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Radiolabeling and In-Silico Study of 131I-(4-fluorobenzoyl-3-methylthiourea) as Radiopharmaceuticals for Breast Cancer Theranostics Pratama, Febby; Ruswanto, Ruswanto; Nofianti, Tita; Pratita, Anindita Tri Kusuma; Daruwati, Isti; Susilo, Veronika Yulianti; Holik, Holis Abdul
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.34258

Abstract

The chemicals produced from thiourea are actively being studied as anticancer possibilities. In complexes with radionuclides like Iodine-131, the 1-(4-Fluorobenzoyl)-3-methyl thiourea is a promising ligand for theragnostic applications. This study aimed to label 1-(4-fluorobenzoyl-3-methylthiourea) with iodine-131 and observe its interaction with breast cancer receptors. The radiolabeling of 131I-(4-fluorobenzoyl-3-methylthiourea) uses the radioiodination method with Chloramine-T, and an in-silico investigation of breast cancer receptors was conducted. According to the results of molecular docking using AutoDockTools, this radiopharmaceutical molecule has the best activity on the HER2 receptor (PDB ID: 3PP0) compared to the native ligand and control positive, with a binding affinity of -6.13 kcal/mol and a Ki value of 32.05 mM. According to the molecular dynamics data using Desmond, the radiopharmaceutical molecule 131I-(4-Fluorobenzoyl-3-methylthiourea) displays good stability starting from the 50ns range. The indirect radioiodination method has successfully labeled 1-(4-Fluorobenzoyl-3-methylthiourea) with iodine-131.
DESAIN DAN STUDI INTERAKSI SENYAWA KOMPLEKS COBALT (II)-(1-BENZOYL-3-METHYL THIOUREAS) DENGAN DNA SEBAGAI KANDIDAT ANTIKANKER Ruswanto Ruswanto; Mardianingrum Richa; Naser Fahmi Muhamad
Pharmacoscript Vol. 6 No. 2 (2023): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v6i2.1264

Abstract

Kompleks logam Cobalt (II) dengan ligan turunan tiourea telah banyak diteliti dan dipelajari dalam pengembangan obat anti kanker. Tujuan penelitian adalah untuk menemukan kandidat antikanker yang lebih poten dari senyawa Cobalt (II)-tiourea dengan cara mempelajari interaksi pada DNA Dodecamer. Metode yang digunakan adalah simulasi docking dan prediksi farmakokinetik dan toksisitas. Dua senyawa Cobalt (II)-tiourea yaitu senyawa Bis-[3-methyl-1-(naphthalene-2-carbonyl)thiourea] Cobalt (III) dan Bis-[1-(4-heptylbenzoyl)-3-methylthiourea] Cobalt (III) yang diprediksi sebagai kandidat antikanker melalui interaksi dengan DNA Dodecamer.
PENYULUHAN KESEHATAN TERHADAP PELAJAR DI SEKOLAH MENENGAH ATAS SEBAGAI UPAYA MEWUJUDKAN PROGRAM PELAYANAN KESEHATAN PEDULI REMAJA Mochamad Fathurohman; Ruswanto Ruswanto; Anindita Tri Kusuma Pratita; Citra Dewi Salasanti; Nurlaili Dwi Hidayati; Nur Rahayuningsih; Rahmawati Rahmawati; Tita Nofianti; Tresna Lestari; Vera Nurviana
JMM (Jurnal Masyarakat Mandiri) Vol 8, No 2 (2024): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v8i2.22064

