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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kedokteran MNJ (Malang Neurology Journal) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Jurnal Pengabdian Magister Pendidikan IPA Jurnal Gema Ngabdi Jurnal Pepadu
Anak Agung Ayu Niti Wedayani
Fakultas Kedokteran Universitas Mataram
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Social Sciences

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EGF Levels in Rattus norvegicus Induced with 40 ppm Formaldehyde for 1 Month in Relation to Nasopharyngeal Cancer Putri, Gabriella Chrisanta Dwi Ananda; Wedayani, Anak Agung Ayu Niti; Yuliyani, Eka Arie; Partiwi, Sekar
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8803

Abstract

Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the ENT department, with a high incidence in Southeast Asia. One of the major risk factors for NPC is formaldehyde exposure, which induces oxidative stress, chronic inflammation, and disruption of growth factors such as Epidermal Growth Factor (EGF). This study aims to analyze changes in EGF levels in Rattus norvegicus exposed to 40 ppm formaldehyde for one month to better understand the molecular mechanisms contributing to nasopharyngeal carcinogenesis. This experimental study measured EGF levels using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Data were analyzed using the Kolmogorov-Smirnov normality test and a Paired T-Test to assess changes in EGF levels before and after treatment. The analysis showed a tendency for increased EGF levels after formaldehyde exposure; however, the difference was not statistically significant (p = 0.355). This suggests that one-month exposure to formaldehyde does not directly affect EGF expression in the tested tissue. This study found that 40 ppm formaldehyde exposure for one month did not significantly alter EGF levels. However, the observed trend in certain groups suggests that the effect of formaldehyde on EGF levels may be dose- and duration-dependent. Further studies with longer exposure durations and higher concentrations are needed to explore the link between formaldehyde exposure and nasopharyngeal carcinogenesis.
The Incidence of Depression in Elderly Patients with Hypertension Stage 2 in Karang Taliwang Tantowi, Natalia; Wedayani, Anak Agung Ayu Niti; Pujiarohman, Pujiarohman; Adni, Azizatul; Kusuma, I Gusti Ketut Artha Jaya
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8804

Abstract

Depression is a common mental health disorder in the elderly, often coexisting with chronic conditions like hypertension. This study examines the relationship between depression and hypertension stage 2 among elderly individuals at Puskesmas Karang Taliwang, considering age and gender. A cross-sectional study of 30 elderly patients used a validated questionnaire to assess depressive symptoms. Results showed a significant association between age (≥60 years) and depression, while gender had no statistical correlation. Hypertension stage 2 was also significantly linked to depression, though with a small effect size. These findings highlight the need for integrated healthcare strategies addressing both mental and cardiovascular health in the elderly. Further research is needed to explore underlying mechanisms and potential interventions.
Antioxidant Effect in Nasopharyngeal Cancer Histopathology Degree on 40 PPM Formaldehyde-Inducted Rattus novergicus Wibawa, Putu Arta; Wedayani, Anak Agung Ayu Niti; Prihatina, Lale Maulin; Yuliani, Eka Ari; Pratiwi, Sekar
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8805

Abstract

Formaldehyde exposure, implicated on the development of nasopharyngeal cancer (NPC), remains a significant concern worldwide, with increasing incidence, morbidity, and mortality cases. This study eager to investigate the antioxidant effect on degree of histopathology from formaldehyde exposure, assessing nasopharyngeal dysplasia progression toward malignancy. Rattus norvegicus divided equally into four groups: control, placebo, formaldehyde-induced (40 PPM), and formaldehyde-induced with antioxidant, followed by dysplasia degree examination under light microscope. The result revealed severe dysplasia in the formaldehyde group, indicating non-keratinizing squamous cell carcinoma. Additionally, antioxidant-treated group presented reduced severity, with lower degree of dysplasia. This result is indicating positive improvement of antioxidant effect toward NPC malignancy, supporting previous studies and further confirming genotoxicity and irritability of formaldehyde. Nevertheless, limitations, existed with lack of sample studied and dose-response analysis, were demanding deeper study need to be done.
Relationship Between Patients with Hypertension Stage 2 and Chronic Kidney Disease (CKD) at Harapan Keluarga Hospital Octivani, Fania; Arsatt, Maz Isa Ansyori; Maulana, Akhada; Wedayani, Anak Agung Ayu Niti
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8806

