Claim Missing Document
Check
Articles

EDUKASI PERILAKU HIDUP BERSIH DAN SEHAT DALAM RANGKA PENANGANAN DIARE PADA SISWA SISWI SDN SIRNAPUTRA Ruswanto, Ruswanto; Lestari, Tresna; Wardani, Gatut Ari; Fadilah, Refi Tazhqiyatul; Nurlita, Putri
Jurnal Pengabdian Masyarakat (Jupemas) Vol 3, No 2 (2022)
Publisher : Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jupemas.v3i2.1309

Abstract

Kesehatan merupakan salah satu elemen terpenting dalam kehidupan manusia. Kesehatan erat kaitanya dengan perilaku individu, terutama perilaku yang berhubungan dengan Kesehatan. Penerapan PHBS dilingkungan sekolah merupakan salah satu strategis untuk menggerakan dan memberdayakan para guru dan siswa untuk hidup bersih dan sehat. Tujuan kegiatan ini yaitu untuk meningkatkan kepedulian anak anak untuk menjaga kebersihan sehingga terhindar dari berbagai penyakit, mengetahui pencegahan diare, juga menggosok gigi dan mencuci tangan yang baik dan benar sehingga anak anak dapat menerapkan ilmunya dalam kehidupan sehari-hari dalam upaya, media yang digunakan yaitu berupa power point serta pemaparan materi mengenai penanganan pertama pada diare, dan demonstrasi menggosok gigi juga mencuci tangan yang baik dan benar. Kegiatan dinilai memiliki dampak yang positif berdasarkan evaluasi yang dilakukan sekitar 67 peserta mempunyai respon yang baik dalam penerimaan materi.
The Potency of Alkaloid Derivates as Anti-Breast Cancer Candidates: In Silico Study Renadi, Sedin; Pratita, Anindita Tri Kusuma; Mardianingrum, Richa; Ruswanto, Ruswanto
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.31481

Abstract

Breast cancer is the most frequent malignancy in women worldwide. One of the target receptors for the treatment of breast cancer are estrogen, progesterone, and HER2 receptors. An alternative treatment using natural ingredients has been developed, one of which is alkaloid compounds. This study aims to determine the activity of alkaloid compounds as anti-breast cancer agents through an in-silico method. Virtual screening (AutoDock Vina), molecular docking (AutoDock Tools), molecular dynamics (Desmond), scanning Lipinski's rule of five, as well as pharmacokinetic and toxicity parameters, were performed. The results of virtual screening, molecular docking, and molecular dynamics show that the compounds daurisoline, solasodine, and sambutoxin have stable interactions with the HER2 receptor, with the lowest values of RMSD (Root Mean Square Deviation) and RMSF (Root Mean Square Fluctuation) compared to other compounds. Based on the results of the study conducted, it was shown that daurisoline, solasodine, and sambutoxin were predicted to be used as anti-HER2 candidates for the treatment of breast cancer.
The Virtual Screening of Flavonoid Derivatives on Progesterone, Estrogen, and HER-2 Receptor for Breast Cancer Treatment Candidate Septian, Ade Dwi; Wardani, Gatut Ari; Mardianingrum, Richa; Ruswanto, Ruswanto
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.31482

Abstract

Cancer is defined as a disease caused by progressive and abnormal cell proliferation in the body. This condition is caused by deoxyribonucleic acid (DNA) changes, which causes cells to lose their normal function. The aim of this study is to find that flavonoid compounds have a more stable interaction than tamoxifen as anti-cancer candidates. Research has been conducted in silico with molecular docking (AutodockTools-1.5.7) and molecular dynamics of 200 flavonoid compounds. Furthermore, pharmacokinetic parameters, toxicity, and the application of the Lipinski Rule of Five were investigated. Based on molecular docking results, the compounds eriocotrin, glabrol, kaempferitrin, linarin, and narirutin have more stable interactions with lower binding energy (∆G) than tamoxifen. From the results of molecular docking, molecular dynamics, and pharmacokinetic studies, it is predicted that the kaempferitrin compound can be used as an anti-cancer candidate and does not cause toxicity through further research.
Radiolabeling and In-Silico Study of 131I-(4-fluorobenzoyl-3-methylthiourea) as Radiopharmaceuticals for Breast Cancer Theranostics Pratama, Febby; Ruswanto, Ruswanto; Nofianti, Tita; Pratita, Anindita Tri Kusuma; Daruwati, Isti; Susilo, Veronika Yulianti; Holik, Holis Abdul
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.34258

