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Journal : The Indonesian Biomedical Journal

The Effect of Polysaccharides Peptides Ganoderma Lucidum to Aortic Foam Cell Count and Lipid Profile in Type 2 Diabetic Model Rattus Norvegicus Strain Wistar Djanggan Sargowo; Titin Andri Wihastuti; Cathrine Theodora Sukotjo; Prasanti Mahesa Anjani; Olivia Handayani; Liemena Harold Adrian
The Indonesian Biomedical Journal Vol 9, No 3 (2017)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v9i3.298

Abstract

BACKGROUND: Type 2 Diabetes Mellitus (DM) is one of dominant factors in cardiovascular deaths and induces endothelial dysfunction. A definite sign of endothelial dysfunction is foam cells formation derived from oxidized LDL. This study was conducted to determine effect of Polysaccharides Peptides (PsP) Ganoderma lucidum to foam cell counts and lipid profile in diabetic model rats with high-fat diet.METHODS: Treatment group was categorized to negative control, positive control, DM-50, DM-150, and DM-300. Type 2 DM induced by Streptozotocin. PsP is administered with predetermined doses on each treatment’s group (50, 150, and 300 mg/kgBW) for 12 weeks. Measurements of foam cell count were held after obtaining rat’s aorta. To assess lipid profile, blood sample was taken from the rat's heart. Data analyzed by One-way ANOVA and Post Hoc Tukey tests.RESULTS: The administration of Ganoderma lucidum PsP to diabetic model rats provided a significant difference in lowering foam cell (p=0.017; CI 95%). It also gave significant difference between levels of each lipid components (Total Cholesterol, Trygliceride, LDL and HDL) in at least two treatment groups (p=0.010; CI 95%). Based on Post Hoc Tukey tests, the relationship between administration of PsP and foam cell is significant (p=0.002).CONCLUSION: PsP has antioxidant and anti-inflammatory effect in type 2 DM model Rattus norvegicus strain wistar, which can inhibit atherosclerosis and endothelial damage process. Further studies are necessary to evaluate the benefits of PsP as an adjuvant therapy in management of diabetic dyslipidemia.KEYWORDS: PsP, Ganoderma lucidum, foam cell, lipid profile, DM
Co-Authors A.A Istri Dalem Hana Yundari A.A. Ketut Agung Cahyawan W Abdul Patawari Abdul Patawari Adi Suyitno Adi Suyitno, Adi Agus Putra Murdani Agustina, Mulya Akbar Farid Hasibuan Aldita Husna Violita Amanda, Efina Amanda, Febrina Andrik Hermanto Antonius Christianto Anwar Santoso Ardhia, Jessica Fio Ardiansyah, Wahyu Arif Wicaksono Arifah, Medisa Roro Putri Nur Ariska, Hanisa Iis Ariyani, Anita Dwi Asti Melani Astari Asy’ary, Qomaruddin Awaliyah Muslimah Suwetty Ayut Merdikawati Ayut Merdikawati, Ayut Balqis, Rani Diana Basyar Adnani Berty Febrianti Rahayu Caressa, Dea Amanda Cathrine Theodora Sukotjo Cece Indriani Cholid Tri Tjahjono Christianingsih, Siska Christianto, Antonius Cipto Susilo Damayanti, Fransiska Erna Debby Hatmalyakin Dewi Kartikawati Ningsih Dewi Kartikawatiningsih Dewi, Heriberta Tabita Marta Dhelya Widasmara