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Journal : Indonesian Journal of Cardiology

Efek Ekstrak Daun Kelor (Moringa Oleifera) Dalam Menghambat Aktifasi NFkB, Ekspresi TNF-adan ICAM-1 pada HUVECS yang Dipapar LDL Teroksidasi Titin Andri Wihastuti; Djanggan Sargowo; M Saifur Rohman
Jurnal Kardiologi Indonesia Vol. 28, No. 3 Mei 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i3.239

Abstract

Background. Atherosclerosis is a chronic inflammation process of vascu-lar endothelial cells. Increased oxydized LDL(OxLDL) is one of the most potent inducer of atherogenesis. OxLDL induces an increased ROS (Reac-tive Oxigen Species) and also acts as cytotoxic and chemotaxis factor for monocytes result in accumulation of inflammatory cells. Nuclear Factor Kappa Beta(NFkB) is a transcription factor that plays an important role in this inflammatory proces. NFkB compose of heterodimer molecules of p50 and p65, which bind to its inhibitor, IkB, leading to its inactive form in cytoplasm. OxLDL activates NFkB complex by phosphorylate IkB resulting in released p50-p65-IkB binding and translocation of p50-p65 into the nucleus. p50-p65 then binds to promoter and activates transcription of target genes. NFkB activation therefore increase gene and protein expressions of target molecules such TNF-a, ICAM-1, VICAM, etc. This study aimed to examine whether Moringa oleiferainhibits activation of NFkB dan expression of cytokine TNF-aand adhesion molecule ICAM-1.Methods and results.Human umbilical vein endothelial cells (HUVECs) treated with OxLDL were used as model of atherosclerosis. The increased NFkB activity was measured by indirect method using p50 subcellular lo-calization by immunohistochemistry. 40ug/mL OxLDL, 0.01 gr/mL and 0.005 gr/mL Moringa oleiferawere used based on preliminary study.Conclusions. This study showed that OxLDL significantly induce NFkB activation and increase protein expression of TNF-aand (ICAM-1). This study also observed that Moringa oleiferasignificantly inhibit NFkB activa-tion, and prevent an increased TNF-aand ICAM-1 expression at protein level in OxLDL-treated HUVECs as compare to the controls. Moringa oleifera dose of 0.01mg/mL has a better inhibition effect as compare to that of 0.005 gr/mL.
Co-Authors A.A Istri Dalem Hana Yundari A.A. Ketut Agung Cahyawan W Abdul Patawari Abdul Patawari Adi Suyitno Adi Suyitno, Adi Agus Putra Murdani Agustina, Mulya Akbar Farid Hasibuan Aldita Husna Violita Amanda, Efina Amanda, Febrina Andrik Hermanto Antonius Christianto Anwar Santoso Ardhia, Jessica Fio Ardiansyah, Wahyu Arif Wicaksono Arifah, Medisa Roro Putri Nur Ariska, Hanisa Iis Ariyani, Anita Dwi Asti Melani Astari Asy’ary, Qomaruddin Awaliyah Muslimah Suwetty Ayut Merdikawati Ayut Merdikawati, Ayut Balqis, Rani Diana Basyar Adnani Berty Febrianti Rahayu Caressa, Dea Amanda Cathrine Theodora Sukotjo Cece Indriani Cholid Tri Tjahjono Christianingsih, Siska Christianto, Antonius Cipto Susilo Damayanti, Fransiska Erna Debby Hatmalyakin Dewi Kartikawati Ningsih Dewi Kartikawatiningsih