Abstract

The chemicals produced from thiourea are actively being studied as anticancer possibilities. In complexes with radionuclides like Iodine-131, the 1-(4-Fluorobenzoyl)-3-methyl thiourea is a promising ligand for theragnostic applications. This study aimed to label 1-(4-fluorobenzoyl-3-methylthiourea) with iodine-131 and observe its interaction with breast cancer receptors. The radiolabeling of 131I-(4-fluorobenzoyl-3-methylthiourea) uses the radioiodination method with Chloramine-T, and an in-silico investigation of breast cancer receptors was conducted. According to the results of molecular docking using AutoDockTools, this radiopharmaceutical molecule has the best activity on the HER2 receptor (PDB ID: 3PP0) compared to the native ligand and control positive, with a binding affinity of -6.13 kcal/mol and a Ki value of 32.05 mM. According to the molecular dynamics data using Desmond, the radiopharmaceutical molecule 131I-(4-Fluorobenzoyl-3-methylthiourea) displays good stability starting from the 50ns range. The indirect radioiodination method has successfully labeled 1-(4-Fluorobenzoyl-3-methylthiourea) with iodine-131.
DESAIN DAN STUDI INTERAKSI SENYAWA KOMPLEKS COBALT (II)-(1-BENZOYL-3-METHYL THIOUREAS) DENGAN DNA SEBAGAI KANDIDAT ANTIKANKER Ruswanto Ruswanto; Mardianingrum Richa; Naser Fahmi Muhamad
Pharmacoscript Vol. 6 No. 2 (2023): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v6i2.1264

Abstract

Kompleks logam Cobalt (II) dengan ligan turunan tiourea telah banyak diteliti dan dipelajari dalam pengembangan obat anti kanker. Tujuan penelitian adalah untuk menemukan kandidat antikanker yang lebih poten dari senyawa Cobalt (II)-tiourea dengan cara mempelajari interaksi pada DNA Dodecamer. Metode yang digunakan adalah simulasi docking dan prediksi farmakokinetik dan toksisitas. Dua senyawa Cobalt (II)-tiourea yaitu senyawa Bis-[3-methyl-1-(naphthalene-2-carbonyl)thiourea] Cobalt (III) dan Bis-[1-(4-heptylbenzoyl)-3-methylthiourea] Cobalt (III) yang diprediksi sebagai kandidat antikanker melalui interaksi dengan DNA Dodecamer.
PENYULUHAN KESEHATAN TERHADAP PELAJAR DI SEKOLAH MENENGAH ATAS SEBAGAI UPAYA MEWUJUDKAN PROGRAM PELAYANAN KESEHATAN PEDULI REMAJA Mochamad Fathurohman; Ruswanto Ruswanto; Anindita Tri Kusuma Pratita; Citra Dewi Salasanti; Nurlaili Dwi Hidayati; Nur Rahayuningsih; Rahmawati Rahmawati; Tita Nofianti; Tresna Lestari; Vera Nurviana
JMM (Jurnal Masyarakat Mandiri) Vol 8, No 2 (2024): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v8i2.22064

Abstract

Abstrak: Program pelayanan kesehatan peduli remaja merupakan langkah penting dalam melindungi remaja dari risiko kesehatan dini, Selain itu, program tersebut dapat memberikan edukasi tentang kesejahteraan kesehatan menuju masa dewasa yang lebih sehat. Tujuan pengabdian kepada masyarakat ini untuk memberikan akses kepada masyarakat dalam memberikan pemahaman kesehatan sejak dini serta memeriksa suhu tubuh, tekanan darah, kadar glukosa, dan berat badan secara gratis serta mengidentifikasi potensi masalah kesehatan pada masyarakat khususnya pelayanan kesehatan peduli remaja. Metode kegiatan dalam bentuk penyuluhan dan pelayanan terhadap remaja dengan cara diskusi dan pembagian pamflet. Sasaran kepada masyarakat terutama remaja sekolah menengah atas jumlah yang hadir 60 siswa. Untuk mengetahui pemahaman peserta dilakukan evaluasi dalam bentuk kuisioner serta tanya jawab terkait materi yang disampaikan. Hasil yang telah dicapai bahwa siswa dapat meningkatkan pengetahuan terkait peduli Kesehatan sejak dini dengan presentase rerata 90%, serta diharapkan dapat meningkatkan kesadaran siswa remaja akan pentingnya menjaga Kesehatan.Abstract: The adolescent care health service program is an important step in protecting adolescents from early health risks, in addition, the program can provide education about health welfare towards a healthier adulthood. The purpose of this community service is to provide access to the community in providing early health understanding and checking body temperature, blood pressure, glucose levels, and body weight for free and identifying potential health problems in the community, especially adolescent care health services. The method of activity is in the form of counseling and services to adolescents by means of discussion and distribution of pamphlets. Targeting the community, especially high school teenagers, the number of attendees was 60 students. To determine the understanding of the participants, an evaluation was carried out in the form of questionnaires and questions and answers related to the material presented. The results that have been achieved are that students can increase knowledge related to early health care with an average percentage of 90%, and are expected to increase teenage students' awareness of the importance of maintaining health. 
In silico study of the active compounds in bitter melon (Momordica charantia L) as antidiabetic medication Ruswanto, Ruswanto; Mardianingrum, Richa; Lestari, Tresna; Nofianti, Tita; Tuslinah, Lilis; Nurmalik, Dudi
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.8993