Dhiar Widianingtyas, Dhiar Dina Dewi Sartika Lestari Ismail Dina Dewi Sartika Lestari Ismail Dina Dewi Sartika Lestari Ismail Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Dudella Desnani Firman Yasin, Dudella Desnani Firman Dwi Agustian Faruk Ibrahim Efris Kartika Sari, Efris Kartika Eko Suyanto Elvira Sari Dewi Emi Wuri Wuryaningsih Endrian Kurniawan, Dicky Erik Irham Lutfi Evie, Sova Fahmi, Muhamad Fajar Ari Nugroho fatchiyah . Fatchiyah Fatchiyah Firman Prastiwi FitriaNugraha Aini Hasibuan, Akbar Farid Hayati, Yati Sri Heri Kristanto Heri Kristianto Hidayat Sujuti Husnul Khotimah I Wayan Edi Sanjana Ida Ayu Putu Sri Widnyani Indah Nur Chomsy Indhiarti, Tantri Refa Indriyani, Damayanti Inggita Kusumastuty Intan Yusuf Habibie Ismail, Dina Dewi Sartika Lestari Jannah, Riska Raudhatul Jatim Sugiyanto Juwitasari Juwitasari Kartika, Annisa Wuri Karyono Mintaroem Katsuhiro Miyajima Kawitantri, Orchidara Herning Kumboyono Kumboyono Kurnianingsih, Nia Kurnianingsih, Novi Kusuma, Ayu Widia Kusumawati, Diana Laily Yuliatun Lidwina Faraline Triprisila Lidwina Faraline Triprisila Liemena Harold Adrian Lilik Supriati Lilik Supriati Lilik Supriati Lilik Supriati, Lilik Lola Ayu Istifiani M Saifur Rohman Machfud, Savinka Salsabiela Iriana Maria Fatimah Fouk Maulidah Maulidah Merry P Mesa, Nofita Dewi Kok Mochamad Ali Sodikin Muhammad Ridwan Mukhamad Fathoni Mukhamad Fathoni Muladefi Choiriyah Munif, Badrul Nana Septiana Widayati Nanang Bagus Sasmito Nanik Setijowati Narwasthu, Sekararum Nawang Wulandari Nawang Wulandari, Nawang Nur 'Aini Nurdiana Nurdiana Nurdiana Nurdiana Nurul Evi Nurul Muslihah Olivia Handayani Palis, Christine Natalia Pamungkas, Akhmad Yanuar Fahmi Patawari, Abdul Prasanti Mahesa Anjani Prasetyawan, Riyan Dwi Putra Agina Widyaswara Suwaryo Rahmawan, Fajri Andi Renny Nova Renny Nova, Renny Retno Lestari Retno Lestari Ridhoyanti Hidayah, Ridhoyanti Rina Anggraini Rislan Faiz Muhammad Rismawan Adi Yunanto Rista Nikmatu Rohmah Rista Nikmatu Rohmah, Rista Nikmatu Rizal, Ardian Roesardhyati, Ratna Roshanti, Dian Rosikhah Al-Maris Rosuli, Ahmad Rudiyanto Rudiyanto, Rudiyanto Safira Dita Arviana Sanjana, I Wayan Edi Saputri, Diana Nanda Sartika Lestari Ismail, Dina Dewi Sasnita Salam Sassanti, Suci Wulandari Satrianto, Anang Satwikajati, Sawitri Septi Dewi Rachmawati Servasius To’o Jala Mulu Setyoadi Setyoadi Setyoadi Setyoadi Shahdevi Nandar Kurniawan, Shahdevi Nandar Siska Christianingsih Siska Puji Lestari Siska Puji Lestari Siska Puji Lestari Suis Galischa Wati Supriyadi, Muchamad Supriyanto Supriyanto Suryanto Suryanto Susilowati Susilowati Susilowati Susilowati Suwaryo, Putra Agina Widyaswara Swastikaputri, Valerina Yogibuana Teuku Heriansyah Tina Handayani Nasution Tita Hariyanti Toga, Erik Tony Suharsono Tony Suharsono Tony Suharsono, Tony Turhadi Turhadi Umar, Ja’far Widiani, Luh Widito, Sasmojo Wisnasari, Shila Yati Sri Hayati Yoga Tribakti Rachmad Yulian Wiji Utami Yulian Wiji Utami Yulian Wiji Utami Yuliatun . Yuliatun ., Yuliatun Yuyun Yueniwati