Dewi, Heriberta Tabita Marta Dhelya Widasmara Dhiar Widianingtyas, Dhiar Dina Dewi Sartika Lestari Ismail Dina Dewi Sartika Lestari Ismail Dina Dewi Sartika Lestari Ismail Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Dudella Desnani Firman Yasin, Dudella Desnani Firman Dwi Agustian Faruk Ibrahim Efris Kartika Sari, Efris Kartika Eko Suyanto Elvira Sari Dewi Emi Wuri Wuryaningsih Endrian Kurniawan, Dicky Erik Irham Lutfi Evie, Sova Fahmi, Muhamad Fajar Ari Nugroho fatchiyah . Fatchiyah Fatchiyah Firman Prastiwi FitriaNugraha Aini Hasibuan, Akbar Farid Hayati, Yati Sri Heri Kristanto Heri Kristianto Hidayat Sujuti Husnul Khotimah I Wayan Edi Sanjana Ida Ayu Putu Sri Widnyani Indah Nur Chomsy Indhiarti, Tantri Refa Indriyani, Damayanti Inggita Kusumastuty Intan Yusuf Habibie Ismail, Dina Dewi Sartika Lestari Jannah, Riska Raudhatul Jatim Sugiyanto Juwitasari Juwitasari Kartika, Annisa Wuri Karyono Mintaroem Katsuhiro Miyajima Kawitantri, Orchidara Herning Kumboyono Kumboyono Kurnianingsih, Nia Kurnianingsih, Novi Kusuma, Ayu Widia Kusumawati, Diana Laily Yuliatun Lidwina Faraline Triprisila Lidwina Faraline Triprisila Liemena Harold Adrian Lilik Supriati Lilik Supriati Lilik Supriati Lilik Supriati, Lilik Lola Ayu Istifiani M Saifur Rohman Machfud, Savinka Salsabiela Iriana Maria Fatimah Fouk Maulidah Maulidah Merry P Mesa, Nofita Dewi Kok Mochamad Ali Sodikin Muhammad Ridwan Mukhamad Fathoni Mukhamad Fathoni Muladefi Choiriyah Munif, Badrul Nana Septiana Widayati Nanang Bagus Sasmito Nanik Setijowati Narwasthu, Sekararum Nawang Wulandari Nawang Wulandari, Nawang Nur 'Aini Nurdiana Nurdiana Nurdiana Nurdiana Nurul Evi Nurul Muslihah Olivia Handayani Palis, Christine Natalia Pamungkas, Akhmad Yanuar Fahmi Patawari, Abdul Prasanti Mahesa Anjani Prasetyawan, Riyan Dwi Putra Agina Widyaswara Suwaryo Rahmawan, Fajri Andi Renny Nova Renny Nova, Renny Retno Lestari Retno Lestari Ridhoyanti Hidayah, Ridhoyanti Rina Anggraini Rislan Faiz Muhammad Rismawan Adi Yunanto Rista Nikmatu Rohmah Rista Nikmatu Rohmah, Rista Nikmatu Rizal, Ardian Roesardhyati, Ratna Roshanti, Dian Rosikhah Al-Maris Rosuli, Ahmad Rudiyanto Rudiyanto, Rudiyanto Safira Dita Arviana Sanjana, I Wayan Edi Saputri, Diana Nanda Sartika Lestari Ismail, Dina Dewi Sasnita Salam Sassanti, Suci Wulandari Satrianto, Anang Satwikajati, Sawitri Septi Dewi Rachmawati Servasius To’o Jala Mulu Setyoadi Setyoadi Setyoadi Setyoadi Shahdevi Nandar Kurniawan, Shahdevi Nandar Siska Christianingsih Siska Puji Lestari Siska Puji Lestari Siska Puji Lestari Suis Galischa Wati Supriyadi, Muchamad Supriyanto Supriyanto Suryanto Suryanto Susilowati Susilowati Susilowati Susilowati Suwaryo, Putra Agina Widyaswara Swastikaputri, Valerina Yogibuana Teuku Heriansyah Tina Handayani Nasution Tita Hariyanti Toga, Erik Tony Suharsono Tony Suharsono Tony Suharsono, Tony Turhadi Turhadi Umar, Ja’far Widiani, Luh Widito, Sasmojo Wisnasari, Shila Yati Sri Hayati Yoga Tribakti Rachmad Yulian Wiji Utami Yulian Wiji Utami Yulian Wiji Utami Yuliatun . Yuliatun ., Yuliatun Yuyun Yueniwati