Abstract

Antidiabetic are many drugs available in the market, but most medications have side effects that are relatively high and cause toxicity, so it needs tobe develoved search of new drug compounds were more potent drugs with side effects as low. Various research have shown that bitter melon (Momordica charantia L) has an effect antidiabetic. But it is not known specifically as antidiabetic compounds that act on bitter melon (Momordica charantia L). This study was conducted to predict the active compounds of bitter melon (Momordica charantia L)potent as antidiabetic in silico, through the molecular docking, Drug scan, PreADMET and molecular dinamics simulation. The results of the 26 active compound bitter melon (Momordica charantia L) obtained one potential compounds that are active against nuclear reseptor RORα that is goyaglikosida-h and more potent than Rosiglitazon
IMPLEMENTASI LITERASI DIGITAL PADA MATA PELAJARAN PENDIDIKAN AGAMA ISLAM DI SMA NEGERI 6 BANDAR LAMPUNG SUPRIADI, HENY; RUSWANTO, RUSWANTO; SUSILAWATI , BETI
LEARNING : Jurnal Inovasi Penelitian Pendidikan dan Pembelajaran Vol. 4 No. 4 (2024)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia (P4I)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/learning.v4i4.3763

Abstract

Islamic Religious Education (PAI) is a crucial subject that supports the development of students’ moral character and Islamic values. In this context, integrating digital literacy strategies into PAI teaching is essential to enhance its effectiveness. This study examines the implementation of digital literacy in PAI at SMA Negeri 6 Bandar Lampung, focusing on the stages of planning, implementation, and evaluation in the learning process. This field research involved 8 respondents, consisting of 3 PAI teachers and 5 students from class X B. Data were collected through interviews, observations, and documentation. The findings reveal that the planning stage includes preparing lesson plans (RPP), digital teaching materials such as e-books and educational videos, and utilizing applications like WhatsApp and YouTube. The implementation stage involves using digital learning media tailored to the subject matter, while the evaluation stage comprises assignments and practice exercises. Supporting factors include school-provided facilities like internet access and laptops, ensuring smooth learning processes. However, challenges arise from students misusing technology, such as accessing irrelevant applications during lessons. This study highlights the importance of effectively managing technology to achieve successful digital literacy integration in PAI education. ABSTRAKPendidikan Agama Islam (PAI) merupakan mata pelajaran penting yang mendukung pembentukan akhlakul karimah dan karakter Islami peserta didik. Dalam konteks ini, pengembangan strategi pembelajaran berbasis literasi digital menjadi relevan untuk meningkatkan efektivitas pengajaran PAI. Artikel ini mengkaji implementasi literasi digital pada mata pelajaran PAI di SMA Negeri 6 Bandar Lampung, dengan fokus pada proses perencanaan, pelaksanaan, dan evaluasi pembelajaran. Penelitian ini menggunakan pendekatan lapangan dengan teknik wawancara, observasi, dan dokumentasi, melibatkan 8 responden, yaitu 3 guru PAI dan 5 siswa kelas X B. Hasil penelitian menunjukkan bahwa tahap perencanaan mencakup pembuatan RPP, penyediaan bahan ajar berbasis digital seperti e-book dan video pembelajaran, serta penggunaan aplikasi seperti WhatsApp dan YouTube. Tahap pelaksanaan menggunakan media pembelajaran digital yang sesuai dengan materi, sedangkan tahap evaluasi dilakukan melalui pemberian latihan soal dan pekerjaan rumah. Faktor pendukung implementasi literasi digital adalah tersedianya fasilitas seperti internet dan laptop yang disediakan sekolah. Namun, terdapat hambatan berupa penyalahgunaan teknologi oleh siswa, seperti membuka aplikasi yang tidak relevan selama pembelajaran. Studi ini menegaskan pentingnya pengelolaan teknologi yang bijak untuk mendukung keberhasilan pembelajaran berbasis literasi digital dalam mata pelajaran PAI.
An Experimental Study of the Team Assisted Individualization Model on Islamic Cultural History Learning Outcomes Nugraha, Hafizh Maulana; Sa’idy, Sa’idy; Azizah, Nurul; Ruswanto, Ruswanto; Susanti, Agus
Journal of Innovation and Research in Primary Education Vol. 4 No. 3 (2025)
Publisher : Papanda Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56916/jirpe.v4i3.1374

