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All Journal Jurnal Ilmiah Universitas Batanghari Jambi As-syifaa Jurnal Farmasi Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Biologi Tropis Manuju : Malahayati Nursing Journal Jurnal Medika Malahayati Poltekita : Jurnal Ilmu Kesehatan UMI Medical Journal PREPOTIF : Jurnal Kesehatan Masyarakat Indonesian Journal of Global Health research Jurnal Promotif Preventif Jurnal Kesehatan Tambusai JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Wal'afiat Hospital Journal Jurnal Ilmiah Kesehatan (JIKA) Journal of Aafiyah Health Research (JAHR) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Formosa Journal of Science and Technology (FJST) YASIN: Jurnal Pendidikan dan Sosial Budaya Jurnal Abdi Kesehatan dan Kedokteran jpki Innovative: Journal Of Social Science Research WAL'AFIAT HOSPITAL JOURNAL JOURNAL OF Qualitative Health Research & Case Studies Reports
Rachmat Faisal Syamsu, Rachmat Faisal
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : JOURNAL LA MEDIHEALTICO

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The Effect of Resveratrol on Fasting Blood Glucose Levels as a Parameter of Type 2 Diabetes Mellitus Rahman, Dinda Briliani; Syamsu, Rachmat Faisal; Safitri, Asrini
Journal La Medihealtico Vol. 6 No. 5 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i5.2714

Abstract

characterized by chronic hyperglycemia, insulin resistance, and increased oxidative stress. Resveratrol, a naturally occurring polyphenolic compound, has been widely investigated for its potential antidiabetic effects in preclinical studies, although findings across animal models remain inconsistent and require systematic synthesis. This study aimed to review and synthesize evidence on the effects of resveratrol on glycemic regulation, insulin signaling, lipid metabolism, and oxidative stress in animal models of T2DM. The review followed PRISMA 2020 guidelines. Electronic searches were conducted in PubMed, Scopus, Sinta, and Google Scholar for articles published between 2019 and 2024. Eligible studies were original experimental investigations employing animal models of T2DM with resveratrol as the primary intervention. Owing to heterogeneity in study designs and outcome measures, data were synthesized using a qualitative narrative approach. Seven studies met the inclusion criteria. Overall, resveratrol administration was associated with reductions in fasting blood glucose, improvements in insulin sensitivity, and modulation of key insulin signaling pathways, particularly the PI3K Akt FOXO1 axis. Most studies also reported favorable effects on lipid profiles and reductions in oxidative stress markers. Although one study reported no significant improvement in glycemic indices, the overall pattern indicated consistent positive metabolic effects. This systematic review suggests that resveratrol exerts antidiabetic effects in animal models of T2DM by improving glycemic control, insulin signaling, lipid metabolism, and oxidative stress regulation. However, further well designed studies are needed to clarify dose response relationships and facilitate clinical translation.
Systematic Review: The Effectiveness of Resveratrol in Inhibiting Colorectal Cancer Cell Proliferation Rifai B, Muh.; Syamsu, Rachmat Faisal; Palloge, Salahuddin Andi
Journal La Medihealtico Vol. 6 No. 5 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i5.2715