Abstract

Hypertension and chronic kidney disease (CKD) are interrelated global health challenges with rising prevalence, particularly in low-resource settings such as Indonesia. This retrospective cohort study aimed to investigate the association between hypertension stage 2 and CKD among 65 patients treated at Harapan Keluarga Hospital between 2023 and 2024. Data were obtained through medical record reviews, and statistical analysis was conducted using Chi-square testing and odds ratio (OR) calculations. A significant association was found between stage 2 hypertension and CKD (p = 0.001), although the OR value of 0.888 (95% CI: 0.821–0.920) suggests a negative correlation, potentially influenced by variations in treatment adherence, demographic characteristics, or other confounding factors. Differences in BMI and blood pressure between male and female patients were also observed, highlighting the role of sex-specific physiological and lifestyle variables in disease progression. The findings emphasize the importance of tailored clinical management strategies for hypertensive patients to prevent CKD progression, particularly in healthcare settings with limited diagnostic and therapeutic resources.
The Knowledge Level of Hypertension Stage 2 Patients at Harapan Keluarga Hospital Regarding Complications in the Form of Aortic Aneurysm Sinaga, Keysha Angelica; Arsatt, Maz Isa Ansyori; Rahmat, Basuki; Wedayani, Anak Agung Ayu Niti
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8807

Abstract

Hypertension is a major contributor to cardiovascular complications, including aortic aneurysms, which can be fatal if left untreated. This study aims to examine the relationship between the level of hypertension, particularly stage 2, and the incidence of aortic aneurysm. A retrospective cohort analysis was conducted using medical records of 24 patients diagnosed with varying degrees of hypertension and aortic aneurysm at Harapan Keluarga Hospital in December 2024. Statistical analysis using the chi-square test revealed a significant association between hypertension severity and the incidence of aortic aneurysm (p = 0.000), with an odds ratio of 2.001 (95% CI: 2.010–2.229). These findings emphasize the need for enhanced patient education and preventive strategies, particularly among those with hypertension stage 2, to mitigate the risk of aneurysm-related complications.
The Knowledge Level of Elderly in Puskesmas Taliwang and the Incidence of Chronic Kidney Disease in 2024 Cahyani, Aulia Putri; Maulana, Akhada; Arsatt, Maz Isa Ansyori; Wedayani, Anak Agung Ayu Niti
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8813

Abstract

Chronic Kidney Disease (CKD) is a gradually progressing condition that frequently remains asymptomatic in it’s early stages, making it an increasingly significant public health concern, particularly among the elderly. Early awareness and preventive behavior are crucial to mitigate it’s impact, yet many elderly individuals lack sufficient knowledge about disease. This study aims to examine the relationship between the knowledge level of elderly individuals and the incidence of CKD in the Puskesmas Taliwang area in 2024. A cross-sectional analytical study was conducted involving 30 elderly participants selected through simple random sampling. Data on knowledge level were collected using a structured was performed using the Chi-square test. The result showed a significant association was found between knowledge level and CKD incidence P-value=0.000 and OR value is between 0,900 and 1,020, indicating that lower knowledge correlates with a higher risk of CKD. There is a significant relation between the knowledge level of elderly individuals and the incidence of CKD in the Puskesmas Taliwang area. Strengthening educational outreach and awareness programs is essential to reduce CKD risk among the elderly.
Analysis of Ferritin Levels as a Risk Factor for Anemia in Adolescent Girls on the West Lombok Coast Lestarini, Ima Arum; Ekawati, Ardiana; Irawati, Deasy; Wedayani, Anak Agung Ayu Niti; Putra, Hendra Susana
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.9269