Abstract

This study aims to investigate the effectiveness of the Team Assisted Individualization (TAI) instructional model in improving students’ learning outcomes in the subject of Islamic Cultural History at MTs Terpadu Labbaik Lahat. The research employed a quasi-experimental design involving experimental and control classes. Data were collected through a multiple-choice test developed based on learning outcome indicators, which was validated and tested for reliability, yielding a moderate Cronbach’s alpha of 0.692. Normality tests indicated that the data were not normally distributed; hence, the Mann-Whitney U test was applied to analyze differences between the two groups. The results revealed a statistically significant improvement in the experimental group’s learning outcomes compared to the control group (p = 0.010). These findings align with prior research demonstrating the positive impact of the TAI model across various subjects and educational levels. The study concludes that the TAI instructional model is an effective strategy for enhancing student achievement, particularly in contexts requiring a balance of cooperative and individualized learning approaches. Limitations concerning sample size and research context suggest further studies with larger and more diverse populations to generalize the findings more broadly.
The PQ4R Learning Model (Preview, Question, Read, Reflect, Recite, Review): Measuring Its Effectiveness on Students’ Learning Outcomes Hasanah, Melati Nur Aini; Ruswanto, Ruswanto; Azizah, Nurul; Sada, Heru Juabdin; Yusnita, Erni
Journal of Educational Sciences Vol. 9 No. 3 (2025): Journal of Educational Sciences
Publisher : FKIP - Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jes.9.3.p.1717-1730