Abstract

Colorectal cancer is one of the leading causes of cancer-related morbidity and mortality worldwide, with increasing incidence particularly in developing countries. Conventional treatments face challenges such as resistance and toxicity. Resveratrol, a natural polyphenol found in grapes, peanuts, and berries, has been reported to exert antioxidant, anti-inflammatory, and anticancer effects. To systematically evaluate the effects of resveratrol on parameters related to colorectal cancer in experimental animal models. Method: A qualitative systematic review was conducted by searching PubMed, Scopus, Sinta, and Google Scholar for studies published between 2020 and 2025. Inclusion criteria were in vivo studies using animal models of colorectal cancer, with resveratrol as the sole intervention, and reporting at least one parameter such as apoptosis, cell proliferation, oxidative stress, or inflammatory markers. Studies in vitro, in humans, or with combined interventions were excluded. A total of 512 articles were initially identified. After screening and applying eligibility criteria, seven studies were included. The findings consistently demonstrated that resveratrol suppressed tumor initiation and progression via multiple mechanisms: inhibition of Wnt/β-catenin signaling, induction of apoptosis and autophagy through FOXQ1 inhibition, reduction of oxidative stress and DNA damage, suppression of NF-κB signaling, and inhibition of epithelial mesenchymal transition and angiogenesis. Furthermore, resveratrol reduced tumor burden, metastasis, and inflammation in various colorectal cancer models. Resveratrol exhibits significant chemopreventive and therapeutic potential against colorectal cancer through pleiotropic mechanisms targeting proliferation, apoptosis, oxidative stress, and inflammation. These findings support resveratrol as a promising candidate for adjunctive therapy, although further clinical studies are required to confirm efficacy and safety in humans.
Co-Authors 'Aisy S.Day, Siti Rahadatul Abdillah, Andi Rachmat Abdullah, A. Adila Permata Abdullah, Rezky Putri Indrawati Adriana, Delvi Ahmad Ahmad Ahyar, Farah Firjatillah Akbar, Muhammad Alief Alfaruq, Zulfi Zain Alhumaerah, Musdalifah Alie, Nuzul Shafira Alimun, Sity Rahmatia Amaliyah B, Ilma Khaerina Amrizal Muchtar Ancha, Annisa Andry Pratama, Andry Anggita, Dwi Aqillah Rahis, Fadiah Dewi Arfah, Arni Isnaini Arifin, Arina Fathiyyah Astri Wahyuni Azis, Arung Anugrah Al Bamahry, Aryanti R. Bazith, Akhmad Bima, Irmayanti Haidir Bima, Irmayanti Johar Bonita, Nita Burhanuddin Bahar Dahlia Dahlia Dahliah, Dahliah Darariani Iskandar Dewi, Anna Sari Domu, Anugrah Julistiar Aksan Efendy, Rizki Amalia Evi Sulastri fatimah Fatimah Fattah, Nurfachanti febriyanti febriyanti Gani, Azis Beru Gayatri, Sri Wahyuni Hadi, Santriani Hakim, Dwi Ashariyanti Hamsah, M. Hasbi, Berry Erida Hazminafni, Nur Zahra Noor Khaerani Hikmah, Annisa Duratul Ida Royani Ikram, Dzul Ilda, Khusnul Indarwati Abdullah, Rezky Putri Indarwati, Rezky Putri Irna Diyana Kartika Jam’an Laoh, Abulkahiril Jannah, Reza Miftahul Jaya, Muh. Alim Jaya, Muhammad Alim Juliani, Sri Julyani, Sry Kamaluddin, Irna Diyana Kartika Karim, Abdul Mubdi Ardiansar Arifuddin Karim, Marzelina Kartika, Andy Visi Khalid, Nur Fadhillah Laddo, Nirwana Latief, Shofiyah Lausiri, Satharia Listin, Nurhalisa M. Yogi Riyantama Isjoni Makmun, Armanto Mamile, Rahmawati Mangarengi, Yusriani Mappaware, Nasrudin Andi Maulidiah, Nurul Farah Mayo, Abbas Ali Mochammad Erwin Rachman, Mochammad Erwin Mochtar, Shulhana Mokhtar, Shulhana Mubarok, Rizqi Muchsin, Achmad Harun Mukhtar, Shulhana Mulyadi, Farah Ekawati Musa, Inna Mutmainnah Muthalib, Iqra Muhamad Zulmadhani Z. N, Hermiaty N. Hamzah, Pratiwi Namirah, Hanna Aulia Nasruddin, Hermiaty Nawawi, Nurafni Maharani Noor, Raehana Norman, Fadhilah Nulanda, Mona Nurdin, Abbas Zavery Nurdin, Abbas Zavey Nurfadhilah, Nadiyah Nurhikma, Nurhikma Nurmadilla, Nesyana Ode Arli, Rosmelidian Safari Oktaviani, Mentari Dwi Palloge, Salahuddin Andi Palo, Nurul Aisyah Pramono, Sigit Dwi Purnamasari, Reeny Putra, Fadil Mula Putri, Riski Astriani Rachman, Moch. Erwin Rachmat, Rizqah Aulyna Rafiqah, Rafiqah Rahman, Dinda Briliani Rahman, Dinda Briliany Rahman, Mochammad Erwin Rasfayanah, Rasfayanah Rifai B, Muh. Rizki Salsabilah R, Andi Fatihah Safitri, Asrini Saifullah, Yayan Yustika Sakti, Muhammad Reyhan Salam, Annisa Salsabilah Salmalia, Raisya Zahra Salsabila, Lu’lu Luqyana Amirah Saputra, Adrian Shamad, Muhammad Ishaq Sholehah, Mar'atun Siska Nuryanti, Siska Sodiqah, Yani Sri Wahyu Surdam, Zulfiyah Suryo, Ersya Putri Alifya Syamsu Rijal Tebi, Tebi Thahir, Ilyas Thahira, Yugni Maula Utami, Dian Fahmi Utami, Nurfika Wardayani Wardayani, Wardayani Wello, Eny Arlini Yusuf, Andini Zahiyah, Azzah Zulfahmidah, Zulfahmidah Zulfitriani Murfat