Abstract

Iron deficiency anemia (ADB) is a nutritional disorder that often occurs, especially in adolescent girls, due to increased nutrient requirements during growth and menstruation. Assessing ferritin levels is an important step in determining the status of iron stores in the body and identifying individuals at risk of iron deficiency anemia, especially in resource-constrained environments such as coastal areas. This study aims to determine the prevalence of anemia and iron deficiency in adolescent girls in the coastal areas of Lombok, Indonesia and analyze the relationship between ferritin levels as a risk factor for the incidence of iron deficiency anemia. The design of this study was a cross-sectional study conducted on 101 young women aged 15 - 19 years in the coastal areas of West Lombok. Ferritin levels were measured to determine iron deficiency status (< 15 ng/ml) and hemoglobin levels were used to determine anemia in adolescent girls (HB < 12 g/dl). The Chi-Squre and relative risk tests were used for statistical analysis of the relationship and risk between iron deficiency and the incidence of anemia. The results of the study found that the prevalence of iron deficiency was 40 (39.6%) and anemia was 21 (20.79%). Of the respondents who experienced anemia, 13 (61.9%) were iron deficiency anemia. There was a significant association between anemia and iron deficiency (p = 0.004) and an odd ratio value of 4.154 was obtained, indicating that adolescent girls with iron deficiency (low ferritin levels) had a 4.154 times greater risk of developing anemia compared to adolescent girls with normal ferritin levels.
Characteristics of Facial Skin Biophysical Parameters Among Medical Students in University of Mataram Hidajat, Dedianto; Sari, Dian Puspita; Octora, Metta; Wedayani, Anak Agung Ayu Niti
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9195

Abstract

Various studies have been widely published regarding the efficacy and adverse effects of facial care products with research populations from adolescent to young adults. However, it is necessary to first identify the characteristics of this parameters in the local population. The purpose of this study is to obtain an overview of the characteristics of the biophysical parameters of facial skin in a population of teenagers and young adults who tend to be active indoors, especially UNRAM medical students. This was an analytical observational study with a cross-sectional approach. Participants filled out questionnaires and followed procedures for examining facial skin biophysical parameters. The results of this study showed that from 147 participants, the average TEWL level was 8,99 g/h/m2; mean degree of erythema was 262,5; the average melanin index was 192,1 and the average sebum level was 192,1. Statistical analysis found that there was an association between gender and all facial skin biophysical parameters, a relationship between age and sebum levels and a relationship between daily activities in an air-conditioned room and the degree of erythema. With the data presented in this study, research related to facial skin biophysical parameters in similar populations can be developed further.
Hepatic Alteration due to Formaldehyde Exposure on Wistar Rats (Rattus norvegicus) Makbul, Hidayat; Wedayani, Anak Agung Ayu Niti; Punagi, Abdul Qadar; Pieter, Nova Audrey Luetta; Cangara, Muhammad Husni; Lestarini, Ima Arum; Restuningdyah, Novia Andansari Putri
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6455

Abstract

Formaldehyde is a hazardous chemical substance that can be found commonly in the environment which has various effects on cellular functions and could induce the cellular oxidative stress. Oxidative stress has a direct impact on the hepatic condition and could induce the activation of inflammatory mediators, lipid peroxidation, proteosomal degradation, and mitochondrial dysfunction resulting in hepatocyte injury that could be marked by hepatic enzyme elevation and hepatic weight alterations. This research was conducted using 16 Wistar rats (Rattus norvegicus), divided into 4 groups each containing 4 Wistar rats. The first group was the control group, while the other groups were exposed to formaldehyde 10% by inhalation at doses of 20, 30, and 40 ppm formaldehyde persistently for 6 hours daily for about 16 weeks. The result of this study reveals that formaldehyde induction has a significant impact on hepatic weight elevations (p=0.007) and ALT enzyme elevations (p=0.000) in the treatment groups compared with the control group. Collectively, our results provide valuable information on the hazardous effects of formaldehyde inhalation, especially on the liver.
Histopathological Comparison of Nasopharyngeal and Lung Tissue on Wistar Rats Induced with Formaldehyde Abdiman, I Made Tobias; Wedayani, Anak Agung Ayu Niti; Prihatina, Lale Maulin; Restuningdyah, Novia Andansari Putri
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6456