Abstract

This study aims to examine the effect of the PQ4R learning model on students’ learning outcomes at the cognitive levels of analysis (C4) and evaluation (C5). Employing a quantitative approach with a quasi-experimental posttest-only control group design, Samples were selected through simple random sampling. Class VIII.1 was assigned as the experimental group receiving the PQ4R learning model, while class VIII.7 served as the control group with conventional instruction. The research instrument was a 15-item multiple-choice test validated for validity and reliability. Data analysis began with assumption testing for normality and homogeneity. Levene’s test indicated an F-value of 1.184 with a significance of 0.281, confirming homogeneity of variance between groups. The hypothesis was tested using an independent samples t-test, yielding a t-value of 5.343 with 59 degrees of freedom and a significance level of 0.001 (p < 0.05), indicating a statistically significant difference between the groups’ mean scores. The mean difference of 1.62366 with a 95% confidence interval ranging from 1.01309 to 2.23168 further supports this result. These findings conclude that the PQ4R learning model significantly improves students’ analytical and evaluative thinking skills. Therefore, the PQ4R model is recommended as an effective instructional strategy for enhancing higher-order cognitive learning outcomes.
Co-Authors A.A. Ketut Agung Cahyawan W Aas Nuraisah Aas Nuraisah Aas Nuraisah Abdul Hakim Agus Susanti Aguslina Kirtishanti Ahmad Tantowi Jaohari Ai Teni Siti Robi`ah Aimi Ratnasari Aimi Ratnasari, Aimi Albie, Fadhlan Adtya Alicia Nadira Alifia Nurfadhilah S Anggi Agustira Anindita Tri Kusuma , Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anisa Pebiansyah Anjuni, Dhea Putri Anna Yuliana, Anna Annazalia Rustandi Putri Annisa Pebiansyah Annisa Pebiansyah Aprillia, Ade Yeni Arry Yanuar Asep Nugraha Ayudia, Sukma Billah, Tazkia Hasna Citra Dewi Salasanti Citra Dewi Salasanti Deden Makbuloh Deliani Deliani Deliaz, Mochamad Fajar Delis Susilawati Desri Lestari Dewi Dewi Dewi, Nida Puspa Dewi, Rika Zahara Diana Sri Zustika Dini Febianeu Ditha Rizqi Aulia Utami Dudi Nurmalik Dwijanto Dwijanto, Dwijanto Elsa Oktavia Angelica Elsi Eryanti Fadilah, Refi Tazhqiyatul FAJAR SETIAWAN Fajar Setiawan Fanisa Riadhiani Fathurohman, Mochamad Fauziah, Mina Febby, Pratama Feri Sandria Firiani, Yuli Firman Gustaman Fujiyanti, Melia Gatut Ari Wardani Gina Maya Lestari Gina Septiani Agustien Gina Yulias Triyani Ginna Sri Nuryani Gustaman, Firman Hasanah, Melati Nur Aini Hendy Suhendy Herdiana, Yana Heri Herdiana Heru Juabdin Sada Hery Wibowo, Hery Himyatul Hidayah Holis Abdul Holik, Holis Abdul Ibnu Hajar Ikram, Nur Kusaira Khairul Ilham Alifiar Ilham Alifiar Ilham Alifiar Ilham Nurfadilah, Asopari Imam Mustaqim Garna Indah Cantika Ira Rahmiyani Irawan, Rudy Isti Daruwati Kamiel Roesman Bachtiar Khoerunisa, Widia Salsabila Korry Novitriani, Korry Kristiana, Wiwin Leli Siti Zaqiah Lestari, Gina Maya Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah, Lilis Lina Rahmawati Rizkuloh Lusi Nurdianti, Lusi M. Faturohman Mardhiah Mardhiah Mardhiah Mardhiah Mardianingrum Richa Melia Fujiyanti Meylany Sity Rossy Lestary Mina Fauziah Mitha Anggitha Moch. Zainuddin, Moch. Mochamad Fajar Deliaz Mochamad Fathurahman Mochamad Fathurohman Mochamad Fathurohman Muhammad Ismail Muharam Priatna Muharam Priatna Muharam Priatna Nadira, Alicia Naser Fahmi Muhamad Nasipah, Anis Neni Sri Gunarti Neta Ekayanti Suganda Nida Puspa Dewi Nisa Uswatun Khasanah Nofianti, Tita Nofianti, Tita Nofriyaldi, Ali Nugraha, Asep Nugraha, Hafizh Maulana Nur Aji Nur Laeli Dwi Hidayati Nur Laili Dwi Hidayati Nur Rahayuningsih Nur Rahayuningsih Nur Rahayuningsih, Nur Nur, Rahayuningsih Nurlaili Dwi Hidayati Nurlita, Putri Nurmalik, Dudi Nurmalik, Dudi NURUL AZIZAH Nurul Kamilah Nurul Kamilah Oktaviani Ayu Saputri Oktaviani, Widya Paras Layna Safa Pebiansyah, Anisa Pertiwi, Nur Ihsani Pikri Adit Praditya R Pratama, Febby Pratita, Anindita Tri Kusuma Putri Pratiwi Rachman, Dineu Septy Ulfiatur Rahmawati Rahmawati Raja Ramadiansyah Ramadan, Fajar Renadi, Sedin Riadhiani, Fanisa Richa Mardianingrum Richa, Mardianingrum Rika Zahara Dewi Rissa Putri Aulia Yulianto Rivaldi Muhsin Roswandi, Wemfi Riska Saeful Amin Safa, Paras Layna Saputri, Oktaviani Ayu Sarah, Ai Sarwatiningsih, Yunia Sa’idy, Sa’idy Septian, Ade Dwi Setiawati, Wina Aprilia Shal Nurdinda Fauziah Silvi Novitasari, Silvi Sindi Lestari Siswandono, Siswandono Sri Asih Sri Mulyani Srie Rezeki Nur Endah Srie Rezeki Nur Endah Sucipto Sucipto Sukma Ayudia SUPRIADI, HENY Surya Amal Susanti Susanti Susanti Susanti SUSILAWATI , BETI Taufik Hidayat Tiara Permata Sari Tifa Nofianti Tira Mutiara Utami Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti, Tita Tresna Lestari Tresna Lestari, Tresna Tuslinah, Lilis Tuslinah, Lilis Ummy, Mardiana Vera Nurviana Vera Nurviana Veronika Yulianti Susilo Wahdah, Lestari Wahyuni, Wini Wemfi Riska Roswandi Widya Oktaviani Wildan Rizki Asilmi Wina Aprilia Setiawati Winda Trisna Wulandari Winda Trisna Wulandari Wini Wahyuni Wiwin Kristiana Yana Herdiana Yulia Salmini Yundari, Yundari YUSNITA, ERNI