Abstract

Abstrak: Program pelayanan kesehatan peduli remaja merupakan langkah penting dalam melindungi remaja dari risiko kesehatan dini, Selain itu, program tersebut dapat memberikan edukasi tentang kesejahteraan kesehatan menuju masa dewasa yang lebih sehat. Tujuan pengabdian kepada masyarakat ini untuk memberikan akses kepada masyarakat dalam memberikan pemahaman kesehatan sejak dini serta memeriksa suhu tubuh, tekanan darah, kadar glukosa, dan berat badan secara gratis serta mengidentifikasi potensi masalah kesehatan pada masyarakat khususnya pelayanan kesehatan peduli remaja. Metode kegiatan dalam bentuk penyuluhan dan pelayanan terhadap remaja dengan cara diskusi dan pembagian pamflet. Sasaran kepada masyarakat terutama remaja sekolah menengah atas jumlah yang hadir 60 siswa. Untuk mengetahui pemahaman peserta dilakukan evaluasi dalam bentuk kuisioner serta tanya jawab terkait materi yang disampaikan. Hasil yang telah dicapai bahwa siswa dapat meningkatkan pengetahuan terkait peduli Kesehatan sejak dini dengan presentase rerata 90%, serta diharapkan dapat meningkatkan kesadaran siswa remaja akan pentingnya menjaga Kesehatan.Abstract: The adolescent care health service program is an important step in protecting adolescents from early health risks, in addition, the program can provide education about health welfare towards a healthier adulthood. The purpose of this community service is to provide access to the community in providing early health understanding and checking body temperature, blood pressure, glucose levels, and body weight for free and identifying potential health problems in the community, especially adolescent care health services. The method of activity is in the form of counseling and services to adolescents by means of discussion and distribution of pamphlets. Targeting the community, especially high school teenagers, the number of attendees was 60 students. To determine the understanding of the participants, an evaluation was carried out in the form of questionnaires and questions and answers related to the material presented. The results that have been achieved are that students can increase knowledge related to early health care with an average percentage of 90%, and are expected to increase teenage students' awareness of the importance of maintaining health. 
In silico study of the active compounds in bitter melon (Momordica charantia L) as antidiabetic medication Ruswanto, Ruswanto; Mardianingrum, Richa; Lestari, Tresna; Nofianti, Tita; Tuslinah, Lilis; Nurmalik, Dudi
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.8993

Abstract

Antidiabetic are many drugs available in the market, but most medications have side effects that are relatively high and cause toxicity, so it needs tobe develoved search of new drug compounds were more potent drugs with side effects as low. Various research have shown that bitter melon (Momordica charantia L) has an effect antidiabetic. But it is not known specifically as antidiabetic compounds that act on bitter melon (Momordica charantia L). This study was conducted to predict the active compounds of bitter melon (Momordica charantia L)potent as antidiabetic in silico, through the molecular docking, Drug scan, PreADMET and molecular dinamics simulation. The results of the 26 active compound bitter melon (Momordica charantia L) obtained one potential compounds that are active against nuclear reseptor RORα that is goyaglikosida-h and more potent than Rosiglitazon
IMPLEMENTASI LITERASI DIGITAL PADA MATA PELAJARAN PENDIDIKAN AGAMA ISLAM DI SMA NEGERI 6 BANDAR LAMPUNG SUPRIADI, HENY; RUSWANTO, RUSWANTO; SUSILAWATI , BETI
LEARNING : Jurnal Inovasi Penelitian Pendidikan dan Pembelajaran Vol. 4 No. 4 (2024)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia (P4I)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/learning.v4i4.3763