Abstract

Formaldehyde is a toxic substance commonly found in everyday life. Formaldehyde is also a carcinogenic exposure that often occurs in industrial areas. Formaldehyde itself is genotoxic and cytotoxic to tissues that can cause dysplasia to carcinoma. Inhalation of formaldehyde will expose the respiratory tract, which includes the nasopharynx and lung tissue to formaldehyde. Therefore, it is important to know the differences in tissue susceptibility to formaldehyde exposure related to the ability to cause dysplasia and carcinoma. Six Wistar rats were induced with formaldehyde through the inhalation method at a dose of 40 ppm for 16 weeks, and then terminated and subjected to histopathological examination. The degree of dysplasia will be assessed in both tissues, and then compared and tested statistically. The Mann-Whitney U statistical test showed a P value of 0.818, meaning that there was no significant difference between the degree of dysplasia in nasopharyngeal tissue and lung tissue. However, there was a difference in the rate of dysplasia progression between the two tissues, with nasopharyngeal tissue having a faster rate of progression. This difference in the rate of progression is related to the higher amount of formaldehyde deposition in the upper airway.
Co-Authors AA Sudharmawan, AA Abdiman, I Made Tobias Abdul Qadar Punagi Akhada Maulana, Akhada Alaydrus, Mukaddam Amalia, Emmy Amrita, Radha Anak Agung Sagung Mas Meisyarawati Putra Aris Doyan Arsatt, Maz Isa Ansyori Azahra, Melita Amaliah Rajwa Azizatul Adni Basuki Rahmat Masdi Siduppa Budiono, Catarina Budiyono, Catarina Cahyani, Aulia Putri Cahyawati, Triana Dyah Cangara, Husni Catarina Budyono, Catarina Deasy Irawati Dedianto Hidajat Dedianto Hidajat Dedianto Hidajat Dedianto Hidajat Dian Puspita Sari Dian Puspita Sari Didit Yudhanto Dijaya, Muhammad Raksa Nagara Eka Arie Yuliani Eka Arie Yuliyani Eka Arie Yuliyani Ekawati, Ardiana Erna Kristin Erwin Astha Triyono Eti Nurwening Sholikhah FAADV FINSDV Fitriatulnisa Gusti Ayu Trisna A Hamsu Kadriyan Hartati , Farida Hartati, Farida Hasbi, Nurmi - Herpan Syafii Harahap I Gede Yasa Asmara I Kadek Dwi Semadi Ida Made Hrisikesa Wejeg Ika Primayanti Ima Arum Lestarini Jurnal Pepadu Kadriyan, Hamsu Karuniawaty, Titi Pambudi Kusuma, I Gusti Ketut Artha Jaya Laksmana, Ngakan Putu Proudy Lalu Muhammad Abiyu Ghafar Lestari, Rizka Vidya Linda Silvana Sari Lioni, Ni Kadek Mahardika, Agustine Makbul, Hidayat Makbul, Ini Hidayat Metta Octora Muhammad fauzan Muliyana, Hifdzil Haq Ni Ketut Susilawati Ni Putu Della Diarna Novia Andansari Novia Andansari Putri Novia Andansari Putri Novia Andansari Putri Restuningdyah Nurhidayati Nurhidayati Ocktaviana Saputri, Legis Octivani, Fania Padauleng, Novrita Partiwi, Sekar Parwata, Wayan Sulaksmana Sandhi Pieter, Nova Audrey Luetta Pratiwi, Sekar Prihatina, Lale Maulin Pujiarohman Pujiarohman Pujiarohman, Pujiarohman Purnaning, Dyah Putra, Anak Agung Sagung Mas Meiswaryasti Putra, Hendra Susana Putri , Novia Andansari Putri R, Novia Andansari Putri, Gabriella Chrisanta Dwi Ananda Putri, Novia Andansari Putu Aditya Wiguna Rabsanjani Rahmansyah, Nafatasya Ayu Ramadhita, Nova Izza Salsa Resti, Nimas Restuningdyah, Novia Andansari Putri Romadoni, Muhammad Aulia Hikmah Rosyunita Sahly, Aliza Raudatin said, muhammad_irfan Sari, Linda Silvana Sari, Putu Suwita Sinaga, Keysha Angelica Sudharmawan, Anak Agung Ketut Tantowi, Natalia Ullyani, Nurul Wibawa, Putu Arta Wiguna, I Made Danuarta Yassa, I Wayan Radityakara Wirasena Yofani Laurintia Yuliani, Eka Ari Yuliyani, Eka Arie