chodilawati; Mgs. Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.869

Background: The role of vitamin D as an inflammation modulator, regulation system renin-angiotensin-aldosterone (RAAS), inhibits the production of parathyroid hormone (PTH), thereby causing left ventricular hypertrophy, causing hypocalcemia which induces hypertrophy in cardiac myocytes and can reduce cardiac contractility. This study aimed to determine the effect of giving vitamin D supplements on improving ejection fraction in heart failure patients at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang, Indonesia. Methods: This study is an experimental study with a double-blind, randomized clinical trial design and uses primary data obtained from clinical examinations and supporting examinations of research subjects. A total of 40 research subjects participated in this study. Results: In this study, the median vitamin D level in the vitamin D supplementation group before treatment was 19.92 ng/dl (18.65-20.22), and in the placebo group was 19.74 ng/dl (18.14 - 20.13). After treatment with 1000 iu of vitamin D given for 3 months, the results showed that in the vitamin D supplementation group, there was an increase in vitamin D levels to 33.06 ng/dl (an increase of 13.14) with statistically significant results (p < 0 .05). In the vitamin D supplementation group, there was an increase in ejection fraction to 37.9% (an increase of 3.65%) with statistically significant results (p<0.05). Contrasting results were shown in the group that received a placebo, where there was a decrease in ejection fraction to 33.15% (2.25% decrease). Conclusion: There is an improving effect of giving vitamin D supplements on increasing ejection fraction in heart failure patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

The Relationship between Skeletal Muscle Strength and Cardiac Senescence Performance in the Elderly at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Muhammad Haryadi Ade Kurnadi; Nur Riviati; Taufik Indrajaya; Mgs. Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.873

Background: The aging process is physiological, but the onset, rate, and extent of the progression of aging at the cell, tissue, organ, and system level are very heterogeneous because they are influenced by genetic and environmental factors. The aging process is known to involve the entire body, including musculoskeletal and cardiovascular components. Several theories explain this association, including reduced muscle mass associated with chronic heart failure, decreased serum myostatin, and cross-talk between skeletal and cardiac muscle mediated by inflammatory cytokines. This study aimed to determine the relationship between skeletal muscle strength and cardiac performance in elderly patients at Dr. Mohammad Hoesin General Hospital, Palembang. Methods: This research is an analytical observational study with a cross-sectional design. The total sample size was 65 individuals who met the inclusion and exclusion criteria. Data analysis was carried out using the SPSS 25 for Windows program. Results: Handgrip strength has a significant relationship with diastolic dysfunction on a numerical scale (p=0.009). Low handgrip strength has a 3 times greater risk of experiencing diastolic dysfunction than patients with Normal Handgrip Strength. Conclusion: Skeletal muscle strength has a relationship with cardiac senescence performance in elderly patients at Dr. Mohammad Hoesin General Hospital, Palembang.

The Relationship Between High-Sensitivity C-Reactive Protein (hs-CRP) and Diastolic Dysfunction in Geriatrics Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Muhammad Hadi Wijaya; Ali Ghanie; Nur Riviati; Mgs. Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.879

Background: Systemic inflammation associated with high hs-CRP levels constitutes one pathway through which diastolic dysfunction develops in older adults. This study aims to determine the relationship between high-sensitivity c-reactive protein (hs-CRP) and diastolic dysfunction in older adults at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This research is an observational analytical study using a cross sectional design. The research was conducted at the geriatrics polyclinic at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia from June to August 2023. A total of 65 people took part in this study. The relationship between hs-CRP and diastolic dysfunction was analyzed using SPSS version 25, univariate and bivariate. Results: Hs-CRP had a significant relationship with diastolic dysfunction on a numerical scale (p=0.012), with a median value of 1.6 mg/dL in subjects with diastolic dysfunction and 0.9 mg/dL in subjects without diastolic dysfunction. On the categorical scale, the hsCRP less than 1 mg/dL group found nine subjects (23.7%) with diastolic dysfunction and 14 subjects (51.9%) without diastolic dysfunction, the hsCRP 1-3 mg/dL group found 21 subjects (55.3%) with diastolic dysfunction and 12 subjects (44.9%) without diastolic dysfunction, in the hsCRP more than 3 mg/dL group (p=0.026) there were eight subjects (21.1%) with diastolic dysfunction and one subject (3.7%) without dysfunction diastolic. Conclusion: There is a significant relationship between hsCRP and left ventricular diastolic dysfunction in geriatrics patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

Polymorphisms of the Progesterone Receptor Gene in Endometriosis Patients of South Sumatra, Indonesia Muhammad Irsan Saleh; Rizki Andini Nawawi; Subandrate
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 9 No. 2 (2022): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v9i2.287

Polimorfisme pada gen reseptor progesteron dapat mengubah ekspresi dua isoform reseptor progesteron, yang terlibat dalam regulasi efek antiproliferatif progesteron di jaringan endometriotik. Studi ini bertujuan mengidentifikasi polimorfisme +331G/A gen reseptor progesteron pada pasien endometriosis di Palembang, Sumatera Selatan. Identifikasi single-nucleotide polymorphism (SNP) +331G/A dilakukan pada 42 pasien endometriosis dengan menggunakan polymerase chain reaction (PCR) dan restriction fragment length polymorphism (RFLP). Pada penelitian ini, didapatkan 26 subjek (61,9%) memiliki genotip heterozigot mutan terhadap SNP +331G/A. Tidak ditemukan subjek dengan genotip homozigot mutan terhadap SNP +331G/A. Frekuensi alel polimorfik SNP +331G/A didapatkan sebesar 30,9%. Dapat disimpulkan bahwa polimorfisme +331G/A gen reseptor progesteron teridentifikasi pada pasien endometriosis di Palembang, Sumatera Selatan. Penelitian selanjutnya diperlukan guna menentukan peran polimorfisme ini dalam patogenesis endometriosis, khususnya pada pasien di Indonesia.

Nephrotoxicity and Kidney Fibrosis Due to Gentamicin in Wistar Rats Lusiana, Evi; Saleh, Irsan; Sinaga, Ernawati; Hafy, Zen
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.909

Background : Gentamicin is an aminoglycoside used as a treatment for various infections. One of the side effects reported on the use of gentamicin is nephrotoxic. However, there are still many uses of gentamicin that have not been precisely indicated. Objective : To analyze the nephrotoxic effects leading to renal fibrosis due to gentamicin induction in Wistar rats. Methods : This research is an in vivo experimental study, pre- and post-test control group design, conducted in September and October 2022 at the Animal House Laboratory of the Faculty of Medicine, Sriwijaya University, and the Palembang Health Laboratory Center. There were 4 treatment groups: Group I, placebo; Group II, gentamicin-induced (GIG I) at 80 mg/kgBW; Group III, gentamicin-induced (GIG II) at 120 mg/kgBW; and Group IV, gentamicin-induced (GIG III) at 240 mg/kgBW. Gentamicin was administered intraperitoneally for 7 days, to 8 Wistar rats per group. Blood was taken from all Wistar rats in each group on days 0, 3, 7, and 14. The results of the study were tested for normality with the Shapiro-Wilk test and homogeneity with the Levene's test. The ANOVA test and the Post-Hoc test were used to conduct the analysis. Results : Induction of gentamicin in the GIG I and GIG II groups was significant in increasing the mean creatinine and urea levels on day 0 and day 14 of treatment (p<0.05). In the GIG III group there was a 50% mortality in experimental animals showing a Lethal dose of 50 (LD50) at that dose. Conclusion : GIG I and GIG II have significant nephrotoxic effects in increasing creatinine and urea levels which lead to renal fibrosi.

Anti-hyperuricemia Potential of Ethyl Acetate Fraction from Ethanolic Stem Extract of Arcangelisia flava Fatmawati, Fatmawati; Saleh, Irsan; Parisa, Nita; Salni, Salni; Izzah, Puspita Nurul; Subandrate, Subandrate; Athiah, Medina
Global Medical & Health Communication (GMHC) Vol 12, No 2 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i2.13510

Arcangelisia flava, with its secondary metabolites in flavonoids, has shown promising potential as an alternative treatment for hyperuricemia. The study aimed to determine the effectiveness of the ethyl acetate fraction from the ethanolic stem extract of Arcangelisia flava in inhibiting xanthine oxidase. This research, conducted at the Medical Basic Chemistry Laboratory Universitas Sriwijaya in September–December 2022, used in vitro study methods. The stem of Arcangelisia flava was extracted by maceration using ethanol. The ethanolic stem extract of Arcangelisia flava was then fractionated using n-hexane and ethyl acetate. The ethyl acetate fraction and ethanolic extract of Arcangelisia flava were measured to inhibit the xanthine oxidase using UV-vis spectrophotometry with allopurinol as a comparison. The IC50 was calculated by linear regression. The ethanol extract and ethyl acetate fraction have flavonoids, alkaloids, terpenoids, and quinones. The IC50 value of the ethanol extract was 30.04 ppm, the ethyl acetate fraction was 23.99 ppm, and the allopurinol was 17.16 ppm. The ethyl acetate fraction inhibited xanthine oxidase better than the ethanol extract. The study's significant finding is that the ethyl acetate fraction of the ethanolic stem extract of Arcangelisia flava strongly inhibits xanthine oxidase, offering a potential new avenue for treating hyperuricemia.

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