Abstract

Islamic Religious Education (PAI) is a crucial subject that supports the development of students’ moral character and Islamic values. In this context, integrating digital literacy strategies into PAI teaching is essential to enhance its effectiveness. This study examines the implementation of digital literacy in PAI at SMA Negeri 6 Bandar Lampung, focusing on the stages of planning, implementation, and evaluation in the learning process. This field research involved 8 respondents, consisting of 3 PAI teachers and 5 students from class X B. Data were collected through interviews, observations, and documentation. The findings reveal that the planning stage includes preparing lesson plans (RPP), digital teaching materials such as e-books and educational videos, and utilizing applications like WhatsApp and YouTube. The implementation stage involves using digital learning media tailored to the subject matter, while the evaluation stage comprises assignments and practice exercises. Supporting factors include school-provided facilities like internet access and laptops, ensuring smooth learning processes. However, challenges arise from students misusing technology, such as accessing irrelevant applications during lessons. This study highlights the importance of effectively managing technology to achieve successful digital literacy integration in PAI education. ABSTRAKPendidikan Agama Islam (PAI) merupakan mata pelajaran penting yang mendukung pembentukan akhlakul karimah dan karakter Islami peserta didik. Dalam konteks ini, pengembangan strategi pembelajaran berbasis literasi digital menjadi relevan untuk meningkatkan efektivitas pengajaran PAI. Artikel ini mengkaji implementasi literasi digital pada mata pelajaran PAI di SMA Negeri 6 Bandar Lampung, dengan fokus pada proses perencanaan, pelaksanaan, dan evaluasi pembelajaran. Penelitian ini menggunakan pendekatan lapangan dengan teknik wawancara, observasi, dan dokumentasi, melibatkan 8 responden, yaitu 3 guru PAI dan 5 siswa kelas X B. Hasil penelitian menunjukkan bahwa tahap perencanaan mencakup pembuatan RPP, penyediaan bahan ajar berbasis digital seperti e-book dan video pembelajaran, serta penggunaan aplikasi seperti WhatsApp dan YouTube. Tahap pelaksanaan menggunakan media pembelajaran digital yang sesuai dengan materi, sedangkan tahap evaluasi dilakukan melalui pemberian latihan soal dan pekerjaan rumah. Faktor pendukung implementasi literasi digital adalah tersedianya fasilitas seperti internet dan laptop yang disediakan sekolah. Namun, terdapat hambatan berupa penyalahgunaan teknologi oleh siswa, seperti membuka aplikasi yang tidak relevan selama pembelajaran. Studi ini menegaskan pentingnya pengelolaan teknologi yang bijak untuk mendukung keberhasilan pembelajaran berbasis literasi digital dalam mata pelajaran PAI.
An Experimental Study of the Team Assisted Individualization Model on Islamic Cultural History Learning Outcomes Nugraha, Hafizh Maulana; Sa’idy, Sa’idy; Azizah, Nurul; Ruswanto, Ruswanto; Susanti, Agus
Journal of Innovation and Research in Primary Education Vol. 4 No. 3 (2025)
Publisher : Papanda Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56916/jirpe.v4i3.1374

Abstract

This study aims to investigate the effectiveness of the Team Assisted Individualization (TAI) instructional model in improving students’ learning outcomes in the subject of Islamic Cultural History at MTs Terpadu Labbaik Lahat. The research employed a quasi-experimental design involving experimental and control classes. Data were collected through a multiple-choice test developed based on learning outcome indicators, which was validated and tested for reliability, yielding a moderate Cronbach’s alpha of 0.692. Normality tests indicated that the data were not normally distributed; hence, the Mann-Whitney U test was applied to analyze differences between the two groups. The results revealed a statistically significant improvement in the experimental group’s learning outcomes compared to the control group (p = 0.010). These findings align with prior research demonstrating the positive impact of the TAI model across various subjects and educational levels. The study concludes that the TAI instructional model is an effective strategy for enhancing student achievement, particularly in contexts requiring a balance of cooperative and individualized learning approaches. Limitations concerning sample size and research context suggest further studies with larger and more diverse populations to generalize the findings more broadly.
The PQ4R Learning Model (Preview, Question, Read, Reflect, Recite, Review): Measuring Its Effectiveness on Students’ Learning Outcomes Hasanah, Melati Nur Aini; Ruswanto, Ruswanto; Azizah, Nurul; Sada, Heru Juabdin; Yusnita, Erni
Journal of Educational Sciences Vol. 9 No. 3 (2025): Journal of Educational Sciences
Publisher : FKIP - Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jes.9.3.p.1717-1730

Abstract

This study aims to examine the effect of the PQ4R learning model on students’ learning outcomes at the cognitive levels of analysis (C4) and evaluation (C5). Employing a quantitative approach with a quasi-experimental posttest-only control group design, Samples were selected through simple random sampling. Class VIII.1 was assigned as the experimental group receiving the PQ4R learning model, while class VIII.7 served as the control group with conventional instruction. The research instrument was a 15-item multiple-choice test validated for validity and reliability. Data analysis began with assumption testing for normality and homogeneity. Levene’s test indicated an F-value of 1.184 with a significance of 0.281, confirming homogeneity of variance between groups. The hypothesis was tested using an independent samples t-test, yielding a t-value of 5.343 with 59 degrees of freedom and a significance level of 0.001 (p < 0.05), indicating a statistically significant difference between the groups’ mean scores. The mean difference of 1.62366 with a 95% confidence interval ranging from 1.01309 to 2.23168 further supports this result. These findings conclude that the PQ4R learning model significantly improves students’ analytical and evaluative thinking skills. Therefore, the PQ4R model is recommended as an effective instructional strategy for enhancing higher-order cognitive learning outcomes.
Pesantren dan Pembaharuan Ruswanto, Ruswanto
Al-Tadzkiyyah: Jurnal Pendidikan Islam Vol 7 No 1 (2016): Al-Tadzkiyyah : Jurnal Pendidikan Islam
Publisher : Universitas Islam Negeri Raden Intan Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/atjpi.v7i1.1496

Abstract

Boarding  School  is  the  oldest  Islamic  institution  in  Indonesia  which  has  a  very important role in the spread and consolidation of public adherence to Islam. But since when actually boarding school began to stand, is not known for certain, but researchers have found that  in  the  16th  century  boarding  school  institutions  has  grown.  Among  the  researchers  are also  differences  of  opinion  about  the  origins  of  the  term  and  the  Pondok  Pesantren,  some argue  comes  from  within  and  in  part  argues  from  the  outside.  The  cottage-boarding  school originally  taught  about  fiqh,  tafsir,  tasawwuf  and  the  classics  as  a  feature  of  Pesantren traditional,  then  with  the  rise  of  reformism  as  the  influence  of  scientific  and  technological advances, the boarding school was also affected reformism, and this is a positive development the boarding school itself. But although affected reformism boarding school, boarding school never  taught  radicalism  /  extremism,  because  schools  are  actually  contrary  to  Islamic teachings and ways of proselytizing Islam.
Rencana Pengembangan dan Kesiapan Sivitas Akademika UIN Raden Intan Lampung Menuju AUN-QA Makbuloh, Deden; Sucipto, Sucipto; ruswanto, ruswanto
Al-Tadzkiyyah: Jurnal Pendidikan Islam Vol 8 No 2 (2017): Al-Tadzkiyyah: Jurnal Pendidikan Islam
Publisher : Universitas Islam Negeri Raden Intan Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/atjpi.v8i2.2252

Abstract

Raden Intan Lampung State Islamic University (UIN RIL) as a State Islamic Religious College in Indonesia needs to gradually carry out various efforts to improve the quality of continuing education. The long-term quality of UIN RIL does not only cover national level competition, but also internationally. This study aims to examine the quality improvement process that has had a development and readiness plan for AUN-QA for the Academic Community of UIN RIL. Data collected is qualitative data. In accordance with the research design in order to find an overview of the planned development of UIN RIL and its readiness towards AUN-QA. The data sources in this study were taken from strategic planning documents and the opinions of the academics. Techniques for collecting data through documentation studies, deep interview, and participant observation. Non-structured interviews, so that data sources actively construct the cognitive world, and researchers try to capture the realm of that meaning. Analysis of data is collected simultaneously while collecting data with the principle of verstehen. The results of the study concluded that since the form changed from IAIN to UIN RIL development plans were discussed which were discussed in several stages and involved various stakeholders directed to the campus as an international reference. This can be seen in the vision, mission and objectives of UIN RIL. Likewise in priority programs and target targets there are points towards international scale achievements. The academics have welcomed with joy the change in form of IAIN to UIN RIL. All have stated that this is an opportunity to further develop the campus to reach international competition. Thoughts and energy were mobilized to develop UIN RIL towards becoming superior and competitive.
Penyuluhan DAGUSIBU (Dapatkan, Gunakan, Simpan dan Buang Obat dengan Benar) di Puskesmas Siliwangi Kabupaten Garut Khoerunisa, Widia Salsabila; Ruswanto, Ruswanto
KOMUNITA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol 4 No 3 (2025): Agustus
Publisher : PELITA NUSA TENGGARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60004/komunita.v4i3.204

Abstract

Tingkat pemahaman masyarakat tentang penggunaan obat yang tepat masih rendah, sehingga berisiko menyebabkan penyalahgunaan obat, medication error, dan pencemaran lingkungan akibat pembuangan obat yang tidak tepat. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan kesadaran masyarakat melalui penyuluhan program DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang Obat dengan Benar). Kegiatan dilaksanakan pada 19 April 2025 di Puskesmas Siliwangi, Kabupaten Garut, dengan melibatkan 46 peserta. Metode yang digunakan adalah penyuluhan berbasis partisipatif yang mencakup ceramah edukatif, distribusi leaflet, dan sesi tanya jawab. Materi yang disampaikan mencakup penggolongan obat, cara memperoleh obat secara legal, penggunaan obat sesuai aturan, penyimpanan yang benar, dan pembuangan obat yang aman. Hasil kegiatan menunjukkan antusiasme tinggi dari peserta serta peningkatan pemahaman mereka terhadap pengelolaan obat di rumah. Sesi tanya jawab memperlihatkan keaktifan peserta dan menjadi indikator keberhasilan penyampaian materi. Program DAGUSIBU terbukti relevan dalam meningkatkan literasi kesehatan masyarakat dan mendukung upaya pencegahan penyalahgunaan obat. Edukasi semacam ini diharapkan dapat membentuk perilaku masyarakat yang lebih bijak, bertanggung jawab, dan rasional dalam penggunaan obat
Co-Authors A.A. Ketut Agung Cahyawan W Aas Nuraisah Abdul Hakim Agus Susanti Aguslina Kirtishanti Ahmad Tantowi Jaohari Ai Sarah Ai Teni Siti Robi`ah Aimi Ratnasari Aimi Ratnasari, Aimi Albie, Fadhlan Adtya Alicia Nadira Alifia Nurfadhilah S Anggi Agustira Anindita Tri Kusuma , Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anis Nasipah Anisa Pebiansyah Anjani, Desti Lara Anjuni, Dhea Putri Anna Yuliana, Anna Annazalia Rustandi Putri Annisa Pebiansyah Annisa Pebiansyah Aprillia, Ade Yeni Arry Yanuar Asep Nugraha Ayudia, Sukma Billah, Tazkia Hasna Citra Dewi Salasanti Citra Dewi Salasanti Deden Makbuloh Deliani Deliani Delis Susilawati Desri Lestari Dewi Dewi Dewi, Nida Puspa Dewi, Rika Zahara Diana Sri Zustika Dini Febianeu Ditha Rizqi Aulia Utami Dudi Nurmalik Dwijanto Dwijanto, Dwijanto Elsa Oktavia Angelica Elsi Eryanti Fadilah, Refi Tazhqiyatul FAJAR SETIAWAN Fajar Setiawan Fanisa Riadhiani Fathurohman, Mochamad Fauziah, Mina Febby, Pratama Feri Sandria Firman Gustaman Fujiyanti, Melia G. Gunawan Gatut Ari Wardani Gina Maya Lestari Gina Septiani Agustien Gina Yulias Triyani Ginna Sri Nuryani Gustaman, Firman Hasan Sastra Negara Hasanah, Melati Nur Aini Hendy Suhendy Herdiana, Yana Heri Herdiana Heru Juabdin Sada Hery Wibowo, Hery Himyatul Hidayah Himyatul, Hidayah Holis Abdul Holik, Holis Abdul Ibnu Hajar Ikram, Nur Kusaira Khairul Ilham Alifiar Ilham Alifiar Ilham Alifiar Ilham Nurfadilah, Asopari Imam Mustaqim Garna Indah Cantika Ira Rahmiyani Irawan, Rudy Isti Daruwati Khoerunisa, Widia Salsabila Korry Novitriani, Korry Kristiana, Wiwin Leli Siti Zaqiah Lestari Wahdah Lestari, Gina Maya Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah, Lilis Lina Rahmawati Rizkuloh Lusi Nurdianti, Lusi M. Faturohman Mardhiah Mardhiah Mardhiah Mardhiah Mardianingrum Richa Melia Fujiyanti Meylany Sity Rossy Lestary Mina Fauziah Mitha Anggitha Moch. Zainuddin, Moch. Mochamad Fajar Deliaz Mochamad Fathurahman Mochamad Fathurohman Mochamad Fathurohman Muhammad Ismail Muharam Priatna Muharam Priatna Muharam Priatna Nadira, Alicia Naser Fahmi Muhamad Neni Sri Gunarti Nida Puspa Dewi Nisa Uswatun Khasanah Nofianti, Tita Nofianti, Tita Nofriyaldi, Ali Nugraha, Asep Nugraha, Hafizh Maulana Nur Aji Nur Laeli Dwi Hidayati Nur Laili Dwi Hidayati Nur Rahayuningsih Nur Rahayuningsih Nur Rahayuningsih, Nur Nur, Rahayuningsih Nurlaili Dwi Hidayati Nurlita, Putri Nurmalik, Dudi Nurmalik, Dudi NURUL AZIZAH Nurul Kamilah Nurul Kamilah Oktaviani Ayu Saputri Oktaviani, Widya Paras Layna Safa Pebiansyah, Anisa Pertiwi, Nur Ihsani Pikri Adit Praditya R Pratama, Febby Pratita, Anindita Tri Kusuma Putri Pratiwi Rachman, Dineu Septy Ulfiatur Rahmawati Rahmawati Raja Ramadiansyah Ramadan, Fajar Renadi, Sedin Riadhiani, Fanisa Richa Mardianingrum Richa Mardianingrum Richa, Mardianingrum Rika Zahara Dewi Rissa Putri Aulia Yulianto Rivaldi Muhsin Roswandi, Wemfi Riska Saeful Amin Safa, Paras Layna Saputri, Oktaviani Ayu Sarwatiningsih, Yunia Sa’idy, Sa’idy Septian, Ade Dwi Setiawati, Wina Aprilia Shal Nurdinda Fauziah Silvi Novitasari Sindi Lestari Siswandono, Siswandono Sri Asih Sri Mulyani Sukma Ayudia SUPRIADI, HENY Surya Amal Surya, Amal Susanti Susanti Susanti Susanti SUSILAWATI , BETI Taufik Hidayat Tiara Permata Sari Tifa Nofianti Tira Mutiara Utami Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti, Tita Tresna Lestari Tresna Lestari Tresna Lestari, Tresna Tuslinah, Lilis Tuslinah, Lilis Ummy, Mardiana Vera Nurviana Vera Nurviana Veronika Yulianti Susilo Wahyuni, Wini Wemfi Riska Roswandi Widya Oktaviani Wildan Rizki Asilmi Wina Aprilia Setiawati Winda Trisna Wulandari, Winda Trisna Wini Wahyuni Wiwin Kristiana Yana Herdiana Yeni Ari Safitri, Dalimunthe Yulia Salmini Yundari, Yundari YUSNITA, ERNI