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All Journal METAMORFOSA Journal of Biological Sciences Jurnal Biologi Udayana Biotika: Jurnal Ilmiah Biologi Indonesian Journal of Applied Sciences Zuriat Jurnal Ilmu Dasar AL KAUNIYAH JURNAL ISTEK Jurnal Florea Jurnal Teknik Sipil Pro-Life Edumatsains Jurnal Bioedukasi Kultivasi Jurnal Biodjati Jurnal Biologi Tropis JMM (Jurnal Masyarakat Mandiri) Jurnal Kreativitas PKM Manuju : Malahayati Nursing Journal Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat Geodika: Jurnal Kajian Ilmu dan Pendidikan Geografi JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI KAIBON ABHINAYA : JURNAL PENGABDIAN MASYARAKAT Didaktik : Jurnal Ilmiah PGSD STKIP Subang Sains dan Matematika Indonesian Journal of Global Health research Jurnal Agrinika : Jurnal Agroteknologi dan Agribisnis Indonesian Journal of Adult and Community Education (IJACE) Journal of Comprehensive Science Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Dewantara: Jurnal Pendidikan Sosial Humaniora Jurnal Asuhan Ibu dan Anak Jurnal Keperawatan 'Aisyiyah Indonesian Research Journal on Education Manilkara: Journal of Bioscience Calakan: Jurnal Sastra, Bahasa, dan Budaya Jurnal Budiman: Pembangunan dan Pengabdian Masyarakat Nusantara Jurnal Riset dan Inovasi Pendidikan Sains (JRIPS) Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat Jurnal Sains dan Kesehatan
Tia Setiawati
Departemen Biologi Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Padjadjaran
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Sildenafil sebagai Molekul Prototipe: Kajian Literatur Struktur-Kimia dan Relevansinya dalam Desain Inhibitor Fosfodiesterase 5 (PDE5) Amin, Saeful; Setiawati, Tia; Jannah, Isma Aenul; Ibadurrahman, Rifki
Indonesian Research Journal on Education Vol. 5 No. 2 (2025): Irje 2025
Publisher : Fakultas Keguruan dan Ilmu Pendidikan, Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/irje.v5i2.2503

Abstract

Sildenafil telah menjadi molekul prototipe yang penting dalam desain inhibitor fosfodiesterase 5 (PDE5), yang digunakan dalam pengobatan disfungsi ereksi dan hipertensi pulmonal. Artikel ini menyajikan kajian literatur yang membahas struktur-kimia sildenafil dan relevansinya dalam desain inhibitor PDE5 generasi baru, dengan merujuk pada lima artikel ilmiah terbaru. Temuan menunjukkan bahwa modifikasi struktural sildenafil, seperti perubahan pada cincin fenil dan gugus piperazin, dapat meningkatkan potensi dan selektivitasnya terhadap PDE5. Penggunaan pendekatan QSAR (Quantitative Structure-Activity Relationship) dan molecular docking dalam desain obat semakin mempercepat identifikasi senyawa dengan potensi lebih baik. Selain itu, sildenafil dan turunannya juga menunjukkan potensi aplikasi lebih luas dalam pengobatan kanker. Secara keseluruhan, sildenafil tetap menjadi molekul prototipe yang relevan dalam pengembangan PDE5 inhibitor yang lebih selektif dan efektif.
Overview of the Effectiveness of Light Emitting Diode (LED) and Compact Fuorescent Lamp (CFL) Phototherapy on Neonatory Jaundice Bilirubin Levels Setiawati, Tia; Amalia, Maya; Astuti, Sipa Dwi
Indonesian Journal of Global Health Research Vol 7 No 2 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i2.3497

Abstract

Neonatal jaundice is the condition of a newborn with high levels of bilirubin, which can cause various negative impacts on the baby, such as neurological abnormalities, mental retardation and seizures. The main treatment that can be done is by administering light phototherapy. Preliminary studies in the city of Bandung, there are still hospitals in Bandung that use phototherapy with the Compact Flourescent Lamp (CFL) type of lamp and there are also hospitals that use phototherapy with the Light Emitting Diode (LED) type. Objective: The aim of this research is to identify the effectiveness of LED and CFL phototherapy in reducing bilirubin levels in babies with neonatal jaundice in Bandung City. Method: This research method is a quasi-experiment with a retrospective approach. The sample for this study was 72 babies who were given phototherapy from January to July 2023. The data collection technique used data recorded at hospitals in Bandung City. Data was collected with checklist sheets and data analysis using the independent sample t test. The research locations were Bandung Kiwari Hospital and Bandung Muhamadiyah Hospital. Results: The results of the independent t-test showed a significant difference in total serum bilirubin values in the two groups before and after phototherapy (sig coefficient = 0.000 < 0.05). The group of neonates with CFL had a bilirubin value of 9.3989 which was higher compared to the group of neonates with LED phototherapy, namely 6.4189. LED phototherapy is more effective in reducing bilirubin compared to CFL phototherapy. Conclusions: Hospital policies to add LED phototherapy facilities can be considered, because they are more effective in reducing bilirubin levels.
Optimalisasi Soft Skill Pada Lembaga Pendidikan Di Era 4.0 Irawan, Andri; Setiawati, Tia; Andiana, Anisa
Journal of Comprehensive Science Vol. 2 No. 4 (2023): Journal of Comprehensive Science (JCS)
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jcs.v2i4.286

Abstract

The purpose of this research is to examine and describe the results of research on Soft Skills in Indonesia, especially in the scope of educational institutions. From these findings, it is used as a basis for finding new ways, especially to optimize Soft Skills in Educational Institutions. The research method uses content analysis of articles from 2015-2022 from the Google Schoolar, Scopus.com and Garuda sites which are searched using the keyword "Soft Skill". The research findings show the diversity of optimizing Soft Skills in various Educational Institutions which provides its own challenges for teachers in implementing Soft Skill optimization in the 4.0 era. Thus the teacher needs to apply suitable learning activities to optimize Soft Skills. The new way that teachers can implement, especially in optimizing Soft Skills in Educational Institutions in the 4.0 era, is an effective learning process, carrying out various kinds of training, inserting an understanding of Soft Skills in each learning process using various methods such as project based learning, implementing character education programs students through teaching factory (TEFA), namely research that recommends the application of soft skills by means of product-based learning models (goods/services) through school and industry synergies to produce graduates who are competent according to industry needs.
THE ABILITY OF WATER HYACINTH (Eichhornia crassipes) AS A BIOACCUMULATOR OF HEAVY METALS IN WASTEWATER FROM THE RUBBER PROCESSING INDUSTRY Hasan, Rusdi; Setiawati, Tia; Nopriyeni, Nopriyeni
JURNAL BIOEDUKASI Vol 8, No 1: Jurnal Bioedukasi Edisi April 2025
Publisher : UNIVERSITAS KHAIRUN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/bioedu.v8i1.9808

Abstract

This study aimed to assess the ability of water hyacinth (Eichhornia crassipes) as a bioaccumulator of heavy metals copper (Cu) and zinc (Zn) in rubber industry wastewater at PT Batanghari, Bengkulu. The research methods included water and water hyacinth sampling from effluent ponds and controls, followed by analysis of Cu and Zn levels using atomic absorption spectrophotometry (AAS). Results showed that Zn levels in wastewater reached 143.0884 mg/l (28 times the quality standard), while Cu was 0.1845 mg/l (still below the quality standard). Water hyacinth accumulated metals in different patterns: Cu was highest in the roots (1.4480 mg/l), while Zn was evenly distributed in the roots (6.7261 mg/l) and leaves (6.6473 mg/l). Analysis of bioaccumulation (BAF) and translocation factors (TF) revealed the efficiency of water hyacinth in absorbing metals, especially Zn, although the absorption mechanism is selective and influenced by environmental conditions such as pH, dissolved oxygen, and the presence of organic compounds. The implications of this study emphasize the potential of water hyacinth as an economical and sustainable phytoremediation solution for the rubber industry, with recommendations of implementing a constructed wetland system and periodic harvesting for optimization.
The Growth of Oyster Mushroom on Ramie Chip Waste-Derived Media was Accelerated by Rice-washed Water Budiono, Ruly; Washfanisa, Handina Alya; Mutaqin, Asep Zainal; Kusmoro, Joko; Nurzaman, Mohamad; Setiawati, Tia; Hasan, Rusdi
Jurnal Biodjati Vol 9 No 2 (2024): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v9i2.33433

Abstract

Rice-washed water is wastewater resulted from the rice cleaning process that is rich in nutrients. The use of ramie chip waste can be considered a potential substrate due to its lignocellulosic nature, similar to other wastes studied. This study aimed to examine the effect of rice-washed water on the mycelium and pinhead growth of white oyster mushrooms grown in the ramie chip waste as the growing medium. The experiment was conducted for three months using a completely randomized design with four rice-washed water treatments and six replications. The rice-washed water concentration treatments were 0% (K0), 25% (K1), 50% (K2), and 100% (K3), which were added to the ramie chip waste as the growing medium for white oyster mushroom. The time of mycelium propagation velocity, the time the first pinhead appearance, the number of mushroom bodies, and the largest cap diameter were observed. The results showed that ramie chip waste-derived media was suitable to cultivate white oyster mushrooms. Adding 100% rice-washed water to the media significantly affected the speed of mycelium propagation (16.51 days) compared to control (30 days) and the appearance of the first pinhead (31.5 days) compared to control (38.5 days) as well as the number of fruiting bodies of mushroom (8.8) compared to control (6.2). However, the rice-washed water application did not significantly affect the diameter of the largest mushroom cap.
Kerapatan Stomata dan Kadar Klorofil Tumbuhan Clausena Excavata berdasarkan Perbedaan Intensitas Cahaya Budiono, Ruly; Sugarti, Dini; Nurzaman, Mohamad; Setiawati, Tia; Supriatun, Titin; Mutaqin, Asep Zainal
Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) 2016: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (748.752 KB)

Abstract

Penelitian ini dilakukan untuk mengetahui kerapatan stomata dan kadar klorofil tumbuhan Clausena excavata atau ki baceta berdasarkan intensitas cahaya di Cagar Alam Bojonglarang Jayanti Kabupaten Cianjur. Teknik pengambilan sampel menggunakan metode survey dan untuk analisis sampel menggunakan spektrofotometer. Pengambilan sampel daun dengan intensitas cahaya 0-500 lux, 500-1000 lux dan 1000-1500 lux dilakukan dengan tiga kali pengulangan. Sampel daun diambil sebanyak 6 helai kemudian dilakukan pengamatan kerapatan stomata dan ekstraksi untuk pengukuran kadar klorofil. Hasil penelitian menunjukan bahwa kerapatan stomata pada intensitas cahaya 0-500 lux sebesar 149,4/mm², pada intensitas cahaya 500-1000 lux sebesar 156,5/mm², dan pada intensitas cahaya 1000-1500 lux sebesar 166,5/mm². Dari hasil pengukuran kadar klorofil didapatkan bahwa total kadar klorofil pada intensitas 0-500 lux adalah sebesar 25,44 mg/L, pada intensitas 500-1000 lux sebesar 47,70 mg/L, dan pada intensitas 1000-1500 lux sebesar 52,45 mg/L
Kadar Klorofil pada Beberapa Tumbuhan Obat di Taman Hutan Raya Ir. H. Djuanda Bandung Nurzaman, Mohamad; Meilinda, Pudji; Budiono, Ruly; Setiawati, Tia; Mutaqin, Asep Zainal
Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) 2016: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (848.257 KB)

Abstract

Penelitian ini bertujuan untuk mengetahui kadar klorofil dari tumbuhan–tumbuhan obat di Taman Hutan Raya Ir. H. Djuanda Bandung. Teknik pengambilan sampel menggunakan metode survey. Sampel dianalisis menggunakan spektrofotometer. Penelitian dilakukan pada lima titik lokasi. Hasil penelitian menunjukan bahwa ditemukan 15 jenis tumbuhan obat dari 15 famili yang berbeda, yaitu Cananga odorata (Annonaceae), Cinnamomum parthenoxylon (Lauraceae), Cordyline fruticosa (Liliacaee), Datura metel (Solanaceae), Gossampynus heptaphylla (Bombacaceae), Intsia bijuga (Fabaceae), Ixora javinca (Rubiaceae), Lagerstromia speciosa (Lythraceae), Lantana camara (Verbenaceae), Melastoma candidum (Melastomaceae), Pileatrinervia (Urticaceae), Psidium guajava (Myrtaceae), Rhoeo discolor (Commelinaceae), Stercullia Oblongata(Streculiaceae), dan Styrax benzoin (Sytraceae). Jenis yang memiliki kadar klorofil tertinggi adalah Lantana camara dari famili verbenaceae, yaitu sebesar 50,52mg/L. Sedangkan Stercullia Oblongata dari famili Streculiaceae memiliki kadar klorofil terendah dengan nilai sebesar 3,96 mg/L.
Efektivitas Fototerapi dan Manajemen Asi terhadap Penurunan Kadar Bilirubin pada Bayi Hiperbilirubinemia Setiawati, Tia; Kurniawan, Heri; Awali, Dian Siti; Kharismala R, Nurlaila
Jurnal Keperawatan 'Aisyiyah Vol. 10 No. 2 (2023): Jurnal Keperawatan 'Aisyiyah
Publisher : Universitas 'Aisyiyah Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33867/jka.v10i2.427

Abstract

Hiperbilirubinemia merupakan ancaman terhadap jiwa bayi baru lahir jika tidak ditanganidengan tepat. Fototerapi dan manajemen pemberian Air Susu Ibu (ASI) menjadi salah satupenatalaksanaan hiperbilirubinemia untuk mencegah terjadinya mortalitas dan kerusakanneurologis pada bayi baru lahir. Penelitian ini bertujuan untuk menganalisis efektivitasfototerapi dan manajemen pemberian ASI dalam menurunkan kadar bilirubin. Rancanganpenelitian ini menggunakan retrospektif yaitu penelitian dilakukan setelah dilakukantindakan. Tehnik pengumpulan data diambil dengan menggunakan studi dokumentasipada bayi baru lahir untuk mengukur perubahan kadar bilirubin serum. Populasi penelitianadalah semua bayi baru lahir yang dirawat di ruang Perinatologi RSM Bandung. Penelitianini menggunakan purposive sampling dalam menetapkan sampel, dan besar sampelsebanyak 50 bayi baru lahir. Pendekatan pengumpulan data yang digunakan adalahcross-sectional. Instrumen penelitian yang digunakan adalah lembar observasi dan daftartilik. Pengumpulan data menggunakan studi dokumentasi. Hasil penelitian menunjukkanbahwa terjadi penuruan nilai bilirubin total rerata sebesar 6,08 mg/dl, bilirubin direct reratasebesar 3,28 mg/dl dan bilirubin indirect rerata sebesar 5,94 mg/dl. Hal ini menunjukkanEfektivitas Fototerapi dan Manajemen ASI dalam menurunkan kadar bilirubin dalamdarah. Saran dari hasil penelitian ini diharapkan Fototerapi dan Manajemen ASI menjadisalah satu standar pelayanan bayi yang mengalami hiperbilirubinemia
The Accumulation of NaCl in The Coastal Plant Leaves of Mangrove, Bariongtonia, and Pes-Caprae Formations Hasan, Rusdi; Setiawati, Tia; Lukitasari, Marheny; Nopriyeni, Nopriyeni
Florea : Jurnal Biologi dan Pembelajarannya Vol. 12 No. 1 (2025)
Publisher : UNIVERSITAS PGRI MADIUN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/florea.v12i1.22210

Abstract

This study aims to compare the salt content (NaCl) in the leaves of several types of coastal plants that grow in different formations, namely Mangrove, Barringtonia, and Pres-Caprae. The study was conducted in the coastal area of Lais District, North Bengkulu Regency using direct survey methods in the field and laboratory analysis using a refractometer. The results showed that there were 10 species of coastal plants from three formations, namely Barringtonia, Mangrove, and Pes-Caprae. The highest salt content was found in the Acanthus species ilicifolius (2.75‰) from the Mangrove formation, while the lowest levels were found in Canavalia maritima (0.75‰) from the Pes-Caprae formation. The difference in salt content is thought to be influenced by the location of its habitat in the coastal area and its ability to adapt both structurally and physiologically so that it can survive in an environment with extreme salt content. The results of this study provide important information about the adaptation of coastal plants to salinity and can be the basis for further research on salt concentration in coastal plants.
Morphological, Anatomical, and Phytochemical Responses of Celosia argentea to Light Intensity Fredella Josenia, Carlen; Setiawati, Tia; Marheny Lukitasari; Hasan, Rusdi
Florea : Jurnal Biologi dan Pembelajarannya Vol. 12 No. 2 (2025)
Publisher : UNIVERSITAS PGRI MADIUN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/florea.v12i2.23218

Abstract

This study investigates the phytochemical content and morpho-anatomical characteristics of Celosia argentea L. plants grown under different light intensities in the Embung Leuwi Padjadjaran area. Leaf samples were collected from shaded and unshaded locations to compare their responses to varying light conditions. Phytochemical analysis revealed that plants in higher light intensity areas tended to have increased levels of specific phytochemical compounds, which is crucial for the plant's defense mechanisms. Furthermore, the research found morphological and anatomical differences, such as greater leaf thickness and a lower stomatal density in unshaded plants. Conversely, shaded plants exhibited higher chlorophyll content and larger leaf areas, which are adapted to low-light environments. The study concludes that varying light intensity significantly influences the morpho-anatomical features and phytochemical composition of Celosia argentea L., with shaded conditions promoting adaptations for light capture and unshaded conditions increasing certain phytochemicals and leaf thickness.
Co-Authors , ,. Mulyadi , ,. Suryana Adityawan, Mohammad Bagus Adnin Laila Agung Karuniawan Agus Irpan Nurhidayat Agustine, Leony Alfira, Ajeng Alma Ayalla Amala Lastari Utami Anandira Witri Andiana, Anisa Andri Irawan Anggita Levi Astuti Anggita Leviastuti Ani Lestari Ani Lestari Anisaa Fauziyah Annisa Annisa Annisa Annisa Annisa Annisa Annisa Nur Arofah Arianti, Tanti Arofah, Annisa Nur Asep Zainal Mutaqin Astuti, Sipa Dwi Auliya Zahra Awali, Dian Siti Ayalla, Alma Azifah An’amillah Bari, Ichsan Budi Irawan Budi Irawan Darmawan, Darwis Debby Ustari Dede Winingsih Delisa Lestari Desak Made Malini Devitri Amisa Dian Latifa Ela Noviani Elah Karimah Eli Lusiani Endang Rosdiana Fadhilla Ramadhona Farhurohman, Oman Fatmawati, Ariani Fikriyah, Nanda adzka Fitria, Sania Septiani Fredella Josenia, Carlen Harkunti P. Rahayu, Harkunti P. Hendi N Wicaksono Heri Kurniawan, Heri Hernandi Sujono Huda, Ida Nurul Ibadurrahman, Rifki Inggriane Puspita Dewi, Inggriane Puspita Inneke Febrihardianti Syamsi Irma Wahyuningsih Irvan Herdiana Jannah, Isma Aenul Johan Iskandar Joko Kusmoro Kartiawati Alipin Kartiawati Alipn Kharismala R, Nurlaila Lia Dewi Juliawaty Libriati, Rika Lusiani, Eli Maitala Sari Marcelline, Karen Marheny Lukitasari Marheny Lukitasari Maryam Alifah Maulani, Susan Maulidiyah Maulidiyah Maya Amalia Meilinda, Pudji Melina Melina Moahamad Nurzaman Moahamad Nurzaman, Moahamad Moch. Nurzaman Mohamad Nurzaman Mohammad Farid Muhammad Syahril Badri Kusuma, Muhammad Syahril Badri Nia Rossiana Nining Ratningsih Nisa Hurin Nisa Hurin Nopriyeni Nopriyeni Nopriyeni, Nopriyeni Noviani, Ela Noviyanti Soleha Nuriman, Muhammad Nurullia Fitriani Nurullia Fitriani Otih Rostiana Putri, Deviana Aulia Rachma, Nadhira Zaachrany Radewi Safira Fauzia Radewi Safira Fauzia, Radewi Safira Rahmawati, Fitryasari Rani Rubiyanti, Rani Rasmiaditya Silasari Revita Yanuarsari Rezekikasari, Rezekikasari Rike Yuniaris Rully Budiono Ruly Budiono Rusdi Hasan Rusdi Hasan Rusdi Hasan Saeful Amin, Saeful Senadi Budiman Sephianti, Selvi Siti Mariyani Sofiyah, Yusi Sri Mulyati Sri Ratu Dewi Pridani Sugarti, Dini Sukrido Sukrido Supriatun, T Syifa Fauzia Zazuli T Supriatun Tentani Buhti Amadea Titin Supriatun Titin Supriatun Titin Supriatun Titin Supriatun Sadeli Valentina Adimurti Kusumaningtyas Vera Octavia Subardja Washfanisa, Handina Alya Wibowo, Sigit Sapto Wicaksono, Hendi N Winingsih, Dede Yana Maolana Syah Yana Maolana Syah Yani Astuti Yuliana, Trisna Yuniar, Muthya Yuniaris, Rike Yusi